36 results on '"Cenci, L."'
Search Results
2. Defining the Optimal Spatio-Temporal Sampling Interval for Observing Soil Moisture Dynamics from Space. Case Study: the GeoSTARe Satellite Mission Design
- Author
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Cenci, L., Pulvirenti, L., Boni, G., Pignone, F., Masoero, A., Basso, V., and Pierdicca, N.
- Published
- 2018
3. Exploiting Sentinel 1 and 2 data for geo-environmental monitoring of sandy coastal areas
- Author
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Persichillo, M. G., Cenci, L., Disperati, L., Meisina, C., Pulvirenti, L., Boni, G., and Squicciarino, G.
- Published
- 2017
4. Erratum to: Effects of Twenty Days of the Ketogenic Diet on Metabolic and Respiratory Parameters in Healthy Subjects (Lung, (2015), 193, (939-945), 10.1007/s00408-015-9806-7)
- Author
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Rubini, A. Bosco, G. Lodi, A. Cenci, L. Parmagnani, A. Grimaldi, K. Zhongjin, Y. Paoli, A.
- Abstract
In the original publication of the article, the given and family names of all the authors were swapped. This has been corrected with this erratum. © 2016, Springer Science+Business Media New York.
- Published
- 2017
5. A Gis-Based, Rapid And Holistic Flash Flood Risk Assessment For Emergency Management Services
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Cenci, L., Squicciarino, G., Rossello, L., DE ANGELI, Silvia, Trasforini, E., Rudari, R., and Boni, G.
- Published
- 2016
6. Understanding the Impact of Spatio-Temporal Resolution in Soil Moisture-Data Assimilation Systems for Flash Flood Early Warning
- Author
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Cenci, L., Pulvirenti, L., Boni, G., Chini, M., Matgen, P., Gabellani, S., Campo, L., Silvestro, F., and Delogu, F.
- Published
- 2016
7. Multi Hazard Assessment: The Azores Archipelagos (PT) case
- Author
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Aifantopoulou, D., Boni, G., Cenci, L., Kaskara, M., Kontoes, H., Papoutsis, I., Paralikidis, S., Psichogyiou, C., Solomos, S., Squicciarino, G., Tsouni, A., and Xerekakis, T.
- Published
- 2016
8. Shoreline to Height (S2H): an algorithm to monitor reservoirs’ water height from satellite images. A flood risk management application
- Author
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Cenci, L., Boni, G., Pulvirenti, L., Gabellani, S., Gardella, F., Squicciarino, G., Pierdicca, N., and Benedetto, C.
- Published
- 2016
9. Validation of a short-term shoreline evolution model and coastal risk management implications
- Author
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Cenci, L., Persichillo, M. G., Disperati, L., Oliveira, E. R., Lopes-Alves, M. F., Boni, G., Pulvirenti, L., and Phillips, M.
- Published
- 2015
10. Verifica delle potenzialità del sensore DAEDALUS nello studio dei sedimenti costieri nel Parco di San Rossore
- Author
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Persichillo, M. G., Barducci, A., Cenci, L., Guzzi, D., Nardino, V., Pippi, I., Rindinella, A., and Disperati, L.
- Subjects
composizione sedimenti ,spectral unmixing ,Telerilevamento multispettrale, spectral unmixing, correzioni atmosferiche, linear mixing model, composizione sedimenti, Parco di Migliarino San Rossore Massaciuccoli ,Telerilevamento multispettrale ,linear mixing model ,correzioni atmosferiche ,Parco di Migliarino San Rossore Massaciuccoli - Published
- 2013
11. La ricarica dei veicoli elettrici: il disturbo armonico sulla rete di alimentazione in MT
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Falvo, Maria Carmen, Lamedica, Regina, Cenci, L., Noce, C., and Silvestri, C.
- Published
- 2012
12. Immagini di Montecitorio
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Carbonara, Giovanni and Cenci, L.
- Published
- 2009
13. MBNL142 and MBNL143 gene isoforms, overexpressed in DM1-patient muscle, encode for nuclear proteins interacting with Src family kinases
- Author
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Botta, A, primary, Malena, A, additional, Tibaldi, E, additional, Rocchi, L, additional, Loro, E, additional, Pena, E, additional, Cenci, L, additional, Ambrosi, E, additional, Bellocchi, M C, additional, Pagano, M A, additional, Novelli, G, additional, Rossi, G, additional, Monaco, H L, additional, Gianazza, E, additional, Pantic, B, additional, Romeo, V, additional, Marin, O, additional, Brunati, A M, additional, and Vergani, L, additional
- Published
- 2013
- Full Text
- View/download PDF
14. BEL -trefoil: A novel lectin with antineoplastic properties in king bolete (Boletus edulis) mushrooms
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Bovi, M., primary, Cenci, L., additional, Perduca, M., additional, Capaldi, S., additional, Carrizo, M. E., additional, Civiero, L., additional, Chiarelli, L. R., additional, Galliano, M., additional, and Monaco, H. L., additional
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- 2012
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15. Evaluating the environmental impact of various dietary patterns combined with different food production systems
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Baroni, L, primary, Cenci, L, additional, Tettamanti, M, additional, and Berati, M, additional
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- 2006
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16. MBNL142 and MBNL143 gene isoforms, overexpressed in DM1-patient muscle, encode for nuclear proteins interacting with Src family kinases.
- Author
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Botta, A., Malena, A., Tibaldi, E., Rocchi, L., Loro, E., Pena, E., Cenci, L., Ambrosi, E., Bellocchi, M.C., Pagano, M.A., Novelli, G., Rossi, G., Monaco, H.L., Gianazza, E., Pantic, B., Romeo, V., Marin, O., Brunati, A.M., and Vergani, L.
