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2. FAST and Agile–the MASLD drift: Validation of Agile 3+, Agile 4 and FAST scores in 246 biopsy-proven NAFLD patients meeting MASLD criteria of prevalent caucasian origin

Author

Taru, Madalina-Gabriela, primary, Tefas, Cristian, additional, Neamti, Lidia, additional, Minciuna, Iulia, additional, Taru, Vlad, additional, Maniu, Anca, additional, Rusu, Ioana, additional, Petrushev, Bobe, additional, Procopciuc, Lucia Maria, additional, Leucuta, Dan Corneliu, additional, Procopet, Bogdan, additional, Ferri, Silvia, additional, Lupsor-Platon, Monica, additional, and Stefanescu, Horia, additional

Published
2024
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3. Validation of NIAAAm-CRP criteria to predict alcohol-associated steatohepatitis on liver histology

Author

Stauber, Rudolf E., primary, Rautou, Pierre-Emmanuel, additional, Stefanescu, Horia, additional, Horhat, Adelina, additional, Thiele, Maja, additional, Lackner, Carolin, additional, Davies, Susan, additional, Denk, Helmut, additional, Detlefsen, Sönke, additional, Dienes, Hans Peter, additional, Gnemmi, Viviane, additional, Gouw, Annette S.H., additional, Guido, Maria, additional, Miquel, Rosa, additional, Paradis, Valerie, additional, Rusu, Ioana, additional, Schirmacher, Peter, additional, Terracciano, Luigi, additional, and Tiniakos, Dina, additional

Published
2024
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4. Decompensation in Advanced Nonalcoholic Fatty Liver Disease May Occur at Lower Hepatic Venous Pressure Gradient Levels Than in Patients With Viral Disease

Author

Bassegoda, Octavi, Olivas, Pol, Turco, Laura, Mandorfer, Mattias, Serra-Burriel, Miquel, Tellez, Luis, Kwanten, Wilhelmus, Laroyenne, Alexia, Farcau, Oana, Alvarado, Edilmar, Moga, Lucile, Vuille-Lessard, Elise, Fortea, Jose Ignacio, Ibañez, Luis, Tosetti, Giulia, Vanwolleghem, Thomas, Larrue, Hélène, Burgos-Santamaría, Diego, Stefanescu, Horia, Paternostro, Rafael, Cippitelli, Annalisa, Lens, Sabela, Augustin, Salvador, Llop, Elba, Laleman, Wim, Trebicka, Jonel, Chang, Johannes, Masnou, Helena, Zipprich, Alexander, Miceli, Francesca, Semmler, Georg, Forns, Xavier, Primignani, Massimo, Bañares, Rafael, Puente, Angela, Berzigotti, Annalisa, Rautou, Pierre Emmanuel, Villanueva, Candid, Ginès, Pere, Garcia-Pagan, J.C., Procopet, Bogdan, Bureau, Cristophe, Albillos, Agustin, Francque, Sven, Reiberger, Thomas, Schepis, Filippo, Graupera, Isabel, and Hernandez-Gea, Virginia

Published
2022
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6. Including Ratio of Platelets to Liver Stiffness Improves Accuracy of Screening for Esophageal Varices That Require Treatment

Author

Huvelin, Sylvie Sacher, Calès, Paul, Valla, Dominique, Bureau, Christophe, Olivier, Anne, Oberti, Frédéric, Boursier, Jérôme, Galmiche, Jean Paul, Vinel, Jean Pierre, Duburque, Clotilde, Attar, Alain, Archambeaud, Isabelle, Benamouzig, Robert, Gaudric, Marianne, Luet, Dominique, Couzigou, Patrice, Planche, Lucie, Coron, Emmanuel, Hiriart, Jean-Baptiste, Chermak, Faiza, Charbonnier, Maude, Nahon, Pierre, Marcellin, Patrick, Guyader, Dominique, Pol, Stanislas, Fontaine, Hélène, Larrey, Dominique, De Lédinghen, Victor, Ouzan, Denis, Zoulim, Fabien, Roulot, Dominique, Tran, Albert, Bronowicki, Jean-Pierre, Zarski, Jean-Pierre, Leroy, Vincent, Riachi, Ghassan, Péron, Jean-Marie, Alric, Laurent, Bourlière, Marc, Mathurin, Philippe, Dharancy, Sebastien, Blanc, Jean-Frédéric, Abergel, Armand, Serfaty, Lawrence, Mallat, Ariane, Grangé, Jean-Didier, Attali, Pierre, Bacq, Yannick, Wartelle, Claire, Dao, Thông, Benhamou, Yves, Pilette, Christophe, Silvain, Christine, Christidis, Christos, Capron, Dominique, Thiefin, Gérard, Hillaire, Sophie, Di Martino, Vincent, Berger, Arthur, Ravaioli, Federico, Farcau, Oana, Festi, Davide, Stefanescu, Horia, Buisson, François, Ganne-Carriè, Nathalie, Berzigotti, Annalisa, de Ledinghen, Victor, and Petta, Salvatore

Published
2021
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9. P- 40 PENTOXIFYLLINE USE IN PATIENTS WITH ALCOHOL-ASSOCIATED HEPATITIS ADMITTED WITH ACUTE KIDNEY INJURY COULD DECREASE SURVIVAL: A GLOBAL STUDY

Author

Idalsoaga, Francisco, Diaz, Luis Antonio, Corsi, Oscar, Ayares, Gustavo, Arnold, Jorge, Dunn, Winston, Li, Yanming, Singal, Ashwani, Simonetto, Doug, Ayala-Valverde, María, Ramirez, Carolina A, Morales-Arraez, Dalia, Zhang, Wei, Qian, Steve, Ahn, Joseph, Buryska, Seth, Mehta, Heer, Waleed, Muhammad, Stefanescu, Horia, Horhat, Adelina, Bumbu, Andreea, Agrawal, Bashar, Agrawal, Rohit, Cabezas, Joaquín, Cuyàs, Berta, Poca, Maria, Pastor, German Soriano, Sarin, Shiv K, Maiwall, Rakhi, Jalal, Prasun K, Tijera, María Fátima Higuera-De La, Kulkarni, Anand, Rao, Nagaraja, Salazar, Patricia Guerra, Skladaný, Lubomir, Bystrianska, Natália, Prado, Veronica, Clemente-Sanchez, Ana, Rincón, Diego, Haider, Tehseen, Chacko, Kristina R, Romero, Gustavo A, Pollarsky, Florencia, Restrepo, Juan Carlos, Toro, Luis G, Yaquich, Pamela, Mendizabal, Manuel, Garrido, Maria Laura, Marciano, Sebastian, Dirchwolf, Melisa, Vargas, Victor, Jimenez, Cesar, García-Tsao, Guadalupe, Ortiz, Guillermo, Abraldes, Juan G, Kamath, Patrick, Shah, Vijay, Bataller, Ramon, and Arab, Juan Pablo

Published
2024
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10. P-19 CHARACTERIZATION, PROGNOSTIC FACTORS, AND SURVIVAL IN MODERATE ALCOHOL-ASSOCIATED HEPATITIS: A MULTICENTER STUDY

