3,762 results
Search Results
2. American College of Rheumatology White Paper on Performance Outcome Measures in Rheumatology
- Author
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Suter, Lisa G, Barber, Claire E, Herrin, Jeph, Leong, Amye, Losina, Elena, Miller, Amy, Newman, Eric, Robbins, Mark, Tory, Heather, and Yazdany, Jinoos
- Subjects
Health Services ,Clinical Research ,Autoimmune Disease ,Arthritis ,8.4 Research design and methodologies (health services) ,Health and social care services research ,Humans ,Outcome Assessment ,Health Care ,Quality of Health Care ,Rheumatic Diseases ,Rheumatology ,Societies ,Medical ,United States ,Clinical Sciences ,Public Health and Health Services ,Psychology - Abstract
ObjectiveTo highlight the opportunities and challenges of developing and implementing performance outcome measures in rheumatology for accountability purposes.MethodsWe constructed a hypothetical performance outcome measure to demonstrate the benefits and challenges of designing quality measures that assess patient outcomes. We defined the data source, measure cohort, reporting period, period at risk, measure outcome, outcome attribution, risk adjustment, reliability and validity, and reporting approach. We discussed outcome measure challenges specific to rheumatology and to fields where patients have predominantly chronic, complex, ambulatory care-sensitive conditions.ResultsOur hypothetical outcome measure was a measure of rheumatoid arthritis disease activity intended for evaluating Accountable Care Organization performance. We summarized the components, benefits, challenges, and tradeoffs between feasibility and usability. We highlighted how different measure applications, such as for rapid cycle quality improvement efforts versus pay for performance programs, require different approaches to measure development and testing. We provided a summary table of key take-home points for clinicians and policymakers.ConclusionPerformance outcome measures are coming to rheumatology, and the most effective and meaningful measures can only be created through the close collaboration of patients, providers, measure developers, and policymakers. This study provides an overview of key issues and is intended to stimulate a productive dialogue between patients, practitioners, insurers, and government agencies regarding optimal performance outcome measure development.
- Published
- 2016
3. Research Paper: The Impact of Synovial NF-ĸB Activation on Apoptosis Pattern Change During Adjuvant-induced Inflammation
- Author
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Sahar Golabi, Jalal Zaringhalam, and Homa Manaheji
- Subjects
Inflammation ,Arthritis ,NF-ĸB ,Apoptosis ,Synovial membrane ,Complete Freund’s Adjuvant ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Introduction: Apoptosis dysregulation plays a substantial role in the pathophysiology of chronic inflammation and its related symptoms such as edema. Regulation of NF-ĸB activation is involved in apoptosis pattern change. The current study aimed at verifying the effects of local inflammation on edema and changes in apoptotic markers, and investigating the possible role of NF-ĸB in apoptosis pattern change during different stages of complete Freund’s adjuvant (CFA)-induced knee arthritis in rats. Methods: A total of 96 male Wistar rats were divided into different experimental groups. Arthritis was evoked into the right knee articular joint. Changes made in knee edema were assessed by caliper on the days 0, 7, 14, and 21 of the study. Synovial NF-ĸB and levels of apoptotic markers were evaluated during different stages of the study using Western blot technique. Results: CFA injection caused intense edema during the whole study period. Synovial NF-ĸB level increased during the whole study period. The level of apoptotic markers increased during the acute phase of study. But during chronic phase, the apoptosis level decreased. Inh-NF-ĸB administration increased synovial apoptosis during the whole study period. Conclusion: It seems that apoptosis pattern change plays an important role in the progression and modulation of CFA-induced inflammation and its related symptoms. Also, it can be concluded that synovial NF-ĸB had a crucial role in synovial apoptosis change during the study period.
- Published
- 2017
4. Objective evaluation of patients with rheumatic diseases. II. Paper electrophoretic studies of serum glycoprotein and protein from patients with rheumatoid arthritis.
- Author
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STIDWORTHY G, PAYNE RW, SHETLAR CL, and SHETLAR MR
- Subjects
- Humans, Arthritis, Arthritis, Rheumatoid blood, Glycoproteins, Rheumatic Diseases
- Published
- 1957
- Full Text
- View/download PDF
5. A White Paper on Collagen Hydrolyzates and Ultrahydrolyzates: Potential Supplements to Support Joint Health in Osteoarthritis?
- Author
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Armaghan Mahmoudian, Ursule Kalvaityte, Lacey J. Favazzo, Cyro Scala de Almeida, Michael J. Zuscik, Stan Kubow, Ali Mobasheri, Christina E. Larder, Pieter J. Emans, Perola Grimberg Plapler, Michèle M. Iskandar, Paulo Cesar Hamdan, Luc J. C. van Loon, Ilona Uzieliene, Humane Biologie, RS: NUTRIM - R3 - Respiratory & Age-related Health, RS: CAPHRI - R3 - Functioning, Participating and Rehabilitation, Orthopedie, MUMC+: MA Orthopedie (9), Physiotherapy, Human Physiology and Anatomy, and Human Physiology and Sports Physiotherapy Research Group
- Subjects
collagen ,medicine.medical_specialty ,Population ,Pain ,Arthritis ,Context (language use) ,Osteoarthritis ,Disease ,METABOLISM ,dietary supplements ,Denatured collagen ,Nutraceutical ,Pharmacotherapy ,Rheumatology ,FOOD ,Complementary and Alternative Medicine (S Kolasinski, Section Editor) ,Osteoarthritis/drug therapy ,Humans ,Medicine ,HYDROLYSATE ,Intensive care medicine ,education ,Nutritional supplement ,education.field_of_study ,business.industry ,Collagen hydrolyzate ,GUT MICROBIOTA ,IN-VITRO DIGESTION ,medicine.disease ,UC-II ,Clinical trial ,Collagen ultra-hydrolyzate ,ORAL TOLERANCE ,II COLLAGEN ,IMMUNE-SYSTEM ,Joint health ,Joint Diseases ,business ,DIETARY-SUPPLEMENTS - Abstract
Purpose of Review Osteoarthritis (OA) is the most common forms of arthritis in the general population, accounting for more pain and functional disability than any other musculoskeletal disease. There are currently no approved disease modifying drugs for OA. In the absence of effective pharmacotherapy, many patients with OA turn to nutritional supplements and nutraceuticals, including collagen derivatives. Collagen hydrolyzates and ultrahydrolyzates are terms used to describe collagens that have been broken down into small peptides and amino acids in the presence of collagenases and high pressure. Recent Findings This article reviews the relevant literature and serves as a White Paper on collagen hydrolyzates and ultrahydrolyzates as emerging supplements often advertised to support joint health in OA. Collagen hydrolyzates have demonstrated some evidence of efficacy in a handful of small scale clinical trials, but their ability to treat and reverse advanced joint disease remains highly speculative, as is the case for other nutritional supplements. Summary The aim of this White Paper is to stimulate research and development of collagen-based supplements for patients with OA and other musculoskeletal diseases at academic and industrial levels. This White Paper does not make any treatment recommendations for OA patients in the clinical context, but simply aims to highlight opportunities for scientific innovation and interdisciplinary collaboration, which are crucial for the development of novel products and nutritional interventions based on the best available and published evidence.
- Published
- 2021
6. Research Paper: The Effect of Orally Administered Probiotics on the Behavioral, Cellular, and Molecular Aspects of Adjuvant-Induced Arthritis
- Author
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Vida Nazemian, Jalal Zaringhalam, Mahdi Shadnoush, and Homa Manaheji
- Subjects
0301 basic medicine ,medicine.medical_treatment ,Arthritis ,Pharmacology ,medicine.disease ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,Subcutaneous injection ,030104 developmental biology ,Cytokine ,Immune system ,Edema ,Rheumatoid arthritis ,Hyperalgesia ,Humoral immunity ,medicine ,Neurology (clinical) ,medicine.symptom - Abstract
Introduction Rheumatoid Arthritis (RA) is a chronic autoimmune disease, which is accompanied with pain, hyperalgesia, and edema. Overproduction of pro-inflammatory cytokines and activation of intracellular signaling pathways sustain the RA symptoms considerably. There is a strong correlation between the expression of cytokines and opioid receptors in the arthritis process. Studies have shown that probiotics via different pathways such as reducing the levels of pro-inflammatory cytokines can alleviate inflammatory symptoms. Therefore, based on the crucial role of cellular and humoral immunity in induction of RA symptoms and potency of probiotics in modulation of immune responses, the purpose of this study was to investigate the effect of orally administered probiotics on the behavioral, cellular and molecular aspects of adjuvant-induced arthritis in male Wistar rats. Methods Complete Freund's Adjuvant (CFA)-induced arthritis was caused by single subcutaneous injection of CFA into the rat's hind paw on day 0. Different doses of probiotics (1/250, 1/500 and 1/1000 [109 CFU/g]) were administered daily (gavage) after CFA injection. Hyperalgesia, edema, serum IL-1β levels, μ-Opioid Receptor (MOR) expression, and p38MAPK (Mitogen-Activated Protein Kinase) activities were assessed on days 0, 7, 14 and 21 of the study. Results The results of this study indicated the efficacy of probiotics in reducing hyperalgesia, edema, serum levels of Interleukin-1β, and p38MAPK pathway activity during different phases of arthritis as well as increasing the expression of MORs during chronic phase of CFA-induced arthritis. Conclusion It seems that probiotics can effectively reduce inflammatory symptoms by inhibiting the intracellular signaling pathway and cytokine production.
- Published
- 2018
7. Comparison of agreement between internet-based registration of patient-reported outcomes and clinic-based paper forms within the Swedish Rheumatology Quality Register
- Author
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D. Di Giuseppe, Gerd-Marie Alenius, Oscar E. Hofstedt, N. Stattin, Lotta Ljung, and Helena Forsblad-d'Elia
- Subjects
Male ,medicine.medical_specialty ,Visual Analog Scale ,media_common.quotation_subject ,Immunology ,Ambulatory Care Facilities ,Severity of Illness Index ,03 medical and health sciences ,Diagnostic Self Evaluation ,0302 clinical medicine ,Rheumatology ,Internet based ,Internal medicine ,Surveys and Questionnaires ,Outcome Assessment, Health Care ,Immunology and Allergy ,Medicine ,Humans ,Medical physics ,Quality (business) ,030212 general & internal medicine ,Patient Reported Outcome Measures ,Registries ,media_common ,Rheumatology and Autoimmunity ,030203 arthritis & rheumatology ,Sweden ,Internet ,Reumatologi och inflammation ,business.industry ,Arthritis ,Outcome measures ,Reproducibility of Results ,General Medicine ,Middle Aged ,Cross-Sectional Studies ,Register (music) ,The Internet ,Female ,business - Abstract
Objective: The Swedish Rheumatology Quality Register has implemented an internet-based method (PER) for registering patient-recorded outcome measures. The aim of this study was to compare the agreement between visual analogue scales (VASs) reported via PER and clinic-based reporting using paper forms. Methods: In a cross-sectional study (70 patients), the results of 79 registrations of VASs for global health, pain, and fatigue from PER were compared with corresponding clinic-based paper registrations. For patients with polyarthritis, 28-joint count Disease Activity Scores (DAS28) were computed. Patients with axial disease also completed Bath Ankylosing Spondylitis Disease Activity Index and Functional Index (BASDAI and BASFI) questionnaires. Mean differences and intraclass correlation coefficients (ICCs) were calculated. Agreement was visualized using Bland–Altman plots. Results: No statistically significant differences in VASs were found comparing PER and paper forms for VAS Global, VAS Pain, and VAS Fatigue (p = 0.295, 0.463, and 0.288, respectively). ICCs for VAS Global, Pain, and Fatigue ranged from 0.889 to 0.952, indicating excellent agreement. Bland–Altman plots for VAS did not show any proportional bias. The mean difference for DAS28 calculated by VASs from paper vs PER was −0.02 (n = 65, p = 0.660), and the mean difference for BASDAI was 0.04 (n = 11, p = 0.742). ICCs for DAS28 and BASDAI were 0.962 and 0.985, respectively. Of the participating patients, 60% preferred PER. Conclusion: Internet-based reporting for patient-reported outcomes in a clinical setting resulted in similar data for VASs and corresponding disease activity scores to clinic-based reporting on paper forms.
- Published
- 2019
- Full Text
- View/download PDF
8. Research Paper: The Impact of Synovial NF-ĸB Activation on Apoptosis Pattern Change During Adjuvant-induced Inflammation
- Author
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Homa Manaheji, Sahar Golabi, and Jalal Zaringhalam
- Subjects
Knee arthritis ,Pathology ,medicine.medical_specialty ,Arthritis ,Inflammation ,Apoptosis ,NF-ĸB ,lcsh:RC321-571 ,Cellular and Molecular Neuroscience ,chemistry.chemical_compound ,Edema ,Medicine ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,business.industry ,NF-κB ,medicine.disease ,Synovial membrane ,Pathophysiology ,Complete Freund’s Adjuvant ,medicine.anatomical_structure ,chemistry ,Neurology (clinical) ,medicine.symptom ,business ,Neuroscience - Abstract
Introduction: Apoptosis dysregulation plays a substantial role in the pathophysiology of chronic inflammation and its related symptoms such as edema. Regulation of NF-ĸB activation is involved in apoptosis pattern change. The current study aimed at verifying the effects of local inflammation on edema and changes in apoptotic markers, and investigating the possible role of NF-ĸB in apoptosis pattern change during different stages of complete Freund’s adjuvant (CFA)-induced knee arthritis in rats. Methods: A total of 96 male Wistar rats were divided into different experimental groups. Arthritis was evoked into the right knee articular joint. Changes made in knee edema were assessed by caliper on the days 0, 7, 14, and 21 of the study. Synovial NF-ĸB and levels of apoptotic markers were evaluated during different stages of the study using Western blot technique. Results: CFA injection caused intense edema during the whole study period. Synovial NF-ĸB level increased during the whole study period. The level of apoptotic markers increased during the acute phase of study. But during chronic phase, the apoptosis level decreased. Inh-NF-ĸB administration increased synovial apoptosis during the whole study period. Conclusion: It seems that apoptosis pattern change plays an important role in the progression and modulation of CFA-induced inflammation and its related symptoms. Also, it can be concluded that synovial NF-ĸB had a crucial role in synovial apoptosis change during the study period.
