16 results on '"Elena Mihaela Carausu"'
Search Results
2. Development and Functionalization of a Novel Chitosan-Based Nanosystem for Enhanced Drug Delivery
- Author
-
Carmen Grierosu, Gabriela Calin, Daniela Damir, Constantin Marcu, Radu Cernei, Georgeta Zegan, Daniela Anistoroaei, Mihaela Moscu, Elena Mihaela Carausu, Letitia Doina Duceac, Marius Gabriel Dabija, Geta Mitrea, Cristian Gutu, Elena Roxana Bogdan Goroftei, and Lucian Eva
- Subjects
polymer composite ,bioactivity ,biodegradability ,metronidazole ,biomedical application ,Biotechnology ,TP248.13-248.65 ,Medicine (General) ,R5-920 - Abstract
Nowadays, infection diseases are one of the most significant threats to humans all around the world. An encouraging strategy for solving this issue and fighting resistant microorganisms is to develop drug carriers for a prolonged release of the antibiotic to the target site. The purpose of this work was to obtain metronidazole-encapsulated chitosan nanoparticles using an ion gelation route and to evaluate their properties. Due to the advantages of the ionic gelation method, the synthesized polymeric nanoparticles can be applied in various fields, especially pharmaceutical and medical. Loading capacity and encapsulation efficiency varFied depending on the amount of antibiotic in each formulation. Physicochemical characterization using scanning electron microscopy revealed a narrow particle size distribution where 90% of chitosan particles were 163.7 nm in size and chitosan-loaded metronidazole nanoparticles were 201.3 nm in size, with a zeta potential value of 36.5 mV. IR spectra revealed characteristic peaks of the drug and polymer nanoparticles. Cell viability assessment revealed that samples have no significant impact on tested cells. Release analysis showed that metronidazole was released from the chitosan matrix for 24 h in a prolonged course, implying that antibiotic-encapsulated polymer nanostructures are a promising drug delivery system to prevent or to treat various diseases. It is desirable to obtain new formulations based on drugs encapsulated in nanoparticles through different preparation methods, with reduced cytotoxic potential, in order to improve the therapeutic effect through sustained and prolonged release mechanisms of the drug correlated with the reduction of adverse effects.
- Published
- 2023
- Full Text
- View/download PDF
3. MANAGEMENT OF THE EQUIPMENT AND INSTRUMENTS INVOLVED IN THE TECHNOLOGY OF FLEXIBLE REMOVABLE PROSTHESES
- Author
-
Ștefan Lucian Burlea, Razvan Constantin Anghel, G.Gabriel Condurache, and Elena Mihaela Carausu
- Subjects
management ,flexible prostheses ,injector ,biomaterials ,Dentistry ,RK1-715 - Abstract
The treatment with partially removable prostheses has become more and more complex over time, especially in the last few decades. And when it is planned correctly, and executed responsibly, it will actually help preserve the remaining dental units. Consequently, performing the treatment in a defective manner, can trigger the resorption of the bone support and can accelerate the degradation of the remaining units, resulting in their loss.Elastic prostheses are the most modern alternative to injectable acrylic prostheses. The material is elastic, with a thinner thickness than conventional prostheses, resistant to pressure and dynamic movements during chewing, and very well approved from a biocompatible point of view by the tissues of the oral cavity. The reasons for choosing to treat partial edentulousness with partially removable elastic prosthesis are the feasibility and reliability of this.
- Published
- 2021
4. THE QUALITY OF DENTAL CARE SERVICES PROVIDED BY THE PRIVATE OFFICES IN IASI – PILOT STUDY RESULTS
- Author
-
Elena Mihaela Carausu, Cristina Gena Dascalu, Iulian Costin Lupu, Daniela Anistoroaei, and Georgeta Zegan
- Subjects
dental care ,dental medicine services ,private provider of dental medicine services. ,quality management ,the level of patient satisfaction ,Dentistry ,RK1-715 - Abstract
Aim of the study was to identify the degree of satisfaction of patients about quality of the private dental medicine practices from Iasi, Romania. Material and methods. The authors of this study tested a representative sample of the population, consisting of 144 people, with different professions and ages. The data collection tool was an original questionnaire. Through its administration, it was intended to assess the patient’s satisfaction with the dental care they received in different dental offices in Iasi during year 2018. Results. The results of the study show that 74.31% of the total patients surveyed are satisfied with the clinical quality of the dental care received, and 18.06% of them are worried about the high prices. The questioned patients believe that dentists with private practice have the necessary equipment and materials to provide dental services at the proper quality. Conclusions. Our study offers useful information for quality management of dental medicine services provided to the local population.
