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10. A method using deep learning to discover new predictors of CRT response from mechanical dyssynchrony on gated SPECT MPI

Author

He, Zhuo, Zhang, Xinwei, Zhao, Chen, Qian, Zhiyong, Wang, Yao, Hou, Xiaofeng, Zou, Jiangang, and Zhou, Weihua

Subjects
Physics - Medical Physics, Computer Science - Artificial Intelligence
Abstract

Background. Studies have shown that the conventional left ventricular mechanical dyssynchrony (LVMD) parameters have their own statistical limitations. The purpose of this study is to extract new LVMD parameters from the phase analysis of gated SPECT MPI by deep learning to help CRT patient selection. Methods. One hundred and three patients who underwent rest gated SPECT MPI were enrolled in this study. CRT response was defined as a decrease in left ventricular end-systolic volume (LVESV) >= 15% at 6 +- 1 month follow up. Autoencoder (AE), an unsupervised deep learning method, was trained by the raw LV systolic phase polar maps to extract new LVMD parameters, called AE-based LVMD parameters. Correlation analysis was used to explain the relationships between new parameters with conventional LVMD parameters. Univariate and multivariate analyses were used to establish a multivariate model for predicting CRT response. Results. Complete data were obtained in 102 patients, 44.1% of them were classified as CRT responders. AE-based LVMD parameter was significant in the univariate (OR 1.24, 95% CI 1.07 - 1.44, P = 0.006) and multivariate analyses (OR 1.03, 95% CI 1.01 - 1.06, P = 0.006). Moreover, it had incremental value over PSD (AUC 0.72 vs. 0.63, LH 8.06, P = 0.005) and PBW (AUC 0.72 vs. 0.64, LH 7.87, P = 0.005), combined with significant clinic characteristics, including LVEF and gender. Conclusions. The new LVMD parameters extracted by autoencoder from the baseline gated SPECT MPI has the potential to improve the prediction of CRT response., Comment: 10 pages, 3 figures, will submit to journal of nuclear cardiology

Published
2021
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14. From mouse to mouse‐ear cress: Nanomaterials as vehicles in plant biotechnology

Author

Xia, Xue, Shi, Bingyang, Wang, Lei, Liu, Yang, Zou, Yan, Zhou, Yun, Chen, Yu, Zheng, Meng, Zhu, Yingfang, Duan, Jingjing, Guo, Siyi, Jang, Ho Won, Miao, Yuchen, Fan, Kelong, Bai, Feng, Tao, Wei, Zhao, Yong, Yan, Qingyu, Cheng, Gang, Liu, Huiyu, Jiao, Yan, Liu, Shanhu, Huang, Yuanyu, Ling, Daishun, Kang, Wenyi, Xue, Xue, Cui, Daxiang, Huang, Yongwei, Cui, Zongqiang, Sun, Xun, Qian, Zhiyong, Gu, Zhen, Han, Gang, Yang, Zhimou, Leong, David Tai, Wu, Aiguo, Liu, Gang, Qu, Xiaogang, Shen, Youqing, Wang, Qiangbin, Lowry, Gregory V, Wang, Ertao, Liang, Xing‐Jie, Gardea‐Torresdey, Jorge, Chen, Guoping, Parak, Wolfgang J, Weiss, Paul S, Zhang, Lixin, Stenzel, Martina M, Fan, Chunhai, Bush, Ashley I, Zhang, Gaiping, Grof, Christopher PL, Wang, Xuelu, Galbraith, David W, Tang, Ben Zhong, Offler, Christina E, Patrick, John W, and Song, Chun‐Peng

Subjects
Medical Biotechnology, Biomedical and Clinical Sciences, Engineering, Nanotechnology, Biotechnology, Bioengineering, nanocarrier, plant nano‐biotechnology
Abstract

Biological applications of nanomaterials as delivery carriers have been embedded in traditional biomedical research for decades. Despite lagging behind, recent significant breakthroughs in the use of nanocarriers as tools for plant biotechnology have created great interest. In this Perspective, we review the outstanding recent works in nanocarrier-mediated plant transformation and its agricultural applications. We analyze the chemical and physical properties of nanocarriers determining their uptake efficiency and transport throughout the plant body.