- Published
- 2017
9. Perspectives of Persons With Arthritis on the Use of Wearable Technology to Self Monitor Physical Activity: A Qualitative Evidence Synthesis.
- Author
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Leese J, Geldman J, Zhu S, Macdonald GG, Pourrahmat MM, Townsend AF, Backman CL, Nimmon L, and Li LC
- Subjects
- Exercise, Humans, Qualitative Research, Arthritis diagnosis, Arthritis therapy, Self-Management, Wearable Electronic Devices
- Abstract
Objective: We aimed to broaden understanding of the perspectives of persons with arthritis on their use of wearables to self-monitor physical activity, through a synthesis of evidence from qualitative studies., Methods: We conducted a systematic search of 5 databases (including Medline, CINAHL, and Embase) from inception to 2018. Eligible studies qualitatively examined the use of wearables from the perspectives of persons with arthritis. All relevant data were extracted and coded inductively in a thematic synthesis., Results: Of 4,358 records retrieved, 7 articles were included. Participants used a wearable during research participation in 3 studies and as part of usual self-management in 2 studies. In remaining studies, participants were shown a prototype they did not use. Themes identified were: 1) the potential to change dynamics in patient-health professional communication: articles reported a common opinion that sharing wearable data could possibly enable patients to improve communication with health professionals; 2) wearable-enabled self-awareness, whether a benefit or downside: there was agreement that wearables could increase self-awareness of physical activity levels, but perspectives were mixed on whether this increased self-awareness motivated more physical activity; 3) designing a wearable for everyday life: participants generally felt that the technology was not obtrusive in their everyday lives, but certain prototypes may possibly embarrass or stigmatize persons with arthritis., Conclusion: Themes hint toward an ethical dimension, as participants perceive that their use of wearables may positively or negatively influence their capacity to shape their everyday self-management. We suggest ethical questions pertinent to the use of wearables in arthritis self-management for further exploration., (© 2021 American College of Rheumatology.)
- Published
- 2022
- Full Text
- View/download PDF
10. Immunoconglutinin in various rheumatic diseases and certain diseases suspected of an autoimmune pathogenesis.
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Bienenstock J and Bloch KJ
- Subjects
- Chromatography, Paper, Complement System Proteins, Coombs Test, Humans, Lupus Erythematosus, Systemic blood, Myasthenia Gravis blood, Sjogren's Syndrome blood, Synovial Fluid analysis, Thyroiditis, Autoimmune blood, Arthritis blood, Autoantibodies analysis, Autoimmune Diseases blood, Myocardial Infarction blood, Pneumonia blood
- Published
- 1967
- Full Text
- View/download PDF
11. Papers Presented at the Annual Meetings of the Knee Society: Editorial Comment
- Author
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Mark W. Pagnano
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Gerontology ,medicine.medical_specialty ,Knee Joint ,Sports medicine ,media_common.quotation_subject ,medicine.medical_treatment ,Population ,Awards and Prizes ,Knee replacement ,Prosthesis Design ,Interim ,Symposium: Papers Presented at the Annual Meetings of The Knee Society ,medicine ,Humans ,Orthopedics and Sports Medicine ,Symposium: 2014 Knee Society Proceedings ,Arthroplasty, Replacement, Knee ,education ,Societies, Medical ,media_common ,education.field_of_study ,business.industry ,Arthritis ,General Medicine ,Osteoarthritis, Knee ,Congresses as Topic ,Orthopedics ,Treatment Outcome ,Family medicine ,Orthopedic surgery ,Physical therapy ,Curiosity ,San Francisco ,Surgery ,Periodicals as Topic ,Outcomes research ,Societies ,Knee Prosthesis ,business - Abstract
The Papers Presented at the Annual Meetings of the Knee Society Symposium includes selected papers read at the 2007 Annual Interim Meeting of the Knee Society held in Sienna, Italy in September 2007, and the 2008 Open Scientific Meeting of the Knee Society, held in San Francisco in March 2008. The wide range and high quality of the scientific material presented here is a credit to the excellent work of the Knee Society education committee and particularly to its Program Chair, Gil Scuderi, MD. Each of these papers is focused, concise and highly readable, which is a credit to the outstanding work of the staff at CORR in providing clear and consistent guidelines for each of the authors whose work was accepted for publication. The 2008 Ranawat Award was authored by Dr. Patricia Franklin and colleagues for their work on patient-specific attributes that affect the functional outcome after total knee replacement. While considerable interest in patient outcomes research has been present for some time now, we are still uncovering the hidden power, and the hidden pitfalls, of such evaluation tools in orthopaedics. Dr. Franklin and colleagues effectively demonstrate the substantial influence of specific patient characteristics in determining the ultimate functional outcome after knee replacement. These data are useful for surgeons and patients alike as part of the preoperative discussion so that expectations can be managed more appropriately. Further, this paper provides some insight into additional strategies that might be employed prior to knee replacement to affect some patient attributes that adversely impact outcome. The 2008 Coventry Award paper was authored by D’Lima, Colwell, and colleagues from the Scripps Clinic for their innovative report that directly measured the in vivo forces that the knee experiences after total knee arthroplasty. In an outstanding collaboration between basic science researchers, engineers, and clinicians, Dr. Colwell’s group designed and implanted in three patients an instrumented tibial component that allowed the direct measurement of both knee forces and moments in vivo. These results begin to give us a true glimpse of the forces that are seen by total knee bearing surfaces and fixation interfaces thus providing us with a more scientific approach to what have otherwise been empiric recommendations regarding physical activities after total knee arthroplasty. The 2008 John Insall Award paper was authored by Dr. Steven MacDonald and colleagues from London, Ontario and addressed the specific impact of gender on the clinical outcome after total knee arthroplasty. The introduction into the marketplace of so-called gender-specific total knee components has been met with a competing mix of interest and skepticism among surgeons, while among patients curiosity might be the most appropriate descriptor. This scientific work again highlights the powerful relationship between preoperative variables and postoperative outcomes. These authors rightly highlight the importance of focusing on the change or improvement in preoperative to postoperative outcomes measures and balance that against the absolute scores. Female gender was associated with lower preoperative scores with these outcomes tools so perhaps it is not surprising some of the postoperative scores remain lower than those observed in males. The change or improvement from preoperative to postoperative, however, appears to be similar between males and females after total knee arthroplasty. The remaining papers in this symposium are grouped to include new information regarding total knee surgical technique, gender-related issues in technique and outcome, computer navigation, patellar resurfacing, total knee materials and design issues and revision total knee concerns. As surgeons we have specific interest in improving our intraoperative skills. In this symposium there is information on a method to determine rotational position of total knee components, data on the impact of a ligament balancing technique on the rate of lateral retinacular release, and the introduction of an extramedullary femoral referencing system to facilitate less invasive surgery. Gender-related issues are addressed in a series of papers that look at both documenting physical measurement differences in knee anatomy and then measuring outcomes differences. While little doubt exists that gender-associated differences can be measured, what remains to be determined is the clinical importance of such findings, and in that area we collectively still have work to do. While it appears that the initial wave of enthusiasm for computer navigation in total knee arthroplasty has crested, we are now at a point where more definitive scientific data are emerging regarding the benefits and drawbacks to this particular technology. Two of the implicit promises of computer navigation have been that it may make the occasional knee surgeon more like the expert surgeon, and that a navigation system can be the eye that facilitates accurate minimally invasive surgery. In this symposium there are scientific data that cast some doubt on promise number two, and all of us in the scientific community continue to look for evidence that navigation is reproducibly accurate when used by the occasional knee surgeon. The added costs of this technology is an issue yet to be addressed. Revision TKA is an area of ascending importance as the demographics of our population point to a growing need in this area. In this Symposium there are useful data on the outcomes differences between primary and revision TKA, comparative data on in-hospital complications between primary and revision TKA, isolated patellar revision, patellar bone loss problems and the use of stems in conjunction with constrained condylar knee designs. The Knee Society remains committed to advancing scientific knowledge and educating clinicians worldwide regarding surgery of the knee. We hope that our readers find this Symposium to be intellectually rigorous and clinically useful.
- Published
- 2011
12. The use of biosimilars in immune-mediated disease: A joint Italian Society of Rheumatology (SIR), Italian Society of Dermatology (SIDeMaST), and Italian Group of Inflammatory Bowel Disease (IG-IBD) position paper
- Author
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Fiorino, G, Girolomoni, Giampiero, Lapadula, G, Orlando, A, Danese, S, Olivieri, I, on behalf of SIR, Sidemast, I. B. D., Ig, Fiorino, G, Girolomoni, G, Lapadula, G, Orlando, A, Danese, S, and Olivieri, I
- Subjects
medicine.medical_specialty ,Immunology ,Arthritis ,Skin Diseases ,Inflammatory bowel disease ,Arthritis, Rheumatoid ,Psoriatic arthritis ,Internal medicine ,Psoriasis ,medicine ,Humans ,Immunology and Allergy ,media_common.cataloged_instance ,biosimilars ,European union ,Biosimilar Pharmaceuticals ,Societies, Medical ,media_common ,Ankylosing spondylitis ,business.industry ,Biosimilar ,Inflammatory Bowel Diseases ,medicine.disease ,Dermatology ,Rheumatology ,immune-mediated disease ,Italy ,business - Abstract
Biological agents are widely used in rheumatology, dermatology and inflammatory bowel disease. Evidence about their efficacy and safety has been strengthened for all those therapeutic indications over the last decade. Biosimilar agents are monoclonal antibodies similar to previously approved biologics. In the European Union, they have been approved for all the indications in the management of immune-mediated inflammatory diseases (IMIDs), although data only in rheumatoid arthritis and ankylosing spondylitis are currently available. Direct evidence on efficacy, safety, and immunogenicity of biosimilars is mandatory in psoriasis, psoriatic arthritis, and inflammatory bowel disease, as well as in children. Based on the current evidence in the literature, we present the joint official position of the Italian Societies of Rheumatology, Dermatology and Inflammatory Bowel Disease on the use of biosimilars in IMIDs.
- Published
- 2014
13. Exploring the Associations Among Occupational Balance and Health of Adults With and Without Inflammatory Arthritis.
- Author
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To-Miles F, Håkansson C, Wagman P, and Backman CL
- Subjects
- Adult, Aged, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Surveys and Questionnaires, Activities of Daily Living, Arthritis complications, Health Status, Quality of Life
- Abstract
Objective: Occupational balance is a person's subjective perception of the amount and variation of their everyday activities. Evidence suggests an association between occupational balance and health. However, the impact of arthritis on occupational balance and its association with health is unclear. This exploratory study was undertaken to examine associations between occupational balance and measures of health and between-group differences in adults with and without inflammatory arthritis (IA)., Methods: In a cross-sectional study, participants completed the 11-item Occupational Balance Questionnaire (OBQ-11) and the Short Form 36 (SF-36) health survey (physical and mental component summary scores) and provided demographic information. Telomere lengths were analyzed from dried blood spots., Results: A total of 143 adults participated (67 with IA, 76 from the healthy comparison [HC] group). Occupational balance was higher in the HC group than in the IA group (mean difference 3.5 [95% confidence interval 1.0, 5.9; P = 0.01]), but this difference was not statistically significant when adjusted for physical health. The association between occupational balance and physical health was stronger in the IA group (R
2 = 0.17, P = 0.001) than in the HC group (R2 = 0.05, P = 0.05). Occupational balance was associated with mental health (R2 = 0.26, P < 0.001) but not associated with telomere length (R2 = 0.02, P = 0.24)., Conclusion: Occupational balance is associated with mental health for all participants and associated with physical health and disease activity in participants with IA. Attention to assessment of and strategies for improving occupational balance in rehabilitation practice and arthritis self-management programs may contribute to sustaining physical and mental health., (© 2021, American College of Rheumatology.)- Published
- 2022
- Full Text
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14. Research Paper: The Impact of Synovial NF-ĸB Activation on Apoptosis Pattern Change During Adjuvant-induced Inflammation.