- Published
- 2019
5. ASSESSMENT OF PATIENT ANXIETY BEFORE DENTAL TREATMENT
- Author
-
Georgeta Zegan, Daniela Anistoroaei, Eduard Radu Cernei, Vasilica Toma, Alina Sodor, and Elena Mihaela Carausu
- Subjects
dental anxiety ,dental phobia ,questionnaire ,Dentistry ,RK1-715 - Abstract
Aim of the study was to identify the prevalence of patient anxiety before treatment and to determine patients’ perception of the dental treatment risks. Material and methods. The cross-sectional study was conducted in 210 patients (69 males and 141 females) aged 11-70 years in northeastern Romania, who completed Corah’s Dental Anxiety Scale, Revised (DAS-R), Modified Dental Anxiety Scale (MDAS) and Dental Concerns Assessment, Revised (DCA-R). Results. The overall scores of DAS-R indicated high anxiety in 4.3% of patients and severe anxiety or phobia in 2.9% of patients. Overall scores of the MDAS questionnaire indicated 5.2% of very anxious patients and 2.3% of highly anxious or phobic patients with dental treatments. DCA-R indicated high anxiety for injection and extraction. We found statistically significant differences between anxiety levels and age ranges as well as patients’ environmental areas (p
- Published
- 2019
6. Blended Learning - The Efficiency of Video Resources and YouTube in the Modern Dental Education
- Author
-
Magda Ecaterina Antohe, Georgeta Zegan, Lucian Stefan Burlea, Elena Mihaela Carausu, Anamaria Ciubara, Victor Lorin Purcarea, and Cristina Gena Dascalu
- Subjects
Medical education ,Health (social science) ,Sociology and Political Science ,Social Psychology ,Teaching method ,Romanian ,media_common.quotation_subject ,Dental education ,language.human_language ,Blended learning ,Opinion survey ,Age groups ,language ,Quality (business) ,Psychology ,media_common - Abstract
The media-enhanced teaching techniques became popular in the last years because they stimulate the students' engagement and motivation. The educational movies uploaded on YouTube became nowadays a highly used resource for learning in the academic environment. We conducted an opinion survey among the students at the Faculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, Romania, about their agreement and interest in using educational movies as didactic tools, compared with the traditional teaching methods, and about the features they prefer in such materials. The study group included 170 students with average age 20.93 ± 2.751. Most students (91.2%) use didactic movies in their practical training; 77.6% think that the didactic movies from YouTube contain correct scientific information. 74.6% of the students like to learn using didactic movies, 39.7% of them appreciate the oral speech accompanied by PowerPoint Presentations and 46.6% like the oral speech accompanied by written explanations, with no significant differences between genders and age groups. The most popular features of the educational movies are: human narrator (94.7%), who speaks in Romanian (82.4%). The narrator’s speech must be accompanied by animated schemes with explanations (90.6%) and drawings (93.5%). The movie must have a clear structure, evolving from basic to complex (85.9%). The educational movies uploaded on YouTube are an adequate source of information for the dental students; the professionals in universities must survey better the scientific quality of such materials.
