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4. Note d'étape sur le Health Data Hub, les entrepôts de données de santé et les questions éthiques posées par la collecte et le traitement de données desanté dites « massives »

Author

Lombrail, Pierre, Nisand, Israël, Dosquet, Christine, Lesaulnier, Frédérique, Bourgain, Catherine, Baertschi, Bernard, Buisson, Anne, Cornu, Catherine, Hirsch, François, Lemaitre, Christine, Ledoux, Sylvie, Mathieu, Flavie, Rémy-Jouet, Isabelle, Sadani, Yamina, Duchange, Nathalie, Comité d'éthique de l'Inserm (CEI), Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris 13 (UP13), Université de Strasbourg (UNISTRA), AP -Comité d'évaluation éthique de l'Inserm, CERMES3 - Centre de recherche Médecine, sciences, santé, santé mentale, société (CERMES3 - UMR 8211 / U988 / UM 7), École des hautes études en sciences sociales (EHESS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université de Genève = University of Geneva (UNIGE), Association François Aupetit, Inserm - Ethique des sciences de la vie, éthique de la recherche dans les pays du Sud, Inserm - Institut Biologie cellulaire, développement et évolution, Inserm - Service Sciences et société, and Inserm - Assurance qualité, technologies pour la santé

Subjects
Note Comité Ethique Inserm, CEI, [SDV.ETH] Life Sciences [q-bio]/Ethics, [SDV.ETH]Life Sciences [q-bio]/Ethics
Abstract

Note du Comité Ethique, Groupe HDH-DSM; Le CEI a mis en place un groupe de travail en octobre 2020 du fait des interrogations soulevées par la décision de confier l’hébergement des données du Système national des Données de Santé (SNDS) rassemblées par le Health Data Hub (HDH ou PDS pour Plateforme des données de santé) à la société Microsoft à travers son « cloud » Azure. Le groupe a été amené rapidement à élargir sa réflexion à un ensemble plus vaste de questions éthiques soulevées par la collecte et le traitement de données dites « massives » pouvant s’apparenter de près ou de loin à des données de santé.

Published
2022

5. Interim Memo on the Health Data Hub, health data warehouses, and the ethical questions raised by the collection and processing of Health Big Data

Author

Lombrail, Pierre, Nisand, Israël, Dosquet, Christine, Lesaulnier, Frédérique, Bourgain, Catherine, Baertschi, Bernard, Buisson, Anne, Cornu, Catherine, Hirsch, François, Lemaitre, Christine, Ledoux, Sylvie, Mathieu, Flavie, Rémy-Jouet, Isabelle, Sadani, Yamina, Duchange, Nathalie, The Inserm Ethics Committee (IEC), Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris 13 (UP13), Université de Strasbourg (UNISTRA), AP -Comité d'évaluation éthique de l'Inserm, CERMES3 - Centre de recherche Médecine, sciences, santé, santé mentale, société (CERMES3 - UMR 8211 / U988 / UM 7), École des hautes études en sciences sociales (EHESS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université de Genève = University of Geneva (UNIGE), Association François Aupetit, Inserm - Ethique des sciences de la vie, éthique de la recherche dans les pays du Sud, Inserm - Institut Biologie cellulaire, développement et évolution, Inserm - Service Sciences et société, and Inserm - Assurance qualité, technologies pour la santé

Subjects
Note Inserm Ethics Committee, Note Comité Ethique Inserm, IEC, CEI, [SDV.ETH] Life Sciences [q-bio]/Ethics, [SDV.ETH]Life Sciences [q-bio]/Ethics
Abstract

Note from the Ethics Committee, "HDH/HBD" Working group; In October 2020, the Inserm Ethics Committee (CEI) set up a Working Group in response to the questions raised by the decision to entrust the hosting of French National Health Data System (SNDS) data gathered by the Health Data Hub (HDH) to Microsoft through its cloud computing platform Azure. However, the group very quickly had to expand its reflection to include a much broader set of ethical questions raised by the collection and processing of Big Data relating to health data however remotely.

