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13 results on '"Cohen, Mitchell D."'

4. Characterization of the Dust/Smoke Aerosol That Settled East of the World Trade Center (WTC) in Lower Manhattan after the Collapse of the WTC 11 September 2001

Author

Lioy, Paul J., Weisel, Clifford P., Millette, James R., Eisenreich, Steven, Vallero, Daniel, Offenberg, John, Buckley, Brian, Turpin, Barbara, Zhong, Mianhua, Cohen, Mitchell D., Prophete, Colette, Yang, Ill, Stiles, Robert, Chee, Glen, Johnson, Willie, Porcja, Robert, Alimokhtari, Shahnaz, Hale, Robert C., Weschler, Charles, and Chen, Lung Chi

Published
2002

6. Longitudinal Impact of WTC Dust Inhalation on Rat Cardiac Tissue Transcriptomic Profiles

Author

Park, Sung-Hyun, primary, Lu, Yuting, additional, Shao, Yongzhao, additional, Prophete, Colette, additional, Horton, Lori, additional, Sisco, Maureen, additional, Lee, Hyun-Wook, additional, Kluz, Thomas, additional, Sun, Hong, additional, Costa, Max, additional, Zelikoff, Judith, additional, Chen, Lung-Chi, additional, Gorr, Matthew W., additional, Wold, Loren E., additional, and Cohen, Mitchell D., additional

Published
2022
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7. Longitudinal impact on rat cardiac tissue transcriptomic profiles due to acute intratracheal inhalation exposures to isoflurane

Author

Park, Sung-Hyun, primary, Lu, Yuting, additional, Shao, Yongzhao, additional, Prophete, Colette, additional, Horton, Lori, additional, Sisco, Maureen, additional, Lee, Hyun-Wook, additional, Kluz, Thomas, additional, Sun, Hong, additional, Costa, Max, additional, Zelikoff, Judith, additional, Chen, Lung-Chi, additional, and Cohen, Mitchell D., additional

Published
2021
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10. Prostate Cancer in World Trade Center Responders Demonstrates Evidence of an Inflammatory Cascade

Author

Gong, Yixuan, primary, Wang, Li, additional, Yu, Haocheng, additional, Alpert, Naomi, additional, Cohen, Mitchell D., additional, Prophete, Colette, additional, Horton, Lori, additional, Sisco, Maureen, additional, Park, Sung-Hyun, additional, Lee, Hyun-Wook, additional, Zelikoff, Judith, additional, Chen, Lung-Chi, additional, Hashim, Dana, additional, Suarez-Farinas, Mayte, additional, Donovan, Michael J., additional, Aaronson, Stuart A., additional, Galsky, Matthew, additional, Zhu, Jun, additional, Taioli, Emanuela, additional, and Oh, William K., additional

Published
2019
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11. A novel system to generate WTC dust particles for inhalation exposures

Author

Vaughan, Joshua M, primary, Garrett, Brittany J, additional, Prophete, Colette, additional, Horton, Lori, additional, Sisco, Maureen, additional, Soukup, Joleen M, additional, Zelikoff, Judith T, additional, Ghio, Andrew, additional, Peltier, Richard E, additional, Asgharian, Bahman, additional, Chen, Lung-Chi, additional, and Cohen, Mitchell D, additional

Published
2013
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12. Comparison of WTC Dust Size on Macrophage Inflammatory Cytokine Release In vivo and In vitro

Author

Weiden, Michael D., primary, Naveed, Bushra, additional, Kwon, Sophia, additional, Segal, Leopoldo N., additional, Cho, Soo Jung, additional, Tsukiji, Jun, additional, Kulkarni, Rohan, additional, Comfort, Ashley L., additional, Kasturiarachchi, Kusali J., additional, Prophete, Colette, additional, Cohen, Mitchell D., additional, Chen, Lung-Chi, additional, Rom, William N., additional, Prezant, David J., additional, and Nolan, Anna, additional

Published
2012
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13. Pulmonary Immunotoxicity of Inhaled Ammonium Metavanadate in Fisher 344 Rats.

Author

COHEN, MITCHELL D., YANG, ZIJIAN, ZELIKOFF, JUDITH T., and SCHLESINGER, RICHARD B.

Subjects
RATS, VANADIUM, AMMONIUM, NEUTROPHILS, MACROPHAGES, PULMONARY alveoli, CYTOKINES
Abstract

Male Fisher 344 rats were exposed to 2 mg vanadium(V)/m3 (as ammonium metavanadate NH4VO3, 0.32 μm MMD) atmospheres for 8 hr/day for 4 days in a nose-only exposure system. In exposed rats, lung V burdens increased in a time-dependent fashion. Analysis of lung cells and lavage fluid 24 hr after the final exposure suggested that tissue damage and a strong inflammatory response was elicited; numbers of neutrophil and small macrophages (Mø), as well as levels of lavageable protein and lactate dehydrogenase, were significantly elevated as compared with levels observed with air-exposed rats. Vanadium also affected pulmonary alveolar Mø (PAM) capacities to produce and respond to immunoregulating cytokines. Inducible PAM production of tumor necrosis factor-a was significantly inhibited, as was the ability to increase cell surface Class II/I-A molecule expression in response to interferon-γ (rFN-γ). PAM from V-exposed hosts were also inhibited in their ability to be primed by EFN-γ to produce superoride anion and hydrogen peroxide in response to stimulation with opsonized zy-mosan. These studies indicate that short-term repeated exposure of rats to atmospheric V, at levels encountered in an occupational setting, can alter host pulmonary immunomocompetence, with one major effect occurring at the level of cytokine-related functions. These alterations may be underlying mechanisms for the well-documented increases in bronchopulmonary infections and cancers in workers chronically exposed to V-containing atmospheres. [ABSTRACT FROM AUTHOR]

Published
1996
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