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- 2013
- Full Text
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17. Ketogenic diet and phytoextracts. Comparison of the efficacy of Mediterranean, Zone and Tisanoreica diet on some health risk factors
- Author
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Paoli, A., Cenci, L., Fancelli, M., Parmagnani, A., Andrea Fratter, Cucchi, A., Bianco, A., PAOLI, A, CENCI, L, FANCELLI, M, PARMAGNANI, A, FRATTER, A, CUCCHI, A, BIANCO, A, Paoli, A, Cenci, L, Fancelli, M, Parmagnani, A, Fratter, A, Cucchi, A, and Bianco, A
- Subjects
Ketogenic diet ,Mediterranean diet ,Phytoextracts ,Tisanoreica ,Weight loss ,Zone diet ,Food Science ,Industrial and Manufacturing Engineering ,Phytoextract ,ketogenic diet, Mediterranean diet, zone diet, phytoextracts, tisanoreica, weight loss ,Weight lo - Abstract
The purpose of this work was to test the efficacy of three kind of different diet on some health risk factors. The primary objective of the present study was to examine the effects of diets, amount of carbohydrate intake and use of phytoextracts on weight loss, body composition and related risk factors and on metabolic values as Resting Energy Expenditure (REE) and Respiratory Ratio (RR).We tested 44 subjects randomly assigned to one of 3 groups of diet: Mediterranean (MED), Zone (ZON) and Tisanoreica® i.e. ketogenic diet plus phytoextracts (TIS). Anthropometry, blood chemistry and urine analysis were performed. After 40 days TIS led to a significant average weight and fat loss compared to ZON and MED. Moreover TIS showed a significant reduction in fasting glucose whilst there weren't significant differences in creatinine, uric acid and urea. A significant reduction in the Respiratory Ratio in the TIS group was observed. In conclusion our data shows that the TIS diet, using supplements that mimic the look and taste of carbohydrates and phytoextracts enhance weight reduction, improved lipid profile and mitigate the side effects of ketosis.
18. Effect of 30 days of ketogenic Mediterranean diet with phytoextracts on athletes' gut microbiome composition
- Author
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Laura Mancin, Stefano Amatori, Massimiliano Caprio, Eleonora Sattin, Loris Bertoldi, Lorenzo Cenci, Davide Sisti, Antonino Bianco, Antonio Paoli, Mancin L., Amatori S., Caprio M., Sattin E., Bertoldi L., Cenci L., Sisti D., Bianco A., and Paoli A.
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athletes ,exercise ,gut microbiota ,ketogenic diet ,sport nutrition ,Nutrition and Dietetics ,Endocrinology, Diabetes and Metabolism ,Food Science - Abstract
BackgroundRecent research suggest that gut microbiome may play a fundamental role in athlete's health and performance. Interestingly, nutrition can affect athletic performance by influencing the gut microbiome composition. Among different dietary patterns, ketogenic diet represents an efficient nutritional approach to get adequate body composition in athletes, however, some concerns have been raised about its potential detrimental effect on gut microbiome. To the best of our knowledge, only one study investigated the effect of ketogenic diet on the gut microbiome in athletes (elite race walkers), whilst no studies are available in a model of mixed endurance/power sport such as soccer. This study aimed to investigate the influence of a ketogenic Mediterranean diet with phytoextracts (KEMEPHY) diet on gut microbiome composition in a cohort of semi-professional soccer players.Methods16 male soccer players were randomly assigned to KEMEPHY diet (KDP n = 8) or western diet (WD n = 8). Body composition, performance measurements and gut microbiome composition were measured before and after 30 days of intervention by 16S rRNA amplicon sequencing. Alpha-diversity measures and PERMANOVA was used to investigate pre-post differences in the relative abundance of all taxonomic levels (from phylum to genus) and Spearman's correlations was used to investigate associations between microbial composition and macronutrient intake. Linear discriminant analysis was also performed at the different taxonomic levels on the post-intervention data.ResultsNo differences were found between pre and post- dietary intervention for microbial community diversity: no significant effects of time (p = 0.056, ES = 0.486 and p = 0.129, ES = 0.388, respectively for OTUs number and Shannon's ENS), group (p = 0.317, ES = 0.180 and p = 0.809, ES = 0.047) or time × group (p = 0.999, ES = 0.01 and p = 0.230, ES = 0.315). Post-hoc paired Wilcoxon test showed a significant time × group effect for Actinobacteriota (p = 0.021, ES = 0.578), which increased in the WD group (median pre: 1.7%; median post: 2.3%) and decreased in the KEMEPHY group (median pre: 4.3%; median post: 1.7%). At genus level, the linear discriminant analysis in the post intervention differentiated the two groups for Bifidobacterium genus (pertaining to the Actinobacteria phylum), Butyricicoccus and Acidaminococcus genera, all more abundant in the WD group, and for Clostridia UCG-014 (order, family, and genus), Butyricimonas, Odoribacterter genera (pertaining to the Marinifilaceae family), and Ruminococcus genus, all more abundant in the KEMEPHY group.ConclusionsOur results demonstrate that 30 days of KEMEPHY intervention, in contrast with previous research on ketogenic diet and gut microbiome, do not modify the overall composition of gut microbiome in a cohort of athletes. KEMEPHY dietary pattern may represent an alternative and safety tool for maintaining and/or regulating the composition of gut microbiome in athletes practicing regular exercise. Due to the fact that not all ketogenic diets are equal, we hypothesized that each version of ketogenic diet, with different kind of nutrients or macronutrients partitioning, may differently affect the human gut microbiome.
- Published
- 2022
19. Effects of Two Months of Very Low Carbohydrate Ketogenic Diet on Body Composition, Muscle Strength, Muscle Area, and Blood Parameters in Competitive Natural Body Builders
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Massimiliano Caprio, Antonino Bianco, Lorenzo Cenci, Pier Luigi Pompei, Neşe Şahin, Tatiana Moro, Marco Neri, Antonio Paoli, Paoli A., Cenci L., Pompei P., Sahin N., Bianco A., Neri M., Caprio M., and Moro T.