Published
2022

6. Impact of NFE2 mutations on AML transformation and overall survival in patients with myeloproliferative neoplasms

Author

Marcault, Clémence, Zhao, Lin-Pierre, Maslah, Nabih, Verger, Emmanuelle, Daltro de Oliveira, Rafael, Soret-Dulphy, Juliette, Cazaux, Marine, Gauthier, Nicolas, Roux, Blandine, Clappier, Emmanuelle, Parquet, Nathalie, Dosquet, Christine, Réa, Delphine, Zini, Jean-Marc, Vainchenker, William, Raffoux, Emmanuel, Giraudier, Stéphane, Kiladjian, Jean-Jacques, Cassinat, Bruno, and Benajiba, Lina

Published
2021
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7. Chronic Exposure to Cytoreductive Treatment Shapes Clonal Evolution in Myeloproliferative Neoplasms

Author

Zhao, Lin-Pierre, primary, Maslah, Nabih, additional, Daltro De Oliveira, Rafael, additional, Verger, Emmanuelle, additional, Soret-Dulphy, Juliette, additional, Marcault, Clemence, additional, Parquet, Nathalie, additional, Dosquet, Christine, additional, Vainchenker, William, additional, Raffoux, Emmanuel, additional, Giraudier, Stephane, additional, Kiladjian, Jean-Jacques, additional, Cassinat, Bruno, additional, Benajiba, Lina, additional, and Cazaux, Marine, additional

Published
2021
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8. Myeloproliferative Neoplasms (MPN) Clonal Evolution Landscape and Its Impact on Patients' Prognosis

Author

Zhao, Lin-Pierre, primary, Cazaux, Marine, additional, Maslah, Nabih, additional, Daltro De Oliveira, Rafael, additional, Verger, Emmanuelle, additional, Soret-Dulphy, Juliette, additional, Marcault, Clemence, additional, Parquet, Nathalie, additional, Dosquet, Christine, additional, Vainchenker, William, additional, Raffoux, Emmanuel, additional, Giraudier, Stephane, additional, Kiladjian, Jean-Jacques, additional, Cassinat, Bruno, additional, and Benajiba, Lina, additional

Published
2021
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10. Evaluation of PReimplantation embryo Aptitude for DEvelopment (EPRADE)

Author

Baertschi, Bernard, Bed’hom, Bertrand, Dosquet, Christine, Grosset, Marie, Dubart-Kupperschmitt, Anne, Jouannet, Pierre, Lemaitre, Christine, Moutel, Grégoire, Nisand, Israël, Remy-Jouet, Isabelle, Duchange, Nathalie, Comité d'éthique de l'Inserm (CEI), Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Genève = University of Geneva (UNIGE), Muséum national d'Histoire naturelle (MNHN), Institut de Systématique, Evolution, Biodiversité (ISYEB ), Muséum national d'Histoire naturelle (MNHN)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), AP -Comité d'évaluation éthique de l'Inserm, Physiopathologie et traitement des maladies du foie, Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Fertilité et reproduction humaines- Université Paris 5, CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Espace régional de réflexion éthique de Normandie (EREN), Biologie de la reproduction, Université de Strasbourg (UNISTRA), and Inserm - Assurance qualité, technologies pour la santé

Subjects
Note Inserm Ethics Committee, Note Comité Ethique Inserm, IEC, CEI, [SDV.ETH] Life Sciences [q-bio]/Ethics, [SDV.ETH]Life Sciences [q-bio]/Ethics
Abstract

Memo by the Inserm Ethics Committee. Embryo and Developmental Group. Written by: Bernard Baertschi and Pierre Jouannet

Published
2021

11. L’évaluation préimplantatoire de l’aptitude au développement embryonnaire (EPRADE)

Author

Baertschi, Bernard, Bed’hom, Bertrand, Dosquet, Christine, Grosset, Marie, Dubart-Kupperschmitt, Anne, Jouannet, Pierre, Lemaitre, Christine, Moutel, Grégoire, Nisand, Israël, Rémy-Jouet, Isabelle, Duchange, Nathalie, Comité d'éthique de l'Inserm (CEI), Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Genève = University of Geneva (UNIGE), Muséum national d'Histoire naturelle (MNHN), Institut de Systématique, Evolution, Biodiversité (ISYEB ), Muséum national d'Histoire naturelle (MNHN)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), AP -Comité d'évaluation éthique de l'Inserm, Physiopathologie et traitement des maladies du foie, Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Fertilité et reproduction humaines- Université Paris 5, CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Espace régional de réflexion éthique de Normandie (EREN), Biologie de la reproduction, Université de Strasbourg (UNISTRA), and Inserm - Assurance qualité, technologies pour la santé