- Author
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Golabi, Sahar, Zaringhalam, Jalal, and Manaheji, Homa
- Subjects
- *
SYNOVIAL fluid , *APOPTOSIS , *IMMUNOLOGICAL adjuvants - Abstract
Introduction: Apoptosis dysregulation plays a substantial role in the pathophysiology of chronic inflammation and its related symptoms such as edema. Regulation of NF-ĸB activation is involved in apoptosis pattern change. The current study aimed at verifying the effects of local inflammation on edema and changes in apoptotic markers, and investigating the possible role of NF-ĸB in apoptosis pattern change during different stages of complete Freund's adjuvant (CFA)-induced knee arthritis in rats. Methods: A total of 96 male Wistar rats were divided into different experimental groups. Arthritis was evoked into the right knee articular joint. Changes made in knee edema were assessed by caliper on the days 0, 7, 14, and 21 of the study. Synovial NF-ĸB and levels of apoptotic markers were evaluated during different stages of the study using Western blot technique. Results: CFA injection caused intense edema during the whole study period. Synovial NF-ĸB level increased during the whole study period. The level of apoptotic markers increased during the acute phase of study. But during chronic phase, the apoptosis level decreased. Inh-NF-ĸB administration increased synovial apoptosis during the whole study period. Conclusion: It seems that apoptosis pattern change plays an important role in the progression and modulation of CFA-induced inflammation and its related symptoms. Also, it can be concluded that synovial NF-ĸB had a crucial role in synovial apoptosis change during the study period. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
15. Agreements and Discrepancies between FDA Reports and Journal Papers on Biologic Agents Approved for Rheumatoid Arthritis: A Meta-Research Project
- Author
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Robin Christensen, Daniel E. Furst, Jennifer M. P. Woo, Gil Amarilyo, Wen Li, Henning Bliddal, and Simon Tarp
- Subjects
Medical Journals ,Alternative medicine ,lcsh:Medicine ,law.invention ,Arthritis, Rheumatoid ,0302 clinical medicine ,Randomized controlled trial ,law ,Medicine and Health Sciences ,030212 general & internal medicine ,lcsh:Science ,Drug Approval ,health care economics and organizations ,Statistical Data ,Randomized Controlled Trials as Topic ,Multidisciplinary ,Research Support, Non-U.S. Gov't ,Research Assessment ,Biologic Agents ,Reporting bias ,Research Design ,Rheumatoid arthritis ,Physical Sciences ,Statistics (Mathematics) ,Research Article ,medicine.medical_specialty ,Drug Research and Development ,Clinical Research Design ,Immunology ,education ,Rheumatoid Arthritis ,Research and Analysis Methods ,Autoimmune Diseases ,03 medical and health sciences ,Rheumatology ,Journal Article ,Confidence Intervals ,medicine ,Humans ,Clinical Trials ,Adverse effect ,Pharmacology ,030203 arthritis & rheumatology ,Biological Products ,United States Food and Drug Administration ,business.industry ,Arthritis ,lcsh:R ,Biology and Life Sciences ,Odds ratio ,medicine.disease ,Randomized Controlled Trials ,United States ,Confidence interval ,Family medicine ,Clinical Immunology ,lcsh:Q ,Adverse Events ,Clinical Medicine ,business ,Medical Humanities ,Mathematics ,Meta-Analysis - Abstract
BACKGROUND: Sponsors that seek to commercialize new drugs apply to the Food and Drug Administration (FDA) which independently analyzes the raw data and reports the results on its website.OBJECTIVES: This study sought to determine if there are differences between the FDA assessments and journal reports on biologic agents developed for the treatment of rheumatoid arthritis.METHODS: Available data on FDA-approved drugs were extracted from the website, and a systematic literature search was conducted to identify matching studies in peer-reviewed medical journals. Outcome measures were the American College of Rheumatology response criteria ACR20 (efficacy) and withdrawal due to adverse events (safety). As effect size odds ratios were estimated for each active trial arm vs. control arm (i.e. for both sources: FDA and journal report), followed by calculation of the ratios of the FDA and journal report odds ratios. A ratio of odds ratios not equal to 1 was categorized as a discrepancy.RESULTS: FDA reports were available for 8 of 9 FDA-approved biologic agents for rheumatoid arthritis; all identified trials (34) except one were published in peer-reviewed journals. Overall, discrepancies were noted for 20 of the 33 evaluated trials. Differences in the apparent benefit reporting were found in 39% (24/61) pairwise comparisons and in 11 cases these were statistically significant; the FDA report showed greater benefit than the journal publication in 15 comparisons and lesser benefit in 9. Differences in the reported harms were found in 51% (28/55) pairwise comparisons and were statistically significant in 5. The "signal" in FDA reports showed a less harmful effect than the journal publication in 17 comparisons whereas a more harmful effect in 11. The differences were attributed to differences in analytic approach, patient inclusion, rounding effect, and counting discrepancies. However, no differences were categorized as critical.CONCLUSION: There was no empirical evidence to suggest biased estimates between the two sources. Increased and detailed transparency in publications would improve the understanding and credibility of published results. Further, the FDA report was found to be a useful source when data are missing in the published report (i.e. reporting bias).
- Published
- 2016
16. Title of presented paper: Still's disease treatment process -- case study.
- Author
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Bogdan, Justyna and Baljon, Benedykt
- Subjects
STILL'S disease ,JOINT pain ,ARTHRITIS ,RHEUMATOLOGY ,TOCILIZUMAB - Abstract
Introduction and aim. Still's disease most often begins before the age of 16. Its symptoms may recur or occur for the first time in adults. The clinical picture is not characteristic. There are four main symptoms of the disease: fever >39°C, arthralgia or arthritis, and a salmon-colored rash. In chronic treatment, disease-modifying drugs and biological drugs are administered. Aim of this paper is to present case of 26 years old. patient with Still's disease. Aim of this paper is to present treatment process of patient with Still's disease. Description of the case. Between June 2014 and August 2022, a 26-year-old patient with diagnosed Still's disease was under treatment at the Rheumatology Department of Provincial Hospital No. 2 in Rzeszów. During that time his disease had high and low activity. Treatment included glucocorticosteroids, Methotrexate, Cyclosporine, Tocilizumab, Infliximab, Etanercept, Anakinra and Canakinumab. The first therapy with Tocilizumab was discontinued due to an increase in bilirubin level. Methotrexate and Cyclosporine were effective, unfortunately after 6 months secondary inefficacy occurred, and administration of them was stopped. The use of Infliximab and Etanercept didn't show any improvement in the activity of the patient's disease. During the second therapy of tocilizumab, no significant increase in bilirubin level was observed, although disease activity was low. Conclusion. In the acute phase of Still's disease, treatment is symptomatic. In chronic therapy, a number of biological drugs of varying effectiveness are used, often depending on the individual response of the patient. Treatment with canakinumab showed the best results, although was stopped due to high costs. [ABSTRACT FROM AUTHOR]
- Published
- 2023
17. Agreements and Discrepancies between FDA Reports and Journal Papers on Biologic Agents Approved for Rheumatoid Arthritis: A Meta-Research Project.
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Amarilyo, Gil, Furst, Daniel E., Woo, Jennifer M. P., Li, Wen, Bliddal, Henning, Christensen, Robin, and Tarp, Simon
- Subjects
- *
RHEUMATOID arthritis , *DRUG approval , *DRUG administration , *RHEUMATOID arthritis treatment , *HEALTH outcome assessment , *META-analysis , *PATIENTS - Abstract
Background: Sponsors that seek to commercialize new drugs apply to the Food and Drug Administration (FDA) which independently analyzes the raw data and reports the results on its website. Objectives: This study sought to determine if there are differences between the FDA assessments and journal reports on biologic agents developed for the treatment of rheumatoid arthritis. Methods: Available data on FDA-approved drugs were extracted from the website, and a systematic literature search was conducted to identify matching studies in peer-reviewed medical journals. Outcome measures were the American College of Rheumatology response criteria ACR20 (efficacy) and withdrawal due to adverse events (safety). As effect size odds ratios were estimated for each active trial arm vs. control arm (i.e. for both sources: FDA and journal report), followed by calculation of the ratios of the FDA and journal report odds ratios. A ratio of odds ratios not equal to 1 was categorized as a discrepancy. Results: FDA reports were available for 8 of 9 FDA-approved biologic agents for rheumatoid arthritis; all identified trials (34) except one were published in peer-reviewed journals. Overall, discrepancies were noted for 20 of the 33 evaluated trials. Differences in the apparent benefit reporting were found in 39% (24/61) pairwise comparisons and in 11 cases these were statistically significant; the FDA report showed greater benefit than the journal publication in 15 comparisons and lesser benefit in 9. Differences in the reported harms were found in 51% (28/55) pairwise comparisons and were statistically significant in 5. The “signal” in FDA reports showed a less harmful effect than the journal publication in 17 comparisons whereas a more harmful effect in 11. The differences were attributed to differences in analytic approach, patient inclusion, rounding effect, and counting discrepancies. However, no differences were categorized as critical. Conclusion: There was no empirical evidence to suggest biased estimates between the two sources. Increased and detailed transparency in publications would improve the understanding and credibility of published results. Further, the FDA report was found to be a useful source when data are missing in the published report (i.e. reporting bias). [ABSTRACT FROM AUTHOR]
- Published
- 2016
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18. Systematic Review of the Impact of Inflammatory Arthritis on Intimate Relationships and Sexual Function.
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Restoux LJ, Dasariraju SR, Ackerman IN, Van Doornum S, Romero L, and Briggs AM
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- Arthritis complications, Arthritis physiopathology, Humans, Sexual Dysfunctions, Psychological physiopathology, Sexual Dysfunctions, Psychological psychology, Arthritis psychology, Interpersonal Relations, Sexual Behavior, Sexual Dysfunctions, Psychological etiology, Sexuality
- Abstract
Objective: To systematically review evidence of the impact of inflammatory arthritis on, or association of inflammatory arthritis with, intimate relationships and sexual function., Methods: Ovid Medline, Ovid PsycINFO, Ovid Embase, and EBSCO CINAHL databases were searched. Two independent reviewers selected articles, extracted data, and conducted manual searches of reference lists from included studies and previous reviews. The quality of evidence was assessed using standard risk-of-bias tools., Results: Fifty-five eligible studies were reviewed. Of these, 49 (89%) were quantitative, 5 (9.1%) were qualitative, and 1 (1.8%) used a mixed-method design. Few quantitative studies were rated as low risk of bias (n = 7 [14%]), many were rated as moderate (n = 37 [74%]) or high risk (n = 6 [12%]). Quantitative study sample sizes ranged from 10 to 1,272 participants, with a reported age range 32-63 years. Qualitative study sample sizes ranged from 8 to 57 participants, with a reported age range 20-69 years. In studies reporting the Female Sexual Function Index, all inflammatory arthritis groups demonstrated mean scores ≤26.55 (range of mean ± SD scores: 14.2 ± 7.8 to 25.7 ± 4.7), indicating sexual dysfunction. In studies reporting the International Index of Erectile Function, all inflammatory arthritis groups reported mean scores ≤25 (range of mean ± SD scores: 16.0 ± 5.3 to 23.8 ± 7.0), indicating erectile dysfunction. Key qualitative themes were impaired sexual function and compromised intimate relationships; prominent subthemes included inflammatory arthritis-related pain and fatigue, erectile dysfunction, diminished sexual desire, and sexual function fluctuations according to disease activity., Conclusion: Sexual dysfunction appears highly prevalent among men and women with inflammatory arthritis, and increased clinician awareness of this impairment may guide provision of tailored education and support., (© 2019, American College of Rheumatology.)
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- 2020
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19. Clinical Evaluation of All Polyethylene Tibial Components in TKA -Review Paper
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Louis Keppler, Robert Kennon, H.S. Timothy McTighe, John Keggi, and Declan Brazil
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musculoskeletal diseases ,Economics and Econometrics ,medicine.medical_specialty ,business.industry ,Total knee arthroplasty ,Arthritis ,Forestry ,Avascular necrosis ,Osteoarthritis ,All polyethylene ,musculoskeletal system ,medicine.disease ,Surgery ,law.invention ,lcsh:RD701-811 ,lcsh:Orthopedic surgery ,Randomized controlled trial ,law ,Materials Chemistry ,Media Technology ,medicine ,Patella ,business ,human activities ,Clinical evaluation - Abstract
This review summarizes published literature that reports on clinical studies and/or randomized controlled trials from 1989 to end 2009 regarding the clinical performance history of several designs / brands of an all-polyethylene (AP) Tibial component used as part of a primary cemented Total Knee System implanted using established Total Knee Arthroplasty procedures. From the mid 1970’s knee systems for replacement of knees diagnosed with osteoarthritis, rheumatoid (inflammatory) arthritis, osteonecrosis, avascular necrosis and other degenerative joint conditions used a plastic tibial component articulating on a chrome - cobalt femoral component. Resurfacing of the patella if required also used a plastic artificial patella button attached surgically with PMMA bone cement. Projections of increase in TKA of +600% increase in annual surgeries over the next 15 years has focused significant interest in reconsideration of using this style tibial component in the growing elderly population. Key Words: Total Knee Arthroplasty, polyethylene, tibial component, clinical performance
- Published
- 2011
20. P10 CAPTURE JIA: paper data collection feasibility and acceptability pilot.
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McErlane, Flora, Smith, Nicola, Lunt, Laura, Smith, Andrew, Al-Abadi, Eslam, Bailey, Kathryn, Compeyrot-Lacassagne, Sandrine, McDonagh, Janet, Riley, Philip, Cleary, Gavin, and Thomson, Wendy
- Subjects
- *
CONFERENCES & conventions , *JUVENILE idiopathic arthritis , *CONTENT mining - Abstract
Background There is a challenging lack of evidence to inform best practice in the routine clinical care of juvenile idiopathic arthritis (JIA). Wide inter-centre variation in the definition and documentation of clinical data items is a major barrier to improvement. In response, we have developed a consensus agreed standardised core dataset called CAPTURE-JIA (n = 62 data items and a 'data dictionary' including agreed definitions of terms) designed to support routine collection of high-quality clinical data. The feasibility and acceptability of CAPTURE-JIA in clinical practice is not yet known and was the focus of this pilot study. Methods A purposeful sample of six paediatric rheumatology centres across England was invited to collect the CAPTURE-JIA dataset using paper collection forms (n = 20 patients/centre). The dataset was analysed for missing data. Six focus groups (n = 3-10) explored clinicians' views on acceptability and feasibility. Results One hundred and twenty-one patients were recruited over three months. The completeness of the dataset was similar across centres, with minor variations. The majority of data items (eg demographics, dates, ILAR type and examination) were >80% completed. However, 14/62 data items received >40% missing data. (Table 1) Further descriptive analyses highlighted incorrect completion of paper forms. Three themes emerged from the focus groups: problematic data items (missing from >10% forms at > 1 centre), format of clinician data forms and the role of digital data collection. Suggested solutions included minor changes to data item definitions and formatting. There were no refinements to the data items. Development of a digital data collection system was identified by all as essential. Due to a lack of clear consensus, the original CAPTURE forms included a number of ways to record joint count data. This proved confusing and a unanimous decision was taken to collect joint count data on all 83 joints in a tabular format. P10 Table 1: CAPTURE JIA data items with >40% missing data Data item % forms with data item missing (if item required) Relevant co-morbidities? 60 Macrophage activation syndrome? 100 Has the ILAR subtype changed? 50 Morning stiffness lasting >15 minutes? 42 History of any form of uveitis? 52 Date started uveitis mediation? 50 Strength of uveitis medication? 83 Counselled prior to new DMARD / biologic? 56 Enrolled in BECS/BCRD if new DMARD / biologic? 48 Joint count (homunculus or table format) 48 Physician assessment of systemic disease activity (VAS) 75 ESR 74 CRP 92 Plasma viscosity 100 Data item % forms with data item missing (if item required) Relevant co-morbidities? 60 Macrophage activation syndrome? 100 Has the ILAR subtype changed? 50 Morning stiffness lasting >15 minutes? 42 History of any form of uveitis? 52 Date started uveitis mediation? 50 Strength of uveitis medication? 83 Counselled prior to new DMARD / biologic? 56 Enrolled in BECS/BCRD if new DMARD / biologic? 48 Joint count (homunculus or table format) 48 Physician assessment of systemic disease activity (VAS) 75 ESR 74 CRP 92 Plasma viscosity 100 P10 Table 1: CAPTURE JIA data items with >40% missing data Data item % forms with data item missing (if item required) Relevant co-morbidities? 60 Macrophage activation syndrome? 100 Has the ILAR subtype changed? 50 Morning stiffness lasting >15 minutes? 42 History of any form of uveitis? 52 Date started uveitis mediation? 50 Strength of uveitis medication? 83 Counselled prior to new DMARD / biologic? 56 Enrolled in BECS/BCRD if new DMARD / biologic? 48 Joint count (homunculus or table format) 48 Physician assessment of systemic disease activity (VAS) 75 ESR 74 CRP 92 Plasma viscosity 100 Data item % forms with data item missing (if item required) Relevant co-morbidities? 60 Macrophage activation syndrome? 100 Has the ILAR subtype changed? 50 Morning stiffness lasting >15 minutes? 42 History of any form of uveitis? 52 Date started uveitis mediation? 50 Strength of uveitis medication? 83 Counselled prior to new DMARD / biologic? 56 Enrolled in BECS/BCRD if new DMARD / biologic? 48 Joint count (homunculus or table format) 48 Physician assessment of systemic disease activity (VAS) 75 ESR 74 CRP 92 Plasma viscosity 100 Conclusion Paper collection of the CAPTURE-JIA data items is feasible and acceptable in the routine clinical setting, but unlikely to be sustainable in the longer term if collected in duplicate with medical notes. A digital tool in the clinical domain, ideally interlocking with local systems, would offer many advantages, including more complete and time-efficient data collection. Conflicts of Interest The authors declare no conflicts of interest. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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21. Therapeutic effect of Periploca forrestii on collagen-induced arthritis in rats through JAK2/Nf-κB pathway.
