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1. Feasibility, safety, efficacy and potential scaling-up of sofosbuvir-based HCV treatment in Central and West Africa: (TAC ANRS 12311 trial)

Author

Lacombe, Karine, Moh, Raoul, Chazallon, Corine, Lemoine, Maud, Sylla, Babacar, Fadiga, Fatoumata, Le Carrou, Jerôme, Marcellin, Fabienne, Kouanfack, Charles, Ciaffi, Laura, Sartre, Michelle Tagni, Sida, Magloire Biwole, Diallo, Alpha, Gozlan, Joel, Seydi, Moussa, Cissé, Viviane, Danel, Christine, Girard, Pierre Marie, Toni, Thomas d’Aquin, Minga, Albert, Boyer, Sylvie, Carrieri, Patrizia, and Attia, Alain

Published
2024
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2. Systematic review and individual-patient-data meta-analysis of non-invasive fibrosis markers for chronic hepatitis B in Africa

Author

Johannessen, Asgeir, Stockdale, Alexander J., Henrion, Marc Y. R., Okeke, Edith, Seydi, Moussa, Wandeler, Gilles, Sonderup, Mark, Spearman, C. Wendy, Vinikoor, Michael, Sinkala, Edford, Desalegn, Hailemichael, Fall, Fatou, Riches, Nicholas, Davwar, Pantong, Duguru, Mary, Maponga, Tongai, Taljaard, Jantjie, Matthews, Philippa C., Andersson, Monique, Mboup, Souleyman, Sombie, Roger, Shimakawa, Yusuke, and Lemoine, Maud

Published
2023
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3. Linear epitope mapping of the humoral response against SARS-CoV-2 in two independent African cohorts

Author

Vigan-Womas, Inès, Spadoni, Jean-Louis, Poiret, Thomas, Taïeb, Fabien, Randrianarisaona, Fanirisoa, Faye, Rokhaya, Mbow, Adji Astou, Gaye, Aboubacry, Dia, Ndongo, Loucoubar, Cheikh, Ny Mioramalala, Diary Juliannie, Ratovoson, Rila, Randremanana, Rindra Vatosoa, Sall, Amadou Alpha, Seydi, Moussa, Noirel, Josselin, Moreau, Gabriel, Simon, Arnaud, Holenya, Pavlo, Meyniel, Jean-Philippe, Zagury, Jean-François, and Schoenhals, Matthieu

Published
2023
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6. Severe dengue in adults and children, Ouagadougou (Burkina Faso), West Africa, October 2015–January 2017

Author

Sondo, Apoline Kongnimissom, Diendéré, Eric Arnaud, Meda, Bertrand Ivlabehire, Diallo, Ismaèl, Zoungrana, Jacques, Poda, Armel, Manga, Noel Magloire, Bicaba, Brice, Gnamou, Arouna, Kagoné, Charles Joel, Sawadogo, Guetawendé, Yaméogo, Issaka, Benzekri, Noelle A., Tarnagda, Zekiba, Kouanda, Séni, Ouédraogo-Traoré, Ramata, Ouédraogo, Macaire S., and Seydi, Moussa

Published
2021
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7. Service delivery challenges in HIV care during the first year of the COVID‐19 pandemic: results from a site assessment survey across the global IeDEA consortium

Author

Brazier, Ellen, Ajeh, Rogers, Maruri, Fernanda, Musick, Beverly, Freeman, Aimee, Wester, C. William, Lee, Man?Po, Shamu, Tinei, Ramírez, Brenda Crabtree, D' Almeida, Marcelline, Wools?Kaloustian, Kara, Kumarasamy, N., Althoff, Keri N., Twizere, Christella, Grinsztejn, Beatriz, Tanser, Frank, Messou, Eugène, Byakwaga, Helen, Duda, Stephany N., Nash, Denis, Chansilpa, Chidchon, Dougherty, Trevor, Karminia, Azar, Law, Matthew, Ross, Jeremy, Sohn, Annette, Aguirre, Ivette, Baker, David, Bloch, Mark, Cabot, Safaa, Carr, Andrew, Couldwell, Deborah, Edwards, Sian, Eu, Beng, Farlow, Heather, Finlayson, Robert, Gunathilake, Manoji, Hazlewood, Cherie, Hoy, Jennifer, Langton?Lockton, Julian, Le, Jacqueline, Leprince, Elizabeth, Minc, Ariane, Moore, Richard, O'Sullivan, Maree, Roth, Norm, Rowling, Dianne, Russell, Darren, Ryder, Nathan, Saunders, Craig, Silvers, Julie, Smith, David J., Sowden, David, Sweeney, Grant, Tan, Lynn, Teague, Ricard, Templeton, David, Thng, Caroline, Woolley, Ian, Khol, Vohith, Ly, Penh Sun, Li, Tsz Hei, Po, Lee Man, Kinikar, Aarti, Kumarasamy, Nagalingeswaran, Mundhe, Sanjay, Pujari, Sanjay, Sangle, Shashikala, Nimkar, Smita, Jassin, Madelein, Kurniati, Nia, Merati, Tuti Parwati, Muktiarti, Dina, Amalia, Rizqi, Sukmawati, Ni Made Dewi Dian, Wati, Ketut Dewi Kumara, Yunihastuti, Evy, Tanuma, Junko, Choi, Jun Yong, Azwa, Raja Iskandar Shah Raja, Cheng, Chan Kwai, Gani, Yasmin Mohamed, Mohamed, Thahira Jamal, Moy, Fong Siew, Nallusamy, Revathy, Nor, Mohamad Zulfahami Mohd, Rudi, Nuraini, Shyan, Wong Peng, Yusoff, Nik Khairulddin Nik, Ditangco, Rossana, Chan, Yu?Jiun, Wu, Pei?Chieh, Wu, Ping?Feng, Avihingsanon, Anchalee, Chaiwarith, Romanee, Chokephaibulkit, Kulkanya, Khusuwan, Suwimon, Kiertiburanakul, Sasisopin, Kosalaraksa, Pope, Lumbiganon, Pagakrong, Ounchanam, Pradtana, Puthanakit, Thanyawee, Rungmaitree, Supattra, Solai, Nuttarika, Sudjaritruk, Tavitiya, An, Vu Thien, Cuong, Do Duy, Do, Chau Viet, Huy, Bui Vu, Quy, Tuan, Van Nguyen, Kinh, Nguyen, Luan, Nguyen, Van Lam, Nguyen, Yen Thi, Nong, Vuong Minh, Truong, Huu Khanh, Tuyen, Ngo Thi Thu, Mcgowan, Catherine C., Duda, Stephany, Cahn, Florencia, Cahn, Pedro, Cesar, Carina, Fink, Valeria, Sued, Omar, Coelho, Lara, Machado, Daisy Maria, Pinto, Jorge, Wolff, Marcelo, Rouzier, Vanessa, Padgett, Denis, Gotuzzo, Eduardo, Biziragusenyuka, Jérémie, Gateretse, Patrick, Nimbona, Pelagie, Niyonkuru, Olive, Twizere, Christelle, Anicetus, Surreng, Djenabou, Amadou, Enow, Priscilla, Mbu, Eyongetah, Manga, Martin, Ndobe, Mercy, Nasah, Judith, Ekossono, Elle Nathalie Syntyche, Bouseko, Mireille Teno, Kitetele, Faustin, Lelo, Patricia, Diafouka, Merlin Isidore Justin, Mafoua, Adolphe, Nsonde, Dominique Mahambou, Bihira, Uitonze Aime Maurice, Dusabe, Marie Chantal, Feza, Rosine, Habanabashaka, Jean Claude, Habumuremyi, Viateur, Igizeneza, Ernestine, Kamigisha, Anne Marie, Kubwimana, Gallican, Maniriho, Gilbert, Mbaraga, Gilbert, Muhoza, Benjamin, Mukakarangwa, Jeanne, Mukamana, Joyce, Mukanyirigira, Patricie, Mukeshimana, Yvone Claude, Munyaneza, Athanase, Murenzi, Gad, Musaninyange, Jacqueline, Nyiraneza, Jules Ndumuhire, Ntarambirwa, Fidele, Nyiraneza, Marie Louise, Tuyishime, Josette, Tuyishimire, Yvonne, Ubandutira, Alexis, Umugiraneza, Florance, Umugwaneza, Rosine, Uwamahoro, Olive, Uwamahoro, Pauline, Uwambaje, Marie Victoire, Uwimpuhwe, Clarisse, Uwiragiye, Siphora, Kuhn, Yee Yee, Adera, Felix, Adhiambo, Beatricec, Aggrey, Khaemba, Akadikor, Daniel, Ambulla, Felix, Apiyo, Dorah, Ariya, Patrick, Atemba, Naftal, Ayodi, Fridah, Benard, Chirchir, Bett, Maureen, Birgen, Serafine, Bwalei, Rael, Chebon, Nancy, Chebor, Valentine Jirry, Chebuiywo, Philip, Chemutai, Jacline, Chepkorir, Emily, Chepseba, Carolyne, Chirchir, John, Diero, Lameck, Dukwa, Benard, Elphas, Alice, Etyang, Tom, Idiama, Agnes, Jebichuko, Ann, Jepchumba, Delvine, Juma, Churchill, Juma, Maureen, Juma, Sheila, Kadima, Julie, Karani, Rose, Keitany, Christopher, Keter, Pricilla, Kiavoga, Lucy, Kibet, Harrison, Kimutai, Ruth, Kiplagat, Mutai, Kiprono, Wilfred, Kipruto, Nicholas Kogei, Kirimi, Asenath, Koech, Zeddy, Kosgei, Carolyne, Kutto, Karen, Kweyu, Mildred, Liech, Ephraim Kenneth, Limo, Milka, Maina, Rose, Marumbu, Priscah, Masese, Agnes, Mochotto, Patricia, Molly, Omudeck, Momanyi, Tom, Murutu, John W., Mwanda, Praxidis, Ndakalu, Lillian, Nderitu, Rose N., Obatsa, Sarah, Obiga, Fredrick, Oboya, Moses, Odhiambo, Joseph, Olaya, George, Omanyala, Oscar, Oray, Christine, Otieno, Molly, Otwane, Modesta Toto, Ouma, Paul, Owuor, Charles, Pepela, Doris Tutu, Pessah, Collins, Rotich, Evans, Rotich, Edwin K., Rutto, Titus C., Shikuku, Monica, Sibweche, Rose Naliaka, Simiyu, Robert Wanyonyi, Siria, Hellen, Some, Michael, Songok, Winnie Cherotich, Tanui, Immaculate, Wafula, Grace, Wambura, Rebecca, Wanjala, Ellah, Wanyama, Carolyne, Wanyonyi, Hellen, Woyakapel, Emmanuel, Zelbabel, Wandera, Gwimo, Dikengela, Kinyota, Ester, Lwali, Jerome, Lyamuya, Rita, Machemba, Richard, Mathias, Julia, Mkombachepa, Lilian, Mokiwa, Athuman, Mushi, Ombeni, Ndunguru, Charles, Ngonyani, Kapella, Nyaga, Charles, Ruta, Happiness, Urassa, Mark, Akanyihayo, James, Arinaitwe, Arnold, Batuuka, Jesca, Birungi, Walusimbi, Bugembe, John Nyanzi, Ddungu, Ahmed, Francis, Kato, Imran, Bangira, Kafuuma, George William, Kalulue, John Bosco, Kanaabi, Grace, Kanyesigye, Michale, Karuhanga, Godfery, Kasozi, Charles, Kasule, Godfrey, Katusime, Assumpta, Kibalama, Donozio, Kimera, Simon Peter, Kulusumu, Namatovu, Lule, Yusuf, Lwanga, Isaac, Mluindwa, Margaret, Moses, Jemba, Mubarak, Sseremba, Muggaga, Daniel, Mukalazi, Evelyn, Muleebwa, Joseph, Mulema, Derick, Musisi, Ivan, Muwawu, John, Muyindike, Winnie, Mwaka, Dick, Naava, Milly, Nabiyki, Immaculate, Nabusulwa, Agnes, Nakabugo, Dorah, Nakamya, Esther, Nakanwagi, Daisy, Nakato, Oliver, Nakayi, Lydian, Nakigozi, Patience, Nakku, Juliet, Nakuya, Juliet, Nakyomu, Justine, Namayanja, Joan, Namirembe, Sarah, Namugumya, Juliet, Namukasa, Ezereth, Namulindwa, Viola, Nankya, Irene, Nannyondo, Grace Mugagga, Nansamba, Harriet, Nansera, Denis, Nanyanzi, Brenda, Nanyonjo, Esther Celina, Nayiga, Irene, Opira, Isaac, Owarwo, Noela C., Resty, Sserunkuma, Semuwemba, Haruna, Senoga, Julius, Sseguya, Gerald, Ssekyewa, John Paul, Ssemakadde, Matthew, Tebajjwa, Jonah, Tugumisirize, Doreen, Tushemerirwe, Robinah, Waliyi, Kawuki, Althoff, Keri, Bishop, Jennifer, Gill, M J., Loutfy, Mona, Smith, Graham, Bamford, Laura, Black, Anthony, Brice, Asia, Brown, Sheldon, Colasanti, Jonathan, Duarte, Piper, Firnhaber, Cynthia, Goetz, Matthew, Grasso, Chris, Gripshover, Barbara, Horberg, Michael, Kelly, Rita, Levine, Ken, Luu, Mitchell, Marconi, Vincent, Maroney, Karen, Mayer, Kenneth, Mayor, Angel, Mcgowan, Catherine, Multani, Ami, Napravnik, Sonia, Nijhawan, Ank, Novak, Richard, Palella, Frank, Rodriguez, Maria C., Scott, Mia, Tedaldi, Ellen, Willig, James, Cornell, Morna, Davies, Mary?Ann, Egger, Matthias, Haas, Andreas, Bereng, Monkoe, Kalake, Maleshoane, Lenela, Keketso, Seretse, Relebohile, Chintenga, Matthews, Chiwoko, Jane, Gumulira, Joe, Huwa, Jacqueline, Maluwa, Rafique, Matanje, Beatrice, Mbewe, Ronald, Mfungwe, Sunshine, Mphande, Zakaliah, Tweya, Hannock, Rafael, Idiovino, Apolles, Patti, Beneke, Eunice, Dlamini, Siphephelo, Edson, Claire, Eley, Brian, Euvrard, Jonathan, Fatti, Geoffrey, Goeieman, Bridgette, Grimwood, Ashraf, Huang, David, Hugo, Susan, Ismail, Zahiera, Jennings, Lauren, Mathenjwa, Thulile, Monteith, Lizette, Mshweshwe, Zamuxolo, Ntuli, Mfundi, Ndlovu, En, Ndlozi, Hloniphile, Noyakaza, Sylvia, Prozesky, Hans, Rabie, Helena, Sipambo, Nosisa, Technau, Karl?Günter, Tembe, Thokozani, Xaba, Nontando, Njobvu, Thandiwe, Munthaly, Mary, Mwetwa, Elly, Kabeba, Gillian, Mwendafilumba, Derrick, Maanguka, Ethel, Manyika, Nelly, Mwansa, Chalwe, Banda, Future, Mwenda, Dickson, Bwalya, Abel, Shapi, Leah, Syame, Kasapo, Sashi, Rita, Mulenga, Chisha, Nanyangwe, Ruth, Chimbetete, Cleophas, Chinofunga, A., Mhike, J., Mubvigwi, E., Nyika, F., Quarter, Kumbirai Pise, Arikawa, Shino Chassagne, Becquet, Renaud, Bernard, Charlotte, Dabis, François, Desmonde, Sophie, Dahourou, Désiré, Ekouevi, Didier Koumavi, Jaquet, Antoine, Jesson, Julie, Leroy, Valeriane, Malateste, Karen, Rabourdin, Elodie, Tiendrebeogo, Thierry, Assogba, Michée, Zannou, Djimon Marcel, Hounhoui, Ghislaine, Bere, Denise, Poda, Armel, Pooda, Gbolo, Traore, Richard, Abauble, Yao, Abby, Ouattara, Acquah, Patrick, Andoble, Valérie, Aude, Yobo N'Dzama, Azani, Jean?Claude, Berete, Oka, Beugre, Jacques Daple, Bohoussou, Caroline Yao, Brou, Simon Boni Emmanuel, Chenal, Henri, Cissé, Abdoulaye, Coulibaly, Nambate, Dainguy, Marie Evelyne, Daligou, Marcelle, D' Aquin, Toni Thomas, Dasse, Claude Desire, Folquet, Madeleine Amorissani, Gnepa, Guy, Gobe, Olivier, Guira, Salif, Hawerlander, Denise, Horo, Apollinaire, Kanga, Guillaume, Messou, Zobo Konan Eugène, Minga, Kla Albert, Moh, Raoul, N'Gbeche, Mariesylvie, Ogbo, Patricia, Oulai, Mathieu, Stéphanie, Se, Eboua, Tanoh, Valère, Itchy Max, Afrane, Adwoa Kumiwa Asare, Akrofi, Esther, Andoh, John Christian, Renner, Lorna, Bagayoko, Awa, Bagayoko, Kadidiatou, Bah, Abdou Salam, Berthe, Alima, Coulibaly, Boureïma, Coulibaly, Fatimata, Coulibaly, Yacouba Aba, Diakité, Aïssata, Bocoum, Fatoumata, Boré, Fatoumata, Dicko, Fatoumata, Koné, Odile, Sylla, Mariam, Tangara, Assitan, Traoré, Mamadou, Seydi, Moussa, Amegatse, Edmond, Djossou, Julienne, Takassi, Elom, and Palanga, Sénam

