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1. State of the Practice for Medical Imaging Software

Author

Smith, W. Spencer, Dong, Ao, Carette, Jacques, and Noseworthy, Michael D.

Subjects
Computer Science - Software Engineering, Computer Science - Computer Vision and Pattern Recognition, D.2.7, I.4.0
Abstract

We selected 29 medical imaging projects from 48 candidates, assessed 10 software qualities by answering 108 questions for each software project, and interviewed 8 of the 29 development teams. Based on the quantitative data, we ranked the MI software with the Analytic Hierarchy Process (AHP). The four top-ranked software products are 3D Slicer, ImageJ, Fiji, and OHIF Viewer. Generally, MI software is in a healthy state as shown by the following: we observed 88% of the documentation artifacts recommended by research software development guidelines, 100% of MI projects use version control tools, and developers appear to use the common quasi-agile research software development process. However, the current state of the practice deviates from the existing guidelines because of the rarity of some recommended artifacts, low usage of continuous integration (17% of the projects), low use of unit testing (about 50% of projects), and room for improvement with documentation (six of nine developers felt their documentation was not clear enough). From interviewing the developers, we identified five pain points and two qualities of potential concern: lack of development time, lack of funding, technology hurdles, ensuring correctness, usability, maintainability, and reproducibility. The interviewees proposed strategies to improve the state of the practice, to address the identified pain points, and to improve software quality. Combining their ideas with ours, we have the following list of recommendations: increase documentation, increase testing by enriching datasets, increase continuous integration usage, move to web applications, employ linters, use peer reviews, design for change, add assurance cases, and incorporate a "Generate All Things" approach., Comment: 73 pages, 14 figures, 12 tables

Published
2024

5. Amyloid-PET of the white matter: Relationship to free water, fiber integrity, and cognition in patients with dementia and small vessel disease

Author

Ottoy, Julie, Ozzoude, Miracle, Zukotynski, Katherine, Kang, Min Su, Adamo, Sabrina, Scott, Christopher, Ramirez, Joel, Swardfager, Walter, Lam, Benjamin, Bhan, Aparna, Mojiri, Parisa, Kiss, Alex, Strother, Stephen, Bocti, Christian, Borrie, Michael, Chertkow, Howard, Frayne, Richard, Hsiung, Robin, Laforce, Robert Jr, Noseworthy, Michael D, Prato, Frank S, Sahlas, Demetrios J, Smith, Eric E, Kuo, Phillip H, Chad, Jordan A, Pasternak, Ofer, Sossi, Vesna, Thiel, Alexander, Soucy, Jean-Paul, Tardif, Jean-Claude, Black, Sandra E, and Goubran, Maged

Published
2023
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8. Lower brown adipose tissue activity is associated with non-alcoholic fatty liver disease but not changes in the gut microbiota

Author

Ahmed, Basma A., Ong, Frank J., Barra, Nicole G., Blondin, Denis P., Gunn, Elizabeth, Oreskovich, Stephan M., Szamosi, Jake C., Syed, Saad A., Hutchings, Emily K., Konyer, Norman B., Singh, Nina P., Yabut, Julian M., Desjardins, Eric M., Anhê, Fernando F., Foley, Kevin P., Holloway, Alison C., Noseworthy, Michael D., Haman, Francois, Carpentier, Andre C., Surette, Michael G., Schertzer, Jonathan D., Punthakee, Zubin, Steinberg, Gregory R., and Morrison, Katherine M.

Published
2021
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10. Distinct spatial contributions of amyloid pathology and cerebral small vessel disease to hippocampal morphology.