Subjects
DPI, Procréation médicalement assistée, Comité Ethique Inserm, Diagnostic préimplantatoire, Assistance médicale à la procréation, CEI, [SDV.ETH] Life Sciences [q-bio]/Ethics, Embryon, FIV, PMA, AMP, Fécondation in vitro, [SDV.ETH]Life Sciences [q-bio]/Ethics
Abstract

Note du groupe « Embryon et développement » du Comité d'Éthique de l'INSERM. Rédaction: Bernard Baertschi et Pierre Jouannet

Published
2021

12. Interferon Alpha Therapy Increases Pro-Thrombotic Biomarkers in Patients with Myeloproliferative Neoplasms

Author

Faille, Dorothée, Lamrani, Lamia, Loyau, Stéphane, Huisse, Marie-Geneviève, Bourrienne, Marie-Charlotte, Alkhaier, Sawsaneh, Cassinat, Bruno, Boulaftali, Yacine, Debus, Jérôme, Jandrot-Perrus, Martine, Chomienne, Christine, Dosquet, Christine, and Ajzenberg, Nadine

Subjects
hemic and lymphatic diseases, prothrombotic markers, interferon, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282, Article, myeloproliferative neoplasms
Abstract

Myeloproliferative neoplasms (MPN) are associated with an increased risk of arterial and venous thrombosis. Pegylated-interferon alpha (IFN) and hydroxyurea (HU) are commonly used to treat MPN, but their effect on hemostasis has not yet been studied. The aim of our study was to determine whether IFN and HU impact the biological hemostatic profile of MPN patients by studying markers of endothelial, platelet, and coagulation activation. A total of 85 patients (50 polycythemia vera and 35 essential thrombocythemia) were included: 28 treated with IFN, 35 with HU, and 22 with no cytoreductive drug (non-treated, NT). Von Willebrand factor, shear-induced platelet aggregation, factor VIII coagulant activity (FVIII:C), fibrinogen, and thrombin generation with and without exogenous thrombomodulin were significantly higher in IFN-treated patients compared to NT patients, while protein S anticoagulant activity was lower. In 10 patients in whom IFN therapy was discontinued, these hemostatic biomarkers returned to the values observed in NT patients, strongly suggesting an impact of IFN therapy on endothelial and coagulation activation. Overall, our study shows that treatment with IFN is associated with significant and reversible effects on the biological hemostatic profile of MPN patients. Whether they could be associated with an increased thrombotic risk remains to be determined in further randomized clinical studies.

Published
2020

13. Anemia and hemodilution: analysis of a single center cohort based on 2,858 red cell mass measurements

Author

Drevon, Louis, primary, Maslah, Nabih, additional, Soret-Dulphy, Juliette, additional, Dosquet, Christine, additional, Ravdan, Odno, additional, Vercellino, Laetitia, additional, Belkhodja, Celia, additional, Parquet, Nathalie, additional, Brignier, Anne C., additional, Schlageter, Marie-Helene, additional, Cassinat, Bruno, additional, Kiladjian, Jean-Jacques, additional, Chomienne, Christine, additional, and Giraudier, Stéphane, additional

Published
2021
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16. SF3B1 mutations in the Driver Clone Increase the Risk of Evolution to Myelofibrosis in Patients with Myeloproliferative Neoplasms (MPN)

Author

Zhao, Lin-Pierre, primary, Daltro De Oliveira, Rafael, additional, Marcault, Clemence, additional, Soret, Juliette, additional, Gauthier, Nicolas, additional, Verger, Emmanuelle, additional, Maslah, Nabih, additional, Roux, Blandine, additional, Parquet, Nathalie, additional, Dosquet, Christine, additional, Rea, Delphine, additional, Zini, Jean-Marc, additional, Vainchenker, William, additional, Raffoux, Emmanuel, additional, Giraudier, Stephane, additional, Cassinat, Bruno, additional, Kiladjian, Jean-Jacques, additional, and Benajiba, Lina, additional

Published
2020
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17. NFE2 Mutations Impact AML Transformation and Overall Survival in Patients with Myeloproliferative Neoplasms (MPN)

Author

Marcault, Clemence, primary, Zhao, Lin-Pierre, additional, Daltro De Oliveira, Rafael, additional, Soret, Juliette, additional, Gauthier, Nicolas, additional, Verger, Emmanuelle, additional, Maslah, Nabih, additional, Roux, Blandine, additional, Parquet, Nathalie, additional, Dosquet, Christine, additional, Rea, Delphine, additional, Zini, Jean-Marc, additional, Vainchenker, William, additional, Raffoux, Emmanuel, additional, Giraudier, Stephane, additional, Cassinat, Bruno, additional, Kiladjian, Jean-Jacques, additional, and Benajiba, Lina, additional

Published
2020
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20. Organoids Research: What are the ethical issues?