Author

Idalsoaga, Francisco, Díaz, Luis Antonio, Corsi, Oscar, Ayares, Gustavo, Arnold, Jorge, Dunn, Winston, Li, Yanming, Singal, Ashwani, Simonetto, Doug, Ayala-Valverde, María, Ramirez, Carolina A., Morales-Arraez, Dalia, Zhang, Wei, Qian, Steve, Ahn, Joseph, Buryska, Seth, Mehta, Heer, Waleed, Muhammad, Stefanescu, Horia, Horhat, Adelina, Bumbu, Andreea, Attar, Bashar, Agrawal, Rohit, Cabezas, Joaquín, Cuyàs, Berta, Poca, Maria, Pastor, German Soriano, Sarin, Shiv K, Maiwall, Rakhi, Jalal, Prasun K, Tijera, María Fátima Higuera-De La, Kulkarni, Anand, Rao, Nagaraja, Salazar, Patricia Guerra, Skladaný, Lubomir, Bystrianska, Natália, Prado, Veronica, Clemente-Sanchez, Ana, Rincón, Diego, Haider, Tehseen, Chacko, Kristina R, Romero, Gustavo A, Pollarsky, Florencia D, Restrepo, Juan Carlos, Toro, Luis G, Yaquich, Pamela, Mendizabal, Manuel, Garrido, Maria Laura, Marciano, Sebastian, Dirchwolf, Melisa, Vargas, Victor, Jimenez, Cesar, García-Tsao, Guadalupe, Ortiz, Guillermo, Abraldes, Juan G, Kamath, Patrick, Shah, Vijay, Bataller, Ramon, and Arab, Juan Pablo

Published
2024
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12. O-25 ASSESSMENT OF MODELS FOR PREDICTING RESPONSE TO CORTICOIDS TREATMENT IN ALCOHOL-ASSOCIATED HEPATITIS: A GLOBAL COHORT STUDY

Author

Idalsoaga, Francisco, primary, Díaz, Luis Antonio, additional, Ayares, Gustavo, additional, Arnold, Jorge, additional, Dunn, Winston, additional, Li, Yanming, additional, Singal, Ashwani, additional, Simonetto, Doug, additional, Ayala-Valverde, María, additional, Perez, Diego, additional, Gomez, Jaime, additional, Escarate, Rodrigo, additional, Fuentes-López, Eduardo, additional, Ramirez, Carolina A, additional, Morales-Arraez, Dalia, additional, Zhang, Wei, additional, Qian, Steve, additional, Ahn, Joseph, additional, Buryska, Seth, additional, Mehta, Heer, additional, Waleed, Muhammad, additional, Stefanescu, Horia, additional, Horhat, Adelina, additional, Bumbu, Andreea, additional, Attar, Bashar, additional, Grawal, Rohit, additional, Cabezas, Joaquín, additional, García-Carrera, Inés, additional, Cuyàs, Berta, additional, Poca, Maria, additional, Pastor, German Soriano, additional, Sarin, Shiv K, additional, Maiwall, Rakhi, additional, Jalal, Prasun K, additional, Tijera, María Fátima Higuera-De La, additional, Kulkarni, Anand, additional, Rao P, Nagaraja, additional, Salazar, Patricia Guerra, additional, Skladaný, Lubomir, additional, Bystrianska, Natália, additional, Prado, Veronica, additional, Clemente-Sanchez, Ana, additional, Rincón, Diego, additional, Haider, Tehseen, additional, Chacko, Kristina R, additional, Romero, Gustavo A, additional, Pollarsky, Florencia D, additional, Restrepo, Juan Carlos, additional, Toro, Luis G, additional, Yaquich, Pamela, additional, Mendizabal, Manuel, additional, Garrido, Maria Laura, additional, Marciano, Sebastian, additional, Dirchwolf, Melisa, additional, Vargas, Victor, additional, Jimenez, Cesar, additional, García-Tsao, Guadalupe, additional, Ortiz, Guillermo, additional, Abraldes, Juan G, additional, Kamath, Patrick, additional, Arrese, Marco, additional, Shah, Vijay, additional, Bataller, Ramon, additional, and Arab, Juan Pablo, additional

Published
2023
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13. Presence of Hepatocellular Carcinoma Does Not Affect Course and Response to Anticoagulation of Bland Portal Vein Thrombosis in Cirrhotic Patients

Author

Benevento, Francesca, primary, Pecorelli, Anna, additional, Stefanescu, Horia, additional, Sparchez, Zeno, additional, Vukotic, Ranka, additional, Pettinari, Irene, additional, Grigoras, Crina-Anca, additional, Tovoli, Francesco, additional, Ravaioli, Federico, additional, Stefanini, Bernardo, additional, Andreone, Pietro, additional, and Piscaglia, Fabio, additional

Published
2023
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17. Navigating through the Lipid Metabolism Maze: Diagnosis and Prognosis Metabolites of Hepatocellular Carcinoma versus Compensated Cirrhosis

Author

Nenu, Iuliana, primary, Stefanescu, Horia, additional, Procopet, Bogdan, additional, Sparchez, Zeno, additional, Minciuna, Iulia, additional, Mocan, Tudor, additional, Leucuta, Daniel, additional, Morar, Corina, additional, Grigorescu, Mircea, additional, Filip, Gabriela Adriana, additional, and Socaciu, Carmen, additional

Published
2022
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19. Assessing the knowledge, attitudes and practices concerning hormonal emergency contraception among female university students from Cluj-Napoca

