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3. SOCIAL SKILLS INTERVENTIONS FOR ADOLESCENTS WITH LEVEL 1 AUTISM SPECTRUM DISORDER: A SYSTEMATIC REVIEW WITH META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS.

Author

Narzisi, Antonio, Sesso, Gianluca, Fabbri-Destro, Maddalena, Berloffa, Stefano, Fantozzi, Pamela, Muccio, Rosy, Bruzzi, Gianina, Scatigna, Stefano, Valente, Elena, Viglione, Valentina, Milone, Annarita, Cortese, Samuele, and Masi, Gabriele

Subjects
SOCIAL skills education, AUTISM spectrum disorders, RANDOMIZED controlled trials, SOCIAL skills, INVESTIGATIONAL therapies
Abstract

Objective: Evidence on the efficacy of social skills training for adolescents with Level 1 Autism Spectrum Disorder (ASD) is unclear. Method: We searched Pubmed, Scopus, and Web of Science until July 27th, 2023, for randomized controlled trials (RCTs) of social skills training for pre-adolescents and adolescents (aged 9-18) with Level 1 ASD. We then pooled data on efficacy from individual RCTs by conducting multivariate mixed-effects meta-analyses in R. We estimated possible bias in the retained RCTs using the RoB2 tool. Results: We retained 36 RCTs (encompassing 2796 participants), including 18 RCTs comparing an experimental treatment to a waiting list, and 18 RCTs comparing it to standard care/control treatment. Meta-analyses showed that experimental treatments were significantly more efficacious than waiting list or standard care/ control treatments in improving social skills (SMD = 0.3745; 95%CI = [0.2396; 0.5093]), as well as reducing behavioral symptoms (0.3154;0.1783, 0.4525) and anxious/depressive symptoms (0.2780; 0.0432, 0.5128). However, for some outcomes there was significant heterogeneity across studies and evidence of publication bias. Subgroup analyses and meta-regressions did not identify any specific clinical or demographic factors as significant predictors of outcome. The most common risk of bias across studies was related to deviations from intended interventions and measurement of the outcomes. Conclusions: At the group level, social skills training for adolescents with Level 1 ASD is efficacious, with small-to-moderate effect size. Future research should focus on personalized medicine approaches, aimed at tailoring interventions to specific characteristics of adolescents with Level 1 ASD. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Persistent Non-Suicidal Self-Injury and Suicidality in Referred Adolescents: A Longitudinal Study Exploring the Role of Cyclothymic Temperament

Author

Masi, Gabriele, primary, Pisano, Simone, additional, Sesso, Gianluca, additional, Mazzullo, Cristina, additional, Berloffa, Stefano, additional, Fantozzi, Pamela, additional, Narzisi, Antonio, additional, Placini, Francesca, additional, Valente, Elena, additional, Viglione, Valentina, additional, and Milone, Annarita, additional

Published
2023
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9. Early Sensory Profile in Autism Spectrum Disorders Predicts Emotional and Behavioral Issues

Author

Fabbri-Destro, Maddalena, primary, Maugeri, Federica, additional, Ianni, Carolina, additional, Corsini, Sofia, additional, Di Stefano, Erica, additional, Scatigna, Stefano, additional, Crifaci, Giulia, additional, Bruzzi, Gianina, additional, Berloffa, Stefano, additional, Fantozzi, Pamela, additional, Prato, Adriana, additional, Muccio, Rosy, additional, Valente, Elena, additional, Pelagatti, Susanna, additional, Pecchini, Edoardo, additional, Zulli, Filippo, additional, Rizzo, Renata, additional, Milone, Annarita, additional, Viglione, Valentina, additional, Barone, Rita, additional, Masi, Gabriele, additional, and Narzisi, Antonio, additional

Published
2022
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10. Neurodevelopmental Disorders, Schizophrenia Spectrum Disorders and Catatonia: The "Iron Triangle" Rediscovered in a Case Report.