Author

Xhima, Kristiana, Ottoy, Julie, Gibson, Erin, Zukotynski, Katherine, Scott, Christopher, Feliciano, Ginelle J., Adamo, Sabrina, Kuo, Phillip H., Borrie, Michael J., Chertkow, Howard, Frayne, Richard, Laforce, Robert, Noseworthy, Michael D., Prato, Frank S., Sahlas, Demetrios J., Smith, Eric E., Sossi, Vesna, Thiel, Alexander, Soucy, Jean‐Paul, and Tardif, Jean‐Claude

Abstract

INTRODUCTION: Cerebral small vessel disease (SVD) and amyloid beta (Aβ) pathology frequently co‐exist. The impact of concurrent pathology on the pattern of hippocampal atrophy, a key substrate of memory impacted early and extensively in dementia, remains poorly understood. METHODS: In a unique cohort of mixed Alzheimer's disease and moderate–severe SVD, we examined whether total and regional neuroimaging measures of SVD, white matter hyperintensities (WMH), and Aβ, as assessed by 18F‐AV45 positron emission tomography, exert additive or synergistic effects on hippocampal volume and shape. RESULTS: Frontal WMH, occipital WMH, and Aβ were independently associated with smaller hippocampal volume. Frontal WMH had a spatially distinct impact on hippocampal shape relative to Aβ. In contrast, hippocampal shape alterations associated with occipital WMH spatially overlapped with Aβ‐vulnerable subregions. DISCUSSION: Hippocampal degeneration is differentially sensitive to SVD and Aβ pathology. The pattern of hippocampal atrophy could serve as a disease‐specific biomarker, and thus guide clinical diagnosis and individualized treatment strategies for mixed dementia. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Reduced Cognitive Assessment Scores Among Individuals With Magnetic Resonance Imaging–Detected Vascular Brain Injury

Author

Anand, Sonia S., Friedrich, Matthias G., Desai, Dipika, Schulze, Karleen M., Awadalla, Philip, Busseuil, David, Dummer, Trevor J.B., Jacquemont, Sébastien, Dick, Alexander, Kelton, David, Kirpalani, Anish, Lear, Scott A., Leipsic, Jonathan, Noseworthy, Michael D., Parker, Louise, Parraga, Grace, Poirier, Paul, Robson, Paula, Tardif, Jean-Claude, Teo, Koon, Vena, Jennifer, Yusuf, Salim, Moody, Alan R., Black, Sandra E., and Smith, Eric E.

Published
2020
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16. EFFECTS OF VASCULAR BURDEN ON COGNITION ARE MEDIATED BY ATROPHY, AMYLOID, AND GLUCOSE METABOLISM: A MULTI-CENTRE MIXED COHORT OF SMALL VESSEL DISEASE AND ALZHEIMER'S PATHOLOGY

Author

Ottoy, Julie, Ozzoude, Miracle, Zukotynski, Katherine, Adamo, Sabrina, Scott, Christopher, Gaudet, Vincent, Ramirez, Joel, Swardfager, Walter, Cogo-Moreira, Hugo, Lam, Benjamin, Bhan, Aparna, Mojiri, Parisa, Kang, Min Su, Rabin, Jennifer, Kiss, Alex, Strother, Stephen, Bocti, Christian, Borrie, Michael, Chertkow, Howard, Frayne, Richard, Hsiung, Robin, Laforce, Robert, Jr., Noseworthy, Michael D., Prato, Frank S., Sahlas, Demetrios J., Smith, Eric E., Kuo, Phillip H., Sossi, Vesna, Thiel, Alexander, Soucy, Jean-Paul, Tardif, Jean-Claude, Black, Sandra E., and Goubran, Maged

Published
2024
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17. Comparison of ventilation defects quantified by Technegas SPECT and hyperpolarized 129Xe MRI

Author

Radadia, Nisarg, primary, Friedlander, Yonni, additional, Priel, Eldar, additional, Konyer, Norman B., additional, Huang, Chynna, additional, Jamal, Mobin, additional, Farncombe, Troy, additional, Marriott, Christopher, additional, Finley, Christian, additional, Agzarian, John, additional, Dolovich, Myrna, additional, Noseworthy, Michael D., additional, Nair, Parameswaran, additional, Shargall, Yaron, additional, and Svenningsen, Sarah, additional

Published
2023
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19. sj-pdf-1-jcb-10.1177_0271678X231152001 - Supplemental material for Amyloid-PET of the white matter: Relationship to free water, fiber integrity, and cognition in patients with dementia and small vessel disease