Author

Sevastre-Berghian, Alexandra, Hanganu, Daniela, Benedec, Daniela, Oniga, Ilioara, Vlase, Laurian, Baldea, Ioana, Olteanu, Diana, Clichici, Simona, Filip, Gabriela Adriana, Ciocan, Andra, Bolboacă, Sorana D., Ciocan, Răzvan A., Nadim, Al Hajjar, Urda-Cîmpean, Andrada Elena, Pop, Cristina, Horon, Bianca, Mogoşan, Emilia, Cazacu, Irina, Cristina, Anamaria, Voştinaru, Oliviu, Anca, Emilia, Lang, Camelia, Roşioru, Corina, Erhan, Sabina, Vlad, Cristina, Capraş, Roxana-Denisa, Cordoş, Ariana-Anamaria, Blebea, Cristina, Perde-Schrepler, Maria, Bindea, Mihaela, Tatomir, Corina, Ujvary, Peter, Maniu, Alma, Tudor, Diana Valentina, Bâldea, Ioana, Lupu, Mihai, Filip, Adriana Gabriela, Schiotis, Ruxandra Elena, Radu, Catalina, Goşa, Dana, Bocşan, Corina, Buzoianu, Anca Dana, Domşa, Elena-Maria, Mureşan, Adriana, David, Luminiţa, Moldovan, Bianca, Para, Ioana, Negrean, Vasile, Andreica, Vasile, Neag, Maria Adriana, Cătinean, Adrian, Muntean, Dana Maria, Pop, Maria Raluca, Bocşan, Ioana Corina, Boţan, Emil Claudiu, Todea, M., Pop-Mureşan, M., Vulpoi, A., Popa, C., Berce, P., Simon, S., Eniu, D., Pop, Raluca M., Sabin, Octavia, Chedea, Veronica S., Boca, Andreea N., Bocşan, Corina I., Buzoianu, Anca D., Lupean, Roxana-Adelina, Crişan, Maria, Şovrea, Alina Simona, Şuşman, Sergiu Valeriu, Boşca, Adina Bianca, Melincovici, Carmen Stanca, Mărginean, Mariana Viorica, Constantin, Anne-Marie, Jianu, Mihaela Elena, Coneac, Andrei, Mocan, Lavinia Patricia, Moldovan, Ioana-Maria, Sufleţel, Rada Teodora, Mihu, Carmen Mihaela, Sitar-Taut, Adela-Viviana, Cozma, Angela, Orasan, Olga, Fodor, Adriana, Coste, Sorina, Tarmure, Simina, Pop, Dana, Zdrenghea, Dumitru, Sampelean, Dorel, Grosu, Alin, Radulescu, Dan, Grosu, Laura, Buzdugan, Elena, Crisan, Sorin, Maierean, Anca Diana, Todea, Doina Adina, Budin, Corina Eugenia, Maierean, Anca, Alexescu, Teodora, Turcanu, Anca, Semenescu, Raluca, Farcas, Loredana, Rohozneanu, Emanuela, Rădulescu, Dan, Răchişan, Andreea Liana, Dubois, Valerie, Ranchin, Bruno, Leclerc, Anne Laure Sellier, Thomas, Aurelia Bertholet, Cochat, Pierre, Bacchetta, Justine, Sava, Bianca, Mocanu, Lorena, Cismaru, Gabriel, Comsa, Horatiu, Pepine, Diana, Boarescu, Paul, Wasmuth, Alexander, Rosu, Radu, Puiu, Mihai, Gusetu, Gabriel, Condor, Ariana, Crişan, Sorin, Chiorescu, R. M., Barta, A., Mocan, M., Stoia, M. A., Anton, F. P., Mocan-Hognogi, D. L., Goidescu, C. M., Farcaş, A. D., Lazea, Cecilia, Al-Khzouz, Camelia, Bucerzan, Simona, Asavoaie, Carmen, Nascu, Ioana, Grigorescu-Sido, Paula, Sirbe, Claudia, Grigore, Madalina, Negrea, Ana-Georgeta, Suroiu, Sabrina, Borodi, Mihaela, Benta, Gabriel, Delean, Dan, Pop, Tudor L., Grama, Alina, Jianu, Cristian, Itu-Muresan, Corina, Topan, Adriana, Filipescu, Irina, Jianu, Mihaela, Bolboaca, Sorana D., Radulescu, Maria L., Neamti, Lidia, Pop, V., Stoicescu, L., Grosu, A., Radulescu, D., Cîmpianu, Mircea, Blachon, Alexandre, Chiorescu, Roxana, Stoia, Mirela, McPherson, CA, Pop, Sorin, Ruskin, Jeremy, Blendea, Dan, Florian, Teodora-Larisa, Florian, Ioan-Alexandru, Frîngu, Florina, Iosip, Adriana, Tomoaia, Raluca, Gurzau, Diana, Comşa, Horatiu, Caloian, Bogdan, Guşetu, Gabriel, Benţa, Gabriel, Căinap, Simona, Sîrbe, Claudia, Miclea, Diana, Pîrvan, Alexandru, Platon, Monica, Pop, Tudor Lucian, Ciulei, George, Orăşan, Olga Hilda, Coste, Sorina-Cezara, Procopciuc, Lucia Maria, Burac, Lucia, Aldea, Cornel, Bizo, Aurel, Bulata, Bogdan, Fufezan, Otilia, Stefanescu, Horia, Hotea, Ioana, Crisan, Tania O., Pamfil, Cristina, Badii, Medeea, Gaal, Orsolya, Peca, Loredana, Mirea, Andreea, Popp, Radu, Rednic, Simona, Joosten, Leo AB, Gheorghiu, Cristina, Simu, Gelu, Haji-Hassan, Mariam, Perné, Mirela-Georgiana, Milaciu, Mircea Vasile, Sâmpelean, Dorel, Coman, Oana-Maria, Ciumărnean, Lorena, Hăşmăşanu, Monica, Matyas, Melinda, Blaga, Ligia, Bolboacă, Sorana, Zaharie, Gabriela, (Tamaş), Adela Pătcaş, Ciule, Dorina Larisa, Vele, Paulina, Silaghi, Ciprian N., Damian, Laura O., Simon, Siao-Pin, Craciun, Alexandra M., Slavescu, Kinga Cristina, Muresan, Rodica, Mititelu, Alexandra, Tomescu, Serban, Chis, Alexandra Micu, Rednic, Mihaela, Vulturar, Romana, Lazăr, Mădălina, Sas, Valentina, Chiş, Adina, Deleanu, Călin, Man, Sorin, Schnell, Cristina, Nicolescu, Alina, Vinţan, Maria, Poliac, Teodora, Damian, Laura, Romitan, M., Radulescu, Maria, Rădulescu, D., Bădărînză, Maria, Şerban, Oana, Maghea, Lavinia, Papp, Iulia, Guţiu, Roxana-Ioana, Fodor, Daniela, Pirvan, Alexandru, Andrei, Adina, Orasan, Remus Aurel, Orasan, Olga Hilda, Bocşan, Corina Delia, Micu, Mihaela Cosmina, Albu, Adriana, Slavescu, Radu Razvan, Stoicescu, Laurenţiu, Ştefan, Georgia, Bâlteanu, Valentin Adrian, Lauzier, Benjamin, Dhot, Justine, Morgovan, Claudiu, Mogoşan, Cristina, Ghibu, Steliana, Ţaranu, Ioana, Răcătăianu, Nicoleta, Vesa, Ştefan Cristian, Pop, Raluca Maria, Matei, Daniela Maria, Paşca, Sergiu, Buzoianu, Anca-Dana, Acalovschi, Monica, Borz, Mihnea Bogdan, Schitcu, Vlad Horia, Cojocaru, Ion, Marica, Nucu Alexandru, Popescu, Dan Sorin, Munteanu, Vlad Cristian, Borz, Paul Cristian, Rădeanu, D., Dragoş, D., Girbe, S., Gondor, G., Stan, C., Maniu, A., Florian, Ioan-Stefan, Olteanu, G., Radu, M., Tui, I., Andercou, O., Stancu, B., Gherman, Claudia, Constantinescu, Ioana, Mihaileanu, F., Pintea, Daniela, Muntean, V., Simon, Ioan, Capîlnean, Teodora-Valeria, Fabian, Ovidiu, RăzvanTogănel, Mureşan, Flaviu, Deceanu, Daniel, Măluţan, Andrei