- Subjects
Blood Glucose ,Male ,medicine.medical_treatment ,Diet, Carbohydrate-Restricted ,0302 clinical medicine ,Neurotrophic factors ,Weight loss ,Insulin ,Testosterone ,Health, Ketogenic diet, Resistance training, Strength ,Insulin-Like Growth Factor I ,Nutrition and Dietetics ,Muscles ,health ,Adipose Tissue ,ketogenic diet ,Body Composition ,Cytokines ,medicine.symptom ,Diet, Ketogenic ,strength ,lcsh:Nutrition. Foods and food supply ,Settore M-EDF/01 - Metodi E Didattiche Delle Attivita' Motorie ,Adult ,medicine.medical_specialty ,Adolescent ,Carbohydrates ,030209 endocrinology & metabolism ,lcsh:TX341-641 ,Article ,Proinflammatory cytokine ,Health ,Ketogenic diet ,Resistance training ,Strength ,03 medical and health sciences ,Young Adult ,Internal medicine ,Weight Loss ,medicine ,Humans ,Muscle Strength ,Triglycerides ,business.industry ,Brain-Derived Neurotrophic Factor ,030229 sport sciences ,Endocrinology ,Glucose ,Athletes ,Diet, Western ,Basal metabolic rate ,Lean body mass ,Basal Metabolism ,resistance training ,business ,Food Science - Abstract
Background: Ketogenic diet (KD) is a nutritional approach that restricts daily carbohydrates, replacing most of the reduced energy with fat, while maintaining an adequate quantity of protein. Despite the widespread use of KD in weight loss in athletes, there are still many concerns about its use in sports requiring muscle mass accrual. Thus, the present study sought to investigate the influence of a KD in competitive natural body builders. Methods: Nineteen volunteers (27.4 ±, 10.5 years) were randomly assigned to ketogenic diet (KD) or to a western diet (WD). Body composition, muscle strength and basal metabolic rate were measured before and after two months of intervention. Standard blood biochemistry, testosterone, IGF-1, brain-derived neurotrophic factor (BDNF) and inflammatory cytokines (IL6, IL1&beta, TNF&alpha, ) were also measured. Results: Body fat significantly decreased in KD (p = 0.030), whilst lean mass increased significantly only in WD (p <, 0.001). Maximal strength increased similarly in both groups. KD showed a significant decrease of blood triglycerides (p <, 0.001), glucose (p = 0.001), insulin (p <, 0.001) and inflammatory cytokines compared to WD whilst BDNF increased in both groups with significant greater changes in KD (p <, 0.001). Conclusions: KD may be used during body building preparation for health and leaning purposes but with the caution that hypertrophic muscle response could be blunted.
- Published
- 2021
- Full Text
- View/download PDF
20. MBNL142 and MBNL143 gene isoforms, overexpressed in DM1-patient muscle, encode for nuclear proteins interacting with Src family kinases
- Author
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Oriano Marin, Lucia Cenci, Anna Maria Brunati, Giuseppe Novelli, Giulio Rossi, Maria Concetta Bellocchi, Emmanuele Ambrosi, Vincenzo Romeo, Mario A. Pagano, Emanuele Loro, Hugo L. Monaco, Annalisa Botta, Boris Pantic, Elena Tibaldi, Adriana Malena, E. Pena, Elisabetta Gianazza, Lodovica Vergani, L. Rocchi, Botta, A., Malena, A., Tibaldi, E., Rocchi, L., Loro, E., Pena, E., Cenci, L., Ambrosi, E., Bellocchi, M.C., Pagano, M.A., Novelli, G., Rossi, G., Monaco, H.L., Gianazza, E., Pantic, B., Romeo, V., Marin, O., Brunati, A.M., and Vergani, L
- Subjects
Cancer Research ,muscle ,Muscle Fibers, Skeletal ,RNA-binding protein ,RNA-binding proteins ,Src-family kinases (SFKs) ,RNA-Binding Protein ,protein binding ,nuclear proteins ,Exon ,chemistry.chemical_compound ,phosphotyrosine ,humans ,muscles ,cell differentiation ,RNA, small interfering ,cell nucleus ,models, biological ,protein isoforms ,src homology domains ,muscle fibers, skeletal ,phosphorylation ,adult ,myotonic dystrophy ,case-control studies ,gene expression regulation ,src-family kinases ,protein transport ,MBNL1 ,DM1 ,Nuclear protein ,Muscular dystrophy ,RNA, Small Interfering ,Cell Nucleu ,SFKs ,Nuclear Protein ,Myogenesis ,Medicine (all) ,skeletal ,muscle fibers ,Original Article ,src-Family Kinase ,Case-Control Studie ,Human ,musculoskeletal diseases ,Immunology ,src Homology Domain ,SFK ,Biology ,Models, Biological ,Cellular and Molecular Neuroscience ,models ,LYN ,medicine ,small interfering ,Alternative splicing ,Protein Isoform ,Cell Biology ,medicine.disease ,Molecular biology ,chemistry ,Settore MED/03 - Genetica Medica ,RNA ,biological - Abstract
Myotonic dystrophy type-1 (DM1) is the most prevalent form of muscular dystrophy in adults. This disorder is an RNA-dominant disease, caused by expansion of a CTG repeat in the DMPK gene that leads to a misregulation in the alternative splicing of pre-mRNAs. The longer muscleblind-like-1 (MBNL1) transcripts containing exon 5 and the respective protein isoforms (MBNL1 42-43) were found to be overexpressed in DM1 muscle and localized exclusively in the nuclei. In vitro assays showed that MBNL1 42-43 bind the Src-homology 3 domain of Src family kinases (SFKs) via their proline-rich motifs, enhancing the SFK activity. Notably, this association was also confirmed in DM1 muscle and myotubes. The recovery, mediated by an siRNA target to Ex5-MBNL1 42-43, succeeded in reducing the nuclear localization of both Lyn and MBNL1 42-43 proteins and in decreasing the level of tyrosine phosphorylated proteins. Our results suggest an additional molecular mechanism in the DM1 pathogenesis, based on an altered phosphotyrosine signalling pathway. © 2013 Macmillan Publishers Limited All rights reserved.
