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7. A New and Practical Synthetic Method for the Synthesis of 6-O-Methyl-scutellarein: One Metabolite of Scutellarin in Vivo

Author

Lin, Hang, primary, Zhang, Wei, additional, Dong, Ze-Xi, additional, Gu, Ting, additional, Li, Nian-Guang, additional, Shi, Zhi-Hao, additional, Kai, Jun, additional, Qu, Cheng, additional, Shang, Guan-Xiong, additional, Tang, Yu-Ping, additional, Fang, Fang, additional, Li, He-Min, additional, Yang, Jian-Ping, additional, and Duan, Jin-Ao, additional

Published
2015
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9. Studies on the Protective Effects of Scutellarein against Neuronal Injury by Ischemia through the Analysis of Endogenous Amino Acids and Ca2+ Concentration Together with Ca2+-ATPase Activity.

Author

Tang, Hao, Dong, Ze-Xi, Gu, Ting, Li, Nian-Guang, Tang, Yu-Ping, Shi, Qian-Ping, Guo, Jian-Ming, Zhang, Peng-Xuan, and Duan, Jin-Ao

Subjects
*NERVOUS system injuries, *EXTRACTION (Chemistry), *PLANT extracts, *MEDICINAL plants, *BIOCHEMISTRY, *THERAPEUTICS
Abstract

Scutellarin, which is extracted from the dried plant of Erigeron breviscapus, has been reported to protect the neural injury against excitotoxicity induced by ischemia. However, there are a few studies on the protective effects of scutellarein, which is the main metabolite of scutellarin in vivo. Thus, this study investigated the neuroprotective effects of scutellarein on cerebral ischemia/reperfusion in rats by bilateral common carotid artery occlusion (BCCAO) model, through the analysis of endogenous amino acids using HILIC-MS/MS, and evaluation of Ca2+ concentration together with Ca2+-ATPase activity. The results showed that scutellarein having good protective effects on cerebral ischemia/reperfusion might by decreasing the excitatory amino acids, increasing the inhibitory amino acids, lowing intracellular Ca2+ level, and improving Ca2+-ATPase activity, which suggested that scutellarein might be a promising potent agent for the therapy of ischemic cerebrovascular disease. [ABSTRACT FROM AUTHOR]

Published
2015
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10. Studies on the Protective Effects of Scutellarein against Neuronal Injury by Ischemia through the Analysis of Endogenous Amino Acids and Ca2+ Concentration Together with Ca2+-ATPase Activity

Author

Tang, Hao, Dong, Ze-Xi, Gu, Ting, Li, Nian-Guang, Tang, Yu-Ping, Shi, Qian-Ping, Guo, Jian-Ming, Zhang, Peng-Xuan, and Duan, Jin-Ao

Abstract

Scutellarin, which is extracted from the dried plant of Erigeron breviscapus, has been reported to protect the neural injury against excitotoxicity induced by ischemia. However, there are a few studies on the protective effects of scutellarein, which is the main metabolite of scutellarin in vivo. Thus, this study investigated the neuroprotective effects of scutellarein on cerebral ischemia/reperfusion in rats by bilateral common carotid artery occlusion (BCCAO) model, through the analysis of endogenous amino acids using HILIC-MS/MS, and evaluation of Ca2+ concentration together with Ca2+-ATPase activity. The results showed that scutellarein having good protective effects on cerebral ischemia/reperfusion might by decreasing the excitatory amino acids, increasing the inhibitory amino acids, lowing intracellular Ca2+ level, and improving Ca2+-ATPase activity, which suggested that scutellarein might be a promising potent agent for the therapy of ischemic cerebrovascular disease.

Published
2015
Full Text
View/download PDF

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