Author

Baertschi, Bernard, Atlan, Henri, Botbol-Baum, Mylène, Bed’hom, Bertrand, Combrisson, Hélène, Dosquet, Christine, Dubart-Kupperschmitt, Anne, Hirsch, François, Jouannet, Pierre, Remy-Jouet, Isabelle, Lemaitre, Christine, Moutel, Grégoire, Duchange, Nathalie, The Inserm Ethics Committee (IEC), Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Genève = University of Geneva (UNIGE), École des hautes études en sciences sociales (EHESS), Université Catholique de Louvain = Catholic University of Louvain (UCL), Muséum national d'Histoire naturelle (MNHN), Institut de Systématique, Evolution, Biodiversité (ISYEB ), Muséum national d'Histoire naturelle (MNHN)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), École nationale vétérinaire - Alfort (ENVA), AP -Comité d'évaluation éthique de l'Inserm, Physiopathologie et traitement des maladies du foie, Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Inserm - Ethique des sciences de la vie, éthique de la recherche dans les pays du Sud, Fertilité et reproduction humaines- Université Paris 5, Inserm - Assurance qualité, technologies pour la santé, Inserm - Institut Biologie cellulaire, développement et évolution, CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), and Espace régional de réflexion éthique de Normandie (EREN)

Subjects
Note Inserm Ethics Committee, Note Comité Ethique Inserm, IEC, CEI, [SDV.ETH] Life Sciences [q-bio]/Ethics, [SDV.ETH]Life Sciences [q-bio]/Ethics
Abstract

Note from the Ethics committee.

Published
2020

21. La recherche sur les organoïdes: quels enjeux éthiques?

Author

Baertschi, Bernard, Atlan, Henri, Botbol-Baum, Mylène, Bed’hom, Bertrand, Combrisson, Hélène, Dosquet, Christine, Dubart-Kupperschmitt, Anne, Hirsch, François, Jouannet, Pierre, Remy-Jouet, Isabelle, Lemaitre, Christine, Moutel, Grégoire, Duchange, Nathalie, Comité d'éthique de l'Inserm (CEI), Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Genève = University of Geneva (UNIGE), École des hautes études en sciences sociales (EHESS), Université Catholique de Louvain = Catholic University of Louvain (UCL), Muséum national d'Histoire naturelle (MNHN), Institut de Systématique, Evolution, Biodiversité (ISYEB ), Muséum national d'Histoire naturelle (MNHN)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), École nationale vétérinaire - Alfort (ENVA), AP -Comité d'évaluation éthique de l'Inserm, Physiopathologie et traitement des maladies du foie, Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Inserm - Ethique des sciences de la vie, éthique de la recherche dans les pays du Sud, Fertilité et reproduction humaines- Université Paris 5, Inserm - Assurance qualité, technologies pour la santé, Inserm - Institut Biologie cellulaire, développement et évolution, CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), and Espace régional de réflexion éthique de Normandie (EREN)

Subjects
Note Comité Ethique Inserm, iPS, MEUS, cellules souches, organe, CEI, organoïdes, [SDV.ETH] Life Sciences [q-bio]/Ethics, [SDV.ETH]Life Sciences [q-bio]/Ethics
Abstract

Note du Comité. Groupe "Recherche sur les organoïdes"

Published
2020

24. Research on Embryos and Embryonic Models for Scientific Use (EMSUs)

Author

Baertschi, Bernard, Brodin, Marc, Dosquet, Christine, Jouannet, Pierre, Lapointe, Anne-Sophie, Merchant, Jennifer, Moutel, Grégoire, Duchange, Nathalie, The Inserm Ethics Committee (IEC), Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Genève = University of Geneva (UNIGE), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Diderot - Paris 7 (UPD7), AP -Comité d'évaluation éthique de l'Inserm, Université Paris Descartes - Paris 5 (UPD5), Ministère de la santé, Université Panthéon-Assas (UP2), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), and Espace régional de réflexion éthique de Normandie (EREN)