Author

Fantozzi, Pamela, Del Grande, Claudia, Berloffa, Stefano, Tolomei, Greta, Salluce, Carmen, Narzisi, Antonio, Salarpi, Gianluca, Capovani, Barbara, and Masi, Gabriele

Subjects
THERAPEUTIC use of lithium, DIAGNOSIS of schizophrenia, DIAGNOSIS of autism, SUBSTANCE abuse, ELECTROCONVULSIVE therapy, CATATONIA, CHILD psychopathology, MENTAL depression, CLASSIFICATION of mental disorders, EMOTION regulation, ANTIPSYCHOTIC agents, VALPROIC acid, GABAPENTIN, TRANQUILIZING drugs, SYMPTOMS, ADOLESCENCE
Abstract

Catatonia is a complex neuropsychiatric syndrome, occurring in the context of different psychiatric and neurodevelopmental disorders, in neurological and medical disorders, and after substance abuse or withdrawal. The relationship between Autism Spectrum Disorder (ASD), Schizophrenia Spectrum Disorders (SSDs) and catatonia has been previously discussed, with the three disorders interpreted as different manifestations of the same underlying brain disorder (the "Iron Triangle"). We discuss in this paper the diagnostic, clinical and therapeutic implications of this complex relationship in an adolescent with ASD, who presented an acute psychotic onset with catatonia, associated with mixed mood symptoms. Second-generation antipsychotics were used to manage psychotic, behavioral and affective symptoms, with worsening of the catatonic symptoms. In this clinical condition, antipsychotics may be useful at the lowest dosages, with increases only in the acute phases, especially when benzodiazepines are ineffective. Mood stabilizers with higher GABAergic effects (such as Valproate and Gabapentin) and Lithium salts may be more useful and well tolerated, given the frequent association of depressive and manic symptoms with mixed features. [ABSTRACT FROM AUTHOR]

Published
2023
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11. Internet Gaming Disorder in Children and Adolescents with Attention Deficit Hyperactivity Disorder

Author

Berloffa, Stefano, primary, Salvati, Andrea, additional, D’Acunto, Giulia, additional, Fantozzi, Pamela, additional, Inguaggiato, Emanuela, additional, Lenzi, Francesca, additional, Milone, Annarita, additional, Muratori, Pietro, additional, Pfanner, Chiara, additional, Ricci, Federica, additional, Ruglioni, Laura, additional, Tacchi, Annalisa, additional, Tessa, Chiara, additional, Villafranca, Arianna, additional, and Masi, Gabriele, additional

Published
2022
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12. Sensory Profiles in School-Aged Children with Autism Spectrum Disorder: A Descriptive Study Using the Sensory Processing Measure-2 (SPM-2)

Author

Narzisi, Antonio, primary, Fabbri-Destro, Maddalena, additional, Crifaci, Giulia, additional, Scatigna, Stefano, additional, Maugeri, Federica, additional, Berloffa, Stefano, additional, Fantozzi, Pamela, additional, Prato, Adriana, additional, Muccio, Rosy, additional, Valente, Elena, additional, Viglione, Valentina, additional, Pecchini, Edoardo, additional, Pelagatti, Susanna, additional, Rizzo, Renata, additional, Milone, Annarita, additional, Barone, Rita, additional, and Masi, Gabriele, additional

Published
2022
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15. Could You Give Me the Blue Brick? LEGO®-Based Therapy as a Social Development Program for Children with Autism Spectrum Disorder: A Systematic Review

Author

Narzisi, Antonio, primary, Sesso, Gianluca, additional, Berloffa, Stefano, additional, Fantozzi, Pamela, additional, Muccio, Rosy, additional, Valente, Elena, additional, Viglione, Valentina, additional, Villafranca, Arianna, additional, Milone, Annarita, additional, and Masi, Gabriele, additional

Published
2021
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17. Autism Spectrum Disorder and Disruptive Behavior Disorders Comorbidities Delineate Clinical Phenotypes in Attention-Deficit Hyperactivity Disorder: Novel Insights from the Assessment of Psychopathological and Neuropsychological Profiles

Author

Sesso, Gianluca, primary, Cristofani, Chiara, additional, Berloffa, Stefano, additional, Cristofani, Paola, additional, Fantozzi, Pamela, additional, Inguaggiato, Emanuela, additional, Narzisi, Antonio, additional, Pfanner, Chiara, additional, Ricci, Federica, additional, Tacchi, Annalisa, additional, Valente, Elena, additional, Viglione, Valentina, additional, Milone, Annarita, additional, and Masi, Gabriele, additional

Published
2020
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18. A Naturalistic Study of Youth Referred to a Tertiary Care Facility for Acute Hypomanic or Manic Episode

