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1. Blood Pressure and Brain Lesions in Patients With Atrial Fibrillation

Author

Aeschbacher, Stefanie, primary, Blum, Steffen, additional, Meyre, Pascal B., additional, Coslovsky, Michael, additional, Vischer, Annina S., additional, Sinnecker, Tim, additional, Rodondi, Nicolas, additional, Beer, Jürg H., additional, Moschovitis, Giorgio, additional, Moutzouri, Elisavet, additional, Hunkeler, Christof, additional, Burkard, Thilo, additional, Eken, Ceylan, additional, Roten, Laurent, additional, Zuern, Christine S., additional, Sticherling, Christian, additional, Wuerfel, Jens, additional, Bonati, Leo H., additional, Conen, David, additional, Osswald, Stefan, additional, Kühne, Michael, additional, Auberson, Chloé, additional, Ceylan, Selinda, additional, Doerpfeld, Simone, additional, Girod, Marc, additional, Hennings, Elisa, additional, Krisai, Philipp, additional, Monsch, Andreas U., additional, Müller, Christian, additional, Springer, Anne, additional, Voellmin, Gian, additional, Aujesky, Drahomir, additional, Fischer, Urs, additional, Fuhrer, Juerg, additional, Jung, Simon, additional, Mattle, Heinrich, additional, Adam, Luise, additional, Elodie Aubert, Carole, additional, Feller, Martin, additional, Loewe, Axel, additional, Schneider, Claudio, additional, Flückiger, Tanja, additional, Groen, Cindy, additional, Ehrsam, Lukas, additional, Hellrigl, Sven, additional, Nuoffer, Alexandra, additional, Rakovic, Damiana, additional, Schwab, Nathalie, additional, Wenger, Rylana, additional, Müller, Andreas, additional, Beynon, Christopher, additional, Dillier, Roger, additional, Deubelbeiss, Michèle, additional, Eberli, Franz, additional, Franzini, Christine, additional, Juchli, Isabel, additional, Liedtke, Claudia, additional, Nadler, Jacqueline, additional, Obst, Thayze, additional, Roth, Jasmin, additional, Schlomowitsch, Fiona, additional, Schneider, Xiaoye, additional, Studerus, Katrin, additional, Tynan, Noreen, additional, Weishaupt, Dominik, additional, Fontana, Simone, additional, Kuest, Silke, additional, Scheuch, Karin, additional, Hischier, Denise, additional, Bonetti, Nicole, additional, Grau, Alexandra, additional, Villinger, Jonas, additional, Laube, Eva, additional, Baumgartner, Philipp, additional, Filipovic, Mark, additional, Frick, Marcel, additional, Montrasio, Giulia, additional, Leuenberger, Stefanie, additional, Rutz, Franziska, additional, Moccetti, Tiziano, additional, Auricchio, Angelo, additional, Anesini, Adriana, additional, Camporini, Cristina, additional, Conte, Giulio, additional, Luce Caputo, Maria, additional, Regoli, Francois, additional, Ammann, Peter, additional, Brenner, Roman, additional, Altmann, David, additional, Gemperle, Michaela, additional, Hayoz, Daniel, additional, Firmann, Mathieu, additional, Foucras, Sandrine, additional, Rime, Martine, additional, Kobza, Richard, additional, Berte, Benjamin, additional, Justi, Virgina, additional, Kellner-Weldon, Frauke, additional, Mehmann, Brigitta, additional, Meier, Sonja, additional, Roth, Myriam, additional, Ruckli-Kaeppeli, Andrea, additional, Russi, Ian, additional, Schmidt, Kai, additional, Young, Mabelle, additional, Zbinden, Melanie, additional, Frangi-Kultalahti, Jane, additional, Pin, Anica, additional, Shah, Dipen, additional, Ehret, Georg, additional, Gallet, Hervé, additional, Guillermet, Elise, additional, Lazeyras, Francois, additional, Lovblad, Karl-Olof, additional, Perret, Patrick, additional, Tavel, Philippe, additional, Teres, Cheryl, additional, Schläpfer, Jürg, additional, Lauriers, Nathalie, additional, Méan, Marie, additional, Salzmann, Sandrine, additional, Stephan, Frank-Peter, additional, Grêt, Andrea, additional, Novak, Jan, additional, Vitelli, Sandra, additional, Di Valentino, Marcello, additional, Gallino, Augusto, additional, Witassek, Fabienne, additional, Schwenkglenks, Matthias, additional, Altermatt, Anna, additional, Amann, Michael, additional, Huber, Petra, additional, Ruberte, Esther, additional, Zuber, Vanessa, additional, Benkert, Pascal, additional, Dutilh, Gilles, additional, Markovic, Milica, additional, Neuschwander, Pia, additional, Simon, Patrick, additional, and Schmid, Ramun, additional