Subjects
animal structures, Note Inserm Ethics Committee, Note Comité Ethique Inserm, embryonic structures, education, IEC, CEI, [SDV.ETH] Life Sciences [q-bio]/Ethics, [SDV.ETH]Life Sciences [q-bio]/Ethics
Abstract

Note from the Ethics Committee 'Embryo and Developemental" Group

Published
2019

27. De la recherche à la thérapie embryonnaire

Author

Baertschi, Bernard, Brodin, Marc, Dosquet, Christine, Jouannet, Pierre, Lapointe, Anne-Sophie, Merchant, Jennifer, Moutel, Grégoire, Duchange, Nathalie, Comité d'éthique de l'Inserm (CEI), Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Diderot - Paris 7 (UPD7), AP -Comité d'évaluation éthique de l'Inserm, Université Paris 2 - Enjeux bioéthiques des politiques publiques comparées, CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), and Espace régional de réflexion éthique de Normandie (EREN)

Subjects
Note Comité Ethique Inserm, embryon, approches thérapeutiques, [SDV.BDD] Life Sciences [q-bio]/Development Biology, CEI, recherche, [SDV.ETH] Life Sciences [q-bio]/Ethics, [SDV.BDD]Life Sciences [q-bio]/Development Biology, [SDV.ETH]Life Sciences [q-bio]/Ethics
Abstract

Notes du Comité; Travaux du groupe "Embryon et Développement"

Published
2017

28. From Embryo Research to Therapy

Author

Baertschi, Bernard, Brodin, Marc, Dosquet, Christine, Jouannet, Pierre, Lapointe, Anne-Sophie, Merchant, Jennifer, Moutel, Grégoire, Duchange, Nathalie, The Inserm Ethics Committee (IEC), Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Genève = University of Geneva (UNIGE), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Diderot - Paris 7 (UPD7), AP -Comité d'évaluation éthique de l'Inserm, Université Paris Descartes - Paris 5 (UPD5), Ministère des Solidarités et de la Santé [Paris, France], Université Panthéon-Assas (UP2), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), and Espace régional de réflexion éthique de Normandie (EREN)

Subjects
therapy, animal structures, Note Inserm Ethics Committee, Note Comité Ethique Inserm, embryonic structures, education, embryo, IEC, CEI, [SDV.ETH] Life Sciences [q-bio]/Ethics, [SDV.ETH]Life Sciences [q-bio]/Ethics
Abstract

Note from the Inserm Ethics Committee. "Embryo and Developmental Research" group

Published
2017

31. Benefits and pitfalls of pegylated interferon-α2a therapy in patients with myeloproliferative neoplasm-associated myelofibrosis: a French Intergroup of Myeloproliferative neoplasms (FIM) study

Author

Ianotto, Jean-Christophe, primary, Chauveau, Aurélie, additional, Boyer-Perrard, Françoise, additional, Gyan, Emmanuel, additional, Laribi, Kamel, additional, Cony-Makhoul, Pascale, additional, Demory, Jean-Loup, additional, de Renzis, Benoit, additional, Dosquet, Christine, additional, Rey, Jerome, additional, Roy, Lydia, additional, Dupriez, Brigitte, additional, Knoops, Laurent, additional, Legros, Laurence, additional, Malou, Mohamed, additional, Hutin, Pascal, additional, Ranta, Dana, additional, Benbrahim, Omar, additional, Ugo, Valérie, additional, Lippert, Eric, additional, and Kiladjian, Jean-Jacques, additional

Published
2017
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33. Assessing Bone Marrow Activity in Patients with Myelofibrosis: Results of a Pilot Study of 18F-FLT PET

Author

Vercellino, Laetitia, primary, Ouvrier, Matthieu John, additional, Barré, Emmanuelle, additional, Cassinat, Bruno, additional, de Beco, Virginie, additional, Dosquet, Christine, additional, Chevret, Sylvie, additional, Meignin, Véronique, additional, Chomienne, Christine, additional, Toubert, Marie-Elisabeth, additional, Merlet, Pascal, additional, and Kiladjian, Jean-Jacques, additional