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Zhenyi Zhang, Yingchun Li, Jian Wu, Jihong Zhang, Ning Chen, and Ning Zhang
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RATS ,COLLAGEN-induced arthritis ,PATHOLOGICAL physiology ,TREATMENT effectiveness ,X-ray computed microtomography ,RHEUMATOID arthritis ,SCARS - Abstract
Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects the body. Periploca forrestii was a miao ethnic drug in China that was used to treat arthritis for hundreds of years. But, the therapeutic mechanism is so far unknown. Therefore, the chemical component and effect of Periploca forrestii on arthritis in rats were studied using HPLC-QTOF MS, micro-CT, and other experiments in this paper. Method: Male Sprague-Dawley rats were used to assess the in vivo activity. HPLC QTOF-MS was used to analyze the chemical profile of the P. forrestii (PF). Bovine type II collagen and Complete Freund's Adjuvant were used to stimulate and construct the collagen-induced arthritis (CIA) model. Three dosages of PF (100 mg/kg, 200 mg/kg, 400 mg/kg) were used to evaluate in vivo activity. Methotrexate was used as the positive drug. H/E staining and micro-CT methods were used to monitor the pathological changes of CIA rats. ELISA method was used to assess the serum level of immune- and inflammationrelated cytokines. Immunohistochemical experiments were used to test the gene expression in JAK and Nf-B pathways. Results: 42 compounds were identified from PF. PF administration lowered the increased spleen index compared with that of control and MTX groups, and partially restored body weight, reduced paw swelling, and arthritis score compared with the model group. Macroscopic assessment indicated inflamed paw with significant swelling in the model group, while the extent of inflammation and swelling was attenuated by both MTX and PF. H/E staining experiments demonstrated that pathological changes of synovial cells and infiltration of inflammatory cells were observed in the model group. In contrast, the MTX and PF treatment partially reversed these pathological changes. Micro-CT examination showed severe injuries and scars caused by inflammation for the model group, and in the high-dosage group (400 mg/kg) the inflammationcaused injuries and scars were dramatically ameliorated. Mechanism study showed that PF restored Nf-B phosphorylation and JAK2 expression compared with the model group. Conclusion: P. forrestii possesses a potent effect on CIA rats. Nf-B and JAK2 pathways are involved in its protective effect on CIA. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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22. Lack of pulmonary involvement leads to a 3 years delay of diagnosis in a childhood sarcoidosis case with arthritis, ocular symptoms, and bilateral parotid swelling.
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Fatih, Mohammed Taib, Saleh, Renaz Sabir, Majeed, Truska Faraidun, and Mahmood, Mohammed Khalid
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DELAYED diagnosis ,SARCOIDOSIS ,MEDICAL personnel ,SYMPTOMS ,ARTHRITIS ,DIFFERENTIAL diagnosis - Abstract
Key Clinical Message: This paper presents a rare sarcoidosis case in a child of 12 years of age presented with arthritis, bilateral parotid enlargement and ocular, but unfortunately the diagnosis has been missed due to lack of pulmonary involvement. Diagnosis of sarcoidosis is by exclusion, and sometimes, it can be challenging. This paper presents a rare sarcoidosis case in a child of 12 years of age presented with bilateral parotid enlargement. The signs of musculoskeletal and ocular involvement were present before the parotid enlargement, and the parotid swelling persisted for 3 years; but unfortunately the definite diagnosis has been missed by the previous healthcare professionals most probably due to the rarity of the situation, especially lack of pulmonary involvement. Therefore, cooperation between different healthcare specialties is important for an effective diagnosis and management. Despite its rarity, sarcoidosis should always be present in the list of differential diagnosis when encountering multisystem entities like arthritis, ocular symptoms and parotid swelling. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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23. New paper gets thumbs up.
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RAISON, LAURA
- Subjects
- *
FINGERS , *WRIST , *ARTHRITIS , *SUFFERING - Abstract
You see, suffering from stiff fingers and wrists from arthritis at my age, holding the page open became painful and tiring. When the magazine's binding and paper were stiffened and thickened a while ago, I nearly cancelled my subscription. [Extracted from the article]
- Published
- 2023
24. Dehydroevodiamine suppresses inflammatory responses in adjuvant-induced arthritis rats and human fibroblast-like synoviocytes
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San-Shan He, Linchong Su, Qing-Chao Wu, Jiao-E Sheng, Yun-Long Wang, and Yu-Fang Dai
- Subjects
musculoskeletal diseases ,rheumatoid arthritis ,Cell Survival ,p38 mitogen-activated protein kinases ,Freund's Adjuvant ,Anti-Inflammatory Agents ,Arthritis ,Pannus ,Bioengineering ,Matrix metalloproteinase ,Pharmacology ,Applied Microbiology and Biotechnology ,Proinflammatory cytokine ,Cell Line ,Alkaloids ,medicine ,Animals ,Humans ,dehydroevodiamine ,Fibroblast ,mapk ,Cell Proliferation ,business.industry ,Body Weight ,General Medicine ,mh7a ,medicine.disease ,Arthritis, Experimental ,Synoviocytes ,Matrix Metalloproteinases ,Rats ,Disease Models, Animal ,medicine.anatomical_structure ,Gene Expression Regulation ,Rheumatoid arthritis ,aia ,Cytokines ,Tumor necrosis factor alpha ,Female ,business ,TP248.13-248.65 ,Research Article ,Research Paper ,Biotechnology - Abstract
Dehydroevodiamine (DHE) is an effective natural active substance extracted from Euodiae Fructus, which is a widely used herbal drug in traditional Chinese medicine. The focus of this study was to test the possibility of using DHE in the treatment of rheumatoid arthritis (RA) diseases. A rat model of adjuvant-induced arthritis (AIA) was generated using Complete Freund’s Adjuvant (CFA). Body weight changes, arthritis scores, ankle pathology, tumor necrosis factor-alpha (TNF-α), interleukin-1β(IL-1β), interleukin-6 (IL-6), and interleukin-17 (IL-17) secretion, as well as matrix metalloproteinase (MMP) expression in joint tissue, were measured as indicators of viability of DHE medicated AIA rats. Human fibroblast-like synoviocytes (MH7A cells) were connected to check these impacts. The results confirmed that DHE administration had an excellent therapeutic impact on the AIA rat model, substantially relieving joint swelling, inhibiting synovial pannus hyperplasia, and decreasing joint scores. In addition, the serum enzyme-linked immunosorbent assay (ELISA) showed that DHE treatment reduced the expression of pro-inflammatory factors in AIA rats. The immunohistochemical results showed that DHE treatment could reduce the synthesis of MMPs such as matrix metalloproteinase-1(MMP-1) and matrix metalloproteinase-3 (MMP-3) in the ankle tissue of AIA rats. In vitro, DHE inhibited cell proliferation, mRNA transcription, protein synthesis of proinflammatory factors such as IL-1βand IL-6, and matrix metalloproteinases such as MMP-1 and MMP-3. Furthermore, DHE inhibited the phosphorylation levels of p38, JNK, and ERK proteins in TNF-α-treated MH7A cells.This work assessed the effect of DHE in AIA rats and revealed its mechanism in vitro.
- Published
- 2022
25. β-arrestin-2 alleviates rheumatoid arthritis injury by suppressing NLRP3 inflammasome activation and NF- κB pathway in macrophages
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Feng Cao, Jiwei Cheng, Cheng Huang, and Zhaochun He
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Male ,musculoskeletal diseases ,rheumatoid arthritis ,Genetic Vectors ,Arthritis ,Bioengineering ,Inflammation ,Pharmacology ,Applied Microbiology and Biotechnology ,Pyrin domain ,Arthritis, Rheumatoid ,Mice ,chemistry.chemical_compound ,Downregulation and upregulation ,NLR Family, Pyrin Domain-Containing 3 Protein ,Animals ,Medicine ,nf-κb ,nlrp3 ,business.industry ,Macrophages ,β-arrestin-2 ,NF-kappa B ,Inflammasome ,NF-κB ,General Medicine ,Dependovirus ,medicine.disease ,beta-Arrestin 2 ,Disease Models, Animal ,RAW 264.7 Cells ,Treatment Outcome ,medicine.anatomical_structure ,chemistry ,Rheumatoid arthritis ,Cytokines ,Collagen ,medicine.symptom ,Ankle ,business ,TP248.13-248.65 ,Signal Transduction ,Research Article ,Research Paper ,medicine.drug ,Biotechnology - Abstract
Rheumatoid arthritis (RA) is a chronic inflammatory joint disorder that inflicts damage to the joints of the hands and wrist. The aim of this study was to investigate the protective effect of β-Arrestin-2 (βArr2) on RA in vivo and in vitro. The βArr2 adenovirus (βArr2-Ad) or the control (Con-Ad) was injected into the ankle joint cavity of collagen-induced arthritis (CIA) mice. According to the results, an improvement was shown in the symptoms and pathological injury of RA after an upregulation of βArr2. Correspondingly, the inflammatory response was attenuated, as evidenced by the decreased serum pro-inflammatory cytokines levels and NF-κB pathway-related proteins. Nucleotide-binding domain leucine-rich repeat and pyrin domain containing receptor 3 (NLRP3) inflammasome activation was inhibited in CIA mice treated with βArr2-Ad injection, as reflected by the diminished IL-18 level and declined protein levels of ankle inflammasome components in the ankle joint. Likewise, the anti-inflammatory effect of macrophages was also validated by in vitro experiments. In summary, βArr2 effectively ameliorates ankle inflammation in CIA mice via NF-κB/NLRP3 inflammasome, providing theoretical and clinical basis for RA therapy.Key wordsRheumatoid arthritis; β-arrestin-2; NF-κB; NLRP3.
- Published
- 2022
26. Current and Future Challenges for Rehabilitation for Inflammatory Arthritis.
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Moe, Rikke Helene and Vliet Vlieland, Thea P. M.
- Subjects
HEALTH care teams ,MUSCULOSKELETAL system diseases ,REHABILITATION ,RHEUMATISM ,ARTHRITIS - Abstract
This narrative review discusses the importance of rehabilitation in rheumatic and musculoskeletal diseases (RMDs), ultimately aiming to reduce their impact on individuals and society. It specifically emphasizes the need for rehabilitation in inflammatory arthritis (IA), particularly in cases where medical management is insufficient. It acknowledges that the complexity of rehabilitation demands a flexible approach. Thereby, it touches on the various models of rehabilitation, which may include multidisciplinary team care, extended practice models, shared care, remote care, and work rehabilitation. It discusses the challenges in research, practice, and policy implementation. In research, the need for innovative research designs is highlighted, whereas regarding clinical practice the importance of early detection of disability and patient engagement is underlined, as well as the role of telehealth and AI in reshaping the rehabilitation landscape. Financial barriers and work force shortages are identified as challenges that hinder the effective delivery of rehabilitative care. On the policy level, this paper suggests that the allocation of healthcare resources often prioritizes acute conditions over chronic diseases, leading to disparities in care. This paper concludes by emphasizing the critical role of evidence-based rehabilitation in improving the quality of life for people with RMDs, in particular for those with IA, and promoting their healthy aging. It also calls for tailored rehabilitation models and the early identification of persons with rehabilitation needs as future challenges in this field. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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27. Psychometric characteristics of the health care empowerment questionnaire in a sample of patients with arthritis and rheumatic conditions
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Karen E. Schifferdecker, Kathleen L. Carluzzo, Emily Creek, Erin Knight, Guy Eakin, and Rebecca L. Butcher
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psychometrics ,Medicine (General) ,Psychometrics ,media_common.quotation_subject ,patient‐reported experience measures ,03 medical and health sciences ,R5-920 ,0302 clinical medicine ,Rheumatic Diseases ,Surveys and Questionnaires ,Nominal group technique ,Health care ,Humans ,030212 general & internal medicine ,Patient participation ,Empowerment ,media_common ,Face validity ,health care empowerment questionnaire ,business.industry ,030503 health policy & services ,Arthritis ,Public Health, Environmental and Occupational Health ,Reproducibility of Results ,Focus group ,Confirmatory factor analysis ,Original Research Paper ,empowerment ,validation study ,Public aspects of medicine ,RA1-1270 ,Patient Participation ,0305 other medical science ,Psychology ,business ,Original Research Papers ,Clinical psychology - Abstract
Background Patient empowerment can improve health‐related outcomes and is important in chronic conditions, such as arthritis. This study aimed to validate the Health Care Empowerment Questionnaire (HCEQ), a patient‐reported experience measure of empowerment, for use with patients with arthritis and other rheumatic diseases. Methods The HCEQ measures Patient Information Seeking (or Involvement in Decisions) and Healthcare Interaction Results (or Involvement in Interactions) and asks respondents to answer questions in two ways: whether they feel something happened and its importance to them. Face validity was assessed through qualitative data (n = 8, nominal group technique; n = 55, focus groups). Measure structure was assessed through confirmatory factor analysis (CFA); internal consistency was also assessed (n = 9226). Test‐retest reliability was assessed with sub‐sample of participants (n = 182). Results We found adequate face validity of the HCEQ for patients with arthritis. The CFA indicated good fit to the data for the two‐factor structure of the HCEQ (RMSEA = 0.075; CFI = 0.987; TLI = 0.978; SRMR = 0.026). Internal consistency was strong (α=0.94 for both subscales). Test‐retest reliability was moderate for Patient Information Seeking (ICC=0.67) and good for Healthcare Interaction Results (ICC=0.77). Conclusions The HCEQ, with modifications, demonstrated promising psychometric properties within this sample, laying the foundation for further assessment. This work supports the HCEQ as an appropriate instrument for examining experiences with and perceived importance of empowerment in individuals with arthritis and other rheumatic conditions. Patient Contribution Patients contributed to the assessment of face validity. As a measure of patient empowerment, the HCEQ’s use can enable further participation of patients in health care.
