15 results on '"de Hoog, Joeri"'
Search Results
2. Potential Biomarkers for Noninfectious Scleritis Identified by Serum and Tear Fluid Proteomics
- Author
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Zorgeenheid Oogheelkunde Medisch, MS Oogheelkunde, Infection & Immunity, Vergouwen, Daphne P.C., Kolijn, P. Martijn, de Hoog, Joeri, de Boer, Joke H., Los, Leonoor I., Gijs, Marlies, Erckens, Roel J., de Jong, Pascal H.P., Rothova, Aniki, Ten Berge, Josianne C., Schreurs, Marco W.J., Zorgeenheid Oogheelkunde Medisch, MS Oogheelkunde, Infection & Immunity, Vergouwen, Daphne P.C., Kolijn, P. Martijn, de Hoog, Joeri, de Boer, Joke H., Los, Leonoor I., Gijs, Marlies, Erckens, Roel J., de Jong, Pascal H.P., Rothova, Aniki, Ten Berge, Josianne C., and Schreurs, Marco W.J.
- Published
- 2024
3. The enigma of sclera-specific autoimmunity in scleritis
- Author
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Vergouwen, Daphne P.C., van Beek, Adriaan A., de Hoog, Joeri, de Boer, Joke H., Los, Leonoor I., Gijs, Marlies, Erckens, Roel J., Verdijk, Rob M., Haasnoot, Geert W., Roelen, Dave L., Rothova, Aniki, Rönnelid, Johan, Ten Berge, Josianne C., Schreurs, Marco W.J., Vergouwen, Daphne P.C., van Beek, Adriaan A., de Hoog, Joeri, de Boer, Joke H., Los, Leonoor I., Gijs, Marlies, Erckens, Roel J., Verdijk, Rob M., Haasnoot, Geert W., Roelen, Dave L., Rothova, Aniki, Rönnelid, Johan, Ten Berge, Josianne C., and Schreurs, Marco W.J.
- Abstract
Scleritis is a severe and painful ophthalmic disorder, in which a pathogenic role for collagen-directed autoimmunity was repeatedly suggested. We evaluated the presence of sclera-specific antibodies in a large cohort of patients with non-infectious scleritis. Therefore, we prospectively collected serum samples from 121 patients with non-infectious scleritis in a multicenter cohort study in the Netherlands. In addition, healthy (n = 39) and uveitis controls (n = 48) were included. Serum samples were tested for anti-native human type II collagen antibodies using a validated enzyme-linked immunosorbent assay (ELISA). Further, sclera-specific antibodies were determined using indirect immunofluorescence (IIF) on primate retinal/scleral cryosections. Lastly, human leukocyte antigen (HLA) typing was performed in 111 patients with scleritis. Anti-type II collagen antibodies were found in 13% of scleritis patients, in 10% of healthy controls and in 11% of uveitis controls (p = 0.91). A specific reaction to scleral nerve tissue on IIF was observed in 33% of patients with scleritis, which was higher than in healthy controls (11%; p = 0.01), but similar to uveitis controls (25%; p = 0.36). Reactivity to the scleral nerve tissue was significantly associated with earlier onset of scleritis (48 versus 56 years; p < 0.001), bilateral involvement (65% versus 42%; p = 0.01), and less frequent development of scleral necrosis (5% versus 22%; p = 0.02). HLA-B27 was found to be twice as prevalent in patients with scleritis (15.3%) compared to a healthy population (7.2%). In conclusion, scleral nerve autoantibody reactivity was more common in scleritis and uveitis patients in contrast to healthy controls. Further research is needed to characterize these scleral-nerve directed antibodies and assess their clinical value.
- Published
- 2024
4. The enigma of sclera-specific autoimmunity in scleritis
- Author
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Vergouwen, Daphne P. C., van Beek, Adriaan A., de Hoog, Joeri, de Boer, Joke H., Los, Leonoor I., Gijs, Marlies, Erckens, Roel J., Verdijk, Rob M., Haasnoot, Geert W., Roelen, Dave L., Rothova, Aniki, Rönnelid, Johan, Berge, Josianne C. Ten, Schreurs, Marco W. J., Vergouwen, Daphne P. C., van Beek, Adriaan A., de Hoog, Joeri, de Boer, Joke H., Los, Leonoor I., Gijs, Marlies, Erckens, Roel J., Verdijk, Rob M., Haasnoot, Geert W., Roelen, Dave L., Rothova, Aniki, Rönnelid, Johan, Berge, Josianne C. Ten, and Schreurs, Marco W. J.