Published
2021
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2. Relationships of Overt and Silent Brain Lesions With Cognitive Function in Patients With Atrial Fibrillation

Author

Conen, David, primary, Rodondi, Nicolas, additional, Müller, Andreas, additional, Beer, Juerg H., additional, Ammann, Peter, additional, Moschovitis, Giorgio, additional, Auricchio, Angelo, additional, Hayoz, Daniel, additional, Kobza, Richard, additional, Shah, Dipen, additional, Novak, Jan, additional, Schläpfer, Jürg, additional, Di Valentino, Marcello, additional, Aeschbacher, Stefanie, additional, Blum, Steffen, additional, Meyre, Pascal, additional, Sticherling, Christian, additional, Bonati, Leo H., additional, Ehret, Georg, additional, Moutzouri, Elisavet, additional, Fischer, Urs, additional, Monsch, Andreas U., additional, Stippich, Christoph, additional, Wuerfel, Jens, additional, Sinnecker, Tim, additional, Coslovsky, Michael, additional, Schwenkglenks, Matthias, additional, Kühne, Michael, additional, Osswald, Stefan, additional, Berger, Sebastian, additional, Bernasconi, Raffaele, additional, Fröhlich, Lorin, additional, Göldi, Tobias, additional, Gugganig, Rebecca, additional, Kofler, Thomas, additional, Krisai, Philipp, additional, Mongiat, Michel, additional, Pudenz, Christiane, additional, Repilado, Javier Ruperti, additional, Schweizer, Aleksandra, additional, Springer, Anne, additional, Stempfel, Samuel, additional, Szucs, Thomas, additional, van der Stouwe, Jan, additional, Voellmin, Gian, additional, Zwimpfer, Leon, additional, Aujesky, Drahomir, additional, Fuhrer, Juerg, additional, Roten, Laurent, additional, Jung, Simon, additional, Mattle, Heinrich, additional, Adam, Luise, additional, Aubert, Carole Elodie, additional, Feller, Martin, additional, Schneider, Claudio, additional, Loewe, Axel, additional, Flückiger, Tanja, additional, Groen, Cindy, additional, Schwab, Nathalie, additional, Beynon, Christopher, additional, Dillier, Roger, additional, Eberli, Franz, additional, Fontana, Simone, additional, Franzini, Christine, additional, Juchli, Isabel, additional, Liedtke, Claudia, additional, Nadler, Jacqueline, additional, Obst, Thayze, additional, Schneider, Xiaoye, additional, Studerus, Katrin, additional, Weishaupt, Dominik, additional, Kuest, Silke, additional, Scheuch, Karin, additional, Hischier, Denise, additional, Bonetti, Nicole, additional, Bello, Corina, additional, Isberg, Henriette, additional, Grau, Alexandra, additional, Villinger, Jonas, additional, Papaux, Mary-Monica, additional, Baumgartner, Philipp, additional, Filipovic, Mark, additional, Frick, Marcel, additional, Anesini, Adriana, additional, Camporini, Cristina, additional, Conte, Giulio, additional, Caputo, Maria Luce, additional, Regoli, Francois, additional, Moccetti, Tiziano, additional, Brenner, Roman, additional, Altmann, David, additional, Forrer, Manuela, additional, Gemperle, Michaela, additional, Firmann, Mathieu, additional, Foucras, Sandrine, additional, Berte, Benjamin, additional, Kaeppeli, Andrea, additional, Mehmann, Brigitta, additional, Pfeiffer, Markus, additional, Russi, Ian, additional, Schmidt, Kai, additional, Weberndoerfer, Vanessa, additional, Young, Mabelle, additional, Zbinden, Melanie, additional, Vicari, Luisa, additional, Frangi, Jane, additional, Terrot, Tatiana, additional, Gallet, Hervé, additional, Guillermet, Elise, additional, Lazeyras, Francois, additional, Lovblad, Karl-Olof, additional, Perret, Patrick, additional, Teres, Cheryl, additional, Lauriers, Nathalie, additional, Méan, Marie, additional, Salzmann, Sandrine, additional, Arenja, Nisha, additional, Grêt, Andrea, additional, Vitelli, Sandra, additional, Gallino, Augusto, additional, Schoenenberger-Berzins, Renate, additional, Witassek, Fabienne, additional, Radue, Ernst-Wilhelm, additional, Benkert, Pascal, additional, Fabbro, Thomas, additional, Simon, Patrick, additional, and Schmid, Ramun, additional