- Published
- 2013
21. Medium term effects of a ketogenic diet and a Mediterranean diet on resting energy expenditure and respiratory ratio
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Keith A. Grimaldi, Alessandra Lodi, Antonino Bianco, Andrea Parmagnani, Lorenzo Cenci, Antonio Paoli, Paoli, A, Grimaldi, K, Bianco, A, Lodi, A, Cenci, L, and Parmagnani, A
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Gerontology ,Mediterranean diet ,business.industry ,medicine.medical_treatment ,General Medicine ,Body weight ,General Biochemistry, Genetics and Molecular Biology ,Medium term ,Respiratory ratio ,Animal science ,ketogenic diet ,Poster Presentation ,medicine ,Resting energy expenditure ,business ,Low carbohydrate ,Fat loss ,Ketogenic diet - Abstract
Background Very low carbohydrate ketogenic type diets (VLCKD) have been shown to be more effective for body weight reduction and fat loss compared to balanced or low-calorie Mediterranean diets, at least in the short-medium term [1,2], although the underlying mechanisms of its efficacy are still not well understood. Despite being a diet in widespread use there are few data available regarding effects on respiratory ratio (RR) [3,4] and resting energy expenditure (REE) and, more specifically, there are no reports about the effects on RR following a return to a non ketogenic diet. The aim of this study was to compare the effects of a 20 day ketogenic Mediterranean diet with phytoextracts (KEMEPHY) and a low-calorie Mediterranean diet (MD) on RR and REE during and 20 days after finishing the ketogenic phase.
- Published
- 2012
22. Ketogenic diet does not affect strength performance in elite artistic gymnasts
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Antonio Paoli, Antonio Palma, Keith A. Grimaldi, Dominic P. D’Agostino, Tatiana Moro, Lorenzo Cenci, Antonino Bianco, Paoli, A., Grimaldi, K., D'Agostino, D., Cenci, L., Moro, T., Bianco, A., and Palma, A.
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Straight leg raise ,medicine.medical_specialty ,Weight loss ,Sports medicine ,medicine.medical_treatment ,Gymnastic ,lcsh:TX341-641 ,Clinical nutrition ,Body composition ,Weight lo ,Animal science ,medicine ,Nutrition and Dietetic ,Very low carbohydrate Ketogenic diet ,lcsh:Sports medicine ,Nutrition and Dietetics ,biology ,medicine.diagnostic_test ,Athletes ,business.industry ,biology.organism_classification ,Push-up ,Biochemistry ,Strength ,medicine.symptom ,business ,lcsh:RC1200-1245 ,lcsh:Nutrition. Foods and food supply ,Ketogenic diet ,Dieting ,Research Article ,Food Science - Abstract
Background Despite the increasing use of very low carbohydrate ketogenic diets (VLCKD) in weight control and management of the metabolic syndrome there is a paucity of research about effects of VLCKD on sport performance. Ketogenic diets may be useful in sports that include weight class divisions and the aim of our study was to investigate the influence of VLCKD on explosive strength performance. Methods 8 athletes, elite artistic gymnasts (age 20.9 ± 5.5 yrs) were recruited. We analyzed body composition and various performance aspects (hanging straight leg raise, ground push up, parallel bar dips, pull up, squat jump, countermovement jump, 30 sec continuous jumps) before and after 30 days of a modified ketogenic diet. The diet was based on green vegetables, olive oil, fish and meat plus dishes composed of high quality protein and virtually zero carbohydrates, but which mimicked their taste, with the addition of some herbal extracts. During the VLCKD the athletes performed the normal training program. After three months the same protocol, tests were performed before and after 30 days of the athletes’ usual diet (a typically western diet, WD). A one-way Anova for repeated measurements was used. Results No significant differences were detected between VLCKD and WD in all strength tests. Significant differences were found in body weight and body composition: after VLCKD there was a decrease in body weight (from 69.6 ± 7.3 Kg to 68.0 ± 7.5 Kg) and fat mass (from 5.3 ± 1.3 Kg to 3.4 ± 0.8 Kg p Conclusions Despite concerns of coaches and doctors about the possible detrimental effects of low carbohydrate diets on athletic performance and the well known importance of carbohydrates there are no data about VLCKD and strength performance. The undeniable and sudden effect of VLCKD on fat loss may be useful for those athletes who compete in sports based on weight class. We have demonstrated that using VLCKD for a relatively short time period (i.e. 30 days) can decrease body weight and body fat without negative effects on strength performance in high level athletes.
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23. Effect of 30 days of ketogenic Mediterranean diet with phytoextracts on athletes' gut microbiome composition.
- Author
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Mancin L, Amatori S, Caprio M, Sattin E, Bertoldi L, Cenci L, Sisti D, Bianco A, and Paoli A
- Abstract
Background: Recent research suggest that gut microbiome may play a fundamental role in athlete's health and performance. Interestingly, nutrition can affect athletic performance by influencing the gut microbiome composition. Among different dietary patterns, ketogenic diet represents an efficient nutritional approach to get adequate body composition in athletes, however, some concerns have been raised about its potential detrimental effect on gut microbiome. To the best of our knowledge, only one study investigated the effect of ketogenic diet on the gut microbiome in athletes (elite race walkers), whilst no studies are available in a model of mixed endurance/power sport such as soccer. This study aimed to investigate the influence of a ketogenic Mediterranean diet with phytoextracts (KEMEPHY) diet on gut microbiome composition in a cohort of semi-professional soccer players., Methods: 16 male soccer players were randomly assigned to KEMEPHY diet (KDP n = 8) or western diet (WD n = 8). Body composition, performance measurements and gut microbiome composition were measured before and after 30 days of intervention by 16S rRNA amplicon sequencing. Alpha-diversity measures and PERMANOVA was used to investigate pre-post differences in the relative abundance of all taxonomic levels (from phylum to genus) and Spearman's correlations was used to investigate associations between microbial composition and macronutrient intake. Linear discriminant analysis was also performed at the different taxonomic levels on the post-intervention data., Results: No differences were found between pre and post- dietary intervention for microbial community diversity: no significant effects of time ( p = 0.056, ES = 0.486 and p = 0.129, ES = 0.388, respectively for OTUs number and Shannon's ENS), group ( p = 0.317, ES = 0.180 and p = 0.809, ES = 0.047) or time × group ( p = 0.999, ES = 0.01 and p = 0.230, ES = 0.315). Post-hoc paired Wilcoxon test showed a significant time × group effect for Actinobacteriota ( p = 0.021, ES = 0.578), which increased in the WD group (median pre: 1.7%; median post: 2.3%) and decreased in the KEMEPHY group (median pre: 4.3%; median post: 1.7%). At genus level, the linear discriminant analysis in the post intervention differentiated the two groups for Bifidobacterium genus (pertaining to the Actinobacteria phylum), Butyricicoccus and Acidaminococcus genera, all more abundant in the WD group, and for Clostridia UCG-014 (order, family, and genus), Butyricimonas, Odoribacterter genera (pertaining to the Marinifilaceae family), and Ruminococcus genus, all more abundant in the KEMEPHY group., Conclusions: Our results demonstrate that 30 days of KEMEPHY intervention, in contrast with previous research on ketogenic diet and gut microbiome, do not modify the overall composition of gut microbiome in a cohort of athletes. KEMEPHY dietary pattern may represent an alternative and safety tool for maintaining and/or regulating the composition of gut microbiome in athletes practicing regular exercise. Due to the fact that not all ketogenic diets are equal, we hypothesized that each version of ketogenic diet, with different kind of nutrients or macronutrients partitioning, may differently affect the human gut microbiome., Competing Interests: Author AP has received a research grant from Gianluca Mech S.p.A. Asigliano Veneto, Vicenza, Italy. Author LC is a Ph.D. student currently supported by a grant from Gianluca Mech SpA, Asigliano Veneto, Vicenza, Italy. The company had no role in the study design, data collection, data analysis, data interpretation, or writing of the article. Authors ES and LB were employed by BMR Genomics srl. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Mancin, Amatori, Caprio, Sattin, Bertoldi, Cenci, Sisti, Bianco and Paoli.)