- Published
- 2021
- Full Text
- View/download PDF
7. Antimicrobial Effect of Drug Incorporated Nanoparticles Against Oral Pathogens
- Author
-
Elena-Mihaela Carausu
- Subjects
Materials Science (miscellaneous) ,Process Chemistry and Technology ,Materials Chemistry ,General Engineering ,General Chemistry ,General Medicine ,General Pharmacology, Toxicology and Pharmaceutics ,General Biochemistry, Genetics and Molecular Biology - Abstract
Last few years antibiotics resistance known a major problem that concerns the specialists in the dentistry field due to the improper usage of anti-infectious drugs. Administration of third generation quinolones, levofloxacin (Lev), in dental practice is preferred since has few nonhazardous adverse effects, is used once daily and can be successfully applied as intra-pocket films.This study investigated the possibility of preparing levofloxacin loaded layered double hydroxides nanoparticles in order to enhance antibiotic efficacy against oral pathogens. The nanoparticles obtained under optimal conditions were physico-chemically analyzed and intercalation efficiency was tested. The results of this work revealed that the use of these nanoparticles type levofloxacin loaded layered double hydroxides has the major advantage of prolonged release of the drug, thus allowing an increase of the period between administration and the diminution of side effects of the antibiotic. Further researches should focus on biocompatible properties and antibacterial effect as these nanomaterials supposed to be a sustainable drug delivery system. Keywords: nanoparticles, drug carriers, antibacterial properties, public health dentistry, oral infections
- Published
- 2020
- Full Text
- View/download PDF
8. Virtual Models Obtained via Intraoral Scanning as Alternated to Clinical Evaluation and b-Hemihydrate Plaster Models
- Author
-
Tiberiu Totu, Corina Marilena Cristache, Liliana Burlibasa, Eugenia Eftimie Totu, Irina Adriana Beuran, and Elena Mihaela Carausu
- Subjects
Process equipment ,Petrochemistry ,Materials Science (miscellaneous) ,Process Chemistry and Technology ,Hemihydrate ,Metallurgy ,Materials Chemistry ,General Engineering ,General Chemistry ,General Medicine ,General Pharmacology, Toxicology and Pharmaceutics ,Clinical evaluation ,General Biochemistry, Genetics and Molecular Biology - Abstract
Digital scanners are currently use in various fields of dentistry such as prosthodontics, dental implantology, orthodontics, with a high degree of accuracy, mostly for replacing conventional impressions. The aim of the present study was to assess the accuracy (trueness and precision) of gingival margin measurements, on virtual models obtained by intraoral scanning, for precise diagnosis and treatment monitoring of periodontal disease. Three methods were compared for accuracy: clinical measurements using periodontal probes, digital intraoral scanning and measurements in MeshLab software and 2D digital measurements on intraoral photography taken during clinical measurements. Intraoral scanning was proved to be a reliable method for measuring the gingival level for diagnosis and clinical monitoring having a good accuracy as compared to the gold standard (clinical measurements).
- Published
- 2019
- Full Text
- View/download PDF
9. The Study of Biochemistry on Myorelaxation of Manducatory Muscles by Influence of Botulinic Toxine in the Context of Oral Rehabilitation in SDSS Patients
- Author
-
Aurora Constantinescu, Daniela Manuc, Iulian Costin Lupu, Ovidiu Stamatin, Laura Elisabeta Checherita, Bogdan Petru Bulancea, and Elena Mihaela Carausu
- Subjects
medicine.medical_specialty ,Rehabilitation ,business.industry ,Materials Science (miscellaneous) ,Process Chemistry and Technology ,medicine.medical_treatment ,General Engineering ,Context (language use) ,General Chemistry ,General Medicine ,General Biochemistry, Genetics and Molecular Biology ,Physical medicine and rehabilitation ,Materials Chemistry ,medicine ,General Pharmacology, Toxicology and Pharmaceutics ,business - Abstract
Hypertonias, observed at stomatognatique level, pathologic expressions of striated musculature may have the opportunity of a large palette of therapeutical ways, so clasics as drugs therapy, and so well the modern therapy injection with botulinic toxin, type A Dysport. The choice upon the type of myorelaxation treatment proper to each case depends upon the severity of manifestations at muscular level, frequently a mixed therapy being the option of choice, based on the superposition of different treatment means. The use of botulinic toxin in the treatment of stomatognatic system dysfunctions is without the morphological impact quickly installed therapeutic effect and it has only short term effects.
- Published
- 2019
- Full Text
- View/download PDF
10. Study on Antibiotic Loaded Nanoparticles for Oral Infection Treatment
- Author
-
Mihaela Moscu, Eduard Radu Cernei, Georgeta Zegan, Daniela Anistoroaei, Elena Mihaela Carausu, and Vasilica Toma
- Subjects
Doxycycline ,business.industry ,medicine.drug_class ,Oral infection ,Materials Science (miscellaneous) ,Process Chemistry and Technology ,Antibiotics ,General Engineering ,General Chemistry ,General Medicine ,General Biochemistry, Genetics and Molecular Biology ,Microbiology ,Materials Chemistry ,Medicine ,General Pharmacology, Toxicology and Pharmaceutics ,business ,medicine.drug - Abstract
Over the past decade, exploitation of antimicrobial effect of nanoparticles on viruses, fungi and bacteria, respectively have developed markedly. A close attention was received by the possibility of nanoparticles type drug delivery systems to limit the biofilm formation within the oral cavity due to their important properties such as delivery abilities, anti-adhesive and biocidal features. The major objective of this work was to obtain doxycycline-loaded chitosan nanoparticles and to analyze the properties of as prepared samples in order to prolong the antibiotic release. The synthesized nanoparticles had less than 100 nm using the classis or improved drug encapsulation technique in chitosan matrix. The study focused on the antimicrobial characteristic of nanoparticles for controlling oral infections.
