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In this article, the properties of solutions of Hadamard fractional differential equations are investigated on an infinite interval. The equations are subject to integral and discrete boundary conditions. A new proper compactness criterion is introduced in a unique space. By applying the monotone iterative technique, we have obtained two positive solutions. And, an error estimate is also shown at the end. This study innovatively uses a monotonic iterative approach to study Hadamard fractional boundary-value problems containing multiple fractional derivative terms on infinite intervals, and it enriches some of the existing conclusions. Meanwhile, it is potentially of practical significance in the research field of computational fluid dynamics related to blood flow problems and in the direction of the development of viscoelastic fluids. [ABSTRACT FROM AUTHOR]

The higher the enrichment factor, the more significant the enrichment of the differential proteins in the pathway Bioinformatics analysis of the gene expression profile of retinal pigmental epithelial cells based in single-cell RNA sequencing in myopic mice Arch Med Sci 2, February / 2021 577 tration of kynurenic acid transiently increases. Through the single-cell RNA sequencing of the RPE cells, it was found that the cells were exposed to hypoxia during the development of myopia and that hypoxia might lead to functional limitations in the RPE cells [8]. Thus, it can be inferred that RPE cells are exposed to hypoxia during myopia; as RPE cells are oxygen-consuming cells, this hypoxia may activate glycolysis and oxidative phosphorylation in the cells [10-12]. [Extracted from the article]

Objective The objective was to observe damage of hippocampus in rats after exposure to infrasound, and to assess HSP70 expression in hippocampus. Methods SD rats in the experimental group were exposed to 140 dB (8 Hz) infrasound for 2 h per day for 3 days. The morphology of the hippocampus was examined by transmission electronic microscopic (TEM). Cell apoptosis was observed by TUNEL staining at 0 h, 24 h, 48 h, and 2 w after exposure. HSP70 expression was detected by immunohistochemistry (IHC) and Western blotting (WB). Results TEM showed that hippocampus was significantly damaged by exposure, and exhibited recovery 1 week after exposure. The TUNEL data showed that neuronal apoptosis after exposure was significantly higher than in the control rats at 24 h and 48 h, and the apoptotic cells decreased one week after exposure. IHC and WB showed HSP70 expression was significantly higher in the exposed rats, peaked at 24 h. Conclusion Exposure to 140 dB (8 Hz) infrasound for 2 h per day for 3 days appeared to induce damage to the hippocampus of rats, based on changes in ultrastructure and increased cell apoptosis. However, recovery from the damage occurred overtime. HSP70 expression also increased after the exposure and decreased by 48 h. [ABSTRACT FROM AUTHOR]

Abstract: This paper considers the decentralized adaptive regulation via output-feedback for nonlinear systems with integral input- to-state stable (iISS) inverse dynamics, nonlinear uncertainties, and unknown control direction. It is shown that all the signals in the closed-loop system obtained are bounded, and the asymptotic regulation is achieved. A numerical example shows the effectiveness of the design. [Copyright &y& Elsevier]