- Published
- 2021
28. Writing papers.
- Author
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Hart, F. Dudley
- Subjects
RHEUMATOLOGY ,ARTHRITIS ,THERAPEUTICS ,ETIOLOGY of diseases ,PERIODICAL publishing - Abstract
The article compares research papers on rheumatological studies appeared in several journals during different periods of time. The first volume of "The Annals of the Rheumatic Diseases," which appeared in 1939, featured three articles on viral causes of arthritis. Two therapeutic and four clinical papers were published in the April 1991 issue of the Annals. Information on the design of the papers published in the "British Medical Journal" is also presented.
- Published
- 1993
29. Correlation between environmental nickel exposure and the development of arthritis: A large-sample cross-sectional investigation.
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Di J, Song L, Chen T, Di Y, Guo Z, Chen S, and Xiang C
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- Humans, Female, Male, Cross-Sectional Studies, Middle Aged, Aged, Adult, Nutrition Surveys, Environmental Pollutants urine, Prevalence, Nickel urine, Arthritis epidemiology, Arthritis chemically induced, Environmental Exposure statistics & numerical data
- Abstract
Background: Nickel is a common metallic element in orthopedic implanted devices and living environment exposures. It is associated with varieties of diseases. The purpose of this investigation was to explore the correlation between nickel exposure and the prevalence of arthritis., Methods: Data were obtained from the National Health and Nutrition Examination Survey (NHANES) database from 2017 to 2018. Multivariate logistic regression was utilized to analyze the relationship between urinary nickel levels and arthritis. In addition, hierarchical modeling further explored the interactions and trends between urinary nickel levels and arthritis. Propensity score matching (PSM) method was used to reduce the effect of confounders. Additionally, restricted cubic spline curve (RCS) was used to assess the possible nonlinear association between urinary nickel and arthritis., Results: The investigation was comprised of 139 arthritis patients and 547 healthy participants. After correction by PSM, there was a positive correlation between arthritis and Nickel exposure levels. The risk of developing arthritis was significantly increased when nickel exposure levels were in the Q4 interval (OR=2.25, 95 % CI=1.03-5.02). When stratified by age and sex, nickel exposure was significantly and positively associated with arthritis in the subgroup aged over 65 years. (OR=2.78,95 %CI=1.20-6.46). Also, the difference between nickel exposure and arthritis was significant in the different gender subgroups (interaction P<0.05). Restricted cubic spline (RCS) results showed a significant linear association between nickel exposure levels and arthritis. In addition, there was a non-linear association between nickel exposure and arthritis across gender and age subgroups., Conclusion: A significant positive association between nickel exposure levels and arthritis was showed by the experimental data. Controlling the use of nickel-containing medical prostheses and reducing exposure to nickel-containing daily necessity could help to slow the onset of arthritis., Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Chuan Xiang reports financial support was provided by Central Guidance of Local Science and Technology Development Funds. Chuan Xiang reports financial support was provided by Shanxi Provincial Scientific and Technological Achievement Transformation Guidance Special Program. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024. Published by Elsevier Inc.)
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- 2024
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30. IL-23 orchestrating immune cell activation in arthritis
- Author
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Najm, Aurelie and McInnes, Iain B.
- Subjects
medicine.medical_treatment ,Arthritis ,Inflammation ,Interleukin-23 ,Immune system ,Rheumatology ,IL-23 ,Interleukin 23 ,Animals ,Humans ,Medicine ,interleukin 23 ,Pharmacology (medical) ,Molecular Targeted Therapy ,AcademicSubjects/MED00360 ,business.industry ,Acquired immune system ,medicine.disease ,immunity ,cytokines ,Cytokine ,arthritis ,inflammation ,Supplement Papers ,Immunology ,Interleukin 12 ,Interleukin 17 ,medicine.symptom ,business - Abstract
IL-23 is a cytokine member of the IL-12 superfamily. These heterodimeric cytokines offer broad immune regulatory activity with potential effector function in inflammatory arthritis. IL-23 is a pro-inflammatory cytokine secreted by dendritic cells and macrophages. It plays a key role in both innate and adaptive immunity. By promoting and maintaining T cell differentiation into Th17 T cells, IL-23 is a key player in the pathogenesis of rheumatic diseases. Data from pre-clinical IL-23 knockout models show the major importance of IL-23 in development of arthritis. The induction and maintenance of type 17 cells, which secrete IL-17A and other pro-inflammatory cytokines, contributes to local synovial inflammation and skin inflammation in PsA, and perhaps in RA. Commensurate with this, therapeutic strategies targeting IL-23 have proven efficient in PsA in several studies, albeit not yet in RA.
- Published
- 2021
31. The use of radiosynovectomy in patients with juvenile idiopathic arthritis. Assessment of treatment efficacy and safety
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Lidia Rutkowska-Sak, Jarosław B. Ćwikła, Piotr Gietka, Izabela Szczygielska, Agnieszka Gazda, Beata Kołodziejczyk, and Elżbieta Hernik
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medicine.medical_specialty ,intraarticular injection ,Immunology ,Arthritis ,Knee Joint ,Pain visual analogue scale ,Rheumatology ,local treatment ,Internal medicine ,radiosynovectomy ,medicine ,Immunology and Allergy ,Juvenile ,Gait disorders ,In patient ,Original Paper ,business.industry ,medicine.disease ,Treatment efficacy ,Joint pain ,juvenile idiopathic arthritis ,Medicine ,medicine.symptom ,business - Abstract
IntroductionThe aim of the study was to evaluate the usefulness of knee joint radiosynovectomy (RS) in patients suffering from juvenile idiopathic arthritis (JIA).Material and methodsOne hundred RS procedures performed in 58 patients with JIA in average age 10.4 years were evaluated.ResultsAfter 6 weeks, a decrease in the number of cases with joint pain from 90.3% to 29%, with joint oedema from 100% to 74.5%, with joint exudate from 100% to 60.6%, with gait disorders from 19.4% to 3.2%, with joint mobility disorders from 51.1% to 26.6% in the RS cases was observed. A reduction of the score in the Colorado scale from 10.9 to 4.66, in the pain visual analogue scale (VAS) from 50 to 10, in the illness VAS assessed by the patient/parent from 69.9 to 32.4, in the illness VAS assessed by the physician from 68.8 to 36.9 was observed. Six months after the RS procedure, a reduction in the number of cases with joint pain from 89.5% prior to the procedure to 29.5%, with oedema from 100% to 58.3%, with exudate from 100% to 46.9%, with gait disorders from 20% to 2.1%, with joint motility disorders from 51.1% to 26.1% was achieved. The score in the Colorado scale was reduced from 10.9 to 4.04, in the pain VAS from 40 to 0, in the illness VAS assessed by the patient/parent from 69.7 to 27.9, in the illness VAS assessed by the physician from 68.8 to 32.4. In ultrasound examinations, the greatest improvement compared to the initial condition was recorded in the 6th month after the RS. Radiosynovectomy was positively evaluated by parents and patients in 34 anonymous surveys. Early and late observations (average 1473 days) did not show lesions at the isotope injection site, and no neoplastic lesions were observed.ConclusionsRadiosynovectomy is a valuable therapeutic option for local treatment in patients with JIA.
- Published
- 2021
32. Appropriating and asserting power on inflammatory arthritis teams: A social network perspective
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Annette M. McKinnon, Laura Nimmon, Linda C. Li, Wendy Hartford, and Catherine L. Backman
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media_common.quotation_subject ,Psychological intervention ,Social Networking ,power ,03 medical and health sciences ,0302 clinical medicine ,Nursing ,Multidisciplinary approach ,treatment decisions ,Agency (sociology) ,Health care ,Humans ,Assertiveness ,030212 general & internal medicine ,Disadvantage ,Qualitative Research ,identity ,inflammatory arthritis ,media_common ,lcsh:R5-920 ,Social network ,business.industry ,030503 health policy & services ,Arthritis ,Communication ,lcsh:Public aspects of medicine ,Public Health, Environmental and Occupational Health ,lcsh:RA1-1270 ,illness stories ,Original Research Paper ,agency ,Thematic analysis ,Patient Participation ,0305 other medical science ,business ,Psychology ,lcsh:Medicine (General) ,Decision Making, Shared ,Original Research Papers ,control - Abstract
Background Therapeutic interventions for people with inflammatory arthritis (IA) increasingly involve multidisciplinary teams and strive to foster patient-centred care and shared decision making. Participation in health-care decisions requires patients to assert themselves and negotiate power in encounters with clinicians; however, clinical contexts often afford less authority for patients than clinicians. This disadvantage may inhibit patients' involvement in their own health care. Objective To identify communication attributes, IA patients use to influence and negotiate their treatment with members of their health-care network. Method A qualitative social network approach was used to analyse data from a larger study that investigated IA patients' overall experiences of multidisciplinary care. Fourteen patients with IA attended individual semi-structured interviews. Researchers used thematic analysis to identify patterns of assertiveness and influence in the data. Results Participants experienced loss of identity, control and agency in addition to the physical symptoms of IA. However, they had a sense of personal responsibility for managing their health care. Perceptions of health-care team support enhanced patients' influence in treatment negotiations. Notably, there appeared to be an underlying tension between being empowered or disempowered. Discussion and conclusions The findings have significant implications for treatment decision communication approaches to IA care. A social network perspective may provide a pathway for clinicians to better understand the complexities of communication with their patients. This approach may reduce unequal power dynamics that occur within clinician/patient interactions and afford people with IA agency, control and affirmation of identity within their health-care network.
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- 2020
33. miR-let-7c-5p and miR-149-5p inhibit proinflammatory cytokine production in osteoarthritis and rheumatoid arthritis synovial fibroblasts
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Wei Fang Lee, Yen You Lin, Min Huan Wu, Chin Jung Hsu, Ju Fang Liu, Chun-Hao Tsai, Chih-Hsin Tang, Chien-Chung Huang, and Yat-Yin Law
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rheumatoid arthritis ,Aging ,medicine.medical_treatment ,Interleukin-1beta ,Anti-Inflammatory Agents ,Arthritis ,Inflammation ,Proinflammatory cytokine ,Arthritis, Rheumatoid ,medicine ,Humans ,miR-let-7c-5p ,Interleukin 6 ,biology ,Interleukin-6 ,Tumor Necrosis Factor-alpha ,business.industry ,Anti-Inflammatory Agents, Non-Steroidal ,Synovial Membrane ,Cell Biology ,Fibroblasts ,medicine.disease ,miR-149-5p ,MicroRNAs ,osteoarthritis ,Cytokine ,inflammation ,Rheumatoid arthritis ,Celecoxib ,Cancer research ,biology.protein ,Cytokines ,Tumor necrosis factor alpha ,medicine.symptom ,business ,Research Paper ,medicine.drug - Abstract
Osteoarthritis (OA) and rheumatoid arthritis (RA) are two of the most common types of arthritis. Both are characterized by the infiltration of a number of proinflammatory cytokines into the joint microenvironment. miRNAs play critical roles in the disease processes of arthritic disorders. However, little is known about the effects of miRNAs on critical inflammatory cytokine production with OA and RA progression. Here, we found higher levels of proinflammatory cytokines including interleukin 1 beta (IL-1β), interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) in human OA and RA synovial fibroblasts (SFs) compared with normal SFs. Searches of open-source microRNA (miRNA) software determined that miR-let-7c-5p and miR-149-5p interfere with IL-1β, IL-6 and TNF-α transcription; levels of all three proinflammatory cytokines were lower in human OA and RA patients compared with normal controls. Anti-inflammatory agents dexamethasone, celecoxib and indomethacin reduced proinflammatory cytokine production by promoting the expression of miR-let-7c-5p and miR-149-5p. Similarly, ibuprofen and methotrexate also enhanced miR-let-7c-5p and miR-149-5p expression in human SFs. The evidence suggests that increasing miR-let-7c-5p and miR-149-5p expression is a novel strategy for OA and RA.
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- 2021
34. A Tribological Comparison of Facet Joint, Sacroiliac Joint, and Knee Cartilage in the Yucatan Minipig
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Rachel C. Nordberg, M. Gabriela Espinosa, Kyriacos A. Athanasiou, and Jerry C. Hu
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Cartilage, Articular ,musculoskeletal diseases ,Facet (geometry) ,Knee Joint ,Swine ,Medical Biotechnology ,Clinical Sciences ,0206 medical engineering ,Biomedical Engineering ,Physical Therapy, Sports Therapy and Rehabilitation ,02 engineering and technology ,Zygapophyseal Joint ,Yucatan Minipig ,Facet joint ,03 medical and health sciences ,0302 clinical medicine ,facet joint ,sacroiliac joint ,Back pain ,medicine ,Animals ,Humans ,Immunology and Allergy ,Miniature ,Clinical Research papers ,Orthodontics ,Sacroiliac joint ,business.industry ,Arthritis ,Sacroiliac Joint ,interferometry ,Tribology ,musculoskeletal system ,020601 biomedical engineering ,Knee cartilage ,Cartilage ,medicine.anatomical_structure ,Musculoskeletal ,tribology ,Swine, Miniature ,lubricin ,medicine.symptom ,business ,030217 neurology & neurosurgery ,Articular - Abstract
Objective Pathology of the facet and sacroiliac (SI) joints contributes to 15% to 45% and 10% to 27% of lower back pain cases, respectively. Although tissue engineering may offer novel treatment options to patients suffering from cartilage degeneration in these joints, the tribological characteristics of the facet and SI joints have not been studied in either the human or relevant large animal models, which hinders the development of joint-specific cartilage implants. Design Cartilage was isolated from the knee, cervical facet, thoracic facet, lumbar facet, and SI joints of 6 skeletally mature Yucatan minipigs ( Sus scrofa). Tribological characteristics were assessed via coefficient of friction testing, interferometry, and immunohistochemistry for lubricin organization. Results Compared with the knee, the coefficient of friction was higher by 43% in the cervical facet, 77% in the thoracic facet, 37% in the lumbar facet, and 28% in the SI joint. Likewise, topographical features of the facet and SI joints varied significantly, ranging from a 114% to 384% increase and a 48% to 107% increase in global and local surface roughness measures, respectively, compared with the knee. Additionally, the amount of lubricin in the SI joint was substantially greater than in the knee. Statistical correlations among the various tribological parameters revealed that there was a significant correlation between local roughness and coefficient of friction, but not global roughness or the presence of lubricin. Conclusion These location-specific tribological characteristics of the articular cartilages of the spine will need to be taken into consideration during the development of physiologically relevant, functional, and durable tissue-engineered replacements for these joints.
