1. Effect of breastfeeding on asthma, lung function and bronchial hyperreactivity in ISAAC Phase II
- Author
-
Weinmayr, G., Forastiere, F., Weiland, S. K., Rzehak, P., Abramidze, T., Annesi-Maesano, Isabella, Björkstén, B., Brunekreef, B., Büchele, G., Cookson, W. O. C., Von Mutius, E., Pistelli, R., Strachan, D. P., Renseigné, Non, Epidémiologie des maladies infectieuses et modélisation (ESIM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), G Büchele, Garcia-Hernandez G, SK Weiland, Groupe d'étude ISAAC Phase II . Collaborateurs (149) Bjorksten B, B Brunekreef, W Cookson, Strachan D, E von Mutius, Kleiner A, G Nagel, P Rzehak, G Weinmayr, Priftanji A, A Shkurti, Simenati J, Grabocka E, Shyti K, S Agolli, Gurakuqi A, RT Stein, de Pereira MU, MH Jones, B Bjorksten, PM Pitrez, Cooper PJ, M Chico, Zhong NS, C Lei, Wong G, MA Riikjärv, T Annus, Annesi-Maesano I, M Gotua, YZ Chen, M Rukhadze, T Abramidze, Kvachadze I, L Karsanidze, M Kiladze, N Dolidze, W Leupold, U Keil, von Mutius E, Arthur P, Wang H, E-Addo Yobo, C Gratziou, C Priftis, Papadopoulou A, C Katsardis, Tsanakas J, E Hatziagorou, Kirvassilis F, M Clausen, JR Shah, W Nystad, RS Mathur, RP Khubchandani, S Mantri, Forastière F, Di Domenicantonio R, De Sario M, S Sammarro, R Pis, Y Saraclar, L Bråbäck, Batlles-Garrido J, and Çocuk Sağlığı ve Hastalıkları
- Subjects
Male ,Pediatrics ,Time Factors ,MESH: Asthma ,MESH: Respiratory Sounds ,Respiratory System ,Breastfeeding ,MESH: Logistic Models ,MESH: Respiratory Function Tests ,Atopy ,MESH: Conjunctivitis ,0302 clinical medicine ,Risk Factors ,MESH: Risk Factors ,Surveys and Questionnaires ,MESH: Child ,030212 general & internal medicine ,Child ,MESH: Rhinitis ,Respiratory Function Tests ,3. Good health ,Breast Feeding ,MESH: Breast Feeding ,Female ,Bronchial Hyperreactivity ,medicine.symptom ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,MESH: Socioeconomic Factors ,MESH: Allergens ,MESH: Hypersensitivity ,03 medical and health sciences ,MESH: Cross-Sectional Studies ,MESH: Skin Tests ,Wheeze ,medicine ,Humans ,MESH: Prevalence ,Respiratory Sounds ,Retrospective Studies ,Asthma ,MESH: Humans ,MESH: Rhinitis, Allergic, Perennial ,business.industry ,MESH: Questionnaires ,MESH: Time Factors ,MESH: Bronchial Hyperreactivity ,MESH: Rhinitis, Allergic, Seasonal ,MESH: Retrospective Studies ,Odds ratio ,medicine.disease ,Confidence interval ,MESH: Male ,Logistic Models ,Socioeconomic Factors ,030228 respiratory system ,El Niño ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,business ,Breast feeding ,MESH: Seasons ,MESH: Female ,MESH: Models, Statistical - Abstract
International audience; The association between breastfeeding and wheezing, lung function and atopy was evaluated in the International Study of Asthma and Allergy in Childhood (ISAAC) Phase II. Cross-sectional studies were performed in 27 centres in 20 countries. Information on disease and exposure factors was collected by parental questionnaires. Data from 54,000 randomly selected school children (aged 8-12 yrs, 31,759 with skin prick testing) and a stratified subsample (n = 4,888) were used for testing the correlation of breastfeeding with bronchial hyperreactivity and lung function. Random effect models for meta-analysis were applied to calculate combined odds ratios (ORs). Any breastfeeding was associated with less wheeze both in affluent (adjusted OR (OR(adj)) 0.87, 95% confidence interval (CI) 0.78-0.97) and nonaffluent countries (OR(adj) 0.80, 95% CI 0.68-0.94). Further analyses revealed that this was true only for nonatopic wheeze in nonaffluent countries (OR(adj) 0.69, 95% CI 0.53-0.90). Breastfeeding was not associated with atopic wheeze and objective measures of allergy in both affluent and nonaffluent countries. In contrast, breastfeeding was associated with higher predicted forced expiratory volume in one second in affluent countries only (mean ratio 1.11, 95% CI 1.02-1.20). Breastfeeding is associated with protection against nonatopic wheeze, which becomes particularly evident in nonaffluent countries. Overall, breastfeeding was not related to any measure of allergy. These findings may explain some of the controversy regarding breastfeeding, since the direction of the association with breastfeeding depends on the predominating wheeze phenotype (e.g. atopic, nonatopic).
- Published
- 2009