- Published
- 2019
- Full Text
- View/download PDF
11. Structural Characteristics of Drug Intercalated Hydrotalcites Used in Dental Medicine
- Author
-
Daniela Anistoroaei, Loredana Golovcencu, Georgeta Zegan, Eduard Radu Cernei, and Elena Mihaela Carausu
- Subjects
Drug ,Hydrotalcite ,Chemistry ,Materials Science (miscellaneous) ,Process Chemistry and Technology ,media_common.quotation_subject ,General Engineering ,General Chemistry ,General Medicine ,Combinatorial chemistry ,General Biochemistry, Genetics and Molecular Biology ,Materials Chemistry ,General Pharmacology, Toxicology and Pharmaceutics ,media_common - Abstract
Metronidazole active molecules were intercalated in the inner space of MgAl layered double hydroxides by simple coprecipitation method. The new synthesized nanohybrid material and the pristine hydrotalcite were characterized by different techniques such as X-ray diffraction, infrared spectroscopy and UV-vis spectroscopy verifying thus the incorporation of the antibiotic into the lamellar gallery of hydrotalcite type anionic clay. Studies regarding metronidazole controlled release from synthetic nanocomposite showed that the organic-inorganic nanohybrid structure can serve as drug controlled release system for a wide variety of antibiotics and other molecules used in dental medicine in order to maintain good public health dentistry.
- Published
- 2019
- Full Text
- View/download PDF
12. Oxidative Stress Applied in Diabetes Mellitus-A New Paradigm
- Author
-
Florian Colceag, Elena Mihaela Carausu, Eugenia Eftimie Totu, Anca Pantea Stoian, Grigorina Mitrofan, Cristian Serafinceanu, Daniela Manuc, and Veronica Mocanu
- Subjects
Alternative methods ,algebraic fractals ,Research groups ,Process (engineering) ,public health ,complexity theory ,lcsh:A ,Type 2 diabetes ,medicine.disease_cause ,medicine.disease ,antioxidants ,Molecular level ,Diabetes mellitus ,diabetes mellitus ,medicine ,oxidative stress ,lcsh:General Works ,Psychology ,Oxidative stress ,Cognitive psychology ,Sedentary lifestyle - Abstract
Although obesity and a sedentary lifestyle are well-known risk factors for type 2 diabetes, at molecular level, the oxidative stress is regarded as the primary contributor to the pathogenic process. Our work intends to evidence how the thinking models influence the way that medical practitioners understand the pathogenic mechanisms. Some research groups focused lately on the system’s dynamics and Complex Systems Theory. The living organisms as a complex system could be analyzed applying the network concept. Alternative methods for characterizing biological processes or phenomena based on feedback node structure have been developed [1].
- Published
- 2019
- Full Text
- View/download PDF
13. The Implication of Reactive Oxygen Species and Antioxidants in Knee Osteoarthritis
- Author
-
Veronica Mocanu, Eugenia Eftimie Totu, Ibrahim Isildak, Cornelia Mircea, Nicoleta Bianca Tudorachi, Valeriu Ardeleanu, Elena Mihaela Carausu, Adrian Fifere, and Katarina Smilkov
- Subjects
0301 basic medicine ,Antioxidant ,Physiology ,medicine.medical_treatment ,Clinical Biochemistry ,Context (language use) ,Review ,RM1-950 ,Newly diagnosed ,Osteoarthritis ,Bioinformatics ,medicine.disease_cause ,Biochemistry ,KOA ,03 medical and health sciences ,Therapeutic approach ,0302 clinical medicine ,Other medical sciences ,medicine ,oxidative stress ,cellular senescence ,Molecular Biology ,pathophysiology ,chemistry.chemical_classification ,Reactive oxygen species ,apoptosis ,Health sciences ,ROS ,Cell Biology ,medicine.disease ,Biological sciences ,Geriatric patient ,antioxidants ,030104 developmental biology ,Chemical sciences ,chemistry ,Clinical medicine ,030220 oncology & carcinogenesis ,Therapeutics. Pharmacology ,Oxidative stress - Abstract
Knee osteoarthritis (KOA) is a chronic multifactorial pathology and a current and essential challenge for public health, with a negative impact on the geriatric patient’s quality of life. The pathophysiology is not fully known; therefore, no specific treatment has been found to date. The increase in the number of newly diagnosed cases of KOA is worrying, and it is essential to reduce the risk factors and detect those with a protective role in this context. The destructive effects of free radicals consist of the acceleration of chondrosenescence and apoptosis. Among other risk factors, the influence of redox imbalance on the homeostasis of the osteoarticular system is highlighted. The evolution of KOA can be correlated with oxidative stress markers or antioxidant status. These factors reveal the importance of maintaining a redox balance for the joints and the whole body’s health, emphasizing the importance of an individualized therapeutic approach based on antioxidant effects. This paper aims to present an updated picture of the implications of reactive oxygen species (ROS) in KOA from pathophysiological and biochemical perspectives, focusing on antioxidant systems that could establish the premises for appropriate treatment to restore the redox balance and improve the condition of patients with KOA.