- Abstract
Scleritis is a severe and painful ophthalmic disorder, in which a pathogenic role for collagen-directed autoimmunity was repeatedly suggested. We evaluated the presence of sclera-specific antibodies in a large cohort of patients with non-infectious scleritis. Therefore, we prospectively collected serum samples from 121 patients with non-infectious scleritis in a multicenter cohort study in the Netherlands. In addition, healthy (n = 39) and uveitis controls (n = 48) were included. Serum samples were tested for anti-native human type II collagen antibodies using a validated enzyme-linked immunosorbent assay (ELISA). Further, sclera-specific antibodies were determined using indirect immunofluorescence (IIF) on primate retinal/scleral cryosections. Lastly, human leukocyte antigen (HLA) typing was performed in 111 patients with scleritis. Anti-type II collagen antibodies were found in 13% of scleritis patients, in 10% of healthy controls and in 11% of uveitis controls (p = 0.91). A specific reaction to scleral nerve tissue on IIF was observed in 33% of patients with scleritis, which was higher than in healthy controls (11%; p = 0.01), but similar to uveitis controls (25%; p = 0.36). Reactivity to the scleral nerve tissue was significantly associated with earlier onset of scleritis (48 versus 56 years; p < 0.001), bilateral involvement (65% versus 42%; p = 0.01), and less frequent development of scleral necrosis (5% versus 22%; p = 0.02). HLA-B27 was found to be twice as prevalent in patients with scleritis (15.3%) compared to a healthy population (7.2%). In conclusion, scleral nerve autoantibody reactivity was more common in scleritis and uveitis patients in contrast to healthy controls. Further research is needed to characterize these scleral-nerve directed antibodies and assess their clinical value.
- Published
- 2024
- Full Text
- View/download PDF
5. IgG4‐related disease as an emerging cause of scleritis
- Author
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Karim, Faiz, de Hoog, Joeri, Paridaens, Dion, Verdijk, Rob, Schreurs, Marco, Rothova, Aniki, van Hagen, Martin, and van Laar, Jan
- Published
- 2017
- Full Text
- View/download PDF
6. Vitreous proteomics, a gateway to improved understanding and stratification of diverse uveitis aetiologies
- Author
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Schrijver, Benjamin, Kolijn, P. Martijn, ten Berge, Josianne C.E.M., Nagtzaam, Nicole M.A., van Rijswijk, Angelique L.C.T., Swagemakers, Sigrid M.A., van der Spek, Peter J., Missotten, Tom O.A.R., van Velthoven, Mirjam E.J., de Hoog, Joeri, van Hagen, P. Martin, Langerak, Anton W., Dik, Willem A., Schrijver, Benjamin, Kolijn, P. Martijn, ten Berge, Josianne C.E.M., Nagtzaam, Nicole M.A., van Rijswijk, Angelique L.C.T., Swagemakers, Sigrid M.A., van der Spek, Peter J., Missotten, Tom O.A.R., van Velthoven, Mirjam E.J., de Hoog, Joeri, van Hagen, P. Martin, Langerak, Anton W., and Dik, Willem A.