Published
2019
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3. Insulin-like growth factor-binding protein 7 and risk of congestive heart failure hospitalization in patients with atrial fibrillation

Author

Steffen Blum, Stefanie Aeschbacher, Pascal Meyre, Michael Kühne, Nicolas Rodondi, Jürg H. Beer, Peter Ammann, Giorgio Moschovitis, Leo H. Bonati, Manuel R. Blum, Peter Kastner, Fiona Baguley, Christian Sticherling, Stefan Osswald, David Conen, Chloé Auberson, Leo Bonati, Selinda Ceylan, Simone Doerpfeld, Ceylan Eken, Marc Girod, Peter Hämmerle, Philipp Krisai, Christine Meyer-Zürn, Andreas U. Monsch, Christian Müller, Anne Springer, Thomas Szucs, Gian Voellmin, Leon Zwimpfer, Drahomir Aujesky, Urs Fischer, Juerg Fuhrer, Laurent Roten, Simon Jung, Heinrich Mattle, Luise Adam, Carole Elodie Aubert, Martin Feller, Axel Loewe, Elisavet Moutzouri, Claudio Schneider, Tanja Flückiger, Cindy Groen, Lukas Ehrsam, Sven Hellrigl, Alexandra Nuoffer, Damiana Rakovic, Nathalie Schwab, Rylana Wenger, Christopher Beynon, Roger Dillier, Michèle Deubelbeiss, Franz Eberli, Christine Franzini, Isabel Juchli, Claudia Liedtke, Jacqueline Nadler, Thayze Obst, Jasmin Roth, Fiona Schlomowitsch, Xiaoye Schneider, Katrin Studerus, Noreen Tynan, Dominik Weishaupt, Andreas Müller, Simone Fontana, Silke Kuest, Karin Scheuch, Denise Hischier, Nicole Bonetti, Alexandra Grau, Jonas Villinger, Eva Laube, Philipp Baumgartner, Mark Filipovic, Marcel Frick, Giulia Montrasio, Stefanie Leuenberger, Franziska Rutz, Jürg-Hans Beer, Angelo Auricchio, Adriana Anesini, Cristina Camporini, Giulio Conte, Maria Luce Caputo, Francois Regoli, Tiziano Moccetti, Roman Brenner, David Altmann, Michaela Gemperle, Mathieu Firmann, Sandrine Foucras, Martine Rime, Daniel Hayoz, Benjamin Berte, Virgina Justi, Frauke Kellner-Weldon, Brigitta Mehmann, Sonja Meier, Myriam Roth, Andrea Ruckli-Kaeppeli, Ian Russi, Kai Schmidt, Mabelle Young, Melanie Zbinden, Richard Kobza, Jane Frangi-Kultalahti, Anica Pin, Luisa Vicari, Georg Ehret, Hervé Gallet, Elise Guillermet, Francois Lazeyras, Karl-Olof Lovblad, Patrick Perret, Philippe Tavel, Cheryl Teres, Dipen Shah, Nathalie Lauriers, Marie Méan, Sandrine Salzmann, Jürg Schläpfer, Andrea Grêt, Jan Novak, Sandra Vitelli, Frank-Peter Stephan, Augusto Gallino, Marcello Di Valentino, Fabienne Witassek, Matthias Schwenkglenks, Jens Würfel, Anna Altermatt, Michael Amann, Petra