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- 2022
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24. Effects of 30 days of ketogenic diet on body composition, muscle strength, muscle area, metabolism, and performance in semi-professional soccer players.
- Author
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Antonio Paoli A, Mancin L, Caprio M, Monti E, Narici MV, Cenci L, Piccini F, Pincella M, Grigoletto D, and Marcolin G
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- Adult, Athletes, Diet, Western, Humans, Male, Prospective Studies, Young Adult, Body Composition, Diet, Ketogenic, Muscle Strength, Muscle, Skeletal physiology, Sports Nutritional Physiological Phenomena
- Abstract
Background: A ketogenic diet (KD) is a nutritional approach, usually adopted for weight loss, that restricts daily carbohydrates under 30 g/day. KD showed contradictory results on sport performance, whilst no data are available on team sports. We sought to investigate the influence of a KD on different parameters in semi-professional soccer players., Methods: Subjects were randomly assigned to a iso-protein (1.8 g/Kg body weight/day) ketogenic diet (KD) or western diet (WD) for 30 days. Body weight and body composition, resting energy expenditure (REE), respiratory exchange ratio (RER), cross sectional area (CSA) and isometric muscle strength of quadriceps, counter movement jump (CMJ) and yoyo intermittent recovery test time were measured., Results: There was a significantly higher decrease of body fat (p = 0.0359), visceral adipose tissue (VAT) (p = 0.0018), waist circumference (p = 0.0185) and extra-cellular water (p = 0.0060) in KD compared to WD group. Lean soft tissue, quadriceps muscle area, maximal strength and REE showed no changes in both groups. RER decreased significantly in KD (p = 0.0008). Yo-yo intermittent test improved significantly (p < 0.0001) in both groups without significant differences between groups. CMJ significantly improved (p = 0.0021) only in KD., Conclusions: This is the first study investigating the effects of a KD on semi-professional soccer players. In our study KD athletes lost fat mass without any detrimental effects on strength, power and muscle mass. When the goal is a rapid weight reduction in such athletes, the use of a KD should be taken into account., Trial Registration: registered retrospectively on Clinical Trial registration number NCT04078971 ., (© 2021. The Author(s).)
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- 2021
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25. Effects of Two Months of Very Low Carbohydrate Ketogenic Diet on Body Composition, Muscle Strength, Muscle Area, and Blood Parameters in Competitive Natural Body Builders.
- Author
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Paoli A, Cenci L, Pompei P, Sahin N, Bianco A, Neri M, Caprio M, and Moro T
- Subjects
- Adipose Tissue, Adolescent, Adult, Athletes, Basal Metabolism, Blood Glucose, Brain-Derived Neurotrophic Factor blood, Carbohydrates, Cytokines blood, Diet, Western, Glucose, Humans, Insulin, Insulin-Like Growth Factor I, Male, Muscles, Resistance Training, Testosterone blood, Triglycerides blood, Weight Loss, Young Adult, Body Composition, Diet, Carbohydrate-Restricted, Diet, Ketogenic, Muscle Strength physiology
- Abstract
Background : Ketogenic diet (KD) is a nutritional approach that restricts daily carbohydrates, replacing most of the reduced energy with fat, while maintaining an adequate quantity of protein. Despite the widespread use of KD in weight loss in athletes, there are still many concerns about its use in sports requiring muscle mass accrual. Thus, the present study sought to investigate the influence of a KD in competitive natural body builders. Methods : Nineteen volunteers (27.4 ± 10.5 years) were randomly assigned to ketogenic diet (KD) or to a western diet (WD). Body composition, muscle strength and basal metabolic rate were measured before and after two months of intervention. Standard blood biochemistry, testosterone, IGF-1, brain-derived neurotrophic factor (BDNF) and inflammatory cytokines (IL6, IL1β, TNFα) were also measured. Results : Body fat significantly decreased in KD ( p = 0.030); whilst lean mass increased significantly only in WD ( p < 0.001). Maximal strength increased similarly in both groups. KD showed a significant decrease of blood triglycerides ( p < 0.001), glucose ( p = 0.001), insulin ( p < 0.001) and inflammatory cytokines compared to WD whilst BDNF increased in both groups with significant greater changes in KD ( p < 0.001). Conclusions : KD may be used during body building preparation for health and leaning purposes but with the caution that hypertrophic muscle response could be blunted.
