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4 results on '"Dian Yu Chen"'

1. Inflammatory cytokines and apoptosis related proteins participate in the formation of deep vein thrombosis of lower extremity in rats

Author

FENG Tao, LI Jing, PAN Jin-qiang, ZHENG Dian-yu, CHEN Hui, Duman BAGODAT, GENG Zhong-li

Subjects
deep vein thrombosis, vein endothelial cells, bcl-2, bax, Medicine
Abstract

Objective To investigate the expression and regulation mechanism of IL-1β, TNF-α, Bcl-2 and BAX in rats with inferior vena cava thrombosis. Methods The rats were randomly divided into control group, inferior vena cava thrombus model group, mir-5189-3p inhibitor group and miR-5189-3p inhibitor NC group. Twenty-four hours later, the animals were killed by cervical vertebrae dislocation, blood samples were taken and tissues were collected; the level of IL-1β and TNF-α in blood samples were detected by ELISA; The morphology of inferior vena cava thrombus was microscopied with HE staining; The expression of Bcl-2 and BAX protein in inferior vena cava was detected by Western blot. Results The level of IL-1β and TNF-α in the model group was significantly higher than those in the control group (P＜0.05); the level of miR-5189-3p inhibitor group was significantly higher than that in the control group (P＜0.05); the level of miR-5189-3p inhibitor group was significantly higher than that in the model group (P＜0.05); the level of miR-5189-3p inhibitor negative control group was significantly lower than that in the model group (P＜0.05). In the model group and miR-5189-3p inhibitor group, red thrombus and mixed thrombus were found; the vessel showed inflammatory cell infiltration, and thrombus in the negative control group of miR-5189-3p inhibitor was obviously organized, with signs of blood flow recanalization. Bcl-2/BAX protein level in the model group was significantly lower than that in the control group (P＜0.05); miR-5189-3p inhibitor group was significantly lower than that in the model group (P＜0.05); while miR-5189-3p inhibitor in negative control group was significantly higher than that in the model group (P＜0.05). Conclusions miR-5189-3p can affect the formation of DVT by regulating the expression of inflammatory cytokines and apoptosis related proteins, which provides a new idea and basis for later research.

Published
2021

2. Isomer directed assembly of two Ca(II) compounds based on 5-(n-pyridyl)tetrazole-2-isopropanoic acid (n = 2, 3) and action against Hela cells

Author

Xin Zhang, Guang Ming Li, Dian Yu Chen, Gao-Wen Yang, Xiao Qing Gu, and Qiao-Yun Li

Subjects
biology, 010405 organic chemistry, Stereochemistry, 010402 general chemistry, biology.organism_classification, 01 natural sciences, In vitro, 0104 chemical sciences, HeLa, chemistry.chemical_compound, chemistry, Materials Chemistry, Tetrazole, Physical and Theoretical Chemistry, Bifunctional
Abstract

Isomers sometimes play a fundamental role in the formation of coordination architectures. In this article, bifunctional 5-(n-pyridyl)tetrazole-2-isopropanoic acid (n = 2, 3) has been designed and prepared. Then, reactions of Ca(NO3)2·4H2O with isomeric 5-(n-pyridyl)tetrazole-2-isopropanoic acid (denoted as Hn-pytzipa, n = 2, 3) afforded mononuclear [Ca(2-pytzipa)2(H2O)4] (1) and one-dimensional [Ca(3-pytzipa)2(H2O)2]n (2), respectively. In 1, 2-pytzipa is a bidentate ligand which chelates one Ca(II) via the nitrogen atoms of the pyridine and tetrazole rings while in 2, 3-pytzipa bridges adjacent Ca(II) centers in a μ 1,1,3-COO mode. PEG-5000 (poly(ethyleneglycol-5000)) coated [Ca(2-pytzipa)2(H2O)4] (1) and [Ca(3-pytzipa)2(H2O)2]n (2) nanoparticles (NPs) show toxicity towards Hela cells, but the ligands are non-toxic in nature and 2 is superior to 1. Furthermore, cell migration across a 2D artificial gap indicates that both NPs can inhibit the migration of Hela cells.