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- 2021
35. Gender differences in activity-limiting pain trajectories over a 17-year period in the Mexican Health and Aging Study
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Rebeca Wong, Bret T. Howrey, Martin A. Rodriguez, Sadaf Arefi Milani, and Rafael Samper-Ternent
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Mexican Health and Aging Study ,Adult ,Male ,Aging ,Arthritis ,Pain ,Odds ,Sex Factors ,Quality of life ,Negatively associated ,Medicine ,Humans ,Longitudinal Studies ,Mexico ,Aged ,business.industry ,Limiting ,Middle Aged ,medicine.disease ,Obesity ,Confidence interval ,Anesthesiology and Pain Medicine ,Neurology ,gender differences ,Older adults ,Quality of Life ,Female ,Neurology (clinical) ,business ,Demography ,Research Paper - Abstract
Supplemental Digital Content is Available in the Text. Older Mexicans had 2 trajectories of activity-limiting pain (low-stable and moderate-increasing) over 17 years. Compared with men, women were more likely to have moderate-increasing pain., Pain increases with age, disproportionately affects women, and is a major contributor to decreased quality of life. Because pain is dynamic, trajectories are important to consider. Few studies have examined longitudinal trajectories of pain, by gender, in Mexico. We used data from 5 waves (over 2001–2018) of the Mexican Health and Aging Study, a nationally representative sample of Mexicans aged 50 years and older. Pain was categorized as self-reported frequent pain that makes it difficult to do usual activities. Latent class mixture models were used to create pain trajectories (n = 9824). The sample was majority female (56.15%), with a mean age of 61.72 years. We identified 2 pain trajectories: low-stable (81.88%) and moderate-increasing (18.12%). Women had 1.75 times the odds of being in the moderate-increasing group compared with men (95% confidence interval= 1.41, 2.17). In addition, having zero years of education was associated with higher odds of being in the moderate-increasing group, compared with having any years of education. Fair/poor self-rated health, obesity, arthritis, elevated depressive symptoms, and falls were positively associated with pain for both trajectory groups. Being married was positively associated with pain in the low-stable group. Insurance status was negatively associated with pain in the low-stable group, but positively associated with pain in the moderate-increasing group. We identified 2 trajectories of activity-limiting pain, among older Mexican adults (50+) over 17 years of follow-up. Understanding gender differences in pain trajectories in later life and the factors associated with trajectory development is crucial to improve quality of life, especially in vulnerable populations.
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- 2021
36. Altered sensory innervation and pain hypersensitivity in a model of young painful arthritic joints: short- and long-term effects
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Luke La Hausse De Lalouviere, Oscar Morice, and Maria Fitzgerald
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musculoskeletal diseases ,Male ,Aging ,medicine.medical_specialty ,Neurology ,Adolescent ,Inflammatory pain ,Calcitonin Gene-Related Peptide ,Freund's Adjuvant ,Immunology ,Pain ,Inflammation ,Calcitonin gene-related peptide ,Joint afferents ,Injections, Intra-Articular ,Rats, Sprague-Dawley ,03 medical and health sciences ,Nerve Fibers ,0302 clinical medicine ,Neurofilament Proteins ,medicine ,Animals ,JIA ,Pain Measurement ,Pediatric ,030203 arthritis & rheumatology ,Pharmacology ,business.industry ,Arthritis ,Nociceptor ,Chronic pain ,medicine.disease ,Original Research Paper ,Disease Models, Animal ,Nociception ,medicine.anatomical_structure ,Hyperalgesia ,Touch ,Anesthesia ,Ankle ,medicine.symptom ,business ,Free nerve ending ,Ankle Joint ,030217 neurology & neurosurgery - Abstract
Background Early life experience can cause long-term alterations in the nociceptive processes underlying chronic pain, but the consequences of early life arthritic joint inflammation upon the sensory innervation of the joint is not known. Here, we measure pain sensitivity and sensory innervation in a young, juvenile and adult rodent model of arthritic joints and test the consequences of joint inflammation in young animals upon adult arthritic pain and joint innervation. Methods Unilateral ankle joint injections of complete Freund’s adjuvant (CFA) (6−20 µl) were performed in young, postnatal day (P)8, adolescent (P21) and adult (P40) rats. A separate cohort of animals were injected at P8, and again at P40. Hindpaw mechanical sensitivity was assessed using von Frey monofilaments (vF) for 10 days. Nerve fibres were counted in sections through the ankle joint immunostained for calcitonin gene-related peptide (CGRP) and neurofilament 200 kDa (NF200). Results Ankle joint CFA injection increased capsular width at all ages. Significant mechanical pain hypersensitivity and increased number of joint CGRP + ve sensory fibres occurred in adolescent and adult, but not young, rats. Despite the lack of acute reaction, joint inflammation at a young age resulted in significantly increased pain hypersensitivity and CGRP+ fibre counts when the rats were re-inflamed as adults. Conclusions Joint inflammation increases the sensory nociceptive innervation and induces acute pain hypersensitivity in juvenile and adult, but not in young rats. However, early life joint inflammation ‘primes’ the joint such that adult inflammatory pain behaviour and nociceptive nerve endings in the joint are significantly increased. Early life joint inflammation may be an important factor in the generation and maintenance of chronic arthritic pain.
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- 2021
37. Global Trends in Research of Gouty Arthritis Over Past Decade: A Bibliometric Analysis.
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Deng, Pin, Wang, Shulong, Sun, Xiaojie, Qi, Yinze, Ma, Zhanhua, Pan, Xuyue, Liang, Huan, Wu, Junde, and Chen, Zhaojun
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ARTHRITIS ,BIBLIOMETRICS ,CHINESE medicine ,CITATION indexes - Abstract
Gouty arthritis (GA), as a multifactorial disease, is characterised by intense pain, active inflammation symptoms, and swollen joints. It has utterly complex pathogenesis, of which the amount of research publications on GA has increased during the last few decades. A bibliometric analysis was carried out to investigate the trends, frontiers, and hot spots in global scientific output in GA research over the last decade. We retrieved the Science Citation Index Expanded (SCI-Expanded) of the Web of Science Core Collection (WoSCC) for publications and recorded information published from 2012 to 2021. we carried out the bibliometric analysis and visualisation analysis of the overall distribution of annual outputs, leading countries, active institutions, journals, authors, co-cited references, and keywords with the VOSviewer and CiteSpace. The impact and quality of papers were assessed using a global citation score (GCS). We retrieved 2052 articles and reviews in total. The annual number of publications (Np) related to GA research has increased during the latest decade. China published the most papers, and the USA achieved the highest H-index and number of citations (Nc). The League of European Research Universities (LERU) and Clinical Rheumatology (Clin Rheumatol) are the most productive institutions and periodicals. The total GCS of the paper written by Kottgen, A. in 2013 was 479, ranking the first. The most common keywords were "Gout," "hyperuricemia," and "gouty arthritis." This research revealed that though there was a slight fluctuation in publications related to GA, the Np raised on the whole. China was an enormous creator, and the USA was an influential nation in this domain. The top three contributor authors were Dalbeth, N., Singh, JA., and Choi, HK. There were few investigations on the treatment of GA by Chinese medicine monomer, and the "mechanism," "pathway", "nf- kappa-b", "injury", "receptor", and "animal model" were growing research hotspots. Our research illustrated the hotspots of research and development trends in the research field of GA during the last decade. Recognition of the most critical indicators (researchers, countries, institutes, and journals for the release of GA research), hotspots in the research field of GA can be helpful for countries, scholars, and policymakers in this field to understand GA better make decisions. [ABSTRACT FROM AUTHOR]
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- 2022
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38. Magnetic resonance imaging of the knee joint in juvenile idiopathic arthritis
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Emil Michalski, Piotr Gietka, Iwona Sudoł-Szopińska, and Monika Ostrowska
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musculoskeletal diseases ,medicine.medical_specialty ,Bursitis ,Immunology ,knee ,Arthritis ,Knee Joint ,magnetic resonance imaging ,03 medical and health sciences ,0302 clinical medicine ,children ,Rheumatology ,Synovitis ,medicine ,Immunology and Allergy ,030203 arthritis & rheumatology ,Review Paper ,Tenosynovitis ,medicine.diagnostic_test ,business.industry ,Enthesitis ,Magnetic resonance imaging ,medicine.disease ,juvenile idiopathic arthritis ,Medicine ,Radiology ,medicine.symptom ,Osteitis ,business - Abstract
Juvenile idiopathic arthritis (JIA) is an umbrella term for a group of diseases in children younger than 16 years old lasting six weeks or longer. Synovitis may lead to destructive and irreversible joint changes with subsequent functional impairment. Prompt diagnosis is essential to prevent permanent joint damage and preserve joint functionality. In the course of JIA both the axial and peripheral skeleton may be involved in the inflammatory process, but the knee joint is most frequently affected. New drugs and treatment protocols have forced the need for diagnosis at the earliest possible stage. Magnetic resonance imaging (MRI) allows early detection of lesions and constitutes a superior diagnostic imaging method. Synovitis, tenosynovitis, enthesitis, bursitis, osteitis, cartilage loss, bone cysts, and erosions are lesions diagnosed in JIA, and they can be precisely imaged in MRI. This article aims to present MRI inflammatory features of the knee in children with JIA based on the literature.
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- 2020
39. Pathogenesis of psoriasis in the 'omic' era. Part IV. Epidemiology, genetics, immunopathogenesis, clinical manifestation and treatment of psoriatic arthritis
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Agata Płoska, Aleksandra Walczak, Adrianna Radulska, Radomir M. Slominski, Bogusław Nedoszytko, Lawrence W. Dobrucki, Agnieszka Owczarczyk-Saczonek, Dominik Strapagiel, Magdalena Górecka-Sokołowska, Marta Stawczyk-Macieja, Aneta Szczerkowska-Dobosz, Marta Sobalska-Kwapis, Aleksandra Batycka-Baran, Iwona T. Dobrucki, Dorota Purzycka-Bohdan, Rafał Czajkowski, Dominik Samotij, Edyta Reszka, Anna Janaszak-Jasiecka, Joanna Bartosińska, Michał A. Żmijewski, Adam Reich, Leszek Kalinowski, Anna Siekierzycka, Justyna Szczęch, Andrzej Slominski, Dorota Krasowska, and Roman Nowicki
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Systemic disease ,medicine.medical_specialty ,Inflammatory arthritis ,Arthritis ,Dermatology ,Disease ,treatment ,Pathogenesis ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Psoriatic arthritis ,0302 clinical medicine ,Psoriasis ,Epidemiology ,medicine ,Immunology and Allergy ,genetics ,Internal medicine ,psoriatic arthritis ,Review Paper ,business.industry ,immunopathogenesis ,medicine.disease ,RC31-1245 ,classification ,RL1-803 ,Immunology ,business - Abstract
Psoriatic arthritis (PsA) is a chronic, progressive, inflammatory arthropathy associated with psoriasis as well as a complex pathogenesis. Genetic and environmental factors trigger the development of the immune-mediated auto-inflammatory response in different sites: skin, bone marrow, entheses and synovial tissues. Studies of the last two decades have changed the view of PsA from a mild, non-progressive arthritis to an inflammatory systemic disease with serious health consequences, not only associated with joint dysfunction, but also with an increased risk of cardiovascular disease and socioeconomic consequences with significantly reduced quality of life. The joint damage starts early in the course of the disease, thus early recognition and treatment with modern biological treatments, which may modify the natural history and slow down progression of this debilitating disease, is essential for the patient long-term outcome.
