6 results on '"Minjie Fang"'
Search Results
2. Inhibition effect of glycyrrhiza polysaccharide (GCP) on tumor growth through regulation of the gut microbiota composition
- Author
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Xiaoyu Zhang, Shuwu Zhao, Xinbo Song, Jianwei Jia, Zhaiyi Zhang, Huifang Zhou, Hui Fu, Huantian Cui, Shuo Hu, Minjie Fang, Xiaomin Liu, and Yuhong Bian
- Subjects
Therapeutics. Pharmacology ,RM1-950 - Abstract
Glycyrrhiza Uralensis Polysaccharide (GCP), as a macromolecular polysaccharide extracted from the Traditional Chinese Medicine (TCM) - Licorice has been proved to inhibit tumor growth in vitro and in vivo; however, the specific anti-tumor mechanism of GCP needs to be further investigated. In this study, we explore the anti-tumor mechanism of GCP from the angle of gut microbiota. Colon carcinoma cells (CT-26) were used to set up a tumor-bearing mouse model. After 14 days of GCP treatment, the weights of tumors were significantly reduced. In addition, HE staining of tissue sections reflected that GCP could effectively inhibit tumor metastasis. 16SrRNA high-throughput sequencing of fecal samples showed a significant change between the model group and GCP group in the composition of gut microbiota. Subsequently, gut microbiota depletion and fecal transplantation experiments further confirmed the relationship between the anti-tumor effects of GCP and gut microbiota. Following depletion of gut microbiota, GCP cannot inhibit tumor growth. Fecal transplantation experiments found that transplanting the feces of GCP-treated mice, to a certain extent, could inhibit tumor growth and metastasis. These results indicate that Glycyrrhiza Polysaccharides exert anti-tumor effects by affecting gut microbiota composition. Keywords: Glycyrrhiza Uralensis Polysaccharides, Gut microbiota, Cancer, TCM, Anti-tumor
- Published
- 2018
- Full Text
- View/download PDF
3. LncRNA SNHG14 promotes non-small cell lung cancer progression by sponging miR-382-5p
- Author
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Minjie Fang, Xianming Li, Zihuang Li, Rencui Quan, Zhanghong Tan, Gang Xu, Shihai Wu, and Yayan Zhou
- Subjects
General Neuroscience ,microRNA ,Cancer research ,medicine ,Non small cell ,Biology ,General Agricultural and Biological Sciences ,Lung cancer ,medicine.disease ,neoplasms ,General Biochemistry, Genetics and Molecular Biology ,Function (biology) ,respiratory tract diseases - Abstract
Long non-coding RNAs (lncRNAs) are involved in development of non-small cell lung cancer (NSCLC) by interacting with microRNAs (miRNAs) and/or mRNAs. However, the function of most lncRNAs in NSCLC ...
- Published
- 2020
4. Stretchable and self-healable organometal halide perovskite nanocrystal-embedded polymer gels with enhanced luminescence stability
- Author
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Hui Peng, Pei Tian, Chunli Jiang, Minjie Fang, Wenlei Yu, Chunhua Luo, Sihui Huang, Dong Li, and Hechun Lin
- Subjects
QC1-999 ,Enhanced luminescence ,Halide ,Nanotechnology ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Nanomaterials ,self-healable ,Electrical and Electronic Engineering ,luminescent ,Perovskite (structure) ,chemistry.chemical_classification ,soft optical devices ,Physics ,Polymer ,021001 nanoscience & nanotechnology ,Atomic and Molecular Physics, and Optics ,0104 chemical sciences ,Electronic, Optical and Magnetic Materials ,chemistry ,Nanocrystal ,organometal halide perovskite nanocrystals ,0210 nano-technology ,Luminescence ,poly(dimethylsiloxane)-urea gel ,Biotechnology - Abstract
Stretchable and self-healing polymer gels with luminescent property are very promising materials for next generation soft optical devices. This work presents the preparation of self-healing and luminescent polymer gels by simply blending organometal halide perovskite nanocrystals (OHP NCs) with poly(dimethylsiloxane)-urea copolymer (PDMS-urea). On the one hand, the obtained luminescent gels are not only flexible, stretchable and relatively transparent, they also exhibit excellent self-healing capability due to the reversible hydrogen bonding network in the PDMS-urea copolymer. On the other hand, the embedding of OHP NCs (MAPbBr3 and MAPbI3 NCs) inside the hydrophobic PDMS-urea gel greatly improved the photoluminescence stability of OHP NCs against water. Their applications as phosphors for LEDs have been demonstrated. Both the MAPbBr3/PDMS-urea gel and MAPbI3/PDMS-urea gel can fully convert the blue emission of GaN chip to green and red emissions, respectively. These gels can be used as photoluminescent materials in flexible optical devices with good self-healing capability.