Published
2023
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3. Regulation of deprotonation of 3,3-di(1H-tetrazol-5-yl)pentanedioic acid: Solvothermal synthesis of La(III) and heterometallic La(III)/Cu(II) compounds for ablation of A549 cells

Author

Dian Yu Chen, Meng Yue Guo, Yue Kang Li, Qiao-Yun Li, Liang Zhao, Gao-Wen Yang, and Xin Zhang

Subjects
inorganic chemicals, Valence (chemistry), 010405 organic chemistry, Chemistry, Metal ions in aqueous solution, Solvothermal synthesis, Crystal structure, 010402 general chemistry, Condensed Matter Physics, 01 natural sciences, Medicinal chemistry, 0104 chemical sciences, Electronic, Optical and Magnetic Materials, Inorganic Chemistry, chemistry.chemical_compound, Deprotonation, Materials Chemistry, Ceramics and Composites, Hydrothermal synthesis, Tetrazole, Carboxylate, Physical and Theoretical Chemistry
Abstract

3,3-di(1H-tetrazol-5-yl)pentanedioic acid (H4dtzpda) can display tunable valence when reacted with different metal ions because it has four acidic hydrogen atoms of both tetrazole rings and carboxylate groups. Solvothermal reactions of H4dtzpda with La(NO3)2·6H2O or La(NO3)3·6H2O/Cu(NO3)2·6H2O afforded a one dimensional [La(Hdtzpda)(H2O)4]·4H2O (1) and a three dimensional [La2Cu(dtzpda)2(H2O)10]·4H2O (2), respectively, where only three acidic hydrogen atoms of H4dtzpda are deprotonated in compound 1 while all the four acidic ones are deprotonated in compound 2. In compound 1, Hdtzpda3- is a penta-dentate ligand to bridge La(III) centers via only oxygen atoms of the carboxylate group while in compound 2, dtzpda4- is a hepta-dentate one via not only the oxygen atoms of the carboxylate group but also the nitrogen atoms of the tetrazole rings. PEG-5000 (poly(ethyleneglycol-5000)) coated compound 1 or 2 nanoparticles (NPs) have good dispersity in water. Cytotoxicity study on A549 cells (human caucasian lung carcinoma) shows that compound 2 (half-maximal inhibitory concentration, IC50～18 μg/mL) is superior to compound 1 (IC50～38 μg/mL). Furthermore, both NPs of the two compounds are able to inhibit the migration of A549 cells, indicating their potential to inhibit the transfer of tumors in vivo.

Published
2018

4. Nd(III) and Dy(III) coordination compounds based on 1H-tetrazolate-5-acetic acid ligands: Synthesis, crystal structures and catalytic properties

Author

Gao-Wen Yang, Ming-Hua He, Wei Shen, Qiao-Yun Li, Jing-Jing Zhao, Kun Gu, Chun Zhai, Dian-Yu Chen, and Lei Shen

Subjects
chemistry.chemical_classification, Inorganic chemistry, Infrared spectroscopy, Crystal structure, Condensed Matter Physics, Electronic, Optical and Magnetic Materials, Styrene, Coordination complex, Catalysis, Inorganic Chemistry, chemistry.chemical_compound, Acetic acid, chemistry, Polymerization, X-ray crystallography, Polymer chemistry, Materials Chemistry, Ceramics and Composites, Physical and Theoretical Chemistry
Abstract

Reactions of 1H-tetrazolate-5-acetic acid(H2tza) with Nd(NO3)3·6H2O or Dy(NO3)3·6H2O with the presence of KOH under solvothermal conditions, produced two new coordination compounds, [M2(tza)3(H2O)6]·2H2O [M=Nd(1), Dy(2)]. Both compounds were structurally characterized by elemental analysis, IR spectroscopy and single-crystal X-ray diffraction. Compounds 1 and 2 reveal 1D structures via bridging tza as linker. Furthermore, the compounds 1 and 2 showed a specific and good catalytic behavior for the polymerization of styrene, and the polymerization showed controlled characteristics.

Published
2012

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