- Published
- 2021
- Full Text
- View/download PDF
26. Ketonemia and Glycemia Affect Appetite Levels and Executive Functions in Overweight Females During Two Ketogenic Diets.
- Author
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Lodi A, Zarantonello L, Bisiacchi PS, Cenci L, and Paoli A
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- Adult, Female, Humans, Young Adult, Appetite physiology, Blood Glucose metabolism, Diet, Ketogenic methods, Executive Function physiology, Ketosis physiopathology, Overweight metabolism
- Abstract
Objective: This study sought to investigate how glycemia and ketonemia variations during two ketogenic diet protocols affect appetite, executive functions, and mood in young women with overweight., Methods: Fifty healthy young females with overweight were randomly assigned to (1) a ketogenic diet without any restriction on energy intake, (2) a commercial energy-restricted ketogenic Mediterranean diet, and (3) an energy-restricted Mediterranean diet for 10 days. A visual analogue scale was used to test appetite, and one mood test and two cognitive tasks (working memory and inhibition control) were performed. Moreover, body composition, fasting blood glucose, and β-hydroxybutyrate (BHB) were measured., Results: A positive correlation was found between glycemia and appetite (P = 0.019), unfullness score (P = 0.001), and desire to eat (P = 0.030) (pre- and postdiet levels). Postdiet BHB levels showed a positive correlation with fullness score (P = 0.002) and a negative correlation with appetite (P = 0.022) and desire to eat (P = 0.009). A positive correlation was found between prediet levels of glycemia and reaction times in the go-trials of the executive function test (P = 0.018). Postdiet BHB level showed a negative correlation with the accuracy of the no-go trials (P = 0.027)., Conclusions: Ketogenic diets, compared with a Mediterranean diet, have a greater effect in terms of appetite reduction but might affect inhibition functions., (© 2020 The Obesity Society.)
- Published
- 2020
- Full Text
- View/download PDF
27. Effects of the Ketogenic diet in overweight divers breathing Enriched Air Nitrox.
- Author
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Bosco G, Rizzato A, Quartesan S, Camporesi E, Mangar D, Paganini M, Cenci L, Malacrida S, Mrakic-Sposta S, Moretti S, and Paoli A
- Subjects
- Adult, Air, Decompression, Decompression Sickness drug therapy, Decompression Sickness urine, Deoxyguanosine urine, Dinoprost analogs & derivatives, Dinoprost urine, Exercise, Humans, Hyperoxia, Interleukin-1beta blood, Interleukin-6 analysis, Interleukin-6 blood, Male, Middle Aged, Nitrogen metabolism, Overweight metabolism, Oxidative Stress drug effects, Pilot Projects, Prospective Studies, Tumor Necrosis Factor-alpha blood, Decompression Sickness diet therapy, Diet, Ketogenic methods, Diving physiology, Nitrogen administration & dosage, Oxygen administration & dosage
- Abstract
Central Nervous System Oxygen Toxicity (CNS-OT) is one of the most harmful effects of Enriched Air Nitrox (EAN) diving. Protective factors of the Ketogenic Diet (KD) are antioxidant activity, the prevention of mitochondrial damage and anti-inflammatory mechanisms. We aimed to investigate if a short-term KD may reduce oxidative stress and inflammation during an hyperoxic dive. Samples from six overweight divers (mean ± SD, age: 55.2 ± 4.96 years; BMI: 26.7 ± 0.86 kg/m
2 ) were obtained a) before and after a dive breathing Enriched Air Nitrox and performing 20-minute mild underwater exercise, b) after a dive (same conditions) performed after 7 days of KD. We measured urinary 8-isoprostane and 8-OH-2-deoxyguanosine and plasmatic IL-1β, IL-6 and TNF-α levels. The KD was successful in causing weight loss (3.20 ± 1.31 Kgs, p < 0.01) and in limiting lipid peroxidation (3.63 ± 1.16 vs. 1.11 ± 0.22; p < 0.01) and inflammatory response (IL-1β = 105.7 ± 25.52 vs. 57.03 ± 16.32, p < 0.05; IL-6 = 28.91 ± 4.351 vs. 14.08 ± 1.74, p < 0.001; TNF-α = 78.01 ± 7.69 vs. 64.68 ± 14.56, p < 0.05). A short-term KD seems to be effective in weight loss, in decreasing inflammation and protective towards lipid peroxidation during hyperoxic diving.- Published
- 2018
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28. Micro- versus nano-sized molecularly imprinted polymers in MALDI-TOF mass spectrometry analysis of peptides.
- Author
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Cenci L, Bertolla M, Anesi A, Ambrosi E, Guella G, and Bossi AM
- Subjects
- Crystallization, Humans, Nanostructures chemistry, Peptides analysis, Peptides isolation & purification, Solid Phase Extraction methods, Molecular Imprinting methods, Peptides blood, Polymers chemistry, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization methods
- Abstract
The integration of molecularly imprinted polymers (MIPs) with MALDI-TOF mass spectrometry (MS) combines MIP selectivity with MS sensitivity. Whether the size of the MIP material-micro versus nano-has an effect on the MS analysis was the object of the study. MIPs, targeting respectively the epitope peptide NR11 of cardiac troponin I and the peptide CK13 of human serum transferrin, were synthesized and characterized. The size-related performance of the MIP materials hyphenated with MALDI-TOF-MS analysis was studied by the incubation of the target peptide with the respective micro- or nano-MIP, followed by rinsing to remove non-specific deposition of the MIP to the MALDI target plate, co-crystallization with the organic matrix, and mass analysis. The quality of the MS analysis was assessed comparing the S/N of the mass peaks of the MIP-bound peptide to that of the same quantity of free peptide. Sweet spots and lower S/N (~ 1 order of magnitude) were observed for micro-MIP materials, while in the case of nano-MIP-bound peptide, the S/N was comparable to that of the free peptide, indicating higher compatibility of the nano-MIPs to MALDI-TOF-MS. The nano-MIP/MALDI-TOF-MS permitted the selective determination of the target peptide in real serum samples. Graphical abstract ᅟ.
- Published
- 2017
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29. Screening of the binding properties of molecularly imprinted nanoparticles via capillary electrophoresis.
