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2. Management of nasal vestibule carcinomas: recommendations by the Oncological Committee of the Italian Society of Otorhinolaryngology – Head and Neck Surgery

Author

Bussu, Francesco, primary, Tagliaferri, Luca, additional, Corbisiero, Michaele Francesco, additional, Lotto, Cecilia, additional, Pellini, Raul, additional, Guarino, Pierre, additional, Mercante, Giuseppe, additional, Galuppi, Andrea, additional, Cariti, Francesco, additional, Almadori, Giovanni, additional, Longo, Francesco, additional, Calabrese, Luca, additional, Galli, Jacopo, additional, Presutti, Livio, additional, Nicolai, Piero, additional, and Molteni, Gabriele, additional

Published
2024
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4. The observational clinical registry (cohort design) of the European Reference Network on Rare Adult Solid Cancers: The protocol for the rare head and neck cancers

Author

Trama, Annalisa, primary, Licitra, Lisa, additional, Cavalieri, Stefano, additional, Bonfarnuzzo, Simone, additional, Baili, Paolo, additional, Ciarfella, Antonio, additional, Parente, Pablo, additional, Almadori, Giovanni, additional, Ansarin, Mohssen, additional, Bacigalupo, Almalina, additional, Baumeister, Philipp, additional, Baujat, Bertrand, additional, Bossi, Paolo, additional, Cavalera, Elisa, additional, Cercato, Maria Cecilia, additional, Dieleman, Francois, additional, Fakhry, Nicolas, additional, Ferraresi, Virginia, additional, Gaino, Francesca, additional, Galizia, Danilo, additional, Halamkova, Jana, additional, Halme, Elina, additional, Hardillo, Jose, additional, Hofauer, Benedikt, additional, Kinloch, Emma, additional, Livi, Lorenzo, additional, Locati, Laura Deborah, additional, Mattheis, Stefan, additional, Mercante, Giuseppe, additional, Mirabile, Aurora, additional, Molteni, Gabriele, additional, Orlandi, Ester, additional, Persio, Roberto, additional, Sciallero, Stefania, additional, Smeele, Ludi, additional, Tagliabue, Marta, additional, Valentini, Valentino, additional, Van Harpen, Carla, additional, Westphalen, Christoph Benedikt, additional, and Botta, Laura, additional

Published
2023
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5. Oral Candida spp. Colonisation Is a Risk Factor for Severe Oral Mucositis in Patients Undergoing Radiotherapy for Head & Neck Cancer: Results from a Multidisciplinary Mono-Institutional Prospective Observational Study

Author

Rupe, Cosimo, primary, Gioco, Gioele, additional, Almadori, Giovanni, additional, Galli, Jacopo, additional, Micciché, Francesco, additional, Olivieri, Michela, additional, Cordaro, Massimo, additional, and Lajolo, Carlo, additional

Published
2022
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7. Bioradiotherapy with Cetuximab May Reduce the Risk of Neck Node Relapse in Locoregionally Advanced Laryngeal Glottic Carcinoma: May HER1-Profile Be Useful in the Bioselection of Patients?

Author

Almadori, Giovanni, primary, Coli, Antonella, additional, De Corso, Eugenio, additional, Settimi, Stefano, additional, Mele, Dario Antonio, additional, Brigato, Francesca, additional, Scannone, Domenico, additional, Galli, Jacopo, additional, Valentini, Vincenzo, additional, Paludetti, Gaetano, additional, Lauriola, Libero, additional, and Ranelletti, Franco Oreste, additional

Published
2022
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8. Clinical outcomes of teeth adjacent to the site of mandibulotomy or mandibulectomy in patients with head and neck cancer: results from a multidisciplinary mono-institutional head and neck tumor board.

Author

Castagnola, Raffaella, Rupe, Cosimo, Gioco, Gioele, Almadori, Giovanni, Galli, Jacopo, Tagliaferri, Luca, Cassano, Alessandra, Gallenzi, Patrizia, and Lajolo, Carlo

Subjects
MANDIBLE surgery, SALIVARY gland tumors, MOUTH tumors, ACADEMIC medical centers, OSTEOTOMY, TOOTH sensitivity, HEAD & neck cancer, SURGICAL complications, SURGERY, PATIENTS, OROPHARYNGEAL cancer, TISSUE viability, TREATMENT effectiveness, CANCER patients, DENTAL pulp, ORAL surgery, SURGICAL site, DIAGNOSIS, DENTAL pathology, NECROSIS, LONGITUDINAL method
Abstract