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- 2020
40. Ca2+ signalling plays a role in celastrol‐mediated suppression of synovial fibroblasts of rheumatoid arthritis patients and experimental arthritis in rats
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Liang Liu, Yuesheng Xie, Xi Chen, Francesco Michelangeli, Hui Wang, Wen Jing Yu, Hudan Pan, Zheng Li, Riqiang Luo, Vincent Kam Wai Wong, Wu Zeng, Yuan Qing Qu, Sami Hamdoun, Wei Zhang, Lu Yu, Betty Yuen Kwan Law, Quan Jiang, Congling Qiu, Thomas Efferth, Ni Zhang, Simon Wing Fai Mok, Su-Wei Xu, Yu Han, Tsz Wai Chan, and Ivo Ricardo de Seabra Rodrigues Dias
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0301 basic medicine ,musculoskeletal diseases ,Male ,Programmed cell death ,SERCA ,Arthritis ,Sarcoplasmic Reticulum Calcium-Transporting ATPases ,Arthritis, Rheumatoid ,Rats, Sprague-Dawley ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,BAPTA ,medicine ,Autophagy ,Animals ,Humans ,Calcium Signaling ,Cells, Cultured ,Pharmacology ,Mice, Knockout ,Gene knockdown ,biology ,Chemistry ,Synovial Membrane ,Calpain ,Fibroblasts ,medicine.disease ,Research Papers ,Arthritis, Experimental ,Triterpenes ,Calcineurin ,030104 developmental biology ,Gene Expression Regulation ,Celastrol ,biology.protein ,Cancer research ,Pentacyclic Triterpenes ,030217 neurology & neurosurgery ,Research Paper - Abstract
Background and purpose Celastrol exhibits anti-arthritic effects in rheumatoid arthritis (RA), but the role of celastrol-mediated Ca2+ mobilization in treatment of RA remains undefined. Here, we describe a regulatory role for celastrol-induced Ca2+ signalling in synovial fibroblasts of RA patients and adjuvant-induced arthritis (AIA) in rats. Experimental approach We used computational docking, Ca2+ dynamics and functional assays to study the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase pump (SERCA). In rheumatoid arthritis synovial fibroblasts (RASFs)/rheumatoid arthritis fibroblast-like synoviocytes (RAFLS), mechanisms of Ca2+ -mediated autophagy were analysed by histological, immunohistochemical and flow cytometric techniques. Anti-arthritic effects of celastrol, autophagy induction, and growth rate of synovial fibroblasts in AIA rats were monitored by microCT and immunofluorescence staining. mRNA from joint tissues of AIA rats was isolated for transcriptional analysis of inflammatory genes, using siRNA methods to study calmodulin, calpains, and calcineurin. Key results Celastrol inhibited SERCA to induce autophagy-dependent cytotoxicity in RASFs/RAFLS via Ca2+ /calmodulin-dependent kinase kinase-β-AMP-activated protein kinase-mTOR pathway and repressed arthritis symptoms in AIA rats. BAPTA/AM hampered the in vitro and in vivo effectiveness of celastrol. Inflammatory- and autoimmunity-associated genes down-regulated by celastrol in joint tissues of AIA rat were restored by BAPTA/AM. Knockdown of calmodulin, calpains, and calcineurin in RAFLS confirmed the role of Ca2+ in celastrol-regulated gene expression. Conclusion and implications Celastrol triggered Ca2+ signalling to induce autophagic cell death in RASFs/RAFLS and ameliorated arthritis in AIA rats mediated by calcium-dependent/-binding proteins facilitating the exploitation of anti-arthritic drugs based on manipulation of Ca2+ signalling.
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- 2019
41. The Assessment of Steroid Injections as a Potential Risk Factor for Osteochondral Lesions in Children with Juvenile Idiopathic Arthritis
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Matthias Rueger, Nisha Grueberger, Christoph Heidt, Franziska Righini-Grunder, Domenic Grisch, Leonhard E. Ramseier, University of Zurich, and Heidt, Christoph
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medicine.medical_specialty ,Adolescent ,Physical Therapy ,medicine.drug_class ,medicine.medical_treatment ,Biomedical Engineering ,2204 Biomedical Engineering ,Arthritis ,610 Medicine & health ,Physical Therapy, Sports Therapy and Rehabilitation ,Inflammation ,Sports Therapy and Rehabilitation ,Injections, Intra-Articular ,Steroid ,Adrenal Cortex Hormones ,Risk Factors ,medicine ,Humans ,Immunology and Allergy ,Juvenile ,10220 Clinic for Surgery ,3612 Physical Therapy, Sports Therapy and Rehabilitation ,Child ,Clinical Research papers ,Retrospective Studies ,business.industry ,Potential risk ,medicine.disease ,Osteochondritis Dissecans ,Osteochondritis dissecans ,Dermatology ,Arthritis, Juvenile ,2723 Immunology and Allergy ,Corticosteroid ,Female ,medicine.symptom ,business - Abstract
Objective Intra-articular corticosteroid injections (IACIs) are frequently used to suppress local inflammation, that is, in children with juvenile idiopathic arthritis (JIA). While systemic high-dosage corticosteroids are known to trigger osteonecrosis and result in osteochondral (OC) lesions, the effect of IACIs on joint cartilage and subchondral bone remains unclear. This study was conceived to analyze the coincidence of IACI and the subsequent manifestation of osteochondral lesions in a large cohort of pediatric JIA patients. Design Retrospective data assessment and comparative analysis of skeletally immature JIA patients treated with IACIs between 1993 and 2017. Results A total of 280 JIA patients were included in the analysis, the majority were girls (64%). Osteochondral lesions were present in 16 patients (5.7%) at a mean age of 10.7 years (range 4-14 years) and appeared on average after 63-month duration of disease. The majority was present at atypical locations such as the lateral femoral condyle. Multivariable analysis using cox regression showed that steroid injections were a risk factor to develop an OC lesion (hazard ratio [95%CI] for number of steroid injections per year, 8.20 [3.18, 21.16]). Conclusions Pediatric patients with JIA show a relatively high incidence of osteochondritic lesions, which present at an early age and in rather atypical locations and repetitive steroid injection need to be considered an associated risk factor.
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- 2020
42. Blood calprotectin in children with juvenile idiopathic arthritis: relationship to flare development after discontinuation of treatment
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Oksana Chubata, Olha Synoverska, Viktoriia Ivanova, Tamila Kozina, Nataliia Shevchenko, Maryna Vakaruk, Nataliia Vaizer, Yaryna Boyko, Anna Havrylyuk, and Olha Marchuk
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medicine.medical_specialty ,Immunology ,Arthritis ,Gastroenterology ,law.invention ,S100A8 ,03 medical and health sciences ,0302 clinical medicine ,Blood serum ,Rheumatology ,law ,Internal medicine ,medicine ,Immunology and Allergy ,flare ,Elisa method ,030203 arthritis & rheumatology ,Original Paper ,business.industry ,blood calprotectin ,biomarkers ,medicine.disease ,Discontinuation ,juvenile idiopathic arthritis ,Medicine ,Calprotectin ,business ,Flare ,Blood sampling - Abstract
ObjectivesThe study aim was to prospectively evaluate the relationship between disease flare development in children with juvenile idiopathic arthritis (JIA) after discontinuation of treatment and serum calprotectin levels (MRP8/14).Material and methodsDetermination of blood serum level of calprotectin was performed in 54 patients with inactive JIA from various regions of Ukraine. The inclusion criterion was the existence of an inactive state of the disease in children with JIA for at least 6 months. During 1 week after blood sampling for determination of serum calprotectin (MRP8/14) level the patients were completely discontinued of all therapy. Determination of calprotectin level in blood serum was performed with reagents EK-MRP8/14 Buhlmann (MRP8/14; S100A8/9), Switzerland, using the ELISA method.ResultsThe trial results showed that 3 months after discontinuation of treatment in patients with inactive JIA, the flares developed in 5 out of 54 patients (9.3%). The median calprotectin level before discontinuation of the treatment was 1,700 ng/ml in patients who developed a flare, and 1,500 ng/ml in other studied patients (not statistically significant). At 6 months, the flare had developed in an additional 3 out of 48 (6.3%) of patients, who continued to be followed up, while their median calprotectin serum levels were 1,300 ng/ml and 1,500 ng/ml respectively (not statistically significant). At 12 months, the flares had developed in 13 more out of 45 (28.9%) patients, who continued to be followed up, while the median calprotectin serum level in these patients before discontinuation of treatment was 1,100 ng/ml and 1,650 ng/ml respectively (not statistically significant).ConclusionAfter discontinuation of treatment a flare over the next year of follow-up developed in 38.9% of patients. The study results did not reveal a significant difference in calprotectin level in patients with JIA prior to complete discontinuation of treatment who developed a flare and those without a flare after 3, 6 and 12 months.
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- 2020
43. Inhibition of BMP3 increases the inflammatory response of fibroblast-like synoviocytes in rheumatoid arthritis
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Sha Wu, Xiao-Ming Meng, Biao Song, Cheng Huang, Su-Qin Yin, Xiao-Feng Li, Jun Li, and Qingqing Xu
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musculoskeletal diseases ,Aging ,inflammatory cytokines ,BMP3 ,Primary Cell Culture ,Pannus ,Arthritis ,chemokines ,Bone Morphogenetic Protein 3 ,Smad Proteins ,SMAD ,Bone morphogenetic protein 3 ,Severity of Illness Index ,Proinflammatory cytokine ,Arthritis, Rheumatoid ,Transforming Growth Factor beta1 ,Cell Movement ,Synovectomy ,medicine ,Animals ,Humans ,skin and connective tissue diseases ,Cells, Cultured ,Autoimmune disease ,biology ,business.industry ,Synovial Membrane ,adjuvant-induced arthritis ,Cell Biology ,musculoskeletal system ,medicine.disease ,Arthritis, Experimental ,Synoviocytes ,Rats ,Gene Knockdown Techniques ,Rheumatoid arthritis ,biology.protein ,Cancer research ,Female ,Signal transduction ,business ,Research Paper ,Signal Transduction - Abstract
Rheumatoid arthritis (RA) is a persistent autoimmune disease. Fibroblast-like synoviocytes (FLS) are a key component of invasive pannus and a pathogenetic mechanism in RA. Expression of bone morphogenetic protein 3 (BMP3) mRNA is reportedly decreased in the arthritic synovium. We previously showed that BMP3 expression is significantly downregulated in the synovial tissues of RA patients and models of adjuvant-induced arthritis (AIA). In the present study, we explored the association between BMP3 and FLS migration and secretion of proinflammatory factors in RA. We found that inhibition of BMP3 expression using BMP3 siRNA increased the proinflammatory chemokines and migration of FLS stimulated with TNF-α. Inhibition of BMP3 expression also increased expression of IL-6, IL-1β, IL-17A, CCL-2, CCL-3, VCAM-1, MMP-3, and MMP-9, but not TIMP-1, in AIA and RA FLS. Correspondingly, induction of BMP3 overexpression through intra-articular injection of ad-BMP3 diminished arthritis severity in AIA rats. We also found that BMP3 may inhibit activation of TGF-β1/Smad signaling. These data indicate that BMP3 may suppress the proliferation and migration of FLS via the TGF-β1/Smad signaling pathway.
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- 2020
44. An update on joint-specific outcome measures in total hip replacement
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Paweł Małdyk, Paweł Łęgosz, Paweł Wojtyński, Krzysztof Romaniuk, Łukasz Pulik, and Kaja Jaśkiewicz
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musculoskeletal diseases ,medicine.medical_specialty ,medicine.medical_treatment ,Immunology ,Arthritis ,Oxford hip score ,Osteoarthritis ,patient outcome assessment ,03 medical and health sciences ,0302 clinical medicine ,Rheumatology ,Quality of life ,medicine ,Immunology and Allergy ,clinical scales ,030203 arthritis & rheumatology ,Review Paper ,clinicalscales ,business.industry ,total hip replacements ,Outcome measures ,medicine.disease ,Arthroplasty ,Clinical trial ,quality of life ,Harris Hip Score ,Physical therapy ,arthroplasty ,Medicine ,business - Abstract
This is the latest review of joint-specific tools used to evaluate patients undergoing total hip replacement (THR) surgery, which is an effective treatment for end-stage osteoarthritis. Due to the large number and multitude of scales and their variants used, a critical assessment of the available tools is necessary. In the article, we briefly describe six different clinical tools: the Western Ontario and McMaster Universities Osteoarthritis Index, the Hip Disability and Osteoarthritis Outcome Score, the Harris Hip Score, the Oxford Hip Score, the Mayo Hip Score, and the Rheumatoid and Arthritis Outcome Score. We present the advantages and constraints of the different outcome measures, providing a helpful resource of information for clinical trials and for everyday routine evaluation.
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- 2020
45. Prevalence and severity of fatigue in psoriasis and psoriatic arthritis
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Agnieszka Owczarczyk-Saczonek, Magdalena Krajewska-Włodarczyk, and Waldemar Placek
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medicine.medical_specialty ,Painful joints ,Arthritis ,Dermatology ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Psoriatic arthritis ,0302 clinical medicine ,Internal medicine ,Psoriasis ,medicine ,Immunology and Allergy ,In patient ,psoriatic arthritis ,Original Paper ,business.industry ,Incidence (epidemiology) ,Swollen joints ,psoriasis ,medicine.disease ,RC31-1245 ,inflammation ,RL1-803 ,fatigue ,business ,Skin lesion - Abstract
Introduction Fatigue is an important and underrated symptom of many chronic diseases. Aim The evaluation of incidence and severity of fatigue as well as the influence of selected factors on fatigue in patients with psoriasis and psoriatic arthritis (PsA). Material and methods The study included 60 patients with PsA, 58 patients with psoriasis and 61 persons in the control group aged 35-70 years. Assessment of fatigue was conducted using a fatigue subscale from the FACIT-F questionnaire. Severity of skin lesions and arthritis was determined with PASI and DAS28, respectively, as well as the number of painful and swollen joints, severity of pain and inflammatory markers. Results Severe fatigue occurred in 17%, 28%, and 1.6% of patients with psoriasis, PsA and the control group, respectively. Severity of fatigue was significantly higher in patients with PsA as compared to patients with psoriasis (p < 0.0001). In patients with psoriasis and PsA, it decreased along with the duration of psoriasis (r = 0.291, p < 0.05 vs. r = 0.382, p < 0.05, respectively). No significant correlation was found between the duration of PsA and fatigue. After using the linear regression model, severity of fatigue in psoriasis was correlated with the age of patients and the duration of psoriasis, while in PsA, with the duration of psoriasis, PASI, DAS28, CRP and the number of painful joints. Conclusions The results of this study may indicate the need for routine fatigue examination among people with psoriasis and psoriatic arthritis.