Author

Ottoy, Julie, Ozzoude, Miracle, Zukotynski, Katherine, Kang, Min Su, Adamo, Sabrina, Scott, Christopher, Ramirez, Joel, Swardfager, Walter, Lam, Benjamin, Bhan, Aparna, Mojiri, Parisa, Kiss, Alex, Strother, Stephen, Bocti, Christian, Borrie, Michael, Chertkow, Howard, Frayne, Richard, Hsiung, Robin, Laforce, Robert Jr, Noseworthy, Michael D, Prato, Frank S, Sahlas, Demetrios J, Smith, Eric E, Kuo, Phillip H, Chad, Jordan A, Pasternak, Ofer, Sossi, Vesna, Thiel, Alexander, Soucy, Jean-Paul, Tardif, Jean-Claude, Black, Sandra E, and Goubran, Maged

Subjects
110320 Radiology and Organ Imaging, FOS: Clinical medicine, FOS: Biological sciences, Medicine, Cell Biology, 110305 Emergency Medicine, 110306 Endocrinology, Biochemistry, 69999 Biological Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, sj-pdf-1-jcb-10.1177_0271678X231152001 for Amyloid-PET of the white matter: Relationship to free water, fiber integrity, and cognition in patients with dementia and small vessel disease by Julie Ottoy, Miracle Ozzoude, Katherine Zukotynski, Min Su Kang, Sabrina Adamo, Christopher Scott, Joel Ramirez, Walter Swardfager, Benjamin Lam, Aparna Bhan, Parisa Mojiri, Alex Kiss, Stephen Strother, Christian Bocti, Michael Borrie, Howard Chertkow, Richard Frayne, Robin Hsiung, Robert Jr Laforce, Michael D Noseworthy, Frank S Prato, Demetrios J Sahlas, Eric E Smith, Phillip H Kuo, Jordan A Chad, Ofer Pasternak, Vesna Sossi, Alexander Thiel, Jean-Paul Soucy, Jean-Claude Tardif, Sandra E Black, Maged Goubran in Journal of Cerebral Blood Flow & Metabolism

Published
2023
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21. Comparison of ventilation defects quantified by Technegas SPECT and hyperpolarized 129Xe MRI.

Author

Radadia, Nisarg, Friedlander, Yonni, Priel, Eldar, Konyer, Norman B., Chynna Huang, Jamal, Mobin, Farncombe, Troy, Marriott, Christopher, Finley, Christian, Agzarian, John, Dolovich, Myrna, Noseworthy, Michael D., Nair, Parameswaran, Shargall, Yaron, and Svenningsen, Sarah

Subjects
SINGLE-photon emission computed tomography, MAGNETIC resonance imaging, VENTILATION, OBSTRUCTIVE lung diseases, K-means clustering
Abstract

Introduction: The ideal contrast agents for ventilation SPECT and MRI are Technegas and 129Xe gas, respectively. Despite increasing interest in the clinical utility of ventilation imaging, these modalities have not been directly compared. Therefore, our objective was to compare the ventilation defect percent (VDP) assessed by Technegas SPECT and hyperpolarized 129Xe MRI in patients scheduled to undergo lung cancer resection with and without pre-existing obstructive lung disease. Methods: Forty-one adults scheduled to undergo lung cancer resection performed same-day Technegas SPECT, hyperpolarized 129Xe MRI, spirometry, and diffusing capacity of the lung for carbon monoxide (DLCO). Ventilation abnormalities were quantified as the VDP using two different methods: adaptive thresholding (VDPT) and k-means clustering (VDPK). Correlation and agreement between VDP quantified by Technegas SPECT and 129Xe MRI were determined by Spearman correlation and Bland-Altman analysis, respectively. Results: VDP measured by Technegas SPECT and 129Xe MRI were correlated (VDPT: r = 0.48, p = 0.001; VDPK: r = 0.63, p < 0.0001). A 2.0% and 1.6% bias towards higher Technegas SPECT VDP was measured using the adaptive threshold method (VDPT: 23.0% ± 14.0% vs. 21.0% ± 5.2%, p = 0.81) and k-means method (VDPK: 9.4% ± 9.4% vs. 7.8% ± 10.0%, p = 0.02), respectively. For both modalities, higher VDP was correlated with lower FEV1/FVC (SPECT VDPT: r = -0.38, p = 0.01; MRI VDPK: r=-0.46, p = 0.002) and DLCO (SPECT VDPT: r=-0.61, p < 0.0001; MRI VDPK: r = -0.68, p < 0.0001). Subgroup analysis revealed that VDP measured by both modalities was significantly higher for participants with COPD (n = 13) than those with asthma (n = 6; SPECT VDPT: p = 0.007, MRI VDPK: p = 0.006) and those with no history of obstructive lung disease (n = 21; SPECT VDPT: p = 0.0003, MRI VDPK: p = 0.0003). Discussion: The burden of ventilation defects quantified by Technegas SPECT and 129Xe MRI VDP was correlated and greater in participants with COPD when compared to those without. Our observations indicate that, despite substantial differences between the imaging modalities, quantitative assessment of ventilation defects by Technegas SPECT and 129Xe MRI is comparable. [ABSTRACT FROM AUTHOR]