- Abstract
Purpose: The vitreous proteome might provide an attractive gateway to discriminate between various uveitis aetiologies and gain novel insights into the underlying pathophysiological processes. Here, we investigated 180 vitreous proteins to discover novel biomarkers and broaden disease insights by comparing (1). primary vitreoretinal lymphoma ((P)VRL) versus other aetiologies, (2). sarcoid uveitis versus tuberculosis (TB)-associated uveitis and (3). granulomatous (sarcoid and TB) uveitis versus other aetiologies. Methods: Vitreous protein levels were determined by proximity extension assay in 47 patients with intraocular inflammation and a prestudy diagnosis (cohort 1; training) and 22 patients with a blinded diagnosis (cohort 2; validation). Differentially expressed proteins identified by t-tests on cohort 1 were used to calculate Youden’s indices. Pathway and network analysis was performed by ingenuity pathway analysis. A random forest classifier was trained to predict the diagnosis of blinded patients. Results: For (P)VRL stratification, the previously reported combined diagnostic value of IL-10 and IL-6 was confirmed. Additionally, CD70 was identified as potential novel marker for (P)VRL. However, the classifier trained on the entire cohort (cohort 1 and 2) relied primarily on the interleukin score for intraocular lymphoma diagnosis (ISOLD) or IL-10/IL-6 ratio and only showed a supportive role for CD70. Furthermore, sarcoid uveitis displayed increased levels of vitreous CCL17 as compared to TB-associated uveitis. Conclusion: We underline the previously reported value of the ISOLD and the IL-10/IL-6 ratio for (P)VRL identification and present CD70 as a potentially valuable target for (P)VRL stratification. Finally, we also show that increased CCL17 levels might help to distinguish sarcoid uveitis from TB-associated uveitis.
- Published
- 2022
7. Successful surgical optic nerve decompression in a patient with hypertrophic pachymeningitis due to granulomatous polyangiitis
- Author
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de Hoog, Joeri, Volovici, Victor, and Dammers, Ruben
- Published
- 2015
- Full Text
- View/download PDF
8. Uveitis causes according to immune status of patients
- Author
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Rothova, Aniki, primary, Hajjaj, Anass, additional, de Hoog, Joeri, additional, Thiadens, Alberta A.H.J., additional, and Dalm, Virgil A.S.H., additional
- Published
- 2018
- Full Text
- View/download PDF
9. Post-operative Refractive Prediction Error After Phacovitrectomy: A Retrospective Study
- Author
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Hötte, Gijsbert J., primary, de Bruyn, Daniël P., additional, and de Hoog, Joeri, additional
- Published
- 2017
- Full Text
- View/download PDF
10. Rhegmatogenous retinal detachment in uveitis
- Author
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De Hoog, Joeri, primary, Ten Berge, Josianne C., additional, Groen, Fahriye, additional, and Rothova, Aniki, additional
- Published
- 2017
- Full Text
- View/download PDF
11. Post-operative Refractive Prediction Error After Phacovitrectomy: A Retrospective Study.
- Author
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Hötte, Gijsbert J., de Bruyn, Daniël P., and de Hoog, Joeri
- Published
- 2018
- Full Text
- View/download PDF
12. Potential Biomarkers for Noninfectious Scleritis Identified by Serum and Tear Fluid Proteomics.
- Author
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Vergouwen DPC, Kolijn PM, de Hoog J, de Boer JH, Los LI, Gijs M, Erckens RJ, de Jong PHP, Rothova A, Ten Berge JC, and Schreurs MWJ
- Abstract
Purpose: Scleritis is an extremely painful and potentially blinding inflammation of the sclera with unknown pathogenesis and unpredictable course. To gain insight in its disease process and identify biomarker candidates, we performed extensive proteomics in serum and tear fluid., Design: Prospective multicenter cohort study., Participants: A total of 121 patients with noninfectious scleritis (of which 39 active cases), 30 healthy controls, and 23 disease controls (uveitis and rheumatoid arthritis) were enrolled in the Netherlands from 2020 to 2022., Methods: Serum, tear fluid of both eyes, and clinical data were gathered. The level of 368 inflammatory proteins was measured using proximity extension assays. Results were validated in an independent cohort of 15 patients with scleritis, and using addressable laser bead immunoassay, or enzyme-linked immunoassays. In addition, we studied an extended panel of matrix metalloproteinases in tear fluid of necrotizing scleritis with addressable laser bead immunoassay., Main Outcome Measures: Statistically significant differences in the level of inflammatory proteins between patients with scleritis and control groups., Results: Proteomics revealed 18 significantly upregulated or downregulated serum proteins in active scleritis cases compared with all control groups in both the discovery cohort and the validation cohort. The most upregulated protein was nuclear migration protein nudC (NudC; P = 0.0032), a protein involved in neurogenesis. The other significant hits included proteins involved in T-cell activation, apoptosis, epithelial barrier maintenance, and angiogenesis. Our tear fluid analysis showed matrix metalloproteinase 9 (MMP9) to be upregulated in the tear fluid of patients with scleral necrosis., Conclusions: The results of our proteomics analysis suggest a role for neurogenesis, T-cell activation, disruption of epithelial barrier, and angiogenesis in the pathogenesis of scleritis, and highlight MMP9 and NudC as biomarkers with potential clinical relevance., Funding Disclosures: The authors have no proprietary or commercial interest in any materials discussed in this article., (© 2023 by the American Academy of Ophthalmology.)