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- 2020
46. RETRACTED ARTICLE: Up-regulated microRNA-411 or declined RIPK1 inhibits proliferation and promotes apoptosis of synoviocytes in rheumatoid arthritis mice via decreased NF-κB pathway
- Author
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Daosen Chen, Yijiang Huang, Kaizhe Chen, Xinghe Xue, Xiaoyun Pan, Huachen Yu, Lianfu Deng, and Yu Zhang
- Subjects
0301 basic medicine ,Arthritis ,Inflammation ,NF-κB ,Cell Biology ,Biology ,medicine.disease ,03 medical and health sciences ,chemistry.chemical_compound ,030104 developmental biology ,0302 clinical medicine ,chemistry ,Downregulation and upregulation ,Apoptosis ,030220 oncology & carcinogenesis ,Synovitis ,microRNA ,Cancer research ,medicine ,medicine.symptom ,Signal transduction ,Molecular Biology ,Research Paper ,Developmental Biology - Abstract
Rheumatoid arthritis (RA) is a chronic and inflammatory synovitis systemic disease. Due to the unknown pathogenesis, this study was to investigate the effect of microRNA (miR)-411 on apoptosis and joint function of synoviocytes in RA mice via RIPK1-mediated NF-κB signaling pathway. The collagen-induced arthritis model mice were induced via collagen type II and Freund’s adjuvant. The mice were injected with miR-411 mimics, si-RIPK1 or miR-411 mimics + oe-RIPK1 to figure out their roles in cell apoptosis and inflammation of synovial tissues. Synoviocytes were grouped as in animal experiments. Proliferation and apoptosis of synoviocytes were detected upon treatment with overexpressed miR-411 and silenced RIPK1. The expression of miR-411, RIPK1 and NF-κB in synovial tissues and synoviocytes of RA mice was detected by RT-qPCR and Western blot analysis. Poorly expressed miR-411, and highly expressed NF-κB and RIPK1 existed in synovial tissue and synoviocytes of RA. Additionally, it was found that si-RIPK1 decreased NF-κB expression, and miR-411 mimics decreased both RIPK1 and NF-κB. MiR-411 had a targeted relationship with RIPK1. si-RIPK1 or miR-411 mimics promoted cell apoptosis and strained inflammation in synovial tissues of mice with RA. Overexpressed miR-411 or silencing RIPK1 inhibited the proliferation and promoted apoptosis of synoviocytes of RA mice. Up-regulation of miR-411 or down-regulation of RIPK1 had a certain inhibitory effect on RA. This study suggests that up-regulated miR-411 or down-regulated RIPK1 promoted apoptosis and inhibited proliferation of synoviocytes of RA mice, which may be related to the inhibition of NF-κB activation.
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- 2020
47. PET Imaging of Liposomal Glucocorticoids using 89Zr-oxine: Theranostic Applications in Inflammatory Arthritis
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Samantha Y.A. Terry, Andrew P. Cope, Peter J. Gawne, Fiona Clarke, Keren Turjeman, Yechezkel Barenholz, Rafael Torres Martin de Rosales, and Nicholas J. Long
- Subjects
PHARMACOKINETICS ,Inflammatory arthritis ,Medicine (miscellaneous) ,Arthritis ,02 engineering and technology ,Research & Experimental Medicine ,PRODRUGS ,Personalised Nanomedicine ,Arthritis, Rheumatoid ,Mice ,0302 clinical medicine ,Drug Delivery Systems ,TUMOR ,In vivo Liposome Imaging ,Positron Emission Tomography Computed Tomography ,NANOPARTICLES ,RETENTION ,Tissue Distribution ,MACROPHAGES ,Precision Medicine ,Pharmacology, Toxicology and Pharmaceutics (miscellaneous) ,medicine.diagnostic_test ,ENHANCED PERMEABILITY ,021001 nanoscience & nanotechnology ,3. Good health ,Nanomedicine ,Medicine, Research & Experimental ,Positron emission tomography ,030220 oncology & carcinogenesis ,Rheumatoid arthritis ,medicine.symptom ,0210 nano-technology ,Life Sciences & Biomedicine ,Research Paper ,Biodistribution ,Inflammation ,Rheumatoid Arthritis ,DELIVERY ,03 medical and health sciences ,Therapeutic index ,In vivo ,medicine ,DRUGS ,Animals ,1112 Oncology and Carcinogenesis ,Glucocorticoids ,Science & Technology ,business.industry ,medicine.disease ,LONG ,Disease Models, Animal ,Positron-Emission Tomography ,Liposomes ,Nuclear medicine ,business ,Positron Emission Tomography - Abstract
The encapsulation of Glucocorticoids (GCs) into long-circulating liposomes (LCLs) is a proven strategy to reduce the side effects of glucocorticoids and improve the treatment of inflammatory diseases, such as rheumatoid arthritis (RA). With the aim of supporting the development of GC-loaded LCLs, and potentially predict patient response to therapy clinically, we evaluated a direct PET imaging radiolabelling approach for preformed GC-LCLs in an animal model of human inflammatory arthritis.Methods: A preformed PEGylated liposomal methylprednisolone hemisuccinate (NSSL-MPS) nanomedicine was radiolabelled using [89Zr]Zr(oxinate)4 (89Zr-oxine), characterised and tracked in vivo using PET imaging in a K/BxN serum-transfer arthritis (STA) mouse model of inflammatory arthritis and non-inflamed controls. Histology and joint size measurements were used to confirm inflammation. The biodistribution of 89Zr-NSSL-MPS was compared to that of free 89Zr in the same model. A therapeutic study using NSSL-MPS using the same time points as the PET/CT imaging was carried out.Results: The radiolabelling efficiency of NSSL-MPS with [89Zr]Zr(oxinate)4 was 69 ± 8 %. PET/CT imaging of 89Zr-NSSL-MPS showed high uptake (3.6 ± 1.5 % ID; 17.4 ± 9.3 % ID/mL) at inflamed joints, with low activity present in non-inflamed joints (0.5 ± 0.1 % ID; 2.7 ± 1.1 % ID/mL). Importantly, a clear correlation between joint swelling and high 89Zr-NSSL-MPS uptake was observed, which was not observed with free 89Zr. STA mice receiving a therapeutic dose of NSSL-MPS showed a reduction in inflammation at the time points used for the PET/CT imaging compared with the control group.Conclusions: PET imaging was used for the first time to track a liposomal glucocorticoid, showing high uptake at visible and occult inflamed sites and a good correlation with the degree of inflammation. A subsequent therapeutic response matching imaging time points in the same model demonstrated the potential of this radiolabeling method as a theranostic tool for the prediction of therapeutic response - with NSSL-MPS and similar nanomedicines – in the treatment of inflammatory diseases.
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- 2020
48. IL-33/ST2 induces neutrophil-dependent reactive oxygen species production and mediates gout pain
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Wenli Mi, Boyi Liu, Xiaomei Shao, Chengyu Yin, Xiaojie Li, Ping Wang, Jie Wang, Yuanyuan Li, Qiyang Shou, Ruixiang Chen, Hong Zhou, Boyu Liu, Yan Tai, Jianqiao Fang, and Yi Liang
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Male ,0301 basic medicine ,Gout ,Neutrophils ,medicine.medical_treatment ,Pain ,Medicine (miscellaneous) ,Arthritis ,Inflammation ,Pharmacology ,Tarsal Joints ,TRPA1 ,Injections, Intra-Articular ,Mice ,03 medical and health sciences ,Transient receptor potential channel ,0302 clinical medicine ,Dorsal root ganglion ,cytokine ,Animals ,Humans ,Medicine ,RNA-Seq ,TRPA1 Cation Channel ,Pharmacology, Toxicology and Pharmaceutics (miscellaneous) ,Mice, Knockout ,reactive oxygen species ,business.industry ,Macrophages ,neutrophil ,Interleukin-33 ,medicine.disease ,Interleukin-1 Receptor-Like 1 Protein ,Uric Acid ,Disease Models, Animal ,RAW 264.7 Cells ,030104 developmental biology ,Cytokine ,medicine.anatomical_structure ,Nociception ,arthritis ,Knockout mouse ,medicine.symptom ,business ,030217 neurology & neurosurgery ,Research Paper - Abstract
Objective: Gout, induced by monosodium urate (MSU) crystal deposition in joint tissues, provokes severe pain and impacts life quality of patients. However, the mechanisms underlying gout pain are still incompletely understood. Methods: We established a mouse gout model by intra-articularly injection of MSU crystals into the ankle joint of wild type and genetic knockout mice. RNA-Sequencing, in vivo molecular imaging, Ca2+ imaging, reactive oxygen species (ROS) generation, neutrophil influx and nocifensive behavioral assays, etc. were used. Results: We found interleukin-33 (IL-33) was among the top up-regulated cytokines in the inflamed ankle. Neutralizing or genetic deletion of IL-33 or its receptor ST2 (suppression of tumorigenicity) significantly ameliorated pain hypersensitivities and inflammation. Mechanistically, IL-33 was largely released from infiltrated macrophages in inflamed ankle upon MSU stimulation. IL-33 promoted neutrophil influx and triggered neutrophil-dependent ROS production via ST2 during gout, which in turn, activated transient receptor potential ankyrin 1 (TRPA1) channel in dorsal root ganglion (DRG) neurons and produced nociception. Further, TRPA1 channel activity was significantly enhanced in DRG neurons that innervate the inflamed ankle via ST2 dependent mechanism, which results in exaggerated nociceptive response to endogenous ROS products during gout. Conclusions: We demonstrated a previous unidentified role of IL-33/ST2 in mediating pain hypersensitivity and inflammation in a mouse gout model through promoting neutrophil-dependent ROS production and TRPA1 channel activation. Targeting IL-33/ST2 may represent a novel therapeutic approach to ameliorate gout pain and inflammation.
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- 2020
49. ASIC1a induces synovial inflammation via the Ca2+/NFATc3/ RANTES pathway
- Author
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Xiaoqing Peng, Chuanjun Zhu, Fei Zhu, Yihao Zhang, Sujing Song, Xuewen Qian, Xiaojuan Yang, Ruowen Niu, and Feihu Chen
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rheumatoid arthritis ,Male ,0301 basic medicine ,NFATC3 ,T cell ,Medicine (miscellaneous) ,Arthritis ,Inflammation ,NFATc3 ,Proinflammatory cytokine ,Arthritis, Rheumatoid ,Rats, Sprague-Dawley ,03 medical and health sciences ,0302 clinical medicine ,ASIC1a ,Downregulation and upregulation ,In vivo ,medicine ,Animals ,Humans ,Chemokine CCL5 ,Pharmacology, Toxicology and Pharmaceutics (miscellaneous) ,Cells, Cultured ,Aged ,NFATC Transcription Factors ,Chemistry ,Synovial Membrane ,Fibroblasts ,Middle Aged ,medicine.disease ,Rats ,Acid Sensing Ion Channels ,030104 developmental biology ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Rheumatoid arthritis ,Cancer research ,Cytokines ,Calcium ,Female ,medicine.symptom ,Research Paper - Abstract
Rationale: Synovial inflammation is one of the main pathological features of rheumatoid arthritis (RA) and is a key factor leading to the progression of RA. Understanding the regulatory mechanism of synovial inflammation is crucial for the treatment of RA. Acid-sensing ion channel 1a (ASIC1a) is an H+-gated cation channel that promotes the progression of RA, but the role of ASIC1a in synovial inflammation is unclear. This study aimed to investigate whether ASIC1a is involved in the synovial inflammation and explore the underlying mechanisms in vitro and in vivo. Methods: The expression of ASIC1a and nuclear factor of activated T cells (NFATs) were analyzed by Western blotting, immunofluorescence, and immunohistochemistry both in vitro and in vivo. The Ca2+ influx mediated by ASIC1a was detected by calcium imaging and flow cytometry. The role of ASIC1a in inflammation was studied in rats with adjuvant-induced arthritis (AA). Inflammatory cytokine profile was analyzed by protein chip in RA synovial fibroblasts (RASF) and verified by a magnetic multi-cytokine assay and ELISA. The NFATc3-regulated RANTES (Regulated upon activation, normal T cell expressed and secreted) gene transcription was investigated by ChIP-qPCR and dual-luciferase reporter assay. Results: The expression of ASIC1a was significantly increased in human RA synovial tissues and primary human RASF as well as in ankle synovium of AA rats. Activated ASIC1a mediated Ca2+ influx to increase [Ca2+]i in RASF. The activation/overexpression of ASIC1a in RASF up-regulated the expression of inflammatory cytokines RANTES, sTNF RI, MIP-1a, IL-8, sTNF RII, and ICAM-1 among which RANTES was increased most remarkably. In vivo, ASIC1a promoted inflammation, synovial hyperplasia, articular cartilage, and bone destruction, leading to the progression of AA. Furthermore, activation of ASIC1a upregulated the nuclear translocation of NFATc3, which bound to RANTES promoter and directly regulated gene transcription to enhance RANTES expression. Conclusion: ASIC1a induces synovial inflammation, which leads to the progression of RA. Our study reveals a novel RA inflammation regulatory mechanism and indicates that ASIC1a might be a potential therapeutic target for RA.
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- 2020
50. S1P promotes IL-6 expression in osteoblasts through the PI3K, MEK/ERK and NF-κB signaling pathways
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Shan-Chi Liu, Sung-Lin Hu, Yi-Chin Fong, Chien-Chung Huang, Tzu-Ting Tzeng, Chun-Hao Tsai, and Chih-Hsin Tang
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MAPK/ERK pathway ,Small interfering RNA ,Osteoimmunology ,Blotting, Western ,Arthritis ,Enzyme-Linked Immunosorbent Assay ,Real-Time Polymerase Chain Reaction ,S1P ,Proinflammatory cytokine ,Phosphatidylinositol 3-Kinases ,03 medical and health sciences ,0302 clinical medicine ,Sphingosine ,Synovial Fluid ,medicine ,Humans ,Interleukin 6 ,IL-6 ,Osteoblasts ,biology ,Interleukin-6 ,Chemistry ,NF-kappa B ,Interleukin ,General Medicine ,medicine.disease ,Cancer research ,biology.protein ,lipids (amino acids, peptides, and proteins) ,030211 gastroenterology & hepatology ,Lysophospholipids ,Signal transduction ,Signal Transduction ,Research Paper - Abstract
Rheumatoid arthritis (RA) is a systemic autoimmune inflammatory disease, in which the immune system attacks joint tissue. Interleukin (IL)-6 is a key proinflammatory cytokine in RA progression. Sphingosine-1-phosphate (S1P), a platelet-derived lysophospholipid mediator, reportedly regulates osteoimmunology. Here, we examined the effects of S1P on IL-6 expression in osteoblasts. Our results and records from the Gene Expression Omnibus (GEO) database demonstrate higher levels of IL-6 in patients with RA compared with those with osteoarthritis. Stimulation of osteoblasts with S1P increased mRNA and protein expression of IL-6. PI3K, MEK, ERK and NF-κB inhibitors and their small interfering RNAs (siRNAs) reduced S1P-promoted IL-6 expression. S1P also facilitated PI3K, MEK/ERK and NF-κB signaling cascades. Our results indicate that S1P promotes the expression of IL-6 in osteoblasts via the PI3K, MEK/ERK and NF-κB signaling pathways.
- Published
- 2020
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