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2. SSBP2-CSF1R is a recurrent fusion in B-lineage acute lymphoblastic leukemia with diverse genetic presentation and variable outcome

Author

Schwab, Claire, primary, Roberts, Kathryn, additional, Boer, Judith M., additional, Göhring, Gudrun, additional, Steinemann, Doris, additional, Vora, Ajay, additional, Macartney, Christine, additional, Hough, Rachael, additional, Thorn, Zoe, additional, Dillon, Richard, additional, Escherich, Gabriele, additional, Cazzaniga, Giovanni, additional, Schlegelberger, Brigitte, additional, Loh, Mignon, additional, den Boer, Monique L., additional, Moorman, Anthony V., additional, and Harrison, Christine J., additional

Published
2021
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3. SSBP2-CSF1Ris a recurrent fusion in B-lineage acute lymphoblastic leukemia with diverse genetic presentation and variable outcome

Author

Schwab, Claire, Roberts, Kathryn, Boer, Judith M., Göhring, Gudrun, Steinemann, Doris, Vora, Ajay, Macartney, Christine, Hough, Rachael, Thorn, Zoe, Dillon, Richard, Escherich, Gabriele, Cazzaniga, Giovanni, Schlegelberger, Brigitte, Loh, Mignon, den Boer, Monique L., Moorman, Anthony V., and Harrison, Christine J.

Published
2021
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4. SSBP2-CSF1R Is a Recurrent Fusion in B-Other Acute Lymphoblastic Leukaemia with Variable Clinical Outcome

Author

Schwab, Claire, primary, Andrews, Rebecca, additional, Chilton, Lucy, additional, Elliott, Alannah, additional, Richardson, Stacey, additional, Ryan, Sarra L., additional, Logan, Amy, additional, Fielding, Adele K., additional, Goulden, Nicholas, additional, Vora, Ajay J., additional, Moorman, Anthony V., additional, Macartney, Christine A., additional, and Harrison, Christine J., additional

Published
2014
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5. SSBP2-CSF1RIs a Recurrent Fusion in B-Other Acute Lymphoblastic Leukaemia with Variable Clinical Outcome

Author

Schwab, Claire, Andrews, Rebecca, Chilton, Lucy, Elliott, Alannah, Richardson, Stacey, Ryan, Sarra L., Logan, Amy, Fielding, Adele K., Goulden, Nicholas, Vora, Ajay J., Moorman, Anthony V., Macartney, Christine A., and Harrison, Christine J.

Abstract

BCR-ABL1-like acute lymphoblastic leukaemia (ALL) is a subgroup of B cell precursor (BCP) ALL, which has a similar gene expression profile to BCR-ABL1positive ALL and shares the same high risk of relapse. BCR-ABL1-like ALL is genetically heterogeneous and no single abnormality defines them. However a number of novel fusion genes have been reported in this subgroup, which involve the kinase genes: PDGFRB, CSF1R, ABL1, ABL2and JAK2. Studies have shown that patients with these fusions may also respond to tyrosine kinase inhibitors (TKI), such as imatinib. Here we present a subset of patients with the SSBP2-CSF1Rfusion, including a patient treated with imatinib after relapse.

Published
2014
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