Huber, Esther Ruberte, Tim Sinnecker, Vanessa Zuber, Michael Coslovsky, Pascal Benkert, Gilles Dutilh, Milica Markovic, Patrick Simon, Ramun Schmid, Clinical sciences, Auberson, Chloé, Bonati, Leo, Ceylan, Selinda, Doerpfeld, Simone, Eken, Ceylan, Girod, Marc, Hämmerle, Peter, Krisai, Philipp, Meyer-Zürn, Christine, Monsch, Andreas U., Müller, Christian, Springer, Anne, Szucs, Thomas, Voellmin, Gian, Zwimpfer, Leon, Aujesky, Drahomir, Fischer, Urs, Fuhrer, Juerg, Roten, Laurent, Jung, Simon, Mattle, Heinrich, Adam, Luise, Aubert, Carole Elodie, Feller, Martin, Loewe, Axel, Moutzouri, Elisavet, Schneider, Claudio, Flückiger, Tanja, Groen, Cindy, Ehrsam, Lukas, Hellrigl, Sven, Nuoffer, Alexandra, Rakovic, Damiana, Schwab, Nathalie, Wenger, Rylana, Beynon, Christopher, Dillier, Roger, Deubelbeiss, Michèle, Eberli, Franz, Franzini, Christine, Juchli, Isabel, Liedtke, Claudia, Nadler, Jacqueline, Obst, Thayze, Roth, Jasmin, Schlomowitsch, Fiona, Schneider, Xiaoye, Studerus, Katrin, Tynan, Noreen, Weishaupt, Dominik, Müller, Andreas, Fontana, Simone, Kuest, Silke, Scheuch, Karin, Hischier, Denise, Bonetti, Nicole, Grau, Alexandra, Villinger, Jonas, Laube, Eva, Baumgartner, Philipp, Filipovic, Mark, Frick, Marcel, Montrasio, Giulia, Leuenberger, Stefanie, Rutz, Franziska, Auricchio, Angelo, Anesini, Adriana, Camporini, Cristina, Conte, Giulio, Caputo, Maria Luce, Regoli, Francois, Moccetti, Tiziano, Brenner, Roman, Altmann, David, Gemperle, Michaela, Firmann, Mathieu, Foucras, Sandrine, Rime, Martine, Hayoz, Daniel, Berte, Benjamin, Justi, Virgina, Kellner-Weldon, Frauke, Mehmann, Brigitta, Meier, Sonja, Roth, Myriam, Ruckli-Kaeppeli, Andrea, Russi, Ian, Schmidt, Kai, Young, Mabelle, Zbinden, Melanie, Kobza, Richard, Frangi-Kultalahti, Jane, Pin, Anica, Vicari, Luisa, Ehret, Georg Benedikt, Gallet, Hervé, Guillermet, Elise, Lazeyras, François, Lövblad, Karl-Olof, Perret, Patrick, Tavel, Philippe, Teres Castillo, Cheryl, Shah, Dipen, Lauriers, Nathalie, Méan, Marie, Salzmann, Sandrine, Schläpfer, Jürg, Grêt, Andrea, Novak, Jan, Vitelli, Sandra, Stephan, Frank-Peter, Gallino, Augusto, Di Valentino, Marcello, Witassek, Fabienne, Schwenkglenks, Matthias, Würfel, Jens, Altermatt, Anna, Amann, Michael, Huber, Petra, Ruberte, Esther, Sinnecker, Tim, Zuber, Vanessa, Coslovsky, Michael, Benkert, Pascal, Dutilh, Gilles, Markovic, Milica, Simon, Patrick, and Schmid, Ramun