Subjects
HIV (Viruses) -- Care and treatment -- Patient outcomes, Public health administration -- Evaluation, Health
Abstract

: Introduction: Interruptions in treatment pose risks for people with HIV (PWH) and threaten progress in ending the HIV epidemic; however, the COVID‐19 pandemic's impact on HIV service delivery across diverse settings is not broadly documented. Methods: From September 2020 to March 2021, the International epidemiology Databases to Evaluate AIDS (IeDEA) research consortium surveyed 238 HIV care sites across seven geographic regions to document constraints in HIV service delivery during the first year of the pandemic and strategies for ensuring care continuity for PWH. Descriptive statistics were stratified by national HIV prevalence ( Results: Questions about pandemic‐related consequences for HIV care were completed by 225 (95%) sites in 42 countries with low (n = 82), medium (n = 86) and high (n = 57) HIV prevalence, including low‐ (n = 57), lower‐middle (n = 79), upper‐middle (n = 39) and high‐ (n = 50) income countries. Most sites reported being subject to pandemic‐related restrictions on travel, service provision or other operations (75%), and experiencing negative impacts (76%) on clinic operations, including decreased hours/days, reduced provider availability, clinic reconfiguration for COVID‐19 services, record‐keeping interruptions and suspension of partner support. Almost all sites in low‐prevalence and high‐income countries reported increased use of telemedicine (85% and 100%, respectively), compared with less than half of sites in high‐prevalence and lower‐income settings. Few sites in high‐prevalence settings (2%) reported suspending antiretroviral therapy (ART) clinic services, and many reported adopting mitigation strategies to support adherence, including multi‐month dispensing of ART (95%) and designating community ART pick‐up points (44%). While few sites (5%) reported stockouts of first‐line ART regimens, 10–11% reported stockouts of second‐ and third‐line regimens, respectively, primarily in high‐prevalence and lower‐income settings. Interruptions in HIV viral load (VL) testing included suspension of testing (22%), longer turnaround times (41%) and supply/reagent stockouts (22%), but did not differ across settings. Conclusions: While many sites in high HIV prevalence settings and lower‐income countries reported introducing or expanding measures to support treatment adherence and continuity of care, the COVID‐19 pandemic resulted in disruptions to VL testing and ART supply chains that may negatively affect the quality of HIV care in these settings., INTRODUCTION The COVID‐19 pandemic has had major direct and indirect impacts on population health globally, through disruptions in the accessibility and quality of basic health services [1], in supply chains [...]

Published
2022
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8. Perceptions, facilitators and barriers to the implementation of interpersonal group therapy to treat depression among people living with HIV in Senegal: a qualitative study

Author

Bernard, Charlotte, primary, Mané, Idrissa, additional, Ziadeh, Salaheddine, additional, Tine, Judicaël Malick, additional, Diaw, Abibatou, additional, Benzekri, Noëlle, additional, Ndiaye, Ibrahima, additional, Samba, Oumar, additional, Font, Hélène, additional, Bottai, Thierry, additional, Jacquesy, Laurent, additional, Verdeli, Helen, additional, Ngom, Ndeye Fatou, additional, Dabis, François, additional, Seydi, Moussa, additional, and de Rekeneire, Nathalie, additional

Published
2024
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9. A Model of the 2014 Ebola Epidemic in West Africa with Contact Tracing

Author

Browne, Cameron, Huo, Xi, Magal, Pierre, Seydi, Moussa, Seydi, Ousmanne, and Webb, Glenn

Subjects
Quantitative Biology - Populations and Evolution
Abstract

A differential equations model is developed for the 2014 Ebola epidemics in Sierra Leone, Liberia, and Guinea. The model describes the dynamic interactions of the susceptible and infected populations of these countries. The model incorporates the principle features of contact tracing, namely, the number of contacts per identified infectious case, the likelihood that a traced contact is either incubating or infectious, and the efficiency of the contact tracing process.The model is first fitted to current cumulative reported case data in each country. The data fitted simulations are then projected forward in time, with varying parameter regimes corresponding to contact tracing efficiencies. These projections quantify the importance of the identification, isolation, and contact tracing processes for containment of the epidemics.

Published
2014

10. Resource and infrastructure challenges on the RESIST-2 Trial: an implementation study of drug resistance genotype-based algorithmic ART switches in HIV-2-infected adults in Senegal

Author

Raugi, Dana N., Diallo, Khardiata, Diallo, Mouhamadou Baïla, Faye, Dominique, Cisse, Ousseynou, Smith, Robert A., Sall, Fatima, Sall, El Hadji Ibrahima, Faye, Khadim, Diatta, Jean Philippe, Diaw, Binetou, Sambou, Jacques, Malomar, Jean Jacques, Hawes, Stephen E., Seydi, Moussa, and Gottlieb, Geoffrey S.