- Published
- 2023
- Full Text
- View/download PDF
13. Vitreous proteomics, a gateway to improved understanding and stratification of diverse uveitis aetiologies.
- Author
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Schrijver B, Kolijn PM, Ten Berge JCEM, Nagtzaam NMA, van Rijswijk ALCT, Swagemakers SMA, van der Spek PJ, Missotten TOAR, van Velthoven MEJ, de Hoog J, van Hagen PM, Langerak AW, and Dik WA
- Subjects
- Biomarkers, Tumor metabolism, Humans, Interleukin-10 metabolism, Interleukin-6 metabolism, Proteomics, Vitreous Body pathology, Eye Neoplasms pathology, Intraocular Lymphoma diagnosis, Intraocular Lymphoma metabolism, Intraocular Lymphoma pathology, Retinal Neoplasms diagnosis, Uveitis diagnosis, Uveitis etiology, Uveitis metabolism
- Abstract
Purpose: The vitreous proteome might provide an attractive gateway to discriminate between various uveitis aetiologies and gain novel insights into the underlying pathophysiological processes. Here, we investigated 180 vitreous proteins to discover novel biomarkers and broaden disease insights by comparing (1). primary vitreoretinal lymphoma ((P)VRL) versus other aetiologies, (2). sarcoid uveitis versus tuberculosis (TB)-associated uveitis and (3). granulomatous (sarcoid and TB) uveitis versus other aetiologies., Methods: Vitreous protein levels were determined by proximity extension assay in 47 patients with intraocular inflammation and a prestudy diagnosis (cohort 1; training) and 22 patients with a blinded diagnosis (cohort 2; validation). Differentially expressed proteins identified by t-tests on cohort 1 were used to calculate Youden's indices. Pathway and network analysis was performed by ingenuity pathway analysis. A random forest classifier was trained to predict the diagnosis of blinded patients., Results: For (P)VRL stratification, the previously reported combined diagnostic value of IL-10 and IL-6 was confirmed. Additionally, CD70 was identified as potential novel marker for (P)VRL. However, the classifier trained on the entire cohort (cohort 1 and 2) relied primarily on the interleukin score for intraocular lymphoma diagnosis (ISOLD) or IL-10/IL-6 ratio and only showed a supportive role for CD70. Furthermore, sarcoid uveitis displayed increased levels of vitreous CCL17 as compared to TB-associated uveitis., Conclusion: We underline the previously reported value of the ISOLD and the IL-10/IL-6 ratio for (P)VRL identification and present CD70 as a potentially valuable target for (P)VRL stratification. Finally, we also show that increased CCL17 levels might help to distinguish sarcoid uveitis from TB-associated uveitis., (© 2021 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation.)