Published
2017
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34. Autologous 111 Indium-Oxinate-Labelled Platelet Sequestration Study in Patients with Immune Thrombocytopenia Treated By Thrombopoietic Receptor-Agonists

Author

Mahevas, Matthieu, primary, Van Eeckhoudt, Sandrine, additional, Moulis, Guillaume, additional, Dosquet, Christine, additional, Michel, Marc, additional, Limal, Nicolas, additional, Languille, Laetitia, additional, Alkaeir, Sawsaneh, additional, Bierling, Philippe, additional, Dossier, Antoine, additional, Duriez, Frédéric, additional, Galicier, Lionel, additional, Morin, Anne-Sophie, additional, Tamburini, Jérôme, additional, Chaoui, Driss, additional, Bouscary, Didier, additional, AL Jijakli, Ahmad, additional, Khellaf, Mehdi, additional, Vaida, Ioana, additional, Godeau, Bertrand, additional, and Chomienne, Christine, additional

Published
2016
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35. Pro-Coagulant and Pro-Inflammatory Effect of Interferon Alpha in Myeloproliferative Neoplasms

Author

Ajzenberg, Nadine, primary, Faille, Dorothee, additional, Lamrani, Lamia, additional, Loyau, Stéphane, additional, Huisse, Marie-Geneviève, additional, Dumontier, Nicolas, additional, Jandrot-Perrus, Martine, additional, Alkhaier, Sawsaneh, additional, Cassinat, Bruno, additional, Chomienne, Christine, additional, and Dosquet, Christine, additional

Published
2016
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37. Hind limb unloading, a model of spaceflight conditions, leads to decreased B lymphopoiesis similar to aging

Author

Lescale, Chloé, Schenten, Véronique, Djeghloul, Dounia, Bennabi, Meriem, Gaignier, Fanny, Vandamme, Katleen, Strazielle, Catherine, Kuzniak, Isabelle, Petite, Hervé, Dosquet, Christine, Frippiat, Jean-Pol, Goodhardt, Michèle, Lescale, Chloé, Schenten, Véronique, Djeghloul, Dounia, Bennabi, Meriem, Gaignier, Fanny, Vandamme, Katleen, Strazielle, Catherine, Kuzniak, Isabelle, Petite, Hervé, Dosquet, Christine, Frippiat, Jean-Pol, and Goodhardt, Michèle

Abstract

Within the bone marrow, the endosteal niche plays a crucial role in B-cell differentiation. Because spaceflight is associated with osteoporosis, we investigated whether changes in bone microstructure induced by a ground-based model of spaceflight, hind limb unloading (HU), could affect B lymphopoiesis. To this end, we analyzed both bone parameters and the frequency of early hematopoietic precursors and cells of the B lineage after 3, 6, 13, and 21 d of HU. We found that limb disuse leads to a decrease in both bone microstructure and the frequency of B-cell progenitors in the bone marrow. Although multipotent hematopoietic progenitors were not affected by HU, a decrease in B lymphopoiesis was observed as of the common lymphoid progenitor (CLP) stage with a major block at the progenitor B (pro-B) to precursor B (pre-B) cell transition (5- to 10-fold decrease). The modifications in B lymphopoiesis were similar to those observed in aged mice and, as with aging, decreased B-cell generation in HU mice was associated with reduced expression of B-cell transcription factors, early B-cell factor (EBF) and Pax5, and an alteration in STAT5-mediated IL-7 signaling. These findings demonstrate that mechanical unloading of hind limbs results in a decrease in early B-cell differentiation resembling age-related modifications in B lymphopoiesis.

Published
2015

38. VEGF and VEGFR-1 are coexpressed by epithelial and stromal cells of renal cell carcinoma.: VEGF and its receptors in renal cell carcinoma

Author

Rivet, Jacqueline, Mourah, Samia, Murata, Hideyuki, Mounier, Nicolas, Pisonero, Helena, Mongiat-Artus, Pierre, Teillac, Pierre, Calvo, Fabien, Janin, Anne, Dosquet, Christine, Ratajczak, Philippe, Gvh et Gvl : Physiopathologie Chez l'Homme et Chez l'Animal, Incidence et Role Therapeutique, Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de pharmacologie expérimentale et clinique : cibles moléculaires en cancérologie ((U 716)), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service d'Urologie [CHU Saint-Louis], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hemostase, Endothelium, Angiogenese (UMR_S_553), Institut Universitaire d'Hématologie (IUH), Université Paris Diderot - Paris 7 (UPD7), and University Paris 7, Inserm, GIP/HMR, PHRC