Published
2023
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22. Effect of Cognitive Reserve on the Association of Vascular Brain Injury With Cognition

Author

Durrani, Romella, Friedrich, Matthias G., Schulze, Karleen M., Awadalla, Philip, Balasubramanian, Kumar, Black, Sandra E., Broet, Philippe, Busseuil, David, Desai, Dipika, Dummer, Trevor, Dick, Alexander, Hicks, Jason, Iype, Thomas, Kelton, David, Kirpalani, Anish, Lear, Scott A., Leipsic, Jonathon, Li, Wei, McCreary, Cheryl R., Moody, Alan R., Noseworthy, Michael D., Parraga, Grace, Poirier, Paul, Rangarajan, Sumathy, Szczesniak, Dorota, Szuba, Andrzej, Tardif, Jean-Claude, Teo, Koon, Vena, Jennifer E., Zatonska, Katarzyna, Zimny, Anna, Lee, Douglas S., Yusuf, Salim, Anand, Sonia S., and Smith, Eric E.

Subjects
Adult, Aged, 80 and over, Brain Infarction, Male, Middle Aged, Cognition, Cross-Sectional Studies, Cognitive Reserve, Humans, Cognitive Dysfunction, Female, Research Article, Aged
Abstract

Background and Objectives To determine whether cognitive reserve attenuates the association of vascular brain injury with cognition. Methods Cross-sectional data were analyzed from 2 harmonized studies: the Canadian Alliance for Healthy Hearts and Healthy Minds (CAHHM) and the Prospective Urban and Rural Epidemiology (PURE) study. Markers of cognitive reserve were education, involvement in social activities, marital status, height, and leisure physical activity, which were combined into a composite score. Vascular brain injury was defined as nonlacunar brain infarcts or high white matter hyperintensity (WMH) burden on MRI. Cognition was assessed using the Montreal Cognitive Assessment Tool (MoCA) and the Digit Symbol Substitution Test (DSST). Results There were 10,916 participants age 35–81. Mean age was 58.8 years (range 35–81) and 55.8% were female. Education, moderate leisure physical activity, being in a marital partnership, being taller, and participating in social groups were each independently associated with higher cognition, as was the composite cognitive reserve score. Vascular brain injury was associated with lower cognition (β –0.35 [95% confidence interval [CI] –0.53 to −0.17] for MoCA and β −2.19 [95% CI −3.22 to −1.15] for DSST) but the association was not modified by the composite cognitive reserve variable (interaction p = 0.59 for MoCA and p = 0.72 for DSST). Conclusions Both vascular brain injury and markers of cognitive reserve are associated with cognition. However, the effects were independent such that the adverse effects of covert vascular brain injury were not attenuated by higher cognitive reserve. To improve cognitive brain health, interventions to both prevent cerebrovascular disease and promote positive lifestyles are needed.