- Published
- 2018
5. Inhibition effect of glycyrrhiza polysaccharide (GCP) on tumor growth through regulation of the gut microbiota composition
- Author
-
Huantian Cui, Xiaomin Liu, Shuwu Zhao, Xiaoyu Zhang, Huifang Zhou, Jianwei Jia, Xinbo Song, Minjie Fang, Hui Fu, Zhaiyi Zhang, Yuhong Bian, and Shuo Hu
- Subjects
0301 basic medicine ,Male ,H&E stain ,Gut flora ,Polysaccharide ,digestive system ,Microbiology ,Metastasis ,03 medical and health sciences ,Polysaccharides ,Cell Line, Tumor ,medicine ,Animals ,Glycyrrhiza uralensis ,Feces ,Pharmacology ,chemistry.chemical_classification ,Mice, Inbred BALB C ,biology ,lcsh:RM1-950 ,Cancer ,Fecal Microbiota Transplantation ,biology.organism_classification ,medicine.disease ,Antineoplastic Agents, Phytogenic ,Gastrointestinal Microbiome ,Disease Models, Animal ,030104 developmental biology ,lcsh:Therapeutics. Pharmacology ,Cell Transformation, Neoplastic ,chemistry ,Colonic Neoplasms ,Molecular Medicine ,Glycyrrhiza ,Phytotherapy - Abstract
Glycyrrhiza Uralensis Polysaccharide (GCP), as a macromolecular polysaccharide extracted from the Traditional Chinese Medicine (TCM) - Licorice has been proved to inhibit tumor growth in vitro and in vivo; however, the specific anti-tumor mechanism of GCP needs to be further investigated. In this study, we explore the anti-tumor mechanism of GCP from the angle of gut microbiota. Colon carcinoma cells (CT-26) were used to set up a tumor-bearing mouse model. After 14 days of GCP treatment, the weights of tumors were significantly reduced. In addition, HE staining of tissue sections reflected that GCP could effectively inhibit tumor metastasis. 16SrRNA high-throughput sequencing of fecal samples showed a significant change between the model group and GCP group in the composition of gut microbiota. Subsequently, gut microbiota depletion and fecal transplantation experiments further confirmed the relationship between the anti-tumor effects of GCP and gut microbiota. Following depletion of gut microbiota, GCP cannot inhibit tumor growth. Fecal transplantation experiments found that transplanting the feces of GCP-treated mice, to a certain extent, could inhibit tumor growth and metastasis. These results indicate that Glycyrrhiza Polysaccharides exert anti-tumor effects by affecting gut microbiota composition. Keywords: Glycyrrhiza Uralensis Polysaccharides, Gut microbiota, Cancer, TCM, Anti-tumor
- Published
- 2017
6. LncRNA SNHG14 promotes non-small cell lung cancer progression by sponging miR-382-5p.
- Author
-
Yayan Zhou, Gang Xu, Minjie Fang, Shihai Wu, Zhanghong Tan, Rencui Quan, Zihuang Li, and Xianming Li
- Subjects
NON-coding RNA ,NON-small-cell lung carcinoma ,CANCER invasiveness ,MICRORNA ,WESTERN immunoblotting - Abstract
Long non-coding RNAs (lncRNAs) are involved in development of non-small cell lung cancer (NSCLC) by interacting with microRNAs (miRNAs) and/or mRNAs. However, the function of most lncRNAs in NSCLC remains unclear. Reverse transcription-quantitative PCR (RT-qPCR) and western blot were applied for detection of mRNA/miRNA and protein level. Interaction between LncRNA small nucleolar RNA host gene 14 (SNHG14) and miR-382-5p was validated by dual luciferase reporter assay. Cell proliferation and apoptosis was detected using Cell Counting Kit 8 (CCK8) and Flow cytometry, while cell migration and invasion was detected by scratch assay and Transwell assay. SNHG14 was upregulated in NSCLC tissues and cell lines. SNHG14 silencing reduced proliferation, migration and invasion, and induced apoptosis in A549 cells. SNHG14 was negatively correlated with miR-382-5p in NSCLC tissues, SNHG14 and miR-382-5p negatively regulated each other in A549 cells. SNHG14 promoted expression of miR-382-5p target genes, including LIM-only protein 3 (LMO3) and SET domain containing lysine methyltransferase 8 (SETD8), in A549 cells. miR-382-5p inhibition reversed SNHG14 knockdown-induced increase in apoptosis and decrease in proliferation, migration and invasion. SNHG14 was correlated with SETD8 and LMO3 in NSCLC tissues. Collectively, SNHG14 promoted NSCLC proliferation, migration and invasion, while inhibited apoptosis by sponging miR-382-5p in A549 cells. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
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