Subjects
[SDV.CAN] Life Sciences [q-bio]/Cancer, MESH: laser microdissection, renal cell carcinoma, VEGF, VEGFR-1, VEGFR-2, [SDV.CAN]Life Sciences [q-bio]/Cancer
Abstract

International audience; BACKGROUND.: Tumor angiogenesis is a dynamic process that plays a major role in cancer progression. Vascular endothelial growth factor (VEGF) and its receptors play a pivotal role in angiogenesis. The expression of VEGF and its receptors VEGFR-1 and VEGFR-2 in renal cell carcinoma (RCC) was investigated in the perspective of anti-VEGF treatments. METHODS.: Total VEGF protein levels were quantified by enzyme-linked immunosorbent assay (ELISA) in tumor tissue samples from surgical specimens of 65 patients with clear cell RCC. At the cellular level the VEGF isoforms VEGFR-1 and VEGFR-2 mRNA were quantified by real-time quantitative reverse-transcriptase polymerase chain reaction (RT-PCR) in laser-microdissected tumoral epithelial as stromal cells and in corresponding normal tissue compartments. Colocalization of VEGF and VEGFR-1 proteins was studied by triple immunofluorescent labeling. RESULTS.: Protein VEGF in cytosolic extracts was significantly higher in tumoral than in nontumoral tissue (P < .0001). Event-free survival was significantly longer for patients with cytosolic VEGF lower than the cutoff (75th percentile of VEGF protein levels, P = .02). In laser-microdissected epithelial cells, VEGF(121) and VEGFR-1 mRNA expressions were higher in RCC than in corresponding nontumoral kidney (P = .007 and P = .002, respectively); they were also higher in stromal cells of RCC compared with nontumoral kidney (P = .02 and P = .003, respectively). There was no differential VEGFR-2 expression in epithelial or in stromal cells of tumoral or nontumoral kidney. By immunofluorescent labeling VEGF and VEGFR-1 colocalized on RCC tumor epithelial and stromal cells. CONCLUSIONS.: Combined laser microdissection and quantitative RT-PCR, as triple immunofluorescent labeling, underlined the preferential expression of the most soluble VEGF isoform, VEGF(121), and its receptor VEGFR-1, but not VEGFR-2, in epithelial and stromal cells of RCC. Cancer 2008. (c) 2007 American Cancer Society.

Published
2008
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39. Long Term Outcome of Patients with MPN-Associated Myelofibrosis Treated with Peg-Interferon-α2a, a French Intergroup of Myeloproliferative Neoplasms (FIM) Study

Author

Ianotto, Jean-Christophe, Chauveau, Aurélie, Boyer-Perrard, Francoise, Gyan, Emmanuel, Laribi, Kamel, Cony-Makhoul, Pascale, Demory, Jean-Loup, De Renzis, Benoit, Dosquet, Christine, Rey, Jerome, Roy, Lydia, Dupriez, Brigitte, Knoops, Laurent, Legros, Laurence, Malou, Mohamed, Hutin, Pascal, Ranta, Dana, Benbrahim, Omar, Ugo, Valerie, Lippert, Eric, and Kiladjian, Jean-Jacques

Published
2017
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41. Reply

Author

Senet, Patricia, Kellouche, Sabrina, Benbunan, Marc, Calvo, Fabien, and Dosquet, Christine

Subjects
Surgery, Cardiology and Cardiovascular Medicine
Published
2004
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42. Impact of the Molecular Profile of Malignant Clones on the Response to Interferon Alpha (IFNa) Therapy in JAK2V617F-Negative Essential Thrombocythemia (ET)

Author

Verger, Emmanuelle, primary, Cassinat, Bruno, additional, Dosquet, Christine, additional, Schlageter, Marie-Helene, additional, Ugo, Valérie, additional, Ianotto, Jean-Christophe, additional, Yassin, Mohamed A., additional, Dewik, Nader, additional, Carillo, Serge, additional, Chomienne, Christine, additional, and Kiladjian, Jean-Jacques, additional