- Author
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Musile G, Cenci L, Andreetto E, Ambrosi E, Tagliaro F, and Bossi AM
- Subjects
- Binding Sites, Chromatography, High Pressure Liquid, Hydrogen-Ion Concentration, Ligands, Temperature, Electrophoresis, Capillary methods, Molecular Imprinting methods, Nanoparticles
- Abstract
In response to the need for straightforward analytical methods to assess the affinity of molecularly imprinted nanoparticles (MIP NPs) for ligands, capillary electrophoresis (CE) was exploited using MIP NPs targeting the iron-regulating hormone hepcidin. In this work, MIP NPs were challenged with their template peptide, i.e., the N-terminal 5-mer of hepcidin, in comparison to unrelated ligand peptides. A CE separation method was developed ex novo achieving, after optimization of the background electrolyte (150 mM sodium phosphate pH 7.4) and of the running temperature (35 °C), the full separation of the free ligand from the complexed MIP NPs. The CE binding isotherm allowed the estimation of a micromolar dissociation constant for the 5-mer template-MIP NPs complex, in agreement with independent measurements. The CE offered the advantages of a direct injection of the MIP NPs/ligand incubation mix, without preliminary fractionation steps, requiring only minimal sample volumes and short analysis times. In conclusion CE proved to be a valid technique for characterizing the interactions of MIP NP libraries for selected target compounds.
- Published
- 2016
- Full Text
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30. Surface plasmon resonance based on molecularly imprinted nanoparticles for the picomolar detection of the iron regulating hormone Hepcidin-25.
- Author
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Cenci L, Andreetto E, Vestri A, Bovi M, Barozzi M, Iacob E, Busato M, Castagna A, Girelli D, and Bossi AM
- Subjects
- Hepcidins metabolism, Humans, Iron metabolism, Limit of Detection, Hepcidins blood, Molecular Imprinting, Nanoparticles chemistry, Surface Plasmon Resonance methods
- Abstract
Background: Molecularly imprinted polymer (MIP) technique is a powerful mean to produce tailor made synthetic recognition sites. Here precipitation polymerization was exploited to produce a library of MIP nanoparticles (NPs) targeting the N terminus of the hormone Hepcidin-25, whose serum levels correlate with iron dis-metabolisms and doping. Biotinylated MIP NPs were immobilized to NeutrAvidin™ SPR sensor chip. The response of the MIP NP sensor to Hepcidin-25 was studied., Findings: Morphological analysis showed MIP NPs of 20-50 nm; MIP NP exhibited high affinity and selectivity for the target analyte: low nanomolar Kds for the interaction NP/Hepcidin-25, but none for the NP/non regulative Hepcidin-20. The MIP NP were integrated as recognition element in SPR allowing the detection of Hepcidin-25 in 3 min. Linearity was observed with the logarithm of Hepcidin-25 concentration in the range 7.2-720 pM. LOD was 5 pM. The response for Hepcidin-20 was limited. Hepcidin-25 determination in real serum samples spiked with known analyte concentrations was also attempted., Conclusion: The integration of MIP NP to SPR allowed the determination of Hepcidin-25 at picomolar concentrations in short times outperforming the actual state of art. Optimization is still needed for real sample measurements in view of future clinical applications.
- Published
- 2015
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31. BEL β-trefoil: a novel lectin with antineoplastic properties in king bolete (Boletus edulis) mushrooms.
- Author
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Bovi M, Cenci L, Perduca M, Capaldi S, Carrizo ME, Civiero L, Chiarelli LR, Galliano M, and Monaco HL
- Subjects
- Amino Acid Sequence, Antineoplastic Agents pharmacology, Apoproteins chemistry, Binding Sites, Caco-2 Cells, Carbohydrates chemistry, Cell Proliferation drug effects, Crystallography, X-Ray, Fungal Proteins pharmacology, Hep G2 Cells, Humans, Lectins pharmacology, MCF-7 Cells, Molecular Sequence Data, Protein Structure, Tertiary, Antineoplastic Agents chemistry, Basidiomycota chemistry, Fungal Proteins chemistry, Lectins chemistry
- Abstract
A novel lectin was purified from the fruiting bodies of king bolete mushrooms (Boletus edulis, also called porcino, cep or penny bun). The lectin was structurally characterized i.e its amino acid sequence and three-dimensional structure were determined. The new protein is a homodimer and each protomer folds as β-trefoil domain and therefore we propose the name Boletus edulis lectin (BEL) β-trefoil to distinguish it from the other lectin that has been described in these mushrooms. The lectin has potent anti-proliferative effects on human cancer cells, which confers to it an interesting therapeutic potential as an antineoplastic agent. Several crystal forms of the apoprotein and of complexes with different carbohydrates were studied by X-ray diffraction. The structure of the apoprotein was solved at 1.12 Å resolution. The interaction of the lectin with lactose, galactose, N-acetylgalactosamine and T-antigen disaccharide, Galβ1-3GalNAc, was examined in detail. All the three potential binding sites present in the β-trefoil fold are occupied in at least one crystal form and are described in detail in this paper. No important conformational changes are observed in the lectin when comparing its co-crystals with carbohydrates with those of the ligand-free protein.
- Published
- 2013
- Full Text
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32. Ketogenic diet does not affect strength performance in elite artistic gymnasts.