Published
2021
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11. The impact of food insecurity on HIV outcomes in Senegal, West Africa: a prospective longitudinal study

Author

Benzekri, Noelle A., Sambou, Jacques F., Ndong, Sanou, Diallo, Mouhamadou Baïla, Tamba, Ibrahima Tito, Faye, Dominique, Sall, Ibrahima, Diatta, Jean Philippe, Faye, Khadim, Cisse, Ousseynou, Sall, Fatima, Guèye, Ndèye Fatou Ngom, Ndour, Cheikh T., Sow, Papa Salif, Malomar, Jean Jacques, Hawes, Stephen E., Seydi, Moussa, and Gottlieb, Geoffrey S.

Published
2021
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12. High prevalence of binge drinking among people living with HIV in four African countries

Author

Nouaman, Marcellin N, Vinikoor, Michael, Seydi, Moussa, Ekouevi, Didier K, Coffie, Patrick A, Mulenga, Lloyd, Tanon, Aristophane, Egger, Matthias, Dabis, Francois, Jaquet, Antoine, and Wandeler, Gilles

Subjects
HIV infections -- Risk factors -- Drug therapy, Drinking (Alcoholic beverages) -- Research -- Health aspects, Antiretroviral agents -- Dosage and administration, Health
Abstract

Introduction: Excessive alcohol consumption leads to unfavourable outcomes in people living with HIV (PLHIV), including reduced adherence to antiretroviral therapy (ART) and engagement into care. However, there is limited information on alcohol consumption patterns among PLHIV in sub-Saharan Africa. Methods: Using a cross-sectional approach, the Alcohol Use Disorders Identification Test (AUDIT-C) was administered to PLHIV attending HIV clinics in Cote d'Ivoire, Togo, Senegal and Zambia (2013 to 2015). Hazardous drinking was defined as an AUDIT-C score [greater than or equal to]4 for men or [greater than or equal to]3 for women, and binge drinking as [greater than or equal to]6 drinks at least once per month. The prevalence of binge drinking was compared to estimates from the general population using data from the World Health Organization. Factors associated with binge drinking among persons declaring any alcohol use in the past year were assessed using a logistic regression model to estimate odds ratio (OR) and their corresponding 95% confidence intervals (CI). Results: Among 1824 PLHIV (median age 39 years, 62.8% female), the prevalence of hazardous alcohol use ranged from 0.9% in Senegal to 38.4% in Zambia. The prevalence of binge drinking ranged from 14.3% among drinkers in Senegal to 81.8% in Zambia, with higher estimates among PLHIV than in the general population. Male sex (OR 2.4, 95% CI 1.6 to 3.7), tobacco use (OR 1.7, 95% CI 1.0 to 2.9) and living in Zambia were associated with binge drinking. Conclusions: Alcohol consumption patterns varied widely across settings and binge drinking was more frequent in HIV-positive individuals compared to the general population. Interventions to reduce excessive alcohol use are urgently needed to optimize adherence in the era of universal ART. Keywords: alcohol; binge drinking; HIV; antiretroviral therapy; viral hepatitis; sub-Saharan Africa, 1 | INTRODUCTION Sub-Saharan Africa (SSA) has the highest prevalence of HIV globally, and accounts for 68% of people living with HIV (PLHIV) [1]. Many countries in the region have [...]

Published
2018
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13. COVID-19 Outbreak, Senegal, 2020

Author

Dia, Ndongo, Lakh, Ndeye Aissatou, Diagne, Moussa Moise, Mbaye, Khardiata Diallo, Taieb, Fabien, Fall, Ndeye Maguette, Barry, Mamadou Alioune, Ka, Daye, Fall, Amary, Diallo, Viviane Marie Pierre Cisse, Faye, Oumar, Jallow, Mamadou Malado, Dieng, Idrissa, Ndiaye, Mamadou, Diop, Mamadou, Bousso, Abdoulaye, Ioucoubar, Cheikh, Ndiaye, Marie Khemesse Ngom, Peyreffite, Christophe, Fortes, Louise, Sall, Amadou Alpha, Faye, Ousmane, and Seydi, Moussa

Subjects
Disease transmission -- Distribution, Epidemics -- Distribution -- Senegal, COVID-19 -- Distribution -- Diagnosis, Contact tracing, Company distribution practices, Health
Abstract

The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was delayed in Africa and Latin America. The earliest recorded case of coronavirus disease (COVID-19) in Africa was identified in [...]

Published
2020
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14. Informing a target product profile for rapid tests to identify HBV-infected pregnant women with high viral loads: a discrete choice experiment with African healthcare workers

Author

Isa, Yasir Shitu, primary, Sicsic, Jonathan, additional, Njuguna, Henry, additional, Ward, John, additional, Chakroun, Mohamed, additional, El-Kassas, Mohamed, additional, Ramanampamonjy, Rado, additional, Chalal, Salim, additional, Vincent, Jeanne Perpétue, additional, Andersson, Monique, additional, Desalegn, Hailemichael, additional, Fall, Fatou, additional, Johannessen, Asgeir, additional, Matthews, Philippa C., additional, Ndow, Gibril, additional, Okeke, Edith, additional, Riches, Nicholas, additional, Seydi, Moussa, additional, Sinkala, Edford, additional, Spearman, C. Wendy, additional, Stockdale, Alexander, additional, Vinikoor, Michael J., additional, Wandeler, Gilles, additional, Sombié, Roger, additional, Lemoine, Maud, additional, Mueller, Judith E., additional, and Shimakawa, Yusuke, additional

Published
2023
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17. Factors associated with verbal fluency in older adults living with HIV in West Africa: A longitudinal study

Author

Bernard, Charlotte, primary, Font, Hélène, additional, Diallo, Zélica, additional, Ahonon, Richard, additional, Tine, Judicaël Malick, additional, Abouo, Franklin N'Guessan, additional, Tanon, Aristophane, additional, Messou, Eugène, additional, Seydi, Moussa, additional, Dabis, François, additional, Dartigues, Jean‐François, additional, and de Rekeneire, Nathalie, additional

Published
2022
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18. Hepatitis B in Senegal: A Successful Infant Vaccination Program but Urgent Need to Scale Up Screening and Treatment (ANRS 12356 AmBASS survey)

Author

Périères, Lauren, Diallo, Aldiouma, Marcellin, Fabienne, Nishimwe, Marie Libérée, Ba, El Hadji, Coste, Marion, Lo, Gora, Halfon, Philippe, Touré Kane, Coumba, Maradan, Gwenaëlle, Carrieri, Patrizia, Diouf, Assane, Shimakawa, Yusuke, Sokhna, Cheikh, Boyer, Sylvie, Bérenger, Cyril, Bousmah, Marwan al Qays, de Seze, Maëlle, Djaogol, Tchadine, Treibich, Carole, Ba, Elhadji, Dièye, Fambaye, Faye, Elhadji Bilal, Ndiaye, Assane, Sow, Mouhamadou Baba, Ndiaye, Anna Julienne Selbé, Ndiour, Samba, Mohamed, Sofiane, Rouveau, Nicolas, Cortès, Maria‐Camila Calvo, Laborde‐Balen, Gabrièle, Audibert, Martine, Fall, Fatou, Gueye, Ibrahima, Lacombe, Karine, Seydi, Moussa, Tuaillon, Edouard, Vray, Muriel, Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD), Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut des sciences de la santé publique [Marseille] (ISSPAM), Aix-Marseille Sciences Economiques (AMSE), École des hautes études en sciences sociales (EHESS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation [Dakar, Sénégal] (IRESSEF), ALPHABIO - Laboratoire de biologie médicale, Hôpital Européen [Fondation Ambroise Paré - Marseille], Observatoire régional de la santé Provence-Alpes-Côte d'Azur [Marseille] (ORS PACA), Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology, Université Paris Cité (UPCité)-Pasteur-Cnam Risques infectieux et émergents (PACRI), Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Paris Cité (UPCité)-Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), ANRS 12356 AmBASS Survey Study Group: Cyril Bérenger, Marwan Al Qays Bousmah, Sylvie Boyer, Patrizia Carrieri, Marion Coste, Maëlle de Seze, Tchadine Djaogol, Gwenaëlle Maradan, Fabienne Marcellin, Carole Treibich, Elhadji Ba, Aldiouma Diallo, Fambaye Dièye, Assane Diouf, Elhadji Bilal Faye, Assane Ndiaye, Lauren Périères, Cheikh Sokhna, Mouhamadou Baba Sow, Coumba Touré Kane, Gora Lo, Anna Julienne Selbé Ndiaye, Samba Ndiour, Philippe Halfon, Sofiane Mohamed, Nicolas Rouveau, Maria-Camila Calvo Cortès, Gabrièle Laborde-Balen, Martine Audibert, Fatou Fall, Ibrahima Gueye, Karine Lacombe, Moussa Seydi, Yusuke Shimakawa, Edouard Tuaillon, Muriel Vray, Lhuillier, Elisabeth, and Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées (IRBA)

Subjects
Adult, Hepatitis B Surface Antigens, Adolescent, Hepatology, Vaccination, Infant, Hepatitis B, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, Senegal, 3. Good health, Young Adult, 03 medical and health sciences, Cross-Sectional Studies, 0302 clinical medicine, Humans, Female, Hepatitis B Vaccines, 030211 gastroenterology & hepatology, 030212 general & internal medicine, [SHS.ECO] Humanities and Social Sciences/Economics and Finance, Child
Abstract

International audience; Senegal introduced the infant hepatitis B virus (HBV) vaccination in 2004 and recently committed to eliminating hepatitis B by 2030. Updated epidemiological data are needed to provide information on the progress being made and to develop new interventions. We estimated the prevalence of hepatitis B surface antigen (HBsAg) in children and adults living in rural Senegal and assessed hepatitis B treatment eligibility. A cross-sectional population-based serosurvey of HBsAg was conducted in 2018-2019 in a large sample (n = 3,118) of residents living in the Niakhar area (Fatick region, Senegal). Individuals positive for HBsAg subsequently underwent clinical and biological assessments. Data were weighted for age and sex and calibrated to be representative of the area's population. Among the 3,118 participants, 206 were HBsAg positive (prevalence, 6.9%; 95% confidence interval [CI], 5.6-8.1). Prevalence varied markedly according to age group in individuals aged 0-4, 5-14, 15-34, and >= 35 years as follows: 0.0% (95% CI, 0.00-0.01); 1.5% (95% CI, 0.0-2.3); 12.4% (95% CI, 9.1-15.6); and 8.8% (95% CI, 6.1-11.5), respectively. Of those subsequently assessed, 50.9% (95% CI, 41.8-60.0) had active HBV infection; 4 (2.9%; 95% CI, 0.9-9.4) were eligible for hepatitis B treatment. Conclusion: In this first population-based serosurvey targeting children and adults in rural Senegal, HBsAg prevalence was very low in the former, meeting the World Health Organization's (WHO) < 1% HBsAg 2020 target; however, it was high in young adults (15-34 years old) born before the HBV vaccine was introduced in 2004. To reach national and WHO hepatitis elimination goals, general population testing (particularly for adolescents and young adults), care, and treatment scale-up need to be implemented.