Mihai, Puşcaş, Mihaela, Ciortea, Răzvan, Mocan-Hognogi, Radu Florin, Bucuri, Carmen Elena, Rada, Maria, Dudea, Marina, Mihu, Dan, Rada, Maria Patricia, Fetica, Bogdan, Clim, Adelina, Roman, Andrei, Lupan-Mureşan, Eugenia-Maria, Voicescu, George Teo, Popa, Stefania-Anda, Golea, Adela, Nechita, Vlad I., Graur, Florin, Moiş, Emil, Hajjar, Nadim A., Suciu, Viorela-Elena, Ignat, Florin Laurenţiu, Boţan, Emil-Claudiu, Bucuri, Carmen, Lăcan, Sorin-Mihai, Ungur, Ovidiu-Mihai, Stan, Constantin, Rădeanu, Doinel, Ujvary, Laszlo Peter, Blebea, Cristina Maria, Bulac, Luiza, Birta, Daiana, Chirilă, Magdalena, Ciocan, Răzvan, Crişan, Doiniţa, Constantinescu, Dan, Muntean, Valentin, Cozma-Petruţ, Anamaria, Badiu-Tişa, Ioana, Filip, Lorena, Banc, Roxana, Stanciu, Oana, Gavrilaş, Laura, Ciobârcă, Daniela, Hegheş, Codruţa, Miere, Doina, Coman, Fana-Maria, Leonte, Denisa, Brém, Balázs, Tötös, Robert, Zaharia, Valentin, Toma, Alexandra, Casoni, Dorina, Gliga, Laura-Elena, Iacob, Bogdan-Cezar, Bodoki, Ede, Oprean, Radu, Hosu, Oana, Melinte, Gheorghe, Casian, Magdolna, Săndulescu, Robert, Cristea, Cecilia, Cernat, Andreea, Irimes, Maria-Bianca, Györfi, Szabolcs János, Tertiş, Mihaela, Suciu, Maria, Anicăi, Liana, Moldovan, Radu-Cristian, Petrache, Alina, Pralea, Ioana-Ecaterina, Cogălniceanu, Gina, Mitoi, Monica, Iuga, Cristina-Adela, Paşca, Denisia, Morariu, Daniel, Buse, Mihail, Ionescu, Corina, Iuga, Cristina Adela, Pricopie, Andreea-Iulia, Ionuţ, Ioana, Marc, Gabriel, Găină, Luiza Ioana, Vodnar, Dan C., Pîrnău, Adrian, Focşan, Monica, Oniga, Ovidiu, Rus, Iulia, Gug, Ioana, Paşcalău, Violeta, Melean, Bianca, Pall, Emoke, Moldovan, Cristian, Stoian, Adrian-Ioan, Dudaş, Cosmina, Moldovan, Rebeca, Toma, Valentin, Ştiufiuc, Rareş I., Stana, Anca, Moldovan, Cadmiel, Gavan, Alexandru, Dias, Maria Inês, Pereira, Carla, Barros, Lillian, Ferreira, Isabel C.F.R., Mocan, Andrei, Crişan, Gianina, Negoi, Oana-Iuliana, Ispas, Georgiana-Ileana, Muşat, Luiza-Georgiana, Muntean, Andrei-Cătălin, Casian, Tibor, Tomuţă, Ioan, Barbălată, Cristina, Porfire, Alina, Cherfan, Anca, Iurian, Sonia, Tomuta, Ioan, Crişan, Ofelia, Hegheş, Simona-Codruţa, Ardelean, Ana-Valentina, Moisescu, Cristina, Negut, Daniel, Ardelean, Ioan, Crişan, Andrea-Gabriela, Ilyés, Kinga, Rus, Lucia, Muntean, Dana-Maria, Kiss, Bela, Loghin, Felicia, Nicoară, Raul, Ilieş, Maria, Herda, Luciana Maria, Polo, Ester, Dawson, Kenneth A., Giudice, Maria Cristina Lo, (Savencu), Ioana Petruşan, Corzo, Carolina, Salar-Behzadi, Sharareh, Fizeşan, Ionel, Pop, Anca, Iacoviţă, Cristian, Topală, Tamara, Scoruş, Lavinia, Ştiufiuc, Rareş, Lucaciu, Constantin Mihai, Rus, Lucia Maria, Kacso, Irina, Pari, Sergiu, Valica, Vladimir, Uncu, Livia, Ştefan, Maria-Georgia, Kiss, Béla, Mogoşan, Cristina Ionela, Ghibu-Morgovan, Steliana Mihaela, Dinte, Elena, Muntean, Dana, Ilea, Aranka, Miclaus, Viorel, Boşca, Bianca, Rusu, Marius Emil, Fizesan, Ionel, Gheldiu, Ana-Maria, Stefan, Maria Georgia, Mates, Letitia, Georgiu, Carmen, Vostinaru, Oliviu, Popa, Daniela-Saveta, Oroian, Monica, Pop, Diana, Marcovici, Adriana, Bhardwaj, Sandeep, Chiş, Amalia-Andreea, Chiş, Mihaela, Picos, Andrei, Badea, Mîndra, Chifor, Ioana, Rotar, Alina, Picos, Alina Monica, Ciurea, Andreea, Roman, Alexandra, Soancă, Andrada, Condor, Daniela, Micu, Iulia Cristina, Kui, Andreea, Berar, Antonela, Negucioiu, Marius, Chisnoiu, Andrea, Ispas, Ana, Buduru, Smaranda, Băbţan, Anida-Maria, Vesa, Ştefan, Boşca, Bianca Adina, Petrescu, Nausica Bianca, Feurdean, Claudia Nicoleta, Uriciuc, Willi Andrei, Ionel, Anca, Buhăţel, Dan, Sava, Arin, Andrei, Vlad, Câmpian, Radu Septimiu, Breban, Ioana Georgiana, Merfea, Mihai, Delean, Ada Gabriela, Cimpean, Sanda Ileana, Tişler, Corina Elena, Picoş, Andrei, Duncea, Ioana, Picoş, Alina Monica, Festila, Dana, Lazar, Alexandra, Selegean, Oana, Ghergie, Mircea, Ostas, Daniel, Hedesiu, Mihaela, Stan, Horatiu, Florian, Alexandru, Florian, Stefan, Bran, Simion, Dinu, Cristian, Armencea, Gabriel, Manea, Avram, Onisor, Florin, Moldovan (Lazar), Madalina Anca, Vacaras, Sergiu, Muresan, Ovidiu, Roman, Rares Calin, Baciut, Mihaela, Baciut, Grigore, Rotar, Horatiu, Crasnean, Emil, Roman, Raluca, Coclici, Alina, Cristian, Dinu, Ţermure, Dragoş Alexandru, (Dascalu), Laura Rusu, Chifor, Radu, Badea, Iulia, Simu, Meda, Badea, Mindra, Lazar, Adela Cristina, Bel, Lucia, Sarpatoczi, Orsolya, Lacatus, Radu, Taulescu, Marian, Campian, Radu Septimiu, Rusnac, Mara Elena, Gasparik, Cristina, Varvara, Bianca Elena, Dudea, Diana, Aluaş, Maria, Lucaciu, Ondine, Bordea, Roxana, Meşter, Alexandru, Colceriu-Şimon, Ioana Maria, Băciuţ, Mihaela, Ştiufiuc, Rareş Ionuţ, Aghiorghiesei, Alexandra, Ţărmure, Viorica, Hedeşiu, Mihaela, Băciuţ, Grigore, Flueraşu, Mirela, Almăşan, Oana, Iacob, Simona, Zaharia, Alina, Balhuc, Silvia, Constantiniuc, Mariana, Mirica, Ioana-Codruta, Furtos, Gabriel, Fontaine, Veronique, Moldovan, Marioara, Campian, Radu-Septimiu, Cadar, Mihai, Fluerasu, Mirela, Almasan, Oana, Sbuciumelea, Ioana, Roman, Raluca A., Ioani, Cosmin-Adrian, Părăian, Alexandra-Mirela, Suciu, Raluca, Ban, Alina, Iozon, Sofia, Şoancă, Andrada, Stoia, Sebastian, Tamaş, Tiberiu, Mitre, Ileana, Rotaru, Horaţiu, Crişan, Liana, Crişan, Bogdan, Onişor, Florin, Roman, Rareş, Mureşan, Ovidiu, Moldovan, Mădălina, Ostaş, Daniel, Almăşan, Horea, Simu, Meda-Romana, Carlot, Clémentine, Ghiran, Raluca, Lupse, Irina, Cosma, Lavinia, and Muntean, Alexandrina