Published
2021

23. Non‐invasive MR imaging techniques for measuring femoral arterial flow in a pediatric and adolescent cohort

Author

Caterini, Jessica E., primary, Rendall, Kate, additional, Cifra, Barbara, additional, Schneiderman, Jane E., additional, Ratjen, Felix, additional, Seed, Mike, additional, Rayner, Tammy, additional, Weiss, Ruth, additional, McCrindle, Brian W., additional, Noseworthy, Michael D., additional, Williams, Craig A., additional, Barker, Alan R., additional, and Wells, Gregory D., additional

Published
2022
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25. Impaired Cold-Stimulated Supraclavicular Brown Adipose Tissue Activity in Young Boys With Obesity

Author

Ahmed, Basma A., primary, Varah, Nina, additional, Ong, Frank J., additional, Blondin, Denis P., additional, Gunn, Elizabeth, additional, Konyer, Norman B., additional, Singh, Nina P., additional, Noseworthy, Michael D., additional, Haman, Francois, additional, Carpentier, Andre C., additional, Punthakee, Zubin, additional, Steinberg, Gregory R., additional, and Morrison, Katherine M., additional

Published
2022
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27. Potential Role of MRI Imaging for Myofascial Pain: A Scoping Review for the Clinicians and Theoretical Considerations

Author

Evans,Valerie, Behr,Michael, Gangwar,Anshika, Noseworthy,Michael D, and Kumbhare,Dinesh

Subjects
Journal of Pain Research
Abstract

Valerie Evans,1,2 Michael Behr,2,3 Anshika Gangwar,2 Michael D Noseworthy,4 Dinesh Kumbhare1– 3 1Institute of Biomaterials and Biomedical Engineering (IBBME), University of Toronto, Toronto, Ontario, Canada; 2University Health Network – Toronto Rehabilitation Institute, Toronto, Ontario, Canada; 3Department of Medicine, Division of Physical Medicine and Rehabilitation, University of Toronto, Toronto, Ontario, Canada; 4Department of Electrical and Computer Engineering, McMaster University, Hamilton, Ontario, CanadaCorrespondence: Dinesh KumbhareDepartment of Medicine and IBBME, University of Toronto, 550 University Ave, Suite 7-131, Toronto, ON, M5G 2A2, CanadaTel +1 416-597-3422 x 4612Email dinesh.kumbhare@uhn.caAbstract: The most common cause of chronic musculoskeletal pain is chronic myofascial pain syndrome (MPS). MPS often presents with increased muscle stiffness, and the myofascial trigger point (MTrP). Imaging modalities have been used to identify the MTrP, but their role in the detection and diagnosis of MPS remains unclear. The purpose of this review was to identify evidence in literature for the use of imaging in the role of classifying and explaining the physiology of MTrPs. Since few imaging techniques have been performed on MTrPs, we explored the imaging techniques that can effectively image complex skeletal muscle microstructure, and how they could be used. As part of a scoping review, we conducted a systematic search from three medical databases (CINAHL, EMBASE and MEDLINE) from year to year to analyze past MTrP imaging, as well as analyzing imaging techniques performed on the microstructure of muscle. Previously, ultrasound has been used to differentiate active, latent MTrPs, but these studies do not adequately address their underlying anatomical structure. MRI remains the standard method of imaging skeletal muscle. The existing MRI literature suggests that the DTI technique can quantify muscle injury, strain, and structure. However, theoretically, HARDI and DKI techniques seem to provide more information for complex structural areas, although these modalities have a disadvantage of longer scan times and have not been widely used on skeletal muscle. Our review suggests that DTI is the most effective imaging modality that has been used to define the microstructure of muscle and hence, could be optimal to image the MTrP. HARDI and DKI are techniques with theoretical potential for analysis of muscle, which may provide more detailed information representative of finer muscle structural features. Future research utilizing MRI techniques to image muscle are necessary to provide a more robust means of imaging skeletal muscle and the MTrP.Keywords: myofascial pain syndrome, MRI, trigger points, chronic pain, imaging