Published
2014
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43. Final Results of a Phase 1 Study of 18F-FLT Positron Emission Tomography (PET)/Computed Tomography Imaging in Myelofibrosis (FLT-MF-2009 Study)

Author

Andreoli, Annalisa, primary, Vercellino, Laetitia, additional, Ouvrier, Matthieu John, additional, Barré, Emmanuelle, additional, Cassinat, Bruno, additional, de Beco, Virginie, additional, Merlet, Pascal, additional, Dosquet, Christine, additional, Chomienne, Christine, additional, Chevret, Sylvie, additional, Toubert, Marie-Elisabeth, additional, and Kiladjian, Jean-Jacques, additional

Published
2014
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45. 18 F-FLT Positron Emission Tomography (PET)/CT Imaging in Myelofibrosis: A Non Invasive Method to Assess Bone Marrow Function and Extramedullary Hematopoiesis

Author

Andreoli, Annalisa, primary, Vercellino, Laetitia, additional, Ouvrier, Mathieu-John, additional, Barré, Emmanuelle, additional, Cassinat, Bruno, additional, de Beco, Virginie, additional, Zini, Jean-Marc, additional, Merlet, Pascal, additional, Dosquet, Christine, additional, Chomienne, Christine, additional, Toubert, Marie-Elisabeth, additional, and Kiladjian, Jean-Jacques, additional

Published
2012
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48. Mutations in the Exon 12 of the JAK2 Gene Appeared To Be a Rare Event Essentially Clustered in V617F JAK2 Negative PV Patients.

Author

Kouroupi, Eirini, primary, Parquet, Nathalie, primary, Zoi, Christine, primary, Kiladjian, Jean-Jacques, primary, Grigoraki, Vassiliki, primary, Zoi, Katerina, primary, Scott, Linda, primary, Dosquet, Christine, primary, Fenaux, Pierre, primary, Loukopoulos, Dimitris, primary, Chomienne, Christine, primary, and Cassinat, Bruno, primary

Published
2007
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50. Interlaboratory Development and Validation of a HRM Method Applied to the Detection of JAK2 Exon 12 Mutations in Polycythemia Vera Patients.

Author

Ugo, Valerie, Tondeur, Sylvie, Menot, Marie-Laurence, Bonnin, Nadine, Le Gac, Gerald, Tonetti, Carole, Mansat-De Mas, Veronique, Lecucq, Lydie, Kiladjian, Jean-Jacques, Chomienne, Christine, Dosquet, Christine, Parquet, Nathalie, Darnige, Luc, Porneuf, Marc, Escoffre-Barbe, Martine, Giraudier, Stephane, Delabesse, Eric, and Cassinat, Bruno

Subjects
MYELOPROLIFERATIVE neoplasms, BLOOD hyperviscosity syndrome, ERYTHROCYTE disorders, POLYCYTHEMIA vera, DNA, DEOXYRIBOSE, BONE marrow diseases, PROTEIN-tyrosine kinases, GENETIC mutation
Abstract

Background: Myeloproliferative disorders are characterized by clonal expansion of normal mature blood cells. Acquired mutations giving rise to constitutive activation of the JAK2 tyrosine kinase has been shown to be present in the majority of patients. Since the demonstration that the V617F mutation in the exon 14 of the JAK2 gene is present in about 90% of patients with Polycythemia Vera (PV), the detection of this mutation has become a key tool for the diagnosis of these patients. More recently, additional mutations in the exon 12 of the JAK2 gene have been described in 5 to 10% of the patients with erythrocytosis. According to the updated WHO criteria the presence of these mutations should be looked for in PV patients with no JAK2 V617F mutation. Reliable and accurate methods dedicated to the detection of these highly variable mutations are therefore necessary. Methods/Findings: For these reasons we have defined the conditions of a High Resolution DNA Melting curve analysis (HRM) method able to detect JAK2 exon 12 mutations. After having validated that the method was able to detect mutated patients, we have verified that it gave reproducible results in repeated experiments, on DNA extracted from either total blood or purified granulocytes. This HRM assay was further validated using 8 samples bearing different mutant sequences in 4 different laboratories, on 3 different instruments. Conclusion: The assay we have developed is thus a valid method, adapted to routine detection of JAK2 exon 12 mutations with highly reproducible results. [ABSTRACT FROM AUTHOR]

Published
2010
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