- Published
- 2022
- Full Text
- View/download PDF
14. Combined cellular and soluble mediator analysis for improved diagnosis of vitreoretinal lymphoma.
- Author
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de Hoog J, Dik WA, Lu L, Heezen KC, Ten Berge JC, Swagemakers SMA, van der Spek PJ, van Dongen JJM, van der Velden VHJ, Rothova A, and Langerak AW
- Subjects
- Biomarkers, Tumor metabolism, Choroid metabolism, Choroid Neoplasms metabolism, Female, Flow Cytometry, Follow-Up Studies, Humans, Immunoassay, Lymphoma diagnosis, Male, Middle Aged, Prospective Studies, Retina metabolism, Retinal Neoplasms metabolism, Vitreous Body metabolism, Choroid diagnostic imaging, Choroid Neoplasms diagnosis, Cytokines metabolism, Lymphoma metabolism, Retina diagnostic imaging, Retinal Neoplasms diagnosis, Vitreous Body diagnostic imaging
- Abstract
Purpose: Primary vitreoretinal lymphoma [(P)VRL]) is a rare malignancy of the eye localized in the retina, vitreous or choroid. Here, we aim to determine the value of the combination of innovative diagnostic methods for accurate differentiation between (P)VRL and non-(P)VRL in patients with suspect uveitis or vitritis., Methods: Multicolour flow cytometric immunophenotyping of cells in the vitreous samples was performed using the EuroFlow small sample tube. Additionally, cytokines/chemokines and growth factors were measured in the vitreous specimens using a multiplex immunoassay. Data were evaluated in predefined clinical subgroups using omniviz unsupervised Pearson's correlation visualization and unsupervised heatmap analysis., Results: A total of 53 patients were prospectively included in the period 2012-2015. In the (P)VRL subgroup (n = 10), nine cases showed aberrant surface membrane immunoglobulin (SmIg) light chain expression. In the non-(P)VRL group (n = 43) clearly skewed SmIg light chain expression was observed in two multiple sclerosis-related uveitis cases, but not in other uveitis types. Soluble mediator measurement revealed high interleukin (IL)-10/IL-6 ratios, and high IL-1RA levels in 9/10 (P)VRL cases, but not in any non-(P)VRL case. Further correlation and heatmap analysis revealed a minimal signature of cellular parameters (CD19+ B cells, aberrant SmIg light chain expression) and cytokine parameters (IL-10/IL-6 ratio >1, high IL-10, high IL-1 RA, high monocyte chemotactic protein-1, high macrophage inflammatory protein-1β) to reliably distinguish (P)VRL from non-(P)VRL., Conclusion: Here, we show the power of a combined cellular and proteomics strategy for detecting (P)VRL in vitreous specimens, especially in cases with minor cellular (P)VRL infiltrates., (© 2019 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.)
- Published
- 2019
- Full Text
- View/download PDF
15. Uveitis causes according to immune status of patients.
- Author
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Rothova A, Hajjaj A, de Hoog J, Thiadens AAHJ, and Dalm VASH
- Subjects
- Adult, Eye Infections diagnosis, Eye Infections epidemiology, Female, Follow-Up Studies, Humans, Male, Middle Aged, Netherlands epidemiology, Prevalence, Retrospective Studies, Uveitis diagnosis, Uveitis epidemiology, Eye Infections immunology, Immunity, Innate, Immunocompromised Host, Uveitis immunology
- Abstract
Purpose: The advances in medicine have led to an increased number of people living with some form of immunodeficiency. Most ocular infections in immunocompromised patients may lead to irreversible blindness. We identify the causes of uveitis in immunocompetent and immunocompromised patients., Methods: A retrospective cohort study of 1354 consecutive patients. All patients underwent a standard work-up for uveitis., Results: An immunocompromised state was identified in 171/1354 patients (13%), of whom 40 had Human immunodeficiency virus (HIV) infection, 52 received immunosuppressive medications, 28 had concurrent malignant disorder and 20 had other causes for their immunosuppression. In addition, 93/1354 patients (7%) had diabetes mellitus (DM). The prevalence of intraocular infections was much higher in immunocompromised patients than in immunocompetent patients and DM (p < 0.001). Causes of uveitis differed between the diverse immunocompromised groups. The non-HIV immunocompromised patients showed primarily intraocular herpes simplex and varicella zoster virus infections, whilst HIV-positive patients exhibited frequently cytomegalovirus (CMV) retinitis and syphilis. Patients with generalized malignancies were characterized by a lower prevalence of infections and higher prevalence of sarcoidosis. Patients with DM typically showed sarcoidosis and bacterial intraocular infections. The percentage of undetermined uveitis diagnoses was markedly lower in immunosuppressed patients (p < 0.001)., Conclusion: In immunocompromised patients with uveitis, infections were diagnosed in 46% of cases in contrast to 12% in the immunocompetent patients. The causes of uveitis differed among the various types of immunosuppression. Immunocompromised patients with uveitis require a rapid assessment for the most expected infections., (© 2018 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation.)
- Published
- 2019
- Full Text
- View/download PDF
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