- Published
- 2021
- Full Text
- View/download PDF
14. The Implication of Reactive Oxygen Species and Antioxidants in Knee Osteoarthritis
- Author
-
Nicoleta Bianca Tudorachi, Eugenia Eftimie Totu, Adrian Fifere, Valeriu Ardeleanu, Veronica Mocanu, Cornelia Mircea, Ibrahim Isildak, Katarina Smilkov, and Elena Mihaela Cărăuşu
- Subjects
oxidative stress ,ROS ,antioxidants ,pathophysiology ,KOA ,cellular senescence ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Knee osteoarthritis (KOA) is a chronic multifactorial pathology and a current and essential challenge for public health, with a negative impact on the geriatric patient’s quality of life. The pathophysiology is not fully known; therefore, no specific treatment has been found to date. The increase in the number of newly diagnosed cases of KOA is worrying, and it is essential to reduce the risk factors and detect those with a protective role in this context. The destructive effects of free radicals consist of the acceleration of chondrosenescence and apoptosis. Among other risk factors, the influence of redox imbalance on the homeostasis of the osteoarticular system is highlighted. The evolution of KOA can be correlated with oxidative stress markers or antioxidant status. These factors reveal the importance of maintaining a redox balance for the joints and the whole body’s health, emphasizing the importance of an individualized therapeutic approach based on antioxidant effects. This paper aims to present an updated picture of the implications of reactive oxygen species (ROS) in KOA from pathophysiological and biochemical perspectives, focusing on antioxidant systems that could establish the premises for appropriate treatment to restore the redox balance and improve the condition of patients with KOA.
- Published
- 2021
- Full Text
- View/download PDF
15. THE IMPORTANCE OF CONTROL ELEMENTS IN THE DENTAL OFFICE MANAGEMENT
- Author
-
Iulian Costin Lupu, Elena Mihaela Cărăuşu, and Norina Forna
- Subjects
dental practice management ,elements of controls ,marketing services ,Dentistry ,RK1-715 - Abstract
In the current economic situation statistical indicators suggest a decline in global and national dental services market under increased competition. So we must take a cost-effective and strengthening market position. Thus it is recommended that the management office to focus on retention and follow active patients and a system of quality control of treatments. In order to achieve these objectives must monitor certain type of control elements medical, economic, management and promotion.
- Published
- 2014
16. Oxidative Stress Applied in Diabetes Mellitus-A New Paradigm
- Author
-
Anca Pantea Stoian, Grigorina Mitrofan, Florian Colceag, Cristian Serafinceanu, Eugenia Eftimie Totu, Veronica Mocanu, Daniela Mănuc, and Elena Mihaela Cărăuşu
- Subjects
oxidative stress ,antioxidants ,complexity theory ,algebraic fractals ,diabetes mellitus ,public health ,General Works - Abstract
Although obesity and a sedentary lifestyle are well-known risk factors for type 2 diabetes, at molecular level, the oxidative stress is regarded as the primary contributor to the pathogenic process. Our work intends to evidence how the thinking models influence the way that medical practitioners understand the pathogenic mechanisms. Some research groups focused lately on the system’s dynamics and Complex Systems Theory. The living organisms as a complex system could be analyzed applying the network concept. Alternative methods for characterizing biological processes or phenomena based on feedback node structure have been developed [1].
- Published
- 2019
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.