Published
2021

19. Chronic viral hepatitis, <scp>HIV</scp> infection and <scp>Non‐Hodgkin</scp> lymphomas in West Africa, a case‐control study

Author

JAQUET, Antoine, BONI, Simon P., BOIDY, Kouakou, TINE, Judicael, TCHOUNGA, Boris, TOURE, Sokhna A., KOFFI, Jean-Jacques, DIAL, Cherif, MONNEREAU, Alain, DIOMANDE, Isidore, TANON, Aristophane, SEYDI, Moussa, DABIS, Francois, DIOP, Saliou, KOFFI, Gustave, IE, D. E. A. West Africa Collaboration, Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), National Cancer Institute, and Eunice Kennedy Shriver National Institute of Child Health and Human Development

Subjects
Adult, Male, Hepatitis B virus, Cancer Research, medicine.medical_specialty, Epidemiology, HIV Infections, Article, Serology, Causes of cancer, 03 medical and health sciences, Hepatitis B, Chronic, 0302 clinical medicine, Acquired immunodeficiency syndrome (AIDS), immune system diseases, hemic and lymphatic diseases, Internal medicine, HBV, Humans, Medicine, Non-Hodgkin lymphoma, business.industry, Lymphoma, Non-Hodgkin, Case-control study, HIV, virus diseases, Odds ratio, Middle Aged, Prognosis, medicine.disease, 3. Good health, Lymphoma, Africa, Western, Oncology, Case-Control Studies, 030220 oncology & carcinogenesis, Africa, HCV, HIV/AIDS, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Female, business, Viral hepatitis, Follow-Up Studies
Abstract

Non-Hodgkin lymphomas (NHL) are underestimated causes of cancer in West Africa where chronic viral hepatitis and HIV are endemic. While the association with HIV infection has already been characterized, limited information is available on the association between chronic viral hepatitis and NHL in sub-Saharan Africa. A case-control study was conducted in referral hospitals of Abidjan (Cote d’Ivoire) and Dakar (Senegal). Cases of NHL were matched with controls on age, gender and participating site. The diagnosis of NHL relied on local pathological examination completed with immunohistochemistry. HIV, HBV and HCV serology tests were systematically performed. A conditional logistic regression model estimated the associations by the Odds Ratio (OR) with their 95% confidence interval (CI). A total of 117 NHL cases (Abidjan n = 97, Dakar n = 20) and their 234 matched controls were enrolled. Cases were predominantly men (68.4%) and had a median age of 50 years (IQR 37-57). While Diffuse Large B-cell lymphoma were the most reported morphological type (n = 35) among mature B-cell NHL, the proportion mature T-cell NHL (30%) was high. The prevalence figures of HBV, HCV and HIV infection were 12.8%, 7.7% and 14.5%, respectively among cases of NHL. In multivariate analysis, HBV, HCV and HIV were independently associated with NHL with OR of 2.23 (CI 1.05-4.75), 4.82 (CI 1.52-15.29) and 3.32 (CI 1.54-7.16), respectively. Chronic viral hepatitis B and C were significantly associated with NHL in West Africa. Timely preventive measures against HBV infection and access to curative anti-HCV treatment might prevent a significant number of NHL.

Published
2021

20. Facteurs associés à la dissociation immunovirologique chez les patients infectés par le VIH-1 sous traitement antirétroviral hautement actif au Centre de Traitement Ambulatoire (CTA) de Dakar

Author

Ké Daye, Manga Noél Magloire, Ngom-Guéye Ndéye Fatou, Diop Ndiaga, Diop Moustapha, Cisse-Diallo Viviane Marie Pierre, Diallo-Mbaye Khardiata, Lakhe Ndéye Aissatou, Louise fortès-Déguenonvo, Ndour Cheikh Tidiane, Diop-Nyafouna Sylvie Audrey, and Seydi Moussa

Subjects
dissociation, immunovirologique, vih, dakar, Medicine
Abstract

INTRODUCTION: l'objection de ce travail est d'évaluer les différents facteurs associés à la dissociation immunovirologique malgré un traitement antirétroviral hautement actif et efficace. METHODES: il s'agissait d'une étude de cohorte historique, descriptive et analytique faite à partir de dossiers de patients infectés par le VIH-1; sous traitement antirétroviral depuis au moins 12 mois, suivis dans la cohorte du CTA de 2001 à 2011 et ayant une charge virale indétectable depuis 6 mois. RESULTATS: durant cette période d'étude de 10 ans, la prévalence de la DIV était de 19,3%. Le sexe féminin était prédominant avec un sexe ratio de 1,9. La dissociation immunovirologique a été plus fréquemment rencontrée chez les patients de sexe masculin (29,7% vs 14,1%) avec une différence statistiquement significative (p = 0,00006). L'âge médian était de 44 ans 10 ans. Un antécédent de tuberculose a été retrouvé dans environ un tiers des cas (31,4%). La dissociation immunovirologique était significativement plus fréquente chez les patients ayant un antécédent de tuberculose (p = 0,00005). La plupart des patients (68%) était au stade SIDA 3 ou 4 de l'OMS. Les patients ayant une dissociation immunovirologique étaient plus souvent aux stades 3 et 4 de l'OMS (p = 0,0001). La dénutrition a été notée dans plus de la moitié des cas (56,2%) et la dissociation immunovirologique prédominait chez les patients dénutris (p=0,005). Le taux moyen de lymphocytes TCD4+ était de 86,7 83 cellules/mm3. La dissociation immunovirologique était plus fréquente chez les patients ayant un taux de lymphocytes TCD4 bas à l'initiation avec une différence statistiquement significative (p = 0,00000). En analyse multivariée ; Seuls l'âge supérieur ou égal à 43 ans, le taux de CD4 initial 100 c/mm3 et le sexe masculin étaient significativement associés à cette dissociation immunovirologique. CONCLUSION: les principaux facteurs associés à la dissociation immunovirologique étant évalués, d'autres études portant sur ce groupe mériteraient d'être envisagées afin de connaitre l'impact de cette réponse immunologique partielle sur la survenue d'infections opportunistes ou bien la mise en place d'une trithérapie spécifique uniquement dans le but d'avoir une restauration immunologique optimale.

Published
2017
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22. Diagnosis and clinical outcomes of extrapulmonary tuberculosis in antiretroviral therapy programmes in low‐ and middle‐income countries: a multicohort study

Author

Zürcher, Kathrin, Ballif, Marie, Kiertiburanakul, Sasisopin, Chenal, Henri, Yotebieng, Marcel, Grinsztejn, Beatriz, Michael, Denna, Sterling, Timothy R., Ngonyani, Kapella M., Mandalakas, Anna M., Egger, Matthias, Pettit, April C., Fenner, Lukas, Veloso, Valdilea, Luz, Paula, Boni, Raquel, Wagner, Sandra Cardoso, Friedman, Ruth, Moreira, Ronaldo, Madero, Juan Sierra, Ramirez, Brenda Crabtree, Belaunzaran, Paco, Vega, Yanink Caro, Gotuzzo, Eduardo, Mejia, Fernando, Carriquiry, Gabriela, Mcgowan, Catherine C., Shepherd, Bryan E., Sterling, Timothy, Jayathilake, Karu, Person, Anna K., Rebeiro, Peter F., Giganti, Mark, Castilho, Jessica, Duda, Stephany N., Maruri, Fernanda, Vansell, Hilary, Uy, E, Bantique, R, Vihingsanon, A, Gatechompol, S, Phanuphak, P, Phadungphon, C, Kiertiburanakul, S, Phuphuakrat, A, Chumla, L, Sanmeema, N, Nguyen, Kv, Bui, Hv, Nguyen, Dth, Nguyen, Dt, Cuong, Dd, An, Nv, Luan, Nt, Sohn, Ah, Ross, Jl, Petersen, B, Cooper, Da, Law, Mg, Jiamsakul, A, Boettiger, Dc, Ssali, John, Ssemakadde, Mathew, Ngonyani, Kapella, Lwali, Jerome, Urassa, Mark, Machemba, Richard, Wools?Kaloustian, Kara, Yiannoutsos, Constantin, Vreeman, Rachel, Musick, Beverly, Elul, Batya, Kantor, Rami, Martin, Jeffrey, Wenger, Megan, Cohen, Craig, Kulzer, Jayne, Zannou, Djimon Marcel, Azon?Kouanou, Angèle, Traore, Hamar Alassane, Minta, Daouda, Toure, Amadou Abathina, Seydi, Moussa, Bassabi, Coumba Cissé, Dabis, François, Bissagnene, Emmanuel, Arrivé, Elise, Coffie, Patrick, Ekouevi, Didier, Jaquet, Antoine, Leroy, Valériane, Lewden, Charlotte, Sasco, Annie J., Amani, Dieudonné, Azani, Jean?Claude, Balestre, Eric, Bessekon, Serge, Bohossou, Franck, Gilbert, Camille, Karcher, Sophie, Gonsan, Jules Mahan, Le Carrou, Jérôme, Lenaud, Séverin, Nchot, Célestin, Malateste, Karen, Yao, Amon Roseamonde, Siloué, Bertine, Clouet, Gwenaelle, Dosso, Madikona, Doring, Alexandra, Kouakou, Adrienne, Rabourdin, Elodie, Rivenc, Jean, Anglaret, Xavier, Ba, Boubacar, Ciaranello, Andrea, Datté, Sébastien, Desmonde, Sophie, Diby, Jean?Serge Elvis, Gottlieb, Geoffrey S., Kangah, Serge N'Zoré, Malvy, Denis, Meless, David, Mounkaila?Harouna, Aida, Ndondoki, Camille, Tchounga, Boris, Thiébaut, Rodolphe, Wandeler, Gilles, Dusingize, Jean Claude, Mutimura, Eugene, Tatwangire, Judy, Izabelle, Izimukwiye, Baramperanye, Evelyne, Edmonds, Andrew, Azinyue, Innocent, and Ayangma, Liliane

Subjects
Antiviral agents -- Statistics -- Patient outcomes, Tuberculosis -- Statistics -- Diagnosis -- Patient outcomes, Developing countries -- Statistics -- Health aspects, HIV patients -- Statistics -- Drug therapy, Health
Abstract

: Introduction: Extrapulmonary tuberculosis (EPTB) is difficult to confirm bacteriologically and requires specific diagnostic capacities. Diagnosis can be especially challenging in under‐resourced settings. We studied diagnostic modalities and clinical outcomes of EPTB compared to pulmonary tuberculosis (PTB) among HIV‐positive adults in antiretroviral therapy (ART) programmes in low‐ and middle‐income countries (LMIC). Methods: We collected data from HIV‐positive TB patients (≥16 years) in 22 ART programmes participating in the International Epidemiology Databases to Evaluate AIDS (IeDEA) consortium in sub‐Saharan Africa, Asia‐Pacific, and Caribbean, Central and South America regions between 2012 and 2014. We categorized TB as PTB or EPTB (EPTB included mixed PTB/EPTB). We used multivariable logistic regression to assess associations with clinical outcomes. Results and Discussion: We analysed 2695 HIV‐positive TB patients. Median age was 36 years (interquartile range (IQR) 30 to 43), 1102 were female (41%), and the median CD4 count at TB treatment start was 114 cells/μL (IQR 40 to 248). Overall, 1930 had PTB (72%), and 765 EPTB (28%). Among EPTB patients, the most frequently involved sites were the lymph nodes (24%), pleura (15%), abdomen (11%) and meninges (6%). The majority of PTB (1123 of 1930, 58%) and EPTB (582 of 765, 76%) patients were diagnosed based on clinical criteria. Bacteriological confirmation (using positive smear microscopy, culture, Xpert MTB/RIF, or other nucleic acid amplification tests result) was obtained in 897 of 1557 PTB (52%) and 183 of 438 EPTB (42%) patients. EPTB was not associated with higher mortality compared to PTB (adjusted odd ratio (aOR) 1.0, 95% CI 0.8 to 1.3), but TB meningitis was (aOR 1.9, 95% CI 1.0 to 3.1). Bacteriological confirmation was associated with reduced mortality among PTB patients (aOR 0.7, 95% CI 0.6 to 0.8) and EPTB patients (aOR 0.3 95% CI 0.1 to 0.8) compared to TB patients with a negative test result. Conclusions: Diagnosis of EPTB and PTB at ART programmes in LMIC was mainly based on clinical criteria. Greater availability and usage of TB diagnostic tests would improve the diagnosis and clinical outcomes of both EPTB and PTB., Introduction In low‐ and middle‐income countries (LMIC), tuberculosis (TB) accounts for approximately 40% of HIV/AIDS‐related deaths among adults, and half of those TB cases are undiagnosed at the time of [...]