Published
2021

32. Comparison of Multivendor Single-Voxel MR Spectroscopy Data Acquired in Healthy Brain at 26 Sites

Author

Považan, Michal, primary, Mikkelsen, Mark, additional, Berrington, Adam, additional, Bhattacharyya, Pallab K., additional, Brix, Maiken K., additional, Buur, Pieter F., additional, Cecil, Kim M., additional, Chan, Kimberly L., additional, Chen, David Y.T., additional, Craven, Alexander R., additional, Cuypers, Koen, additional, Dacko, Michael, additional, Duncan, Niall W., additional, Dydak, Ulrike, additional, Edmondson, David A., additional, Ende, Gabriele, additional, Ersland, Lars, additional, Forbes, Megan A., additional, Gao, Fei, additional, Greenhouse, Ian, additional, Harris, Ashley D., additional, He, Naying, additional, Heba, Stefanie, additional, Hoggard, Nigel, additional, Hsu, Tun-Wei, additional, Jansen, Jacobus F. A., additional, Kangarlu, Alayar, additional, Lange, Thomas, additional, Lebel, R. Marc, additional, Li, Yan, additional, Lin, Chien-Yuan E., additional, Liou, Jy-Kang, additional, Lirng, Jiing-Feng, additional, Liu, Feng, additional, Long, Joanna R., additional, Ma, Ruoyun, additional, Maes, Celine, additional, Moreno-Ortega, Marta, additional, Murray, Scott O., additional, Noah, Sean, additional, Noeske, Ralph, additional, Noseworthy, Michael D., additional, Oeltzschner, Georg, additional, Porges, Eric C., additional, Prisciandaro, James J., additional, Puts, Nicolaas A. J., additional, Roberts, Timothy P. L., additional, Sack, Markus, additional, Sailasuta, Napapon, additional, Saleh, Muhammad G., additional, Schallmo, Michael-Paul, additional, Simard, Nicholas, additional, Stoffers, Diederick, additional, Swinnen, Stephan P., additional, Tegenthoff, Martin, additional, Truong, Peter, additional, Wang, Guangbin, additional, Wilkinson, Iain D., additional, Wittsack, Hans-Jörg, additional, Woods, Adam J., additional, Xu, Hongmin, additional, Yan, Fuhua, additional, Zhang, Chencheng, additional, Zipunnikov, Vadim, additional, Zöllner, Helge J., additional, Edden, Richard A.E., additional, and Barker, Peter B., additional

Published
2020
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33. MRI Reveals Human Brown Adipose Tissue Is Rapidly Activated in Response to Cold

Author

Oreskovich, Stephan M, primary, Ong, Frank J, additional, Ahmed, Basma A, additional, Konyer, Norman B, additional, Blondin, Denis P, additional, Gunn, Elizabeth, additional, Singh, Nina P, additional, Noseworthy, Michael D, additional, Haman, Francois, additional, Carpentier, Andre C, additional, Punthakee, Zubin, additional, Steinberg, Gregory R, additional, and Morrison, Katherine M, additional

Published
2019
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36. Reproducibility of Hyperpolarized 129Xe MRI Ventilation Defect Percent in Severe Asthma to Evaluate Clinical Trial Feasibility.

Author

Svenningsen, Sarah, McIntosh, Marrissa, Ouriadov, Alexei, Matheson, Alexander M, Konyer, Norman B, Eddy, Rachel L, McCormack, David G, Noseworthy, Michael D, Nair, Parameswaran, and Parraga, Grace

