1. Revised 2017 international consensus on ANCA testing in small vessel vasculitis: support from an external quality assessment
- Author
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Jean-Paul Tomasi, Sofie Schouwers, René-Louis Humbel, Martine Vercammen, Xavier Bossuyt, Lieve Van Hoovels, Laurence Lutteri, Sylvia Broeders, Sylvie Goletti, Carolien Bonroy, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de microbiologie, Biology, Basic (bio-) Medical Sciences, and Reproductive immunology and implantation
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Consensus ,autoantibodies ,Immunology ,Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis ,medicine.disease_cause ,urologic and male genital diseases ,General Biochemistry, Genetics and Molecular Biology ,Autoimmunity ,Antibodies, Antineutrophil Cytoplasmic ,03 medical and health sciences ,0302 clinical medicine ,Rheumatology ,Proteinase 3 ,immune system diseases ,External quality assessment ,medicine ,Immunology and Allergy ,Humans ,autoimmune diseases ,cardiovascular diseases ,Fluorescent Antibody Technique, Indirect ,skin and connective tissue diseases ,Anti-neutrophil cytoplasmic antibody ,030203 arthritis & rheumatology ,Immunoassay ,Medicine(all) ,business.industry ,autoimmunity ,Autoantibody ,IIf ,medicine.disease ,Dermatology ,respiratory tract diseases ,030104 developmental biology ,Microscopic polyangiitis ,Granulomatosis with polyangiitis ,business - Abstract
We read with great interest the multicentre study of Damoiseaux et al 1–3 on the detection of antineutrophil cytoplasmic antibodies (ANCA). ANCAs are important laboratory markers to support the diagnosis of ANCA-associated small vessel vasculitis (AAV), including granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). Traditionally, laboratories screen for ANCA by indirect immunofluorescence (IIF) and IIF positive samples are further evaluated for antibodies to proteinase 3 (PR3) or myeloperoxidase (MPO) by specific immunoassays. Such diagnostic algorithm is based on an international consensus statement on ANCA testing issued in 1999.4 Over the last two decades, the diagnostic performance of immunoassays has significantly improved. The recent multicentre study showed a …
- Published
- 2019