- Author
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Paoli A, Grimaldi K, D'Agostino D, Cenci L, Moro T, Bianco A, and Palma A
- Abstract
Background: Despite the increasing use of very low carbohydrate ketogenic diets (VLCKD) in weight control and management of the metabolic syndrome there is a paucity of research about effects of VLCKD on sport performance. Ketogenic diets may be useful in sports that include weight class divisions and the aim of our study was to investigate the influence of VLCKD on explosive strength performance., Methods: 8 athletes, elite artistic gymnasts (age 20.9 ± 5.5 yrs) were recruited. We analyzed body composition and various performance aspects (hanging straight leg raise, ground push up, parallel bar dips, pull up, squat jump, countermovement jump, 30 sec continuous jumps) before and after 30 days of a modified ketogenic diet. The diet was based on green vegetables, olive oil, fish and meat plus dishes composed of high quality protein and virtually zero carbohydrates, but which mimicked their taste, with the addition of some herbal extracts. During the VLCKD the athletes performed the normal training program. After three months the same protocol, tests were performed before and after 30 days of the athletes' usual diet (a typically western diet, WD). A one-way Anova for repeated measurements was used., Results: No significant differences were detected between VLCKD and WD in all strength tests. Significant differences were found in body weight and body composition: after VLCKD there was a decrease in body weight (from 69.6 ± 7.3 Kg to 68.0 ± 7.5 Kg) and fat mass (from 5.3 ± 1.3 Kg to 3.4 ± 0.8 Kg p < 0.001) with a non-significant increase in muscle mass., Conclusions: Despite concerns of coaches and doctors about the possible detrimental effects of low carbohydrate diets on athletic performance and the well known importance of carbohydrates there are no data about VLCKD and strength performance. The undeniable and sudden effect of VLCKD on fat loss may be useful for those athletes who compete in sports based on weight class. We have demonstrated that using VLCKD for a relatively short time period (i.e. 30 days) can decrease body weight and body fat without negative effects on strength performance in high level athletes.
- Published
- 2012
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33. Effect of ketogenic Mediterranean diet with phytoextracts and low carbohydrates/high-protein meals on weight, cardiovascular risk factors, body composition and diet compliance in Italian council employees.
- Author
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Paoli A, Cenci L, and Grimaldi KA
- Subjects
- Adult, Female, Humans, Italy, Male, Middle Aged, Patient Compliance, Pilot Projects, Plant Extracts administration & dosage, Risk Factors, Body Composition, Cardiovascular Diseases etiology, Diet, Carbohydrate-Restricted, Diet, Ketogenic, Diet, Mediterranean, Weight Loss
- Abstract
Background: There has been increased interest in recent years in very low carbohydrate ketogenic diets (VLCKD) that, even though they are much discussed and often opposed, have undoubtedly been shown to be effective, at least in the short to medium term, as a tool to tackle obesity, hyperlipidemia and some cardiovascular risk factors. For this reason the ketogenic diet represents an interesting option but unfortunately suffers from a low compliance. The aim of this pilot study is to ascertain the safety and effects of a modified ketogenic diet that utilizes ingredients which are low in carbohydrates but are formulated to simulate its aspect and taste and also contain phytoextracts to add beneficial effects of important vegetable components., Methods: The study group consisted of 106 Rome council employees with a body mass index of ≥ 25, age between 18 and 65 years (19 male and 87 female; mean age 48.49 ± 10.3). We investigated the effects of a modified ketogenic diet based on green vegetables, olive oil, fish and meat plus dishes composed of high quality protein and virtually zero carbohydrate but which mimic their taste, with the addition of some herbal extracts (KEMEPHY ketogenic Mediterranean with phytoextracts). Calories in the diet were unlimited. Measurements were taken before and after 6 weeks of diet., Results: There were no significant changes in BUN, ALT, AST, GGT and blood creatinine. We detected a significant (p < 0.0001) reduction in BMI (31.45 Kg/m2 to 29.01 Kg/m2), body weight (86.15 kg to 79.43 Kg), percentage of fat mass (41.24% to 34.99%), waist circumference (106.56 cm to 97.10 cm), total cholesterol (204 mg/dl to 181 mg/dl), LDLc (150 mg/dl to 136 mg/dl), triglycerides (119 mg/dl to 93 mg/dl) and blood glucose (96 mg/dl to 91 mg/dl). There was a significant (p < 0.0001) increase in HDLc (46 mg/dl to 52 mg/dl)., Conclusions: The KEMEPHY diet lead to weight reduction, improvements in cardiovascular risk markers, reduction in waist circumference and showed good compliance.
- Published
- 2011
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34. Squamous cell carcinoma of the breast. Report of two cases.
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Manzelli A, Rossi P, De Maio A, Bonano E, Battista S, Cenci L, Tognoni V, and Gaspari AL
- Subjects
- Adult, Axilla, Biopsy, Fine-Needle, Breast Neoplasms diagnosis, Breast Neoplasms therapy, Carcinoma, Squamous Cell diagnosis, Carcinoma, Squamous Cell therapy, Female, Humans, Lymph Node Excision, Middle Aged, Neoplasm Invasiveness, Neoplasms, Second Primary pathology, Neoplasms, Second Primary surgery, Treatment Outcome, Breast Neoplasms pathology, Breast Neoplasms surgery, Carcinoma, Squamous Cell pathology, Carcinoma, Squamous Cell surgery, Mastectomy, Simple
- Abstract
Squamous Cell Carcinoma (SCC) of the breast is a rare entity, not well known, nevertheless literature reports several signalings from different authors. Regarding ethiopathogenesis, SCC of the breast is still the object of numerous discordances and controversies. We report two cases of SCC of the breast referred to our institution in the last year. The first case interests a 35 years-old woman with a lesion of the left breast referred to us with a 3 month history of breast mass. The second case regards a 49 year-old women with multicentric lesions of the right breast operated in two different times. The SCC is a rare breast entity with a controversial histogenesis. The development is characterized by metastasis frequency. The treatment remains not codified. The treatment is currently the same as for infiltrating ductal carcinoma. Indeed, the limited number of this kind of tumor doesn't allow the assessment of different therapeutic protocols.
- Published
- 2007
35. Sensitivity to rubber chemicals and latex among hemodialysis patients.
- Author
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Nettis E, Dambra P, Paradiso MT, Montinaro V, Carabellese S, Cenci L, Ferrannini A, and Tursi A
- Subjects
- Female, Humans, Latex Hypersensitivity diagnosis, Male, Middle Aged, Renal Dialysis instrumentation, Skin Tests, Latex Hypersensitivity etiology, Renal Dialysis adverse effects
- Published
- 2001
- Full Text
- View/download PDF
36. Smoking and the workplace.
- Author
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Cenci L
- Subjects
- Health Education, Humans, United States, Occupational Medicine, Smoking Prevention
- Published
- 1982
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