Subjects
physical streiss, Medical Sciences, subclinical atherosclerosis, composite materials, fetal outcome, Pharmacy, cortisol, mechanical properties, Rhodiola Rosea, Surgical Specialties, citrus, smoking, physical training, stress, Abstracts, carotid intima- media thickness, cycle ergometer, insulin resistance, salivary pH, heart rate, oxidative stress, music, shade system, Dental Medicine, flowable resin composites, hypoxia, visceral fat thickness, Basic Sciences, modulus of elasticity, indirect aesthetic reconstruction, PubMed filters, anxiety, inflammation, cocoa, Pharmaceutical Specialties, Medicine, neuroprotection, fatigue, memantine, non-alcoholic steatohepatitis, pregnancy, Fundamental Research, hypothermia, physical effort
Published
2019

21. Development and prognostic relevance of a histologic grading and staging system for alcohol-related liver disease

Author

Lackner, Carolin Stauber, Rudolf E. Davies, Susan Denk, Helmut Dienes, Hans Peter Gnemmi, Viviane Guido, Maria and Miquel, Rosa Paradis, Valerie Schirmacher, Peter and Terracciano, Luigi Berghold, Andrea Pregartner, Gudrun and Binder, Lukas Douschan, Philipp Rainer, Florian Sygulla, Stephan Jager, Marion Rautou, Pierre-Emmanuel Bumbu, Andreea and Horhat, Adelina Rusu, Ioana Stefanescu, Horia Detlefsen, Sonke Krag, Aleksander Thiele, Maja Cortez-Pinto, Helena and Moreno, Christophe Gouw, Annette S. H. Tiniakos, Dina G.

Abstract

Background & Aims: The SALVE Histopathology Group (SHG) developed and validated a grading and staging system for the clinical and full histological spectrum of alcohol-related liver disease (ALD) and evaluated its prognostic utility in a multinational cohort of 445 patients. Methods: SALVE grade was described by semiquantitative scores for steatosis, activity (hepatocellular injury and lobular neutrophils) and cholestasis. The histological diagnosis of steatohepatitis due to ALD (histological ASH, hASH) was based on the presence of hepatocellular ballooning and lobular neutrophils. Fibrosis staging was adapted from the Clinical Research Network staging system for non-alcoholic fatty liver disease and the Laennec staging system and reflects the pattern and extent ALD fibrosis. There are 7 SALVE fibrosis stages (SFS) ranging from no fibrosis to severe cirrhosis. Results: Interobserver ic-value for each grading and staging parameter was >0.6. In the whole study cohort, long-term outcome was associated with activity grade and cholestasis, as well as cirrhosis with very broad septa (severe cirrhosis) (p

Published
2021

23. Including Ratio of Platelets to Liver Stiffness Improves Accuracy of Screening for Esophageal Varices That Require Treatment

Author

Berger, Arthur, primary, Ravaioli, Federico, additional, Farcau, Oana, additional, Festi, Davide, additional, Stefanescu, Horia, additional, Buisson, François, additional, Nahon, Pierre, additional, Bureau, Christophe, additional, Ganne-Carriè, Nathalie, additional, Berzigotti, Annalisa, additional, de Ledinghen, Victor, additional, Petta, Salvatore, additional, Calès, Paul, additional, Huvelin, Sylvie Sacher, additional, Valla, Dominique, additional, Olivier, Anne, additional, Oberti, Frédéric, additional, Boursier, Jérôme, additional, Galmiche, Jean Paul, additional, Vinel, Jean Pierre, additional, Duburque, Clotilde, additional, Attar, Alain, additional, Archambeaud, Isabelle, additional, Benamouzig, Robert, additional, Gaudric, Marianne, additional, Luet, Dominique, additional, Couzigou, Patrice, additional, Planche, Lucie, additional, Coron, Emmanuel, additional, Hiriart, Jean-Baptiste, additional, Chermak, Faiza, additional, Charbonnier, Maude, additional, Marcellin, Patrick, additional, Guyader, Dominique, additional, Pol, Stanislas, additional, Fontaine, Hélène, additional, Larrey, Dominique, additional, De Lédinghen, Victor, additional, Ouzan, Denis, additional, Zoulim, Fabien, additional, Roulot, Dominique, additional, Tran, Albert, additional, Bronowicki, Jean-Pierre, additional, Zarski, Jean-Pierre, additional, Leroy, Vincent, additional, Riachi, Ghassan, additional, Péron, Jean-Marie, additional, Alric, Laurent, additional, Bourlière, Marc, additional, Mathurin, Philippe, additional, Dharancy, Sebastien, additional, Blanc, Jean-Frédéric, additional, Abergel, Armand, additional, Serfaty, Lawrence, additional, Mallat, Ariane, additional, Grangé, Jean-Didier, additional, Attali, Pierre, additional, Bacq, Yannick, additional, Wartelle, Claire, additional, Dao, Thông, additional, Benhamou, Yves, additional, Pilette, Christophe, additional, Silvain, Christine, additional, Christidis, Christos, additional, Capron, Dominique, additional, Thiefin, Gérard, additional, Hillaire, Sophie, additional, and Di Martino, Vincent, additional

Published
2021
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28. Imaging of combined hepatocellular‐cholangiocarcinoma in cirrhosis and risk of false diagnosis of hepatocellular carcinoma

Author

Sagrini, Elisabetta, primary, Iavarone, Massimo, additional, Stefanini, Federico, additional, Tovoli, Francesco, additional, Vavassori, Sara, additional, Maggioni, Marco, additional, Renzulli, Matteo, additional, Salvatore, Veronica, additional, Stefanescu, Horia, additional, Colombo, Massimo, additional, Bolondi, Luigi, additional, and Piscaglia, Fabio, additional

Published
2019
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30. Point quantification elastography in the evaluation of liver elasticity in healthy volunteers: a reliability study based on operator expertise

Author

Felicani, Cristina, primary, De Molo, Chiara, additional, Stefanescu, Horia, additional, Conti, Fabio, additional, Mazzotta, Elena, additional, Gabusi, Veronica, additional, Nardi, Elena, additional, Morselli-Labate, Antonio Maria, additional, Andreone, Pietro, additional, and Serra, Carla, additional

Published
2018
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34. IMPULSIONAL, POINT AND BIDIMENSIONAL SHEAR WAVE ELASTOMETRY FOR PORTAL HYPERTENSION: SAME STIFFNESS THRESHOLDS?