Published
2021

29. Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells

Author

Hong, Weiqi, Yang, Jingyun, Zou, Jun, Bi, Zhenfei, He, Cai, Lei, Hong, He, Xuemei, Li, Xue, Alu, Aqu, Ren, Wenyan, Wang, Zeng, Jiang, Xiaohua, Zhong, Kunhong, Jia, Guowen, Yang, Yun, Yu, Wenhai, Huang, Qing, Yang, Mengli, Zhou, Yanan, Zhao, Yuan, Kuang, Dexuan, Wang, Junbin, Wang, Haixuan, Chen, Siyuan, Luo, Min, Zhang, Ziqi, Lu, Tianqi, Chen, Li, Que, Haiying, He, Zhiyao, Sun, Qiu, Wang, Wei, Shen, Guobo, Lu, Guangwen, Zhao, Zhiwei, Yang, Li, Yang, Jinliang, Wang, Zhenling, Li, Jiong, Song, Xiangrong, Dai, Lunzhi, Chen, Chong, Geng, Jia, Gou, Maling, Chen, Lu, Dong, Haohao, Peng, Yong, Huang, Canhua, Qian, Zhiyong, Cheng, Wei, Fan, Changfa, Wei, Yuquan, Su, Zhaoming, Tong, Aiping, Lu, Shuaiyao, Peng, Xiaozhong, and Wei, Xiawei

Published
2022
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34. Research Progress on Mechanism and Intervention of Renal Function Injury in Hyperlipidemia Animal Model

Author

ZHOU Xiaoli, ZHANG Qian, and QIAN Zhiyong

Subjects
hyperlipidemia, kidney injury, animal model, Medicine
Abstract

Hyperlipidemia is closely related to renal function damage, and they influence each other. Lipid deposition in the kidney affects the function and structure of glomerulus and renal tubules directly and indirectly, resulting in renal function injury. On the contrary, renal function damage further affects lipid metabolism and aggravates the progress of hyperlipidemia. At present, besides synthetic drugs, there are many non-synthetic drugs which have been well verified in the intervention of kidney injury in hyperlipidemia animal model. In this paper, the research progress in the mechanism of renal function damage and the related intervention using hyperlipidemia animal model at home and abroad in recent years were summarized.

Published
2022
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50. Inflammation‐Targeted Nanomedicines Alleviate Oxidative Stress and Reprogram Macrophages Polarization for Myocardial Infarction Treatment.

Author

Hu, Danrong, Li, Ran, Li, Yicong, Wang, Meng, Wang, Lu, Wang, Shiqi, Cheng, Hongxin, Zhang, Qing, Fu, Chenying, Qian, Zhiyong, and Wei, Quan

Subjects
MYOCARDIAL infarction, OXIDATIVE stress, MACROPHAGES, NANOMEDICINE, HEART diseases, CELL communication
Abstract

Myocardial infarction (MI) is a critical global health challenge, with current treatments limited by the complex MI microenvironment, particularly the excessive oxidative stress and intense inflammatory responses that exacerbate cardiac dysfunction and MI progression. Herein, a mannan‐based nanomedicine, Que@MOF/Man, is developed to target the inflammatory infarcted heart and deliver the antioxidative and anti‐inflammatory agent quercetin (Que), thereby facilitating a beneficial myocardial microenvironment for cardiac repair. The presence of mannan on the nanoparticle surface enables selective internalization by macrophages rather than cardiomyocytes. Que@MOF/Man effectively neutralizes reactive oxygen species in macrophages to reduce oxidative stress and promote their differentiation into a reparative phenotype, reconciling the inflammatory response and enhancing cardiomyocyte survival through intercellular communication. Owing to the recruitment of macrophages into inflamed myocardium post‐MI, in vivo, administration of Que@MOF/Man in MI rats revealed the specific distribution into the injured myocardium compared to free Que. Furthermore, Que@MOF/Man exhibited favorable results in resolving inflammation and protecting cardiomyocytes, thereby preventing further myocardial remodeling and improving cardiac function in MI rats. These findings collectively validate the rational design of an inflammation‐targeted delivery strategy to mitigate oxidative stress and modulate the inflammation response in the injured heart, presenting a therapeutic avenue for MI treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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