Introduction: The aim of this case series was to evaluate the necrosis of teeth adjacent to the site of mandibulotomy or mandibulectomy in a cohort of patients suffering from head and neck cancers. Methods: Fourteen patients who underwent segmental mandibulectomy or paramedian mandibulotomy for oral, oropharynx or major salivary gland cancer and a total of 23 teeth were included in this case series. Twelve patients underwent adjuvant head and neck radiotherapy. Cold sensitivity pulp testing and/or electric pulp testing were performed on teeth at the margin of mandibulectomy and on teeth adjacent to mandibulotomy after surgery. A "positive" response was considered the healthy state, and "negative" was considered the diseased state of the tooth. Results: The 10 patients who underwent mandibulotomy had 12 teeth with a negative response. The 4 patients treated by mandibulectomy had two positive and three negative responses to cold and electric pulp tests. Fifteen out of 23 teeth (65.2%) showed a negative response to sensitivity testing. Conclusions: Tooth necrosis seems to be a common event after mandibulectomy and mandibulotomy. Clinical Relevance: To avoid post-surgery complications, performing root canal therapy before surgery on the teeth adjacent to the surgical site could be an appropriate strategy. [ABSTRACT FROM AUTHOR]

Published
2023
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9. Additional file 1 of Parathyroid hormone-related peptide and parathyroid hormone-related peptide receptor type 1 in locally advanced laryngeal cancer as prognostic indicators of relapse and survival

Author

Almadori, Giovanni, Coli, Antonella, De Corso, Eugenio, Mele, Dario Antonio, Settimi, Stefano, Di Cintio, Giovanni, Brigato, Francesca, Scannone, Domenico, Lauriola, Libero, and Ranelletti, Franco Oreste

Abstract

Additional file 1: Supplementary Table 1.

Published
2022
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13. Erratum to “Prognostic Role of Serum Amino Acids in Head and Neck Cancer”

Author

Cadoni, Gabriella, primary, Giraldi, Luca, additional, Chiarla, Carlo, additional, Gervasoni, Jacopo, additional, Persichilli, Silvia, additional, Primiano, Aniello, additional, Settimi, Stefano, additional, Galli, Jacopo, additional, Paludetti, Gaetano, additional, Arzani, Dario, additional, Boccia, Stefania, additional, Giovannini, Ivo, additional, and Almadori, Giovanni, additional

Published
2021
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14. Prognostic Role of Serum Amino Acids in Head and Neck Cancer

Author

Cadoni, Gabriella, primary, Giraldi, Luca, additional, Chiarla, Carlo, additional, Gervasoni, Jacopo, additional, Persichilli, Silvia, additional, Primiano, Aniello, additional, Settimi, Stefano, additional, Galli, Jacopo, additional, Paludetti, Gaetano, additional, Arzani, Dario, additional, Boccia, Stefania, additional, Giovannini, Ivo, additional, and Almadori, Giovanni, additional

Published
2020
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16. Expression of ras oncogene p21 protein in normal and neoplastic laryngeal tissues: correlation with histopathological features and epidermal growth factor receptors

Author

Scambia, Giovanni, Catozzi, L., Benedetti Panici, P., Ferrandina, Maria Gabriella, Almadori, Giovanni, Paludetti, Gaetano, Cadoni, Gabriella, Distefano, M., Piffanelli, A., Mancuso, Salvatore, and Maurizi, Maurizio

Subjects
Adult, Male, Cancer Research, medicine.medical_specialty, Pathology, Stromal cell, Blotting, Western, Proto-Oncogene Proteins p21(ras), N/a, Reference Values, Epidermal growth factor, medicine, Humans, Epidermal growth factor receptor, Laryngeal Neoplasms, Aged, Neoplasm Staging, Mucous Membrane, Oncogene, biology, Cancer, Middle Aged, Laryngeal Neoplasm, medicine.disease, Immunohistochemistry, ErbB Receptors, Molecular Weight, Settore MED/40 - GINECOLOGIA E OSTETRICIA, Genes, ras, Oncology, Lymphatic Metastasis, Cancer research, biology.protein, rasp21, Female, Histopathology, Settore MED/31 - OTORINOLARINGOIATRIA, Larynx, Research Article
Abstract

Western blotting analysis of the p21 ras oncoprotein was performed in seven normal laryngeal mucosa specimens and 43 primary laryngeal cancers. Varying p21 levels, expressed as optical density (OD), were found in normal mucosa (median 1.94 OD, range 0.90-2.17 OD) and in primary laryngeal tumours (median 1.74 OD, range 0.30-6.37 OD). When p21 expression in laryngeal cancer was compared with the normal counterpart, higher levels were found in neoplastic than in normal laryngeal tissue (median 2.54 OD, range 1.76-6.37 OD, vs median 1.94 OD, range 0.90-2.17 OD) (P = 0.023). Immunohistochemical analysis demonstrated that most of the tumour cells (more than 70%) were immunostained while the stromal component was unreactive. No correlation between p21 expression and tumour location, stage and histopathological grade was observed. The correlation between ras p21 protein expression and epidermal growth factor receptor (EGFR) levels was also investigated. EGFR-positive cases did not show any difference in p21 expression with respect to EGFR-negative cases (median 1.52 OD, range 0.30-6.37 OD, vs median 1.84 OD, range 0.93-3.71 OD). Our findings suggest that overexpression of p21 protein is associated with a malignant phenotype in laryngeal cancer. Further studies should be undertaken to evaluate whether the assessment of p21 protein expression may have clinical significance in laryngeal cancer. Images Figure 1 Figure 2 Figure 3