Published
2019
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23. Implementation of 'Treat‐all' at adult HIV care and treatment sites in the Global IeDEA Consortium: results from the Site Assessment Survey

Author

Brazier, Ellen, Maruri, Fernanda, Duda, Stephany N., Tymejczyk, Olga, Wester, C William, Somi, Geoffrey, Ross, Jeremy, Freeman, Aimee, Cornell, Morna, Poda, Armel, Musick, Beverly S., Zhang, Fujie, Althoff, Keri N., Mugglin, Catrina, Kimmel, April D., Yotebieng, Marcel, Nash, Denis, Karminia, Azar, Sohn, Annette H., Allen, Debbie, Bloch, Mark, Boyd, Susan, Brown, Katherine, Costa, Jess, Donohue, William, Gunathilake, Manoji, Hoy, Jennifer, Macrae, Karen, Moore, Richard, Roth, Norman, Rowling, Diane, Silvers, Julie, Smith, David J., Sowden, David, Templeton, David, Varma, Rick, Woolley, Ian, Youds, David, Meng, Somanithd Chhay, Vannary, Bun, Chan, Yun Ting, Lam, Wilson, Lee, Man Po, Ning, Han, Pansy, Yu Po Chu, Kumarasamy, N., Pujari, Sanjay, Kurniati, Nia, Merati, Tuti Parwati, Muktiarti, Dina, Parwata, Wayan Sandhi, Ratni, Made, Sukmawati, Ni Made Dewi Dian, Vedaswari, Dian Sulistya Putu Diah, Wati, Ketut Dewi Kumara, Yunihastuty, Evy, Tanuma, Junko, Mills, Graham, Raymond, Nigel, Ditangco, Rossana, Papa, Ohnmar Seinn, Tek, Ng Oon, Azwa, Raja, Daud, Fauziah, Juin, Wong Ke, Kamarulzaman, Adeeba Binti, Khairulddin, Nik, Li, Chong Meng, Moy, Fong Siew, Shah, Raja Iskandar, Shyan, Wong Peng, Sim, Benedict, Thahira, Jamal Mohamed, Tuang, Koh Mia, Yusoff, Nik, Choi, Jun Yong, Chan, Yu?Jiun, Huang, Chih?Sheng, Wing?Wai, Wong, Avihingsanon, Anchalee, Chokephaibulkit, Kulkanya, Hansudewechakul, Rawiwan, Khumcha, Benjhawan, Khusuwan, Suwimon, Kiertiburanakul, Sasisopin, Lumbiganon, Pagakrong, Maleesatharn, Alan, Praparattanapan, Jutarat, Puthanakit, Thanyawee, Sricharoenchai, Sirintip, Sudjaritruk, Tavitiya, Watanaporn, Suporn, An, Vu Thien, Cuong, Do Duy, H?ng, Bùi Thu, Huy, Bùi V?, Quy, Du Tuan, Van, Lam Nguyen, Baragunzwa, Agathomfue, Gakima, Dévote, Ingabire, Gloria, Kankinoi, Floride, Manyundo, Risase Scholastique, Misago, Celestin, Nahimana, Thierry, Nimbona, Pélagie, Ntirampeba, Felicite, Twizere, Christella, Ajeh, Rogers, Djenabou, Amadou, Dzudie, Anastase, Ewanoge, Alice Ndelle, Tchassem, Edmond, Bampapa, Therese, Lelo, Patricia, Kitetele, Faustin, Paul, Marie, Tytyna, Amida, Akolbout, Maryse, Bitsindou, Parfait, Diafouka, Merlin, Mafoua, Adolphe, Mahinga, Nadine, Moudila, Ella, Moutoula, Antoinette, Ndala, Ulrich, Nsonde, Dominique Mahambou, Ayinkamiye, Josephine, Dusabe, Chantal, Hakizimana, Theogene, Mbaraga, Gilbert, Mukamana, Joyce, Mukantwali, Sandrine, Munyaneza, Athanase, Murangwa, Anthere, Musenguwera, J. Claude, Ngutegure, Marie Immanculee, Ntarambirwa, Fidele, Nyiransabimana, Diane, Sinayobye, Jean D'Amour, Tuyishimire, Yvonne, Uwamahoro, Olive, Viateur, Habumuremyi, Vincent, Sugira, Kuhn, Yee Yee, Musick, Beverly, Rodriguez, Israel, Wools?Kaloustian, Kara, Yiannoutsos, Constantin, Akajoroit, Esinasi, Ariya, Peter, Atsimale, Meshack, Barua, Zeruya, Busaka, Oscar, Bukusi, Elizabeth, Chebor, Valentine, Chemweno, Timothy, Chirchir, John, Esendi, Lameck Diero Sagida, Fwamba, Aisha, Mmella, Anne, Githumbi, Eunice, Hussein, Marcia Nasimiyu, Kandie, Xavier, Kemunto, Martha, Khaemba, Elizabeth, Kipchumba, Mary, Koech, Emily, Kosgei, Caroline, Laundrick, Barasa, Merongo, Ruth, Mochotto, Patricia, Munyisi, Consolata, Ndakalu, Lilian, Ochieng, William Okoth, Odalo, Paul, Okumu, Wicklife, Omari, Lilian, Omondi, Alphoce, Osia, Lydia, Owino, Magret, Oyoo, Maureen, Pepela, Doris, Rono, Millicent, Simon, Omar, Tenge, Angie, Too, Mary, Toto, Modesta, Towett, Cathrine, Wawire, Kennedy, Kimambo, Mensaria, Kinyota, Ester, Lyamuya, Rita, Mathias, Julia, Mfuko, Athuman Ramadhan, Michael, Denna, Ngonyani, Kapella Zacharia, Nyaga, Charles, Somi, G.R., Urassa, Mark S., Batte, James, Bwana, Mwebesa Bosco, Castelnuovo, Barbara, Kanyesigye, Michael, Kisakye, Alice, Nalugoda, Fred, Semuwemba, Haruna, Ssali, John, Ssemakadde, Matthew, Castilho, Jessica, Cesar, Carina, De Alencastro, Paulo Ricardo, Barbosa, Eduardo Luiz, Brites, Carlos, Caricol, Renata, Carmo, Fabiana Bononi Do, Coelho, Lara Esteves, Escuder, Maria Mercedes, Estevam, Denize Lotufo, Ferreira, Flavia Gomes Faleiro, Gonçalves, Alexandre, Gouvêa, Aída Barbosa, Ikeda, Maria Leticia Rodrigues, Kalichman, Artur O., Machado, Daisy Maria, Queiroz, Simone, Souza, Rosa, Succi, Regina Célia, Trindade, Kátia Valeska, Tupinambás, Unai, Wolff, Marcelo, Rouzier, Vanessa, Padgett, Denis, Crabtree, Brenda, Martin, Carlos Eduardo Verne, Mejia, Fernando, Chang, Benny, Done, Brenda, Gabe, Larry, Gill, John, Gough, Kevin, Howlett, Gail, Klein, Marin, Latendre?Paquette, Judy, Leung, Victor, Macphee, Paul, Macpherson, P., Maharaj, Raj, Medina, Lorna Carrasco, Page, Suzanne, Pexos, Costas, Rachlis, Anita, Salters, Kate, Sterling, Sherine, Boswell, Stephen, Burkholder, Greer, Cesteros, Gisela, Chagaris, Kalliope, Franklin, Rosa, Fuhrer, Jack, Gilbert, Cynthia L., Goetz, Matthew, Grasso, Chris, Horberg, Michael, Hunter?Mellado, Robert F., Kell, Rita, Kitahata, Mari, Klein, Daniel, Levine, Ken, Marconi, Vincent, Mathews, Christopher, Mayor, Angel M., Mcgowan, Catherine, Napravnik, Sonia, Novak, Richard, Oursler, Kris Ann, Ramos, Shellier, Rodriguez, Benigno, Rodriguez, Maria C., Silverberg, Michael, Simberkoff, Michael S., Varshney, Mohit, Ward, Douglas, Widick, Barb, Yangco, Bienvenido G., Davies, Mary?Ann, Smith, Lilian, Von Groote, Per Maximilian, Muhairwe, Josephine, Balakasi, Steve, Banda, Quietus, Kalepa, Getrude, Bello, Andrew, Bulla, J.W., Chigeda, Maria, Chikaphupha, Joyce, Chikwekwere, Flora, Kachoka, Jack, Kapito, Allan, Katondo, Alinafe Nathan, Kumwenda, Molly, Labein, Felix Phewa, Magombo, Ronald, Malumbe, Bridget, Makuwira, I., Marico, Patricia, Masangale, Betha, Mchiela, Angella, Midian, Dan, Phiri, Kezia, Tambe, Mary, Thomas, Baid, Thomson, Charles, Hector, Jonas, Cross, Anna, Dlamini, Siphephelo, Eley, Brian, Euvrard, Jonathan, Fatti, Geoffrey, Hilderbrand, Katherine, Hsiao, Marvin, Mpye, Michael, Prozesky, Hans, Reubenson, Gary, Rose, Lesley, Sawry, Shobna, Sibambo, Nosisa, Technau, Karl, Vinikoor, Michael, Chimbetete, Cleophas, Kamenova, Kamelia, Balestre, Eric, Leroy, Valeriane, Malasteste, Karen, Djimon, Marcel Zannou, D' Almeida, Marcelline, Hounhoui, Ghislaine, Assogba, Michee, Zoungrana, Jacques, Yaméogo, Issouf, Tapsoba, Achille, Abdelh, Sidibé, Bosse, Clarisse Amani, Diabaté, Mamoudou, Eboua, Tanoh Kassi François, Folquet, Madeleine Amorissani, Hawelander, Denise, Konaté, Mamadou, Kouakou, Kouadio, Lambert, Dohoun, Minga, Albert Kla, N'Gbeche, Marie Sylvie, Tanon, Aristophane, Yao, Abo, Renner, Lorna, N'Diaye, Clémentine, Berthé, Mme Alima, Seydi, Moussa, Tine, Judicaël, Elom, Takassi Ounoo, Kariylare, Benjamin, and Patassi, Akessiwe

