1. Work-related asthma in France: recent trends for the period 2001–2009
- Author
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M. Telle-Lamberton, Jacques Ameille, Patrick Brochard, Alain Bergeret, Lynda Larabi, Christophe Paris, Dominique Choudat, Roseanne McNamee, D. Dupas, Vincent Bonneterre, Lynda Bensefa-Colas, Joseph Ngatchou-Wandji, Fabrice Herin, Robert Garnier, Amandine Luc, Jean-Claude Pairon, Raymond Agius, Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Institut Élie Cartan de Nancy (IECN), and Institut National de Recherche en Informatique et en Automatique (Inria)-Université Henri Poincaré - Nancy 1 (UHP)-Université Nancy 2-Institut National Polytechnique de Lorraine (INPL)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Adult ,Male ,Negative binomial distribution ,Air Pollutants, Occupational ,Work related asthma ,Logistic regression ,Occupational safety and health ,03 medical and health sciences ,0302 clinical medicine ,[MATH.MATH-ST]Mathematics [math]/Statistics [math.ST] ,Occupational Exposure ,Odds Ratio ,medicine ,Humans ,Industry ,030212 general & internal medicine ,Asthma, Occupational ,Social sector ,ComputingMilieux_MISCELLANEOUS ,Asthma ,Objective knowledge ,[STAT.AP]Statistics [stat]/Applications [stat.AP] ,business.industry ,Incidence ,Public Health, Environmental and Occupational Health ,Middle Aged ,medicine.disease ,Health Surveys ,Ammonium compounds ,3. Good health ,Logistic Models ,030228 respiratory system ,Population Surveillance ,Female ,France ,business ,[STAT.ME]Statistics [stat]/Methodology [stat.ME] ,Demography - Abstract
Objective Knowledge on the time-course (trends) of work-related asthma (WRA) remains sparse. The aim of this study was to describe WRA trends in terms of industrial activities and the main causal agents in France over the period 2001–2009. Method Data were collected from the French national network of occupational health surveillance and prevention ( Reseau National de Vigilance et de Prevention des Pathologies Professionnelles (RNV3P)). Several statistical models (non-parametric test, zero-inflated negative binomial, logistic regression and time-series models) were used and compared with assess trends. Results Over the study period, 2914 WRA cases were included in the network. A significant decrease was observed overall and for some agents such as isocyanates (p=0.007), aldehydes (p=0.01) and latex (p=0.01). Conversely, a significant increase was observed for cases related to exposure to quaternary ammonium compounds (p=0.003). The health and social sector demonstrated both a growing number of cases related to the use of quaternary ammonium compounds and a decrease of cases related to aldehyde and latex exposure. Conclusions WRA declined in France over the study period. The only significant increase concerned WRA related to exposure to quaternary ammonium compounds. Zero-inflated negative binomial and logistic regression models appear to describe adequately these data.
- Published
- 2012