Abstract

Rationale and Objectives: 129Xe MRI has been developed to noninvasively visualize and quantify the functional consequence of airway obstruction in asthma. Its widespread application requires evidence of intersite reproducibility and agreement. Our objective was to evaluate reproducibility and agreement of 129Xe ventilation MRI measurements in severe asthmatics at two sites.Materials and Methods: In seven adults with severe asthma, 129Xe ventilation MRI was acquired pre- and post-bronchodilator at two geographic sites within 24-hours. 129Xe MRI signal-to-noise ratio (SNR) was calculated and ventilation abnormalities were quantified as the whole-lung and slice-by-slice ventilation defect percent (VDP). Intraclass correlation coefficients (ICC) and Bland-Altman analysis were used to determine intersite 129Xe VDP reproducibility and agreement.Results: Whole-lung and slice-by-slice 129Xe VDP measured at both sites were correlated and reproducible (pre-bronchodilator: whole-lung ICC = 0.90, p = 0.005, slice-by-slice ICC = 0.78, p < 0.0001; post-bronchodilator: whole-lung ICC = 0.94, p < 0.0001, slice-by-slice ICC = 0.83, p < 0.0001) notwithstanding intersite differences in the 129Xe-dose-equivalent-volume (101 ± 15 mL site 1, 49 ± 6 mL site 2, p < 0.0001), gas-mixture (129Xe/4He site 1; 129Xe/N2 site 2) and SNR (40 ± 19 site 1, 23 ± 5 site 2, p = 0.02). Qualitative 129Xe gas distribution differences were observed between sites and slice-by-slice 129Xe VDP, but not whole-lung 129Xe VDP, was significantly lower at site 1 (pre-bronchodilator VDP: whole-lung bias = -3%, p > 0.99, slice-by-slice bias = -3%, p = 0.0001; post-bronchodilator VDP: whole-lung bias = -2%, p = 0.59, slice-by-slice-bias = -2%, p = 0.0003).Conclusion: 129Xe MRI VDP at two different sites measured within 24-hours in the same severe asthmatics were correlated. Qualitative and quantitative intersite differences in 129Xe regional gas distribution and VDP point to site-specific variability that may be due to differences in gas-mixture composition or SNR. [ABSTRACT FROM AUTHOR]

Published
2021
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37. Cardiovascular risk scoring and magnetic resonance imaging detected subclinical cerebrovascular disease

Author

Anand, Sonia S, primary, Tu, Jack V, primary, Desai, Dipika, primary, Awadalla, Phillip, primary, Robson, Paula, primary, Jacquemont, Sébastien, primary, Dummer, Trevor, primary, Le, Nhu, primary, Parker, Louise, primary, Poirier, Paul, primary, Teo, Koon, primary, Lear, Scott A, primary, Yusuf, Salim, primary, Tardif, Jean-Claude, primary, Marcotte, Francois, primary, Busseuil, David, primary, Després, Jean-Pierre, primary, Black, Sandra E, primary, Kirpalani, Anish, primary, Parraga, Grace, primary, Noseworthy, Michael D, primary, Dick, Alexander, primary, Leipsic, Jonathan, primary, Kelton, David, primary, Vena, Jennifer, primary, Thomas, Melissa, primary, Schulze, Karleen M, primary, Larose, Eric, primary, Moody, Alan R, primary, Smith, Eric E, primary, and Friedrich, Matthias G, primary

Published
2019
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44. Abstract W MP119: Sensitivity and Reliability of MRI SWI Compared With GRE Sequences for Detecting Microbleeds in a Community Population

Author

Batool, Saima, primary, Patil, Shivanand, additional, Noseworthy, Michael D, additional, O'Donnell, Martin, additional, Sharma, Mukul, additional, Islam, Shofiqul, additional, Teo, Koon, additional, Black, Sandra, additional, Lauzon, M L, additional, McCreary, Cheryl R, additional, Frayne, Richard, additional, DeJesus, Jane, additional, Rangarajan, Sumathy, additional, Yusuf, Salim, additional, and Smith, Eric E, additional

Published
2015
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45. Evidence against the Involvement of Chronic Cerebrospinal Venous Abnormalities in Multiple Sclerosis. A Case-Control Study

Author

Rodger, Ian W., primary, Dilar, Dorothy, additional, Dwyer, Janet, additional, Bienenstock, John, additional, Coret, Andu, additional, Coret-Simon, Judith, additional, Foster, Gary, additional, Franchetto, Arlene, additional, Franic, Slobodan, additional, Goldsmith, Charles H., additional, Koff, David, additional, Konyer, Norman B., additional, Levine, Mitchell, additional, McDonald, Ellen, additional, Noseworthy, Michael D., additional, Paulseth, John, additional, Ribeiro, Luciana, additional, Sayles, Mary Jane, additional, and Thabane, Lehana, additional

Published
2013
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