Author

Masi, Gabriele, primary, Berloffa, Stefano, additional, Muratori, Pietro, additional, Mucci, Maria, additional, Viglione, Valentina, additional, Villafranca, Arianna, additional, Inguaggiato, Emanuela, additional, Levantini, Valentina, additional, Placini, Francesca, additional, Pfanner, Chiara, additional, D’Acunto, Giulia, additional, Lenzi, Francesca, additional, Liboni, Francesca, additional, and Milone, Annarita, additional

Published
2020
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20. Could You Give Me the Blue Brick? LEGO ® -Based Therapy as a Social Development Program for Children with Autism Spectrum Disorder: A Systematic Review.

Author

Narzisi, Antonio, Sesso, Gianluca, Berloffa, Stefano, Fantozzi, Pamela, Muccio, Rosy, Valente, Elena, Viglione, Valentina, Villafranca, Arianna, Milone, Annarita, and Masi, Gabriele

Subjects
CHILDREN with autism spectrum disorders, SOCIAL development, SOCIAL services, CHILD development, SOCIAL skills
Abstract

LEGO®-based therapy is a social skills development program aimed at children with autism spectrum disorder (ASD). A systematic review of the literature was conducted using PRISMA guidelines. PubMed, Scopus and Web of Science bibliographic databases were searched from their date of inception to August 2020. The review included 19 studies. Studies were classified according to experimental designs (e.g., Randomized Control Trial, Non-Randomized Studies of Interventions and case report and series) and a narrative synthesis of each was provided, along with a critical discussion of the strengths and weaknesses of the available literature on the topic. Although LEGO®-based therapy appears a promising treatment for social interaction in ASD, the findings of LEGO®-based therapy studies should be interpreted and generalized with caution, due to the low quality of the studies and the small sample sizes. [ABSTRACT FROM AUTHOR]

Published
2021
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21. Lithium treatment in bipolar adolescents: a follow-up naturalistic study

Author

Stefano Berloffa, Simone Pisano, Annarita Milone, Valentina Viglione, Gabriele Masi, Gabriella Bruni, Maria Mucci, Giulia Scrinzi, Masi, Gabriele, Milone, Annarita, Scrinzi, Giulia, Mucci, Maria, Viglione, Valentina, Bruni, Gabriella, Berloffa, Stefano, and Pisano, Simone

Subjects
safety, medicine.medical_specialty, Neuropsychiatric Disease and Treatment, Lithium (medication), Sedation, QT interval, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, White blood cell, Internal medicine, medicine, 0501 psychology and cognitive sciences, adolescents, Bipolar disorder, Original Research, bipolar disorder, business.industry, 05 social sciences, Thyroid, medicine.disease, 3. Good health, 030227 psychiatry, medicine.anatomical_structure, lithium, adolescent, Long term data, medicine.symptom, business, 050104 developmental & child psychology, Hormone, medicine.drug
Abstract

Gabriele Masi,1 Annarita Milone,1 Giulia Scrinzi,2 Maria Mucci,1 Valentina Viglione,1 Gabriella Bruni,1 Stefano Berloffa,1 Simone Pisano3 1IRCCS Stella Maris Foundation, Developmental Psychiatry and Psychopharmacology Unit, Pisa, Italy; 2Child Neuropsychiatry Unit, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Verona, Italy; 3Clinic of Child and Adolescent Neuropsychiatry, Department of Medicine and Surgery, University of Salerno, Salerno, Italy Background: Although lithium is currently approved for the treatment of bipolar disorders in youth, long term data, are still scant. The aim of this study was to describe the safety and efficacy of lithium in referred bipolar adolescents, who were followed up at the 4th (T1) and 8th (T2) month of treatment.Methods: The design was naturalistic and retrospective, based on a clinical database, including 30 patients (18 males, mean age 14.2±2.1 years).Results: Mean blood level of lithium was 0.69±0.20 mEq/L at T1 and 0.70±0.18 mEq/L at T2. Both Clinical Global Impression-Severity (CGI-S) and Children Global Assessment Scale (C-GAS) scores improved from baseline (CGI-S 5.7±0.5, C-GAS 35.1±3.7) to T1 (CGI-S 4.2±0.70, C-GAS 46.4±6.5; P

Published
2018

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