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6 results on '"Zeng, Tiebo"'

2. miR-370 is stage-specifically expressed during mouse embryonic development and regulates Dnmt3a

Author

Xing Yanjiang, Han Zhengbin, He Hongjuan, Wu Qiong, Gu Ning, Liu Qi, Huang Zhijun, and Zeng Tiebo

Subjects
Time Factors, Molecular Sequence Data, Biophysics, Morphogenesis, Spatiotemporal expression, Dnmt3a, Biology, Biochemistry, DNA Methyltransferase 3A, Mice, miR-370, Western blot, Structural Biology, Genes, Reporter, microRNA, Adrenal Glands, Genetics, medicine, Animals, DNA (Cytosine-5-)-Methyltransferases, Luciferases, Molecular Biology, Gene, Regulation of gene expression, Mice, Inbred ICR, medicine.diagnostic_test, Base Sequence, Embryogenesis, Brain, Gene Expression Regulation, Developmental, Embryo, Cell Biology, Embryo, Mammalian, Molecular biology, MicroRNAs, Organ Specificity, Embryonic development, Female, Signal transduction, Signal Transduction
Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that participate in a large variety of biological processes. In this paper, the spatiotemporal expression pattern of miR-370 was characterized during mouse embryonic development, and was found to be stage- and tissue-specifically expressed. In addition, through luciferase reporter assays and western blot analyses, DNA methyltransferase 3A (Dnmt3a) was identified as a directly regulated target of miR-370. Altogether, our results indicate that miR-370 may play important roles in the morphogenesis of diverse organs, especially brain and adrenal glands, by mediating Dnmt3a expression during mouse development.

Published
2012

6. Identification and Epigenetic Analysis of a Maternally Imprinted Gene Qpct.

Author

Guo J, He H, Liu Q, Zhang F, Lv J, Zeng T, Gu N, and Wu Q

Subjects
Animals, Chromatin Immunoprecipitation, DNA Methylation, Embryonic Development genetics, Female, Gene Expression Regulation, Developmental, Histones genetics, Liver embryology, Liver metabolism, Lung embryology, Lung metabolism, Male, Mesencephalon embryology, Mesencephalon metabolism, Mice, Mice, Inbred C57BL, Mothers, Pregnancy, Rhombencephalon embryology, Rhombencephalon metabolism, Telencephalon embryology, Telencephalon metabolism, Aminoacyltransferases genetics, Genomic Imprinting, Histones metabolism, Placenta metabolism, Placentation genetics
Abstract

Most imprinted genes are concerned with embryonic development, especially placental development. Here, we identified a placenta-specific imprinted gene Qpct. Our results show that Qpct is widely expressed during early embryonic development and can be detected in the telecephalon, midbrain, and rhombencephalon at E9.5b-E11.5. Moreover, Qpct is strikingly expressed in the brain, lung and liver in E15.5. Expression signals for Qpct achieved a peak at E15.5 during placental development and were only detected in the labyrinth layer in E15.5 placenta. ChIP assay results suggest that the modification of histone H3K4me3 can result in maternal activating of Qpct.

Published
2015
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