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1. Smart chitosan-folate hybrid magnetic nanoparticles for targeted delivery of doxorubicin to osteosarcoma cells

Author

Nazanin Amiryaghoubi, Elaheh Dalir Abdolahinia, Ailar Nakhlband, Shaghayegh Aslzad, Marziyeh Fathi, Jaleh Barar, and Yadollah Omidi

Subjects
Chitosan, Osteosarcoma, Drug Carriers, Surfaces and Interfaces, General Medicine, Colloid and Surface Chemistry, Folic Acid, Drug Delivery Systems, Doxorubicin, Spectroscopy, Fourier Transform Infrared, Humans, Nanoparticles, Physical and Theoretical Chemistry, Magnetite Nanoparticles, Biotechnology
Abstract

Chitosan (CS)-based pH-sensitive nanocomposites were fabricated for the targeted delivery of doxorubicin (DOX) to osteosarcoma cells. To prepare the nanocomposite, CS was functionalized with succinic anhydride (SA) (CS-SA). CS-folic acid (FA) conjugates were produced by the conjugation of CS with FA via an amide bond. Next, Fe

Published
2022

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