1. The way forward for assessing the human health safety of cosmetics in the EU workshop proceedings
- Author
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Petra S. Kern, Kirstin Kosemund-Meynen, Maciej Stępnik, Christophe Rousselle, Natalie von Goetz, Janine Ezendam, Gladys Ouedraogo, Ulrike Bernauer, Emilio Benfenati, Mark T. D. Cronin, Carsten Goebel, Qasim Chaudhry, Paul L. Carmichael, Eric Gaffet, Pieter Jan Coenraads, Heli M. Hollnagel, Laurent Bodin, Berit Granum, Corrado L. Galli, Andrew Worth, Vera Rogiers, Matthew P. Dent, Maria Dusinska, Tamara Vanhaecke, Eirini Panteri, Corie A. Ellison, Pharmaceutical and Pharmacological Sciences, Connexin Signalling Research Group, Experimental in vitro toxicology and dermato-cosmetology, Vriendenkring VUB, Institut Jean Lamour (IJL), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Scientific Committee for Consumer Safety (European Commission) (SCCS), Scientific Committee for Consumer Safety (SCCS) (SCCS), Vrije Universiteit Brussel (VUB), Mario Negri Institute- IRCCS, Bundesinstitut für Risikobewertung - Federal Institute for Risk Assessment (BfR), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Unilever-Safety & Environmental Assurance Centre, Unilever, University of Chester, University Medical Center Groningen [Groningen] (UMCG), Liverpool John Moores University (LJMU), Norsk Institutt for Luftforskning (NILU), Procter & Gamble (P&G), National Institute for Public Health and the Environment [Bilthoven] (RIVM), Université de Lorraine (UL)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), University of Milan, Norwegian Institute of Public Health [Oslo] (NIPH), Dow Europe GmbH, L'Oréal Recherche France (L'Oréal Recherche), L'OREAL, National and Kapodistrian University of Athens (NKUA), Direction de l'Evaluation des Risques (DER), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Nofer Institute of Occupational Medicine (NIOM), Swiss Federal Office of Public Health, European Commission - Joint Research Centre [Ispra] (JRC), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), and Università degli Studi di Milano = University of Milan (UNIMI)
- Subjects
0301 basic medicine ,READ-ACROSS ,Next generation risk assessment ,media_common.quotation_subject ,MESH: Consumer Product Safety ,Context (language use) ,UNCERTAINTY ,SUBSTANCES ,Cosmetics ,Hazard analysis ,Toxicology ,RS ,THRESHOLD ,03 medical and health sciences ,Human health ,0302 clinical medicine ,TOXICOLOGICAL CONCERN VALUES ,Product (category theory) ,EXPOSURE ,Animal testing alternatives ,ComputingMilieux_MISCELLANEOUS ,media_common ,Alternative methods ,RISK ,CONCERN TTC ,IDENTIFICATION ,Animal-Free method ,Replacement method ,MESH: Cosmetics ,DEVELOPMENTAL TOXICITY ,030104 developmental biology ,Risk analysis (engineering) ,New approach methodology ,Safety assessment ,Animal Testing Alternative ,Alternative method ,Cosmetic Products ,[PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci] ,Risk assessement ,Business ,Risk assessment ,030217 neurology & neurosurgery - Abstract
International audience; Although the need for non-animal alternatives has been well recognised for the human health hazard assessment of chemicals in general, it has become especially pressing for cosmetic ingredients due to the full implementation of testing and marketing bans on animal testing under the European Cosmetics Regulation. This means that for the safety assessment of cosmetics, the necessary safety data for both the ingredients and the finished product can be drawn from validated (or scientifically-valid), so-called "Replacement methods". In view of the challenges for safety assessment without recourse to animal test data, the Methodology Working Group of the Scientific Committee on Consumer Safety organised a workshop in February 2019 to discuss the key issues in regard to the use of animal-free alternative methods for the safety evaluation of cosmetic ingredients. This perspective article summarises the outcomes of this workshop and reflects on the state-of-the-art and possible way forward for the safety assessment of cosmetic ingredients for which no experimental animal data exist. The use and optimisation of "New Approach Methodology" that could be useful tools in the context of the "Next Generation Risk Assessment" and the strategic framework for safety assessment of cosmetics were discussed in depth.
- Published
- 2020