Subjects
Male, medicine.medical_specialty, medicine.drug_class, Epidemiology, Heart failure, 030204 cardiovascular system & hematology, ddc:616.0757, 03 medical and health sciences, 0302 clinical medicine, Insulin-Like Growth Factor Binding Proteins/blood, Physiology (medical), Internal medicine, Atrial Fibrillation, Clinical endpoint, Natriuretic peptide, medicine, Heart Failure/blood, Humans, 030212 general & internal medicine, cardiovascular diseases, Hospitalization/statistics & numerical data, Aged, Retrospective Studies, ddc:616, Heart Failure, Proportional hazards model, business.industry, Insulin-like growth factor-binding protein 7, Hazard ratio, Atrial fibrillation, Middle Aged, medicine.disease, Prognosis, Confidence interval, Hospitalization, Insulin-Like Growth Factor Binding Proteins, Atrial Fibrillation/blood, Cardiology, Disease Progression, Female, business, Cardiology and Cardiovascular Medicine, Biomarkers/blood, Biomarkers, Cohort study, Follow-Up Studies
Abstract

BACKGROUND: The occurrence of congestive heart failure (CHF) hospitalization among patients with atrial fibrillation (AF) is a poor prognostic marker. OBJECTIVE: The purpose of this study was to assess whether insulin-like growth factor-binding protein 7 (IGFBP-7), a marker of myocardial damage, identifies AF patients at high risk for this complication. METHODS: We analyzed 2 prospective multicenter observational cohort studies that included 3691 AF patients. Levels of IGFBP-7 and N-terminal pro-brain natriuretic peptide (NT-proBNP) were measured from frozen plasma samples at baseline. The primary endpoint was hospitalization for CHF. Multivariable adjusted Cox regression analyses were constructed. RESULTS: Mean patient age was 69 ± 12 years, 1028 (28%) were female, and 879 (24%) had a history of CHF. The incidence per 1000 patient-years across increasing IGFBP-7 quartiles was 7, 10, 32, and 85. The corresponding multivariable adjusted hazard ratios (aHRs) (95% confidence interval [CI]) were 1.0, 1.05 (0.63-1.77), 2.38 (1.50-3.79), and 4.37 (2.72-7.04) (P for trend