Subjects
Public health administration -- Evaluation, HIV infection -- Diagnosis -- Drug therapy, Health
Abstract

: Introduction: Since 2015, the World Health Organization (WHO) has recommended that all people living with HIV (PLHIV) initiate antiretroviral treatment (ART), irrespective of CD4+ count or clinical stage. National adoption of universal treatment has accelerated since WHO's 2015 “Treat All” recommendation; however, little is known about the translation of this guidance into practice. This study aimed to assess the status of Treat All implementation across regions, countries, and levels of the health care delivery system. Methods: Between June and December 2017, 201/221 (91%) adult HIV treatment sites that participate in the global IeDEA research consortium completed a survey on capacity and practices related to HIV care. Located in 41 countries across seven geographic regions, sites provided information on the status and timing of site‐level introduction of Treat All, as well as site‐level practices related to ART initiation. Results: Almost all sites (93%) reported that they had begun implementing Treat All, and there were no statistically significant differences in site‐level Treat All introduction by health facility type, urban/rural location, sector (public/private) or country income level. The median time between national policy adoption and site‐level introduction was one month. In countries where Treat All was not yet adopted in national guidelines, 69% of sites reported initiating all patients on ART, regardless of clinical criteria, and these sites had been implementing Treat All for a median period of seven months at the time of the survey. The majority of sites (77%) reported typically initiating patients on ART within 14 days of confirming diagnosis, with 60% to 62% of sites implementing Treat All in East, Southern and West Africa reporting same‐day ART initiation for most patients. Conclusions: By mid‐ to late‐2017, the Treat All strategy was the standard of care at almost all IeDEA sites, including rural, primary‐level health facilities in low‐resource settings. While further assessments of site‐level capacity to provide high‐quality HIV care under Treat All and to support sustained viral suppression after ART initiation are needed, the widespread introduction of Treat All at the service delivery level is a critical step towards global targets for ending the HIV epidemic as a public health threat., Introduction WHO's 2015 recommendation for immediate treatment of all PLHIV, regardless of CD4+ cell count, represented a paradigm shift in HIV care and treatment. By preventing morbidity and mortality among [...]

Published
2019
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24. Additional file 1 of Cost-utility analysis of four WHO-recommended sofosbuvir-based regimens for the treatment of chronic hepatitis C in sub-Saharan Africa

Author

Boyer, Sylvie, Baudoin, Ma��l, Nishimwe, Marie Lib��r��e, Santos, Melina, Lemoine, Maud, Maradan, Gwena��lle, Sylla, Babacar, Kouanfack, Charles, Carrieri, Patrizia, Mourad, Abbas, Rouveau, Nicolas, Moh, Raoul, Seydi, Moussa, Attia, Alain, Woode, Maame Esi, and Lacombe, Karine

Subjects
Data_FILES
Abstract

Additional file 1.

Published
2022
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25. Liver Disease and Treatment Needs of Asymptomatic Persons Living With Hepatitis B in Senegal

Author

Ramírez Mena, Adrià, Thioubou, Mame Aissé, Diallo, Kalilou, Tine, Judicaël, Ngom, Ndeye Fatou, Fortes, Louise, Ndiaye, Kiné, Karasi, Jean-Claude, Seguin-Devaux, Carole, Goedertz, Henri, Diouf, Daouda, Seydi, Moussa, Sambou, Benjamin Amaye, Arendt, Vic, Wandeler, Gilles, and Manga, Noël Magloire

Subjects
Infectious Diseases, Oncology, 360 Social problems & social services, 360 Soziale Probleme, Sozialdienste, 610 Medicine & health, 610 Medizin und Gesundheit
Abstract

The prevalence of active hepatitis B among asymptomatic persons remains unclear in Africa. Of 1206 newly diagnosed persons in Senegal, 12.3% had significant fibrosis and 31.3% had hepatitis B virus (HBV) DNA levels >2000 IU/mL. Overall, 128 (12.9%) were eligible for antiviral therapy. Generalized HBV screening allowed the identification of a large population requiring HBV care.

Published
2022
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26. Ebola virus imported from Guinea to Senegal, 2014

Author

Ka, Daye, FalL, Gamou, Diallo, Viviane Cisse, Faye, Ousmane, Fortes, Louise Deguenonvo, Faye, Oumar, Bah, Elhadji Ibrahim, Diallo, Kadia Mbaye, Balique, Fanny, Ndour, Cheikh Tidiane, Seydi, Moussa, and Sall, Amadou Alpha

Subjects
Ebola hemorrhagic fever -- Health aspects, Ebola virus -- Health aspects, Public health -- Health aspects, Health, World Health Organization
Abstract

Ebola virus disease (EVD) is a hemorrhagic fever caused by Ebola virus (EBOV); the mortality rate is high (1,2). EBOV was discovered in 1976, simultaneously in Zaire (now the Democratic [...]

Published
2017
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28. Impact of Traditional Healers on the HIV Care Cascade in Senegal, West Africa: A Longitudinal Study

Author

Benzekri, Noelle A., primary, Sambou, Jacques F., additional, Ndong, Sanou, additional, Diallo, Mouhamadou Baïla, additional, Tamba, Ibrahima Tito, additional, Faye, Dominique, additional, Sall, Ibrahima, additional, Diatta, Jean Philippe, additional, Faye, Khadim, additional, Sall, Fatima, additional, Cisse, Ousseynou, additional, Ndour, Cheikh T., additional, Sow, Papa Salif, additional, Malomar, Jean Jacques, additional, Hawes, Stephen E., additional, Seydi, Moussa, additional, and Gottlieb, Geoffrey S., additional

Published
2021
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29. Intrinsic resistance of HIV-2 and SIV to the maturation inhibitor GSK2838232.

Author

Smith, Robert A., Raugi, Dana N., Nixon, Robert S., Song, Jennifer, Seydi, Moussa, and Gottlieb, Geoffrey S.

Subjects
PEPTIDES, HIV
Abstract

GSK2838232 (GSK232) is a novel maturation inhibitor that blocks the proteolytic cleavage of HIV-1 Gag at the junction of capsid and spacer peptide 1 (CA/SP1), rendering newly-formed virions non-infectious. To our knowledge, GSK232 has not been tested against HIV-2, and there are limited data regarding the susceptibility of HIV-2 to other HIV-1 maturation inhibitors. To assess the potential utility of GSK232 as an option for HIV-2 treatment, we determined the activity of the compound against a panel of HIV-1, HIV-2, and SIV isolates in culture. GSK232 was highly active against HIV-1 isolates from group M subtypes A, B, C, D, F, and group O, with IC50 values ranging from 0.25–0.92 nM in spreading (multi-cycle) assays and 1.5–2.8 nM in a single cycle of infection. In contrast, HIV-2 isolates from groups A, B, and CRF01_AB, and SIV isolates SIVmac239, SIVmac251, and SIVagm.sab-2, were highly resistant to GSK232. To determine the role of CA/SP1 in the observed phenotypes, we constructed a mutant of HIV-2ROD9 in which the sequence of CA/SP1 was modified to match the corresponding sequence found in HIV-1. The resulting variant was fully susceptible to GSK232 in the single-cycle assay (IC50 = 1.8 nM). Collectively, our data indicate that the HIV-2 and SIV isolates tested in our study are intrinsically resistant to GSK232, and that the determinants of resistance map to CA/SP1. The molecular mechanism(s) responsible for the differential susceptibility of HIV-1 and HIV-2/SIV to GSK232 require further investigation. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Hepatitis B in Africa Collaborative Network: cohort profile and analysis of baseline data.

Author

Riches, Nicholas, Vinikoor, Michael, Guingane, Alice, Johannessen, Asgeir, Lemoine, Maud, Matthews, Philippa, Okeke, Edith, Shimakawa, Yusuke, Sombie, Roger, Stockdale, Alexander, Wandeler, Gilles, Andersson, Monique, Davwar, Pantong, Desalegn, Hailemichael, Duguru, Mary, Fall, Fatou, Maponga, Tongai, Paul, David Nyam, Seydi, Moussa, and Sinkala, Edford

Abstract

Approximately 80 million people live with chronic hepatitis B virus (HBV) infection in the WHO Africa Region. The natural history of HBV infection in this population is poorly characterised, and may differ from patterns observed elsewhere due to differences in prevailing genotypes, environmental exposures, co-infections, and host genetics. Existing research is largely drawn from small, single-centre cohorts, with limited follow-up time. The Hepatitis B in Africa Collaborative Network (HEPSANET) was established in 2022 to harmonise the process of ongoing data collection, analysis, and dissemination from 13 collaborating HBV cohorts in eight African countries. Research priorities for the next 5 years were agreed upon through a modified Delphi survey prior to baseline data analysis being conducted. Baseline data on 4,173 participants with chronic HBV mono-infection were collected, of whom 38.3% were women and the median age was 34 years (interquartile range 28–42). In total, 81.3% of cases were identified through testing of asymptomatic individuals. HBeAg-positivity was seen in 9.6% of participants. Follow-up of HEPSANET participants will generate evidence to improve the diagnosis and management of HBV in this region. [ABSTRACT FROM AUTHOR]

Published
2023
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31. Factors associated with verbal fluency in older adults living with HIV in West Africa: A longitudinal study.

Author

Bernard, Charlotte, Font, Hélène, Diallo, Zélica, Ahonon, Richard, Tine, Judicaël Malick, Abouo, Franklin N'Guessan, Tanon, Aristophane, Messou, Eugène, Seydi, Moussa, Dabis, François, Dartigues, Jean‐François, and de Rekeneire, Nathalie

Subjects
OLDER people, HIV infections, HIV, HIV-positive persons, LONGITUDINAL method
Abstract

Objective: Verbal fluency decline, observed both in aging and HIV infection, has been related to lower quality of life. This study aimed to evaluate the factors associated with categorical fluency in people living with HIV (PLHIV) aged ≥60 years living in West Africa. Methods: In this longitudinal study, PLHIV aged ≥60 years, on antiretroviral therapy (ART) for ≥6 months were included in three clinics (two in Côte d'Ivoire, one in Senegal) participating in the West Africa International epidemiological Databases to Evaluate AIDS (IeDEA) collaboration. Categorical fluency was evaluated with the Isaacs Set Test at 60 s at baseline and 2 years later. Factors associated with verbal fluency baseline performance and annual rates of changes were evaluated using multivariate linear regression models. Results: Ninety‐seven PLHIV were included with 41 of them (42%) having a 2‐year follow‐up visit. The median age was 64 (62–67), 45.4% were female, and 89.7% had an undetectable viral load. The median annual change in categorical fluency scores was −0.9 (IQR: −2.7 to 1.8). Low baseline categorical fluency performance and its decline were associated with older age and being a female. Low educational level was associated with low baseline categorical fluency performance but not with its decline. Categorical fluency decline was also associated with marital status and hypertension. Conclusions: Among older West African PLHIV, usual socio‐demographic variables and hypertension were the main factors associated with low categorical fluency performance and/or its decline. Interventions that focus on supporting cardiometabolic health are highly recommended to prevent cognitive disorders in PLHIV. [ABSTRACT FROM AUTHOR]

Published
2023
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32. Management of depression in people living with HIV/AIDS in Senegal: Acceptability, feasibility and benefits of group interpersonal therapy.