Author

STEFANESCU, HORIA OCTAVIAN, ALLEGRETTI, GIULIA, SERRA, CARLA, MARASCO, GIOVANNI, CONTI, FABIO, COLECCHIA, ANTONIO, FESTI, DAVIDE, ANDREONE, PIETRO, BOLONDI, LUIGI, PISCAGLIA, FABIO, Gamal, N., Stefanescu, H., Allegretti, G., Serra, C., Marasco, G., Gamal, N., Conti, F., Colecchia, A., Festi, D., Andreone, P., Bolondi, L., and Piscaglia, F.

Subjects
elastometry, portal hypertension
Published
2015

35. Value of hepatic elastography and Doppler indexes for predictions of esophageal varices in liver cirrhosis

Author

Bintintan, Adriana, primary, Chira, Romeo Ioan, additional, Bintintan, Vasile Virgil, additional, Nagy, Georgiana, additional, Manzat-Saplacan, Roberta Maria, additional, Lupsor Platon, Monica, additional, Stefanescu, Horia, additional, Duma, Maria Magdalena, additional, Valean, Simona Doina, additional, and Mircea, Petru Adrian, additional

Published
2015
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40. Performance of Unidimensional Transient Elastography in Staging Chronic Hepatitis C. Results from a Cohort of 1,202 Biopsied Patients from one Single Center.

Author

Lupsor Platon, Monica, Stefanescu, Horia, Feier, Diana, Maniu, Anca, and Badea, Radu

Subjects
*CHRONIC hepatitis C, *LIVER diseases, *FIBROSIS, *LIVER biopsy, *BODY mass index, *AMINOTRANSFERASES, *DIAGNOSIS, *THERAPEUTICS
Abstract

Background & Aims. The current study aimed to establish the liver stiffness (LS) cut-off values and their performance in the prediction of the fibrosis stage in chronic hepatitis C (CHC) patients, to find the anthropometric and biochemical factors leading to overestimation of the fibrosis stage and to analyze the factors leading to the technique failure. Methods. 1,202 consecutive CHC patients were prospectively included in the study. All of them underwent percutaneous liver biopsy for grading and staging the disease (METAVIR) and were referred to LS measurement 1 day prior to biopsy. Results. LS values varied between 2.8-75 kPa. Transient elastography success rate (SR) ranged between 0-100% (84.82±24.46%). In 27 patients (2.2%), no valid measurement was obtained; high BMI influenced independently the measurement failure. In 11.2% of cases, the SR was <60%, but 10 valid measurements were nevertheless recorded; the female sex and high BMI were the only factors independently leading to a SR<60%. AUROCs for the diagnosis of fibrosis F≥1, F≥2, F≥3, and F=4 were 0.879,0.889,0.941 and 0.970, for the cut-off values of 5.3 kPa, 7.4 kPa, 9.1 kPa and 13.2 kPa respectively, and they did not significantly differ from the adjusted AUROC values. The patients with false positive results were younger and had significantly higher serum aminotransferase (ALT, AST) and gamma glutamyl-transpeptidase levels than the patients with concordant results. The multivariate analysis showed that only high ALT levels influenced independently the occurrence of false positive results. Conclusion. Transient elastography is a useful non-invasive method for the assessment of fibrosis in CHC patients. However, it must be interpreted in the clinical and biochemical context, in order to insure high-quality results. [ABSTRACT FROM AUTHOR]

Published
2013

41. A New and Simple Algorithm for the Noninvasive Assessment of Esophageal Varices in Cirrhotic Patients Using Serum Fibrosis Markers and Transient Elastography.

Author

Stefanescu, Horia, Grigorescu, Mircea, Lupsor, Monica, Maniu, Anca, Crisan, Dana, Procopet, Bogdan, Feier, Diana, and Badea, Radu

Subjects
*FIBROSIS, *CIRRHOSIS of the liver, *ESOPHAGEAL varices, *GASTROSCOPY, *NONINVASIVE diagnostic tests, *ALGORITHMS
Abstract

Background and aim: Noninvasive serum liver fibrosis markers and liver stiffness could be used as predictors of esophageal varices in cirrhotic patients because portal hypertension is related to liver fibrosis. The aim of this study was to compare the performance of common serum fibrosis scores and transient elastography in diagnosing esophageal varices and to propose a new algorithm for predicting large varices. Methods: 231 consecutive cirrhotic patients (58.4% males, mean age 55.9 years) were enrolled. Routine biological tests were performed, so that APRI, FIB-4, Forns Index and Lok Score could be calculated. All patients underwent transient elastography and eso-gastroscopy. The diagnostic performance of the methods was assessed using sensitivity, specificity, positive predictive value, negative predictive value, accuracy, likelihood ratios and receiver operating characteristic curves. Results: The Lok Score was the best among all the serum scores for diagnosing the varices. For a value higher than 0.8, it had a 45.5% positive predictive value, 86.4% negative predictive value and 67.72% diagnostic accuracy for prediction of large varices. For liver stiffness higher than 30.8KPa, the positive predictive value was 47.3%, negative predictive value 81% and diagnostic accuracy 68.32%. Using both tests simultaneously, the presence of large varices was predicted with a diagnostic accuracy of 78.12%, obtaining an increment in NPV and -LR up to 93.67% and 0.21, respectively. Conclusion: The Lok Score is a good predictor for excluding the presence of large varices in cirrhotic patients, similarly with liver stiffness. The two methods can be successfully combined into a noninvasive algorithm for the assessment of esophageal varices in cirrhotic patients. [ABSTRACT FROM AUTHOR]

Published
2011

42. Is spleen stiffness a predictor of clinical decompensation in cirrhotic patients?

Author

Radu, Corina, Stefanescu, Horia, Procopet, Bogdan, Platon, Monica Lupsor, Tantau, Marcel, and Grigorescu, Mircea

Subjects
*SPLEEN, *CIRRHOSIS of the liver, *TISSUE mechanics, *GASTROINTESTINAL diseases, *DIGESTIVE system diseases, *PATIENTS
Abstract

The article presents a study which examines whether spleen stiffness is a pedictor of clinical decompensation in cirrhotic patients. A real life experience using spleen stiffness measurement (SSM) and modified SSM (MSSM) as long-term predictors of clinical decompensation in patients with cirrhosis is discussed. The study found MSSM to be an independent predictor of CD.

Published
2014

43. Imaging in Gastroenterology.

Author

Badea, Radu, Sudol-Szopinska, Iwona, Mueller, Sebastian, Stefanescu, Horia, and Platon, Monica Lupsor

Subjects
GASTROENTEROLOGY, IMAGING systems
Published
2014
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44. Diagnostic Accuracy of Controlled Attenuation Parameter Measured by Transient Elastography for the Non-invasive Assessment of Liver Steatosis: a Prospective Study.