Published
2020

4. Blood Pressure and Brain Lesions in Patients With Atrial Fibrillation

Author

Aeschbacher, Stefanie, Blum, Steffen, Meyre, Pascal B., Coslovsky, Michael, Vischer, Annina S., Sinnecker, Tim, Rodondi, Nicolas, Beer, Jürg H., Moschovitis, Giorgio, Moutzouri, Elisavet, Hunkeler, Christof, Burkard, Thilo, Eken, Ceylan, Roten, Laurent, Zuern, Christine S., Sticherling, Christian, Wuerfel, Jens, Bonati, Leo H., Conen, David, Osswald, Stefan, Kühne, Michael, Swiss-AF Investigators, Auberson, Chloé, Ceylan, Selinda, Doerpfeld, Simone, Girod, Marc, Hennings, Elisa, Krisai, Philipp, Monsch, Andreas U., Müller, Christian, Springer, Anne, Voellmin, Gian, Aujesky, Drahomir, Fischer, Urs, Fuhrer, Juerg, Jung, Simon, Mattle, Heinrich, Adam, Luise, Elodie Aubert, Carole, Feller, Martin, Loewe, Axel, Schneider, Claudio, Flückiger, Tanja, Groen, Cindy, Ehrsam, Lukas, Hellrigl, Sven, Nuoffer, Alexandra, Rakovic, Damiana, Schwab, Nathalie, Wenger, Rylana, Müller, Andreas, Beynon, Christopher, Dillier, Roger, Deubelbeiss, Michèle, Eberli, Franz, Franzini, Christine, Juchli, Isabel, Liedtke, Claudia, Nadler, Jacqueline, Obst, Thayze, Roth, Jasmin, Schlomowitsch, Fiona, Schneider, Xiaoye, Studerus, Katrin, Tynan, Noreen, Weishaupt, Dominik, Fontana, Simone, Kuest, Silke, Scheuch, Karin, Hischier, Denise, Bonetti, Nicole, Grau, Alexandra, Villinger, Jonas, Laube, Eva, Baumgartner, Philipp, Filipovic, Mark, Frick, Marcel, Montrasio, Giulia, Leuenberger, Stefanie, Rutz, Franziska, Moccetti, Tiziano, Auricchio, Angelo, Anesini, Adriana, Camporini, Cristina, Conte, Giulio, Luce Caputo, Maria, Regoli, Francois, Ammann, Peter, Brenner, Roman, Altmann, David, Gemperle, Michaela, Hayoz, Daniel, Firmann, Mathieu, Foucras, Sandrine, Rime, Martine, Kobza, Richard, Berte, Benjamin, Justi, Virgina, Kellner-Weldon, Frauke, Mehmann, Brigitta, Meier, Sonja, Roth, Myriam, Ruckli-Kaeppeli, Andrea, Russi, Ian, Schmidt, Kai, Young, Mabelle, Zbinden, Melanie, Frangi-Kultalahti, Jane, Pin, Anica, Shah, Dipen, Ehret, Georg Benedikt, Gallet, Hervé, Guillermet, Elise, Lazeyras, François, Lövblad, Karl-Olof, Perret, Patrick, Tavel, Philippe, Teres Castillo, Cheryl, Schläpfer, Jürg, Lauriers, Nathalie, Méan, Marie, Salzmann, Sandrine, Stephan, Frank-Peter, Grêt, Andrea, Novak, Jan, Vitelli, Sandra, Di Valentino, Marcello, Gallino, Augusto, Witassek, Fabienne, Schwenkglenks, Matthias, Altermatt, Anna, Amann, Michael, Huber, Petra, Ruberte, Esther, Zuber, Vanessa, Benkert, Pascal, Dutilh, Gilles, Markovic, Milica, Neuschwander, Pia, Simon, Patrick, and Schmid, Ramun

Subjects
Brain Infarction, Male, brain, ddc:616.0757, White Matter Lesions, Magnetic resonance imaging, Atrial Fibrillation, Humans, Aged, Aged, 80 and over, ddc:616, White matter, blood pressure, Brain, Original Articles, Middle Aged, Magnetic Resonance Imaging, White Matter, Atrial fibrillation, Cross-Sectional Studies, Hypertension, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Blood pressure, Female
Abstract

Supplemental Digital Content is available in the text., The association of blood pressure (BP) and hypertension with the presence of different types of brain lesions in patients with atrial fibrillation is unclear. BP values were obtained in a multicenter cohort of patients with atrial fibrillation. Systolic and diastolic BP was categorized in predefined groups. All patients underwent brain magnetic resonance imaging and neurocognitive testing. Brain lesions were classified as large noncortical or cortical infarcts, small noncortical infarcts, microbleeds, or white matter lesions. White matter lesions were graded according to the Fazekas scale. Overall, 1738 patients with atrial fibrillation were enrolled in this cross-sectional analysis (mean age, 73 years, 73% males). Mean BP was 135/79 mm Hg, and 67% of participants were taking BP-lowering treatment. White matter lesions Fazekas ≥2 were found in 54%, large noncortical or cortical infarcts in 22%, small noncortical infarcts in 21%, and microbleeds in 22% of patients, respectively. Compared with patients with systolic BP

Published
2020

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