Author

Bernard, Charlotte, Font, Hélène, Ziadeh, Salaheddine, Tine, Judicaël M., Diaw, Abibatou, Ndiaye, Ibrahima, Samba, Oumar, Bottai, Thierry, Jacquesy, Laurent, Verdeli, Helena, Ngom, Ndeye F., Dabis, François, Seydi, Moussa, and de Rekeneire, Nathalie

Abstract

Depression is highly prevalent in people living with HIV (PLWH) and has negative consequences for daily life and care. We evaluated for the first time the acceptability, feasibility and benefits of group interpersonal therapy (IPT), combined with a task-shifting approach, to treat depression in PLWH in Senegal. PLWH with depression received group IPT following the World Health Organization protocol. Acceptability and feasibility criteria were defined from the literature data. The PHQ-9, the WHODAS, and the 12-item-stigma scale were used, pre- and post-treatment, including a 3-month follow-up, to assess depressive symptom severity, functioning and stigma, respectively. General linear mixed models were used to describe changes in outcomes over time. Of 69 participants, 60 completed group IPT. Refusal to enroll and dropout rates were 6.6 and 12.7%, respectively. Ninety-seven percent of participants attended at least seven out of eight sessions. Patients and facilitators endorsed group IPT, with willingness to recommend it. Depressive symptoms and disability improved drastically and sustainably. We showed that group IPT is well accepted and feasible in Senegal as treatment for depression in PLWH. Combined with a taskshifting approach, it can narrow the gap in mental health treatment. Implementation may be enhanced by refining patient identification procedures and increasing treatment accessibility. [ABSTRACT FROM AUTHOR]

Published
2023
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33. Liver Disease and Treatment Needs of Asymptomatic Persons Living With Hepatitis B in Senegal.

Author

Mena, Adrià Ramírez, Thioubou, Mame Aissé, Diallo, Kalilou, Tine, Judicaël, Ngom, Ndeye Fatou, Fortes, Louise, Ndiaye, Kiné, Karasi, Jean-Claude, Seguin-Devaux, Carole, Goedertz, Henri, Diouf, Daouda, Seydi, Moussa, Sambou, Benjamin Amaye, Arendt, Vic, Wandeler, Gilles, Manga, Noël Magloire, and CARES, for SEN-B and

Subjects
HEPATITIS B, ASYMPTOMATIC patients, THERAPEUTICS, LIVER diseases, DISEASE prevalence
Abstract

The prevalence of active hepatitis B among asymptomatic persons remains unclear in Africa. Of 1206 newly diagnosed persons in Senegal, 12.3% had significant fibrosis and 31.3% had hepatitis B virus (HBV) DNA levels >2000 IU/mL. Overall, 128 (12.9%) were eligible for antiviral therapy. Generalized HBV screening allowed the identification of a large population requiring HBV care. [ABSTRACT FROM AUTHOR]

Published
2022
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34. No Difference in Clinical Progression between Patients Infected with the Predominant Human Immunodeficiency Virus Type 1 Circulating Recombinant Form (CRF) 02 _AG Strain and Patients Not Infected with CRF02 _AG, in Western and West-Central Africa: A Four-Year Prospective Multicenter Study

Author

Laurent, Christian, Bourgeois, Anke, Faye, Mame Awa, Mougnutou, Rose, Seydi, Moussa, Gueye, Mandoumbé, Liégeois, Florian, Kane, Coumba Touré, Butel, Christelle, Mbuagbaw, Josephine, Zekeng, Léopold, Mboup, Souleymane, Mpoudi-Ngolé, Eitel, Peeters, Martine, and Delaporte, Eric

Published
2002

35. Severe Dengue in Adults and children, Ouagadougou (Burkina Faso), West Africa. October 2015 to january 2017

Author

Sondo, Kongnimissom Apoline, primary, Diendéré, Eric Arnaud, additional, Meda, Bertrand Ivlabehire, additional, Diallo, Ismaèl, additional, Zoungrana, Jacques, additional, Poda, Armel, additional, Manga, Noel Manga, additional, Bicaba, Brice, additional, Gnamou, Arouna, additional, Kagoné, Charles Joel, additional, Sawadogo, Guetawendé, additional, Yaméogo, Issaka, additional, Benzekri, Noelle A, additional, Tarnagda, Zekiba, additional, Kouanda, Séni, additional, Ouédraogo Traoré, Ramata, additional, Ouédraogo, Macaire S., additional, and Seydi, Moussa, additional

Published
2021
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36. Factors Associated with Severe COVID-19 in an Epidemic Treatment Center at Dakar

Author

Fall Becaye, Dia Ndongo, Faye Ousmane, Lo Moustapha, Fall Betty, Seydi Moussa, Degenonvo Louise Fortes, Lakhe Ndèye Aissatou, Sarr Mathilde Ndèye, Dieng Mame Thierno, Wembulua Bruce, Niang Abdourahmane, Sall Amadou Alpha, Mbaye Khardiata Diallo, Ndiaye Abdou Rajack, Ndiaye Mouhamadou, Soumah Fatou Kiné Mbaye, Essomba Ndong, Diop Moustapha, and Ba Papa Samba

Subjects
Treatment center, Pediatrics, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), business.industry, medicine, business
Published
2021

37. Hydroxychloroquine and Azithromycin Treatment of Hospitalized Patients Infected with SARS-CoV-2 in Senegal from March to October 2020

Author

Taieb, Fabien, primary, Mbaye, Khardiata Diallo, additional, Tall, Billo, additional, Lakhe, Ndèye Aïssatou, additional, Talla, Cheikh, additional, Thioub, Daouda, additional, Ndoye, Amadou Moustapha, additional, Ka, Daye, additional, Gaye, Aboubacry, additional, Cissé Diallo, Viviane Marie-Pierre, additional, Dia, Ndongo, additional, Ba, Pape Samba, additional, Cissé, Mamadou, additional, Diop, Moustapha, additional, Diagne, Cheikh Tidiane, additional, Fortes, Louise, additional, Diop, Mamadou, additional, Fall, Ndèye Maguette, additional, Sarr, Fatoumata Diène, additional, Diatta, Margarite, additional, Barry, Mamadou Aliou, additional, Badiane, Aboubakar Sidikh, additional, Seck, Abdoulaye, additional, Dubrous, Philippe, additional, Faye, Ousmane, additional, Vigan-Womas, Inès, additional, Loucoubar, Cheikh, additional, Sall, Amadou Alpha, additional, and Seydi, Moussa, additional

Published
2021
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38. Additional file 1 of The impact of food insecurity on HIV outcomes in Senegal, West Africa: a prospective longitudinal study

Author

Benzekri, Noelle A., Sambou, Jacques F., Sanou Ndong, Mouhamadou Baïla Diallo, Ibrahima Tito Tamba, Faye, Dominique, Ibrahima Sall, Diatta, Jean Philippe, Faye, Khadim, Ousseynou Cisse, Sall, Fatima, Ndèye Fatou Ngom Guèye, Cheikh T. Ndour, Papa Salif Sow, Malomar, Jean Jacques, Hawes, Stephen E., Seydi, Moussa, and Gottlieb, Geoffrey S.

Abstract

Additional file 1. English translation of study questionnaire

Published
2021
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39. Sibling status, home birth, tattoos and stitches are risk factors for chronic hepatitis B virus infection in Senegalese children: A cross‐sectional survey

Author

Périères, Lauren, Protopopescu, Camelia, Lo, Gora, Marcellin, Fabienne, Ba, El Hadji, Coste, Marion, Touré Kane, Coumba, Diallo, Aldiouma, Sokhna, Cheikh, Boyer, Sylvie, Anrs 12356 Ambass Survey Study, Grp, Bérenger, Cyril, Bousmah, Marwân-Al-Qays, Carrieri, Patrizia, de Sèze, Maëlle, Djaogol, Tchadine, Maradan, Gwenaëlle, Treibich, Carole, Ba Ba, El Hadji, Dièye, Fambaye, Diouf, Assane, Faye, Elhadji Bilal, Ndiaye, Assane, Sow, Mouhamadou Baba, Ndiaye, Anna Julienne Selbé, Ndiour, Samba, Halfon, Philippe, Mohamed, Sofiane, Rouveau, Nicolas, Cortès, Maria‐camila Calvo, Laborde‐balen, Gabrièle, Audibert, Martine, Fall, Fatou, Gueye, Ibrahima, Lacombe, Karine, Seydi, Moussa, Shimakawa, Yusuke, Tuaillon, Edouard, Vray, Muriel, Maladies infectieuses persistantes et émergentes en Afrique de l’Ouest [Dakar, Sénégal] (Equipe 3 - VITROME), Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées (IRBA)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées (IRBA), Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation [Dakar, Sénégal] (IRESSEF), Aix-Marseille Sciences Economiques (AMSE), École des hautes études en sciences sociales (EHESS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées (IRBA), The AmBASS research project was funded in full by the French ANRS Emerging Infectious Diseases research agency under the auspices of the French National Institute for Health and Medical Research (INSERM) (INSERM-ANRS), grant number 12356., Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Pathogenesis and Control of Chronic and Emerging Infections (PCCEI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Université des Antilles (UA)-Etablissement français du don du sang [Montpellier], Lhuillier, Elisabeth, and École des hautes études en sciences sociales (EHESS)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)

Subjects
HBsAg, Cross-sectional study, medicine.disease_cause, 0302 clinical medicine, Pregnancy, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Infection control, risk factors, 030212 general & internal medicine, [SHS.ECO] Humanities and Social Sciences/Economics and Finance, Home Childbirth, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, child, Tattooing, virus diseases, Hepatitis B, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, Senegal, 3. Good health, Vaccination, Infectious Diseases, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Female, 030211 gastroenterology & hepatology, Hepatitis B virus, prevalence, 03 medical and health sciences, Hepatitis B, Chronic, Virology, medicine, Humans, Hepatitis B Vaccines, Sibling, Aged, Hepatitis B Surface Antigens, Hepatology, business.industry, Siblings, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, medicine.disease, [SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, Infectious Disease Transmission, Vertical, digestive system diseases, Cross-Sectional Studies, hepatitis B, business, Home birth, Demography
Abstract

International audience; Sub-Saharan Africa's hepatitis B virus (HBV) burden is primarily due to infection in infancy. However, data on chronic HBV infection prevalence and associated risk factors in children born post-HBV vaccination introduction are scarce. We estimated hepatitis B surface antigen (HBsAg) prevalence and risk factors in Senegalese children born during the HBV vaccination era. In 2018-2019, a community-based cross-sectional survey was conducted in Senegal among children born between 2004 and 2015 (ie after the three-dose HBV vaccine series was introduced (2004) but before the birth dose's introduction (2016)). HBsAg-positive children were identified using dried blood spots. A standardized questionnaire collected socioeconomic information. Data were age-sex weighted and calibrated to be representative of children living in the study area. Risk factors associated with HBsAg positivity were identified using negative binomial regression. Among 1,327 children, 17 were HBsAg-positive (prevalence = 1.23% (95% confidence interval [CI] 0.61-1.85)). Older age (adjusted incidence-rate ratio [aIRR] 1.31 per one-year increase, 95% CI 1.10-1.57), home vs healthcare facility delivery (aIRR 3.55, 95% CI 1.39-9.02), stitches (lifetime) (aIRR 4.79; 95% CI 1.84-12.39), tattoos (aIRR 8.97, 95% CI 1.01-79.11) and having an HBsAg-positive sibling with the same mother (aIRR 3.05, 95% CI 1.09-8.57) were all independently associated with HBsAg positivity. The low HBsAg prevalence highlights the success of the Senegalese HBV vaccination program. To further reduce HBV acquisition in children, high-risk groups, including pregnant women and siblings of HBsAg-positive individuals, must be screened. Vital HBV infection prevention measures include promoting delivery in healthcare facilities, and increasing awareness of prevention and control procedures.