Published
1994

18. Association of Laryngeal Cancer With Previous Gastric Resection

Author

Cammarota, Giovanni, primary, Galli, Jacopo, additional, Cianci, Rossella, additional, De Corso, Eugenio, additional, Pasceri, Vincenzo, additional, Palli, Domenico, additional, Masala, Giovanna, additional, Buffon, Antonio, additional, Gasbarrini, Antonio, additional, Almadori, Giovanni, additional, Paludetti, Gaetano, additional, Gasbarrini, Giovanni, additional, and Maurizi, Maurizio, additional

Published
2004
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19. A rare case of iliac crest metastasis from acinic cell carcinoma of parotid gland

Author

Sergio Sessa, Giulio Di Giacomo, Giulio Maccauro, A Ziranu, and Almadori Giovanni

Subjects
Adult, Male, Pathology, medicine.medical_specialty, Appendicular skeleton, Case Report, Iliac crest, Metastasis, Acinic cell carcinoma, Ilium, medicine, Carcinoma, Humans, Pelvic metastasis, Pelvic Neoplasms, Carcinoma, Acinar Cell, business.industry, Prognosis, medicine.disease, Parotid Neoplasms, Parotid gland, medicine.anatomical_structure, Oncology, Cervical lymph nodes, Lymphatic Metastasis, Malignant Salivary Gland Neoplasm, Surgery, business
Abstract

A case of acinic cell carcinoma of the right parotid gland metastasizing to the right iliac crest is presented. Generally, for this rare low-grade malignant salivary gland neoplasm, 20% of cases may have local recurrences whereas about 10% of cases have distant metastases. They may arise many years after the initial presentation of the original tumor. The most frequent locations are the cervical lymph nodes, liver, lungs, contralateral orbit and bones. Occurrence in the appendicular skeleton is very rare and in our knowledge this is the first report of metastases to the pelvis.

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20. Diminished expression of S100A2, a putative tumour suppressor, is an independent predictive factor of neck node relapse in laryngeal squamous cell carcinoma

Author

Almadori, G., Francesco Bussu, Gall, J., Rigante, M., Lauriola, L., Michett, F., Maggiano, N., Schafer, B. W., Heizmann, C. W., Ranelletti, F. O., Paludetti, G., University of Zurich, and Almadori, Giovanni

Subjects
Settore BIO/16 - ANATOMIA UMANA, Chemotactic Factors, S100 Proteins, Laryngectomy, Radiotherapy Dosage, 610 Medicine & health, Combined Modality Therapy, Immunohistochemistry, 2746 Surgery, 2733 Otorhinolaryngology, Predictive Value of Tests, Recurrence, 10036 Medical Clinic, Carcinoma, Squamous Cell, Humans, Genetic Predisposition to Disease, Lymph Nodes, S100A2, CELL, Neoplasm Recurrence, Local, Laryngeal Neoplasms, Neck, Follow-Up Studies, Neoplasm Staging
Abstract

In primary squamous cell carcinoma of the larynx (LSCC), Ca(2+) binding S100A2 protein underexpression was already found to be associated with poor tumour differentiation and shorter overall survival. In the present work, the role of S100A2 protein expression in the prediction of regional metastasis-free survival (MFS) was investigated to guide neck management in LSCC.Specimens of LSCC from 62 consecutive untreated patients were examined for S100A2 content by immunocytochemistry; the patients were followed up for a median of 44 months (range 2-90 months) after initial surgical resection. MFS was calculated from the date of first surgery to that of regional neck node recurrence.S100A2 was detected in 18 of 19 (95%) low-grade tumours and in 22 of 43 (51%) high-grade tumours. The 5-year regional MFS was 81% for patients with S100A2-positive tumours and 55% for patients with S100A2-negative tumours. By multivariate analysis, the S100A2 status appeared to be a significant independent predictive factor for MFS (p = .02).Our results suggest that the assessment of S100A2 status at diagnosis may identify a subset of LSCC patients highly susceptible to neck node metastases and may thus help define therapy accordingly.

Published
2009

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