Author

Lupsor-Platon, Monica, Feier, Diana, Stefanescu, Horia, Tamas, Attila, Botan, Emil, Sparchez, Zeno, Maniu, Anca, and Badea, Radu

Subjects
*FATTY degeneration, *DEGENERATION (Pathology), *FATTY heart, *FATTY liver, *PATIENTS
Abstract

Background & Aims: A novel non-invasive tool based on the evaluation of ultrasound attenuation using transient elastography (TE) has been developed, called controlled attenuation parameter (CAP). We aim to establish the histopathological parameters that significantly influence CAP, the cutoff values and their performance in predicting each steatosis grade on a group of biopsied patients with chronic liver diseases (CLD) from Romania. Methods. We prospectively analyzed 201 consecutive CLD patients who underwent CAP measurements using TE. Steatosis, liver fibrosis and necroinflammatory activity were staged and graded during the pathological analysis of bioptic specimens. Univariate and multivariate regression analyses were applied to identify the variables correlated with CAP values. The diagnostic performance of CAP for steatosis prediction was assessed using an AUC analysis. Results. Among the histopathological factors correlating with CAP, the multivariate analysis found steatosis as the only factor independently influencing CAP values (p<0.001). Maximal diagnostic accuracy (DA) was obtained for the prediction of ⩾34-66% (S2) fatty load and of 67-100% (S3) fatty load (82.06%, respectively 81.59%) while, for the prediction of ⩾11-33% (SI) fatty load, DA reached only 76.11%. The negative predictive value for the exclusion of ⩾S2 and S3 was 93.5% and 98.7%, respectively. AUCs calculated between each two steatosis grades were: 0.772 (SO vs SI), 0.874 (SO vs S2), 0.904 (SO vs S3), 0.659 (Slvs S2), 0.777 (SI vs S3), and 0.665 (S2 vs S3). Conclusion. Steatosis is the only histopathological factor independently influencing CAP. Maximal DA could be obtained for the prediction of ⩾S2 and S3 (82.06% and 81.59%), while for the prediction of Si, the accuracy reached only 76.11%. [ABSTRACT FROM AUTHOR]

Published
2015
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45. Transient Elastography for the Detection of Hepatocellular Carcinoma in Viral C Liver Cirrhosis. Is there something else than Increased Liver Stiffness?

Author

Feier, Diana, Platon, Monica Lupsor, Stefanescu, Horia, and Badea, Radu

Subjects
*CIRRHOSIS of the liver, *LIVER cancer, *BODY mass index, *ENDOSCOPY, *MULTIPLE regression analysis, *ALPHA fetoproteins
Abstract

Background & Aims: Liver stiffness (LS) is increased in liver cirrhosis, higher values being associated with complications, among them the development of hepatocellular carcinoma (HCC). However, LS values alone cannot accurately differentiate patients with HCC. Therefore, our aim was to study the performance of LS measurement data and common biomarkers for the detection of HCC in HCV related liver cirrhosis. Methods: We performed a case matching study comparing HCV cirrhotic patients with and without HCC (72 in each group) that were identical in terms of sex, age, BMI and duration of HCV infection. All patients underwent LS measurement, endoscopy, liver imaging and liver function tests. A multiple regression analysis was performed and a HCC detection model was calculated, which was further validated in another group of 40 HCV infected cirrhotics, of whom 52% had HCC. Results: In the HCC group, LS was significantly higher (42 vs 27 kPa, p<0.0001). In the multivariate analysis higher values of LS, alanine-aminotransferase (ALAT), alpha-fetoprotein (AFP) and interquartile range (IQR) of LS measurements were independently associated with the presence of HCC (p<0.0001 for all parameters; Odds Ratios of 8.27, 1.01, 1.04 and 1.16, respectively). The detection model combining the four variables showed a good diagnostic performance in both training and validation groups, with AUROCs of 0.86 and 0.8, respectively. All variables were also positively correlated with tumor size. Conclusion: In HCV related cirrhosis, HCC is associated with increased LS and IQR values and high ALAT and AFP levels. By combining these four parameters into a regression model, liver cancer may be noninvasively predicted with good accuracy. [ABSTRACT FROM AUTHOR]

Published
2013

46. Performance of a New Elastographic Method (ARFI technology) Compared to Unidimensional Transient Elastography in the Noninvasive Assessment of Chronic Hepatitis C. Preliminary Results.

Author

Lupsor, Monica, Badea, Radu, Stefanescu, Horia, Sparchez, Zeno, Branda, Horaţiu, Serban, Alexandru, and Maniu, Anca

Subjects
*HEPATITIS C, *FIBROSIS, *FATTY degeneration, *CIRRHOSIS of the liver, *LIVER diseases, *FLAVIVIRAL diseases, *COLLAGEN diseases, *MAGNETIC resonance imaging, *DIAGNOSTIC imaging
Abstract

Background and aims: The current study aims to evaluate the performance of a new elastographic method (ARFI) in noninvasive fibrosis assessment and to compare it to another validated technology (transient elastography, TE). Method: 112 consecutive chronic hepatitis C patients (histologically proven according to the Metavir scoring system: 12.5% F0, 26.6% F1, 16.1% F2, 7.1% F3, 37.5% F4) were prospectively included in this study. They were examined on the same day, using both ARFI (with shear wave velocity - SWV- quantification) and TE (with liver stiffness quantification). Results: SWV is correlated only with fibrosis (r=0.717, p<0.0001) and necroinfiammatory activity (r=0.328, p=0.014), but not with steatosis (r=0.122, p=0.121). There is a significant increase of SWV in parallel with the increase in the fibrosis stage: 1.079±0.150 (F0-F1), 1.504±0.895 (F2), 1.520±0.575 (F3), 2.552±0.782 (F4), p<0.0001, but there is a certain degree of overlap between the consecutive stages F1-F2 (p=0.072), F2-F3 (p=0.965). SWV cut-off values (m/s) that were predictive for each fibrosis stage were: 1.19 (F≥1), 1.34 (F≥2), 1.61 (F≥3) and 2.00 (F4). AUROC for ARFI vs TE were: 0.709 vs 0.902, p=0.006 (F≥1), 0.851 vs 0.941, p=0.022 (F≥2), 0.869 vs 0.926, p=0.153 (F≥3) and 0.911 vs 0.945, p=0.331 (F4). Conclusions: ARFI allows SWV quantification, in strong correlation with the fibrosis stage. Steatosis does not influence SWV. The maximal performance of the method consists of the prediction in severe fibrosis and cirrhosis. The diagnostic accuracy is strongly comparable to TE only for the prediction of severe fibrosis and cirrhosis, whereas for earlier stages, TE performs better. [ABSTRACT FROM AUTHOR]

Published
2009

47. THE FEASIBILITY AND SAFETY OF THE ENDOSCOPIC ULTRASOUND-GUIDED PORTOSYSTEMIC PRESSURE GRADIENT USING A 22 G FINE NEEDLE ASPIRATION. A PILOT STUDY IN A TERTIARY CENTRE.