Published
2021

41. Alcohol use, viral hepatitis and liver fibrosis among HIV-positive persons in West Africa: a cross-sectional study

Author

Jaquet, Antoine, Wandeler, Gilles, Nouaman, Marcellin, Ekouevi, Didier K., Tine, Judicael, Patassi, Akouda, Coffie, Patrick A., Tanon, Aristophane, Seydi, Moussa, Attia, Alain, and Dabis, Francois

Subjects
HIV patients -- Analysis -- Health aspects, Drinking (Alcoholic beverages) -- Analysis -- Health aspects, Hepatitis C -- Analysis -- Health aspects, Antiretroviral agents -- Analysis -- Health aspects -- Dosage and administration, Health
Abstract

Introduction: Liver fibrosis is often the first stage of liver disease in people living with HIV (PLWHIV) in industrialized countries. However, little is known about liver fibrosis and its correlates among PLWHIV in sub-Saharan Africa. Methods: The study was undertaken in three HIV referral clinics in Cote d'Ivoire, Senegal and Togo. Enrolled PLWHIV underwent a non-invasive assessment of liver fibrosis combining liver stiffness measure (LSM) with transient elastography and the aspartate aminotransferase-to-platelet ratio index (APRI). Significant liver fibrosis was defined as LSM [greater than or equal to]7.1 kPa. Patients were screened for alcohol use (alcohol use disorder identification test (AUDIT)-C questionnaire), hepatitis B virus (HBV) antigen, hepatitis Delta virus (HDV) antibody and anti-hepatitis C (HCV) antibody. A logistic regression model was used to identify the factors associated with significant liver fibrosis. Results: A total of 807 PLWHIV were screened at a median age of 43 years (interquartile range (IQR): 36-50). Their median CD4 count was 393 cells/[mm.sup.3] (IQR: 234-563) and 682 (84.5%) were on antiretroviral therapy (ART). The prevalence of significant fibrosis was 5.3% (3.8-6.7). Infections with HBV and HCV were identified in 74 (9.2%) and nine (1.1%) participants. Main factors associated with liver fibrosis were alcohol use (AUDIT-C >6): (odds ratio (OR) = 4.0, confidence interval (CI): 1.2-14.0), (Ref. AUDIT-C Conclusions: Considering the WHO recommendations to screen for HBV infection and treat coinfected patients with tenofovir-based ART, screening of alcohol use and brief interventions to prevent alcohol abuse should be implemented in West Africa, especially in HBV/HIV coinfected patients. Keywords: liver fibrosis; HIV; alcohol; hepatitis B; hepatitis D; hepatitis C; Africa, Introduction Liver diseases now represent one of the leading causes of mortality in people living with HIV (PLWHIV) in industrialized countries [1,2]. Of these liver-related deaths, over 60% are attributable [...]

Published
2017
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42. Tuberculosis Re-Treatment Cases and Factors Associated with Unfavourable Outcome at the Fann University Hospital of Dakar, Senegal between 2011 and 2016: A Follow-Up Study

Author

Waberi Farah Djamal, Guèye Ndèye Fatou Ngom, AminataMassaly, Diouf Assane, Soumaré Masserigne, Diop Cheikh Tacko, Baye Khardiata Diallo M, Dieye Alassane, Ka Daye, Seydi Moussa, Lakhe Ndèye Aissatou, Nyafouna Sylvie Diop, Déguénonvo Louise Fortes, Fall Ndeye Maguette, Diallo Viviane Marie Pierre Cissé, and Ndour Cheikh Tidiane

Subjects
Pediatrics, medicine.medical_specialty, Tuberculosis, business.industry, medicine, Follow up studies, medicine.disease, University hospital, business, Outcome (game theory)
Published
2019

43. HIV-2 Drug Resistance Genotyping from Dried Blood Spots

Author

Raugi, Dana N., primary, Nixon, Robert S., additional, Leong, Sally, additional, Faye, Khadim, additional, Diatta, Jean Phillipe, additional, Sall, Fatima, additional, Smith, Robert A., additional, Sall, ElHadji Ibrahima, additional, Malomar, Jean Jacques, additional, Seydi, Moussa, additional, and Gottlieb, Geoffrey S., additional

Published
2020
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44. Chloroquine and Hydroxychloroquine for the Prevention or Treatment of COVID-19 in Africa: Caution for Inappropriate Off-label Use in Healthcare Settings

Author

Abena, Pascale M., primary, Decloedt, Eric H., additional, Bottieau, Emmanuel, additional, Suleman, Fatima, additional, Adejumo, Prisca, additional, Sam-Agudu, Nadia A., additional, Muyembe TamFum, Jean-Jacques, additional, Seydi, Moussa, additional, Eholie, Serge P., additional, Mills, Edward J., additional, Kallay, Oscar, additional, Zumla, Alimuddin, additional, and Nachega, Jean B., additional

Published
2020
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45. Clinical characteristics and outcomes of COVID-19 infection in nine pregnant women: a report from a sub-Saharan African country, Senegal

Author

Diouf, Abdoul Aziz, primary, Mbaye, Khardiata Diallo, additional, Gueye, Mamour, additional, Thioub, Daouda, additional, Niang, Ndama, additional, Dekou, Christelle Yonta, additional, Gueye, Mame Diarra Ndiaye, additional, Diallo, Moussa, additional, Mbaye, Magatte, additional, Dieme, Marie Edouard Faye, additional, Diouf, Alassane, additional, and Seydi, Moussa, additional

Published
2020
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46. Low-level CD4+ T cell activation in HIV-exposed seronegative subjects: influence of gender and condom use

Author

Camara, Makhtar, Dieye, Tandakha Ndiaye, Seydi, Moussa, Diallo, Abdoul Aziz, Fall, Marema, Diaw, Papa Alassane, Sow, Papa Salif, Mboup, Souleymane, Kestens, Luc, and Jennes, Wim

Subjects
Lymphocyte transformation -- Research, HIV infection -- Risk factors, HIV infection -- Research, Condoms -- Usage, Condoms -- Research, Disease transmission -- Research, Immune response -- Research, Health
Published
2010

47. No difference in clinical progression between patients infected with the predominant human immunodeficiency virus type 1 circulating recombinant form (CRF) 02_AG strain and patients not infected with CRF02_AG, in western and west-central Africa: a four-year prospective multicenter study

Author

Laurent, Christian, Bourgeois, Anke, Faye, Mame Awa, Mougnutou, Rose, Seydi, Moussa, Gueye, Mandoumbe, Liegeois, Florian, Kane, Coumba Toure, Butel, Christelle, Mbuagbaw, Josephine, Zekeng, Leopold, Mboup, Souleymane, Mpoudi-Ngole, Eitel, Peeters, Martine, and Delaporte, Eric

Subjects
HIV infection -- Development and progression, Health
Published
2002

48. Prevalence and Associated Factors to Cryptococcosis in the Infectious Diseases Department of the National University Hospital Center of Fann in Dakar (Senegal)

Author

Manga Nm, Dieng Yemou, NDour Tidiane Cheik, Ossibi Ibara Br, Daye Ka, and Seydi Moussa

Subjects
medicine.medical_specialty, business.industry, Family medicine, Infectious diseases department, Cryptococcosis, medicine, Center (algebra and category theory), General Medicine, University hospital, medicine.disease, business
Published
2018

49. Comparing Treatment Outcomes of Antiretroviral Therapy in HIV-1 and HIV-2 Infected Patients, in Bamako, Mali

Author

Oumar, Aboubacar Alassane, Cissoko, Yacouba, Konaté, Issa, Kane, Adam, Dembélé, Jean Paul, Cissé, Mamadou, Murphy, Robert Leo, Yombi, Jean Cyr, Seydi, Moussa, Dao, Sounkalo, Maiga, Mamoudou, UCL - SSS/IREC/SLUC - Pôle St.-Luc, and UCL - (SLuc) Service de médecine interne générale

Subjects
HIV-2, HIV-1, Adverse Effects Taxonomy Topics, Mali, ART, Article
Abstract

BACKGROUND: HIV-2 leads to a less-severe disease than HIV-1 but is known to be resistant to Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs). We goaled to evaluate the clinical and biological outcomes of HIV-1 and HIV-2 infected-patients under Antiretroviral Therapy (ART) that do not include NNRTIs. METHODS: This is a case-control study of 100 participants (half in each group) to measure the frequency of clinical and biological adverse effects, and disease outcome at 6 and 12 months of treatment (M6 and M12) We included. RESULTS: Opportunistic infections were more frequent in HIV-1 infected patients with 82% when compared to HIV-2, 68%. However, the prevalence of treatment adverse events was slightly higher in HIV-2 infected patients. The average increase of CD4 cell count at M6 of treatment was 139.93 and 159.41 cells/mm3, for HIV-2 and HIV-1 groups respectively, and at 153 and 217 cells/mm3, at M12 for HIV-2 and HIV-1 respectively. A total of nine HIV-2 and six HIV-1 deaths were reported during the study. CONCLUSION: This study has shown that ART regimens that do not include NNRTIs are effective equally in the treatment of HIV-1 and HIV-2 infections. Nevertheless, we recommend regular and continuous laboratory monitoring for all HIV treated patients.

Published
2018

50. Nutrition support for HIV-TB co-infected adults in Senegal, West Africa: A randomized pilot implementation study

Author

Benzekri, Noelle A., primary, Sambou, Jacques F., additional, Tamba, Ibrahima Tito, additional, Diatta, Jean Philippe, additional, Sall, Ibrahima, additional, Cisse, Ousseynou, additional, Thiam, Makhtar, additional, Bassene, Gaetan, additional, Badji, Ndeye Maguette, additional, Faye, Khadim, additional, Sall, Fatima, additional, Malomar, Jean Jacques, additional, Seydi, Moussa, additional, and Gottlieb, Geoffrey S., additional

Published
2019
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