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1. Design and synthesis of gene-directed caged cyclic nucleotides exhibiting cell type selectivity

Author

Hirona Sasaki, Masaki Sone, Toshiaki Furuta, Taichi Sakano, Akinobu Z. Suzuki, Kazuki Horikawa, and Rei Watahiki

Subjects
Cell type, Light, Catalysis, Text mining, Materials Chemistry, Tumor Cells, Cultured, Humans, Nucleotide, Gene, chemistry.chemical_classification, Molecular Structure, business.industry, fungi, Metals and Alloys, food and beverages, General Chemistry, Photochemical Processes, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Enzyme, chemistry, Biochemistry, Ceramics and Composites, Nucleotides, Cyclic, Selectivity, business, HeLa Cells
Abstract

We designed a new caging group that can be photoactivated only in the presence of a non-endogenous enzyme when exposed to 405 nm light. Because cells or tissues can be genetically tagged by an exogenously expressed enzyme, this novel method can serve as a strategy for adding targeting abilities to photocaged compounds.

Published
2021

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