Author

Nicoara-Farcau, Oana, Procopeț, Bogdan Dumitru, Pojoga, Cristina, Hagiu, Claudia, Rednic, Voicu, Stefanescu, Horia, Fischer, Petra, and Seicean, Andrada

Subjects
*NEEDLE biopsy, *PARACENTESIS, *PLATELET count, *PATIENT portals, *VENOUS pressure, *HEPATIC veins, *PORTAL vein
Abstract

Background. In patients with cirrhosis, the gold standard for assessment of portal hypertension is the measurement of the hepatic venous pressure gradient (HVPG), a minimally invasive radiological technique that determines indirectly the porto systemic pressure gradient (PPG). However, the technique is available only in referral centres and requires special expertise. Recently, EUS-guided techniques for the measurement of the PPG (EUSPPGm) by directly puncturing the portal vein and the hepatic vein, have shown promising results in terms of feasibility and safety. Nevertheless, the equipment for this procedure uses special devises that require a high purchase cost, and the pressure results are difficult to interpret. The aim of our study was to evaluate the feasibility and safety of EUS-PPGm using a 22 G FNA in a cohort of patients with cirrhosis undergoing TIPS placement for the indication of recurrent variceal bleeding or refractory ascites. Methodology. The patients were included prospectively. Patients with complete portal vein thrombosis were excluded. The EUS-PPGm was performed under general anesthesia, prior to TIPS procedure, by experienced endosonographers, using a linear echoendoscope and a 22-G FNA transgastrically, close to the cardia. After checking the intravascular position of FNA by injecting saline, the pressures were recorded using the same hemodynamic unit as the HVPG, XperFlex Cardio (Philips). The systemic pressure was measured at the level of the median SHV and the portal pressure was measured at the level of the portal trunk. Feasibility was defined as successful PPGm in each patient. Safety was based on adverse events captured during the perioperative period and in a the postprocedural interview. Results. The study included 7 patients (5 male and 2 female), mean age 57 years, mean platelets count 104/mm3, range [52-172]. The indication for TIPS was refractory ascites in 5 patients and variceal bleeding in the other 2 patients. In two patients, the direct puncture of the SHV was not feasible due to poor visualization of portal vein in an obese patient and narrow SHV in a patient with advanced cirrhosis. The mean PPG-EUS was 12.2 mmHg SD 2.68 and mean PPG-TIPS was 15 mmHg, SD 3.317. There were no intraprocedural or post procedural complications recorded. Conclusion. EUS-PPGm using a 22-G FNA is feasible and appears safe. Given the availability of EUS, EUS-PPGm may represent a promising breakthrough for procuring indispensable information in the management of patients with liver disease. [ABSTRACT FROM AUTHOR]

Published
2023

48. Comparison of screening strategies with two new tests to score and diagnose varices needing treatment

Author

Paul Calès, Federico Ravaioli, Arthur Berger, Oana Farcau, Davide Festi, Horia Stefanescu, Carole Vitellius, Pierre Nahon, Christophe Bureau, Nathalie Ganne-Carriè, Annalisa Berzigotti, Victor de Ledinghen, Salvatore Petta, Calès, Paul, Ravaioli, Federico, Berger, Arthur, Farcau, Oana, Festi, Davide, Stefanescu, Horia, Vitellius, Carole, Nahon, Pierre, Bureau, Christophe, Ganne-Carriè, Nathalie, Berzigotti, Annalisa, de Ledinghen, Victor, and Petta, Salvatore

Subjects
Liver Cirrhosis, Hepatology, Non-invasive test, Platelet Count, Gastroenterology, Esophageal and Gastric Varices, Varicose Veins, Elastometry, Non-alcoholic Fatty Liver Disease, Oesophageal varice, Screening, Elasticity Imaging Techniques, Humans, Portal hypertension, Retrospective Studies
Abstract

Background and aims: We aimed to improve non-invasive screening of varices needing treatment (VNT) and compare different screening strategies. Methods: 2,290 patients with chronic liver disease were included in a retrospective study. Etiologies were: virus: 50.0%, NAFLD: 29.5%, alcohol: 20.5%, VNT: 14.9%. Test descriptors were performance (spared endoscopy) and safety (missed VNT). VNT tests were evaluated according to their safety levels either for individual screening (95% negative predictive value (NPV)), population screening (95% sensitivity) or undifferentiated screening (100% sensitivity/NPV) without missed VNT. The tests provided three categories: missed VNT

Published
2022

49. Point quantification elastography in the evaluation of liver elasticity in healthy volunteers: a reliability study based on operator expertise

Author

Chiara De Molo, Elena Nardi, Fabio Conti, Pietro Andreone, Horia Stefanescu, Carla Serra, Antonio Maria Morselli-Labate, Cristina Felicani, Veronica Gabusi, Elena Mazzotta, Felicani, Cristina, De Molo, Chiara, Stefanescu, Horia, Conti, Fabio, Mazzotta, Elena, Gabusi, Veronica, Nardi, Elena, Morselli-Labate, Antonio Maria, Andreone, Pietro, and Serra, Carla

Subjects
Adult, Male, Intraclass correlation, Body Mass Index, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Operator (computer programming), Liver stiffness, Healthy volunteers, Internal Medicine, Elastography, Elastosonography, Point shear wave, Reproducibility, Radiology, Nuclear Medicine and Imaging, Humans, Medicine, Radiology, Nuclear Medicine and imaging, Prospective Studies, Aged, Observer Variation, medicine.diagnostic_test, business.industry, Liver stiffne, Reproducibility of Results, General Medicine, Middle Aged, Overweight, Liver, Liver biopsy, Elasticity Imaging Techniques, Female, Original Article, 030211 gastroenterology & hepatology, business, Transient elastography, Nuclear medicine
Abstract

PURPOSE: The assessment of liver fibrosis is essential in the management of patients with chronic liver diseases. Liver biopsy is considered the gold standard procedure for this purpose, though the recent development of new elastosonographic techniques to measure liver stiffness (LS) noninvasively is promising. Point quantification elastography (PQE) showed good results but less is known about the level of skill needed to obtain reliable results. The aim of the study was to evaluate the reproducibility of PQE in assessing LS in healthy subjects comparing three operators with different expertise. METHODS: Between December 2012 and April 2013, 50 consecutive healthy volunteers (18 males, 32 females), median age 30 years (range 25–66) and BMI 22.4 (range 16.7–33.6) were submitted to PQE (iU22 Philips, Bothell, WA, USA) by three operators: two US and elastography providers (one expert and one with intermediate skill) and a skilled transient elastography (Fibroscan) operator with no expertise in US. Intra- and inter-observer agreements were assessed by intraclass correlation coefficient (ICC). RESULTS: PQE measurement was obtained in all subjects by all evaluators. No significant differences of mean liver stiffness were found among operators (P = 0.980). Intra-observer agreement was excellent 0.918 (0.941 for expert, 0.917 for intermediate and 0.888 for novice). The ICC of the inter-observer agreement among the three ratters was excellent (0.882) and was higher in normal than overweight patients (0.923 vs. 0.603; P = 0.011). CONCLUSION: PQE is a reliable and reproducible non-invasive method for the assessment of LE, and can be performed also by a non-experienced operator.

Published
2018

50. Metabolomics for genomics: the role of vitamin D in nonalcoholic fatty liver disease.

Author

Crisan, Dana, Radu, Corina, Suciu, Alina, Grigorescu, Mircea D., Stefanescu, Horia, Romanciuc, Florina, Socaciu, Carmen, and Grigorescu, Mircea

Subjects
*VITAMIN D, *FATTY liver, *METABOLOMICS
Abstract

The article discusses the role of vitamin D in nonalcoholic fatty liver disease in metabolomics for genomics.

Published
2015

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