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1. Abatacept/Ruxolitinib and Screening for Concomitant Respiratory Muscle Failure to Mitigate Fatality of Immune-Checkpoint Inhibitor Myocarditis.

Author

Salem, Joe-Elie, Bretagne, Marie, Abbar, Baptiste, Leonard-Louis, Sarah, Ederhy, Stéphane, Redheuil, Alban, Boussouar, Samia, Nguyen, Lee S, Procureur, Adrien, Stein, Frederic, Fenioux, Charlotte, Devos, Perrine, Gougis, Paul, Dres, Martin, Demoule, Alexandre, Psimaras, Dimitri, Lenglet, Timothee, Maisonobe, Thierry, De Chambrun, Marc Pineton, Hekimian, Guillaume, Straus, Christian, Gonzalez-Bermejo, Jesus, Klatzmann, David, Rigolet, Aude, Guillaume-Jugnot, Perrine, Champtiaux, Nicolas, Benveniste, Olivier, Weiss, Nicolas, Saheb, Samir, Rouvier, Philippe, Plu, Isabelle, Gandjbakhch, Estelle, Kerneis, Mathieu, Hammoudi, Nadjib, Zahr, Noel, Llontop, Claudia, Morelot-Panzini, Capucine, Lehmann, Lorenz, Qin, Juan, Moslehi, Javid J, Rosenzwajg, Michelle, Similowski, Thomas, and Allenbach, Yves

Subjects
Lung, Clinical Research, Rare Diseases, Humans, Myocarditis, Immune Checkpoint Inhibitors, Abatacept, Antineoplastic Agents, Immunological, Myotoxicity, Myositis, Respiratory Muscles, Oncology and Carcinogenesis
Abstract

Immune-checkpoint-inhibitor (ICI)-associated myotoxicity involves the heart (myocarditis) and skeletal muscles (myositis), which frequently occur concurrently and are highly fatal. We report the results of a strategy that included identification of individuals with severe ICI myocarditis by also screening for and managing concomitant respiratory muscle involvement with mechanical ventilation, as well as treatment with the CTLA4 fusion protein abatacept and the JAK inhibitor ruxolitinib. Forty cases with definite ICI myocarditis were included with pathologic confirmation of concomitant myositis in the majority of patients. In the first 10 patients, using recommended guidelines, myotoxicity-related fatality occurred in 60%, consistent with historical controls. In the subsequent 30 cases, we instituted systematic screening for respiratory muscle involvement coupled with active ventilation and treatment using ruxolitinib and abatacept. The abatacept dose was adjusted using CD86 receptor occupancy on circulating monocytes. The myotoxicity-related fatality rate was 3.4% (1/30) in these 30 patients versus 60% in the first quartile (P < 0.0001). These clinical results are hypothesis-generating and need further evaluation.SignificanceEarly management of respiratory muscle failure using mechanical ventilation and high-dose abatacept with CD86 receptor occupancy monitoring combined with ruxolitinib may be promising to mitigate high fatality rates in severe ICI myocarditis. See related commentary by Dougan, p. 1040. This article is highlighted in the In This Issue feature, p. 1027.

Published
2023

2. PFMG2025–integrating genomic medicine into the national healthcare system in France

Author

Abadie, Caroline, Abderrahmane, Aldja, Abdous, Ouarda, Abel, Carine, Ackermann, Oanez, Acquaviva, Cécile, Ader, Flavie, Adham, Salma, Adjaoud, Dalila, Afenjar, Alexandra, Aladjidi, Nathalie, Alary, Anne-Sophie, Albarel, Frédérique, Albert, Sabrina, Allard, Lise, Allix, Ingrid, Alunni, Violaine, Amado, Inês F., Amouroux, Cyril, André, Nicolas, Angelini, Chloé, Anheim, Mathieu, Sanfelliz, Ignacio Antolin, Aparicio, Thomas, Arfeuille, Chloé, Arlet, Jean-Benoît, Arnaud, Lionel, Arnaud, Pauline, Arnold, Guilhem, Attie-Bitach, Tania, Aubert-Mucca, Marion, Audo, Isabelle, Audrezet, Marie-Pierre, Auroux, Maxime, Auzanneau, Céline, Ayrignac, Xavier, Ba, Ibrahima, Bachelot, Anne, Bacq, Delphine, Bacrot, Séverine, Bader-Meunier, Brigitte, Baer, Sarah, Baert-Desurmont, Stéphanie, Bal-Theoleyre, Laurence, Balogoun, Ralyath, Baltzinger, Philippe, Banneau, Guillaume, Bar, Claire, Barbet, Audrey, Barcia, Giulia, Barjhoux, Laure, Barlier, Anne, Barlogis, Vincent, Barritault, Marc, Barth, Magalie, Barthod-Malat, Aurore, Baudouin-Cornu, Peggy, Baujat, Geneviève, Baurand, Amandine, Bay, Jacques-Olivier, Beau-Faller, Michèle, Beaudoin, Jean-Christophe, Bellance, Rémi, Bellanné-Chantelot, Christine, Bellera, Carine, Belot, Alexandre, Ben Abdeljelil, Raihane, Ben Sghaier, Rihab, Benadiba, Joy, Benard, Stéphanie, Beneteau, Claire, Benistan, Karelle, Benkerdou, Fouzia, Benkirane, Mehdi, Benoist, Jean-François, Benusiglio, Patrick R., Bergès, Camille, Bergougnoux, Anne, Bernadach, Maureen, Bernard, Emilien, Bernard, Valérie, Bernard, Virginie, Beroug, Dounia, Berrard, Aurélie, Bertherat, Jérôme, Berthet, Pascaline, Berthier, Clotilde, Bertholet-Thomas, Aurélia, Bertocchio, Jean-Philippe, Bertucci, François, Besse, Céline, Besse-Pinot, Elsa, Bessis, Didier, Beuvain, Pauline, Bezieau, Stéphane, Bidart, Marie, Bièche, Ivan, Biehler, Margaux, Bienvenu, Thierry, Bilan, Frédéric, Billon, Clarisse, Binquet, Christine, Bismuth, Elise, Bizaoui, Varoona, Blanc, Pierre, Blanché, Hélène, Blay, Jean-Yves, Bloch, Adrien, Bloch, Gilles, Bloch-Zupan, Agnes, Bocquet, Béatrice, Boedec, Morgane, Boileau, Catherine, Boissinot, Maureen, Boland, Anne, Bolze, Pierre-Adrien, Bonadona, Valérie, Bonastre, Julia, Bonello-Palot, Nathalie, Bonnard, Adeline-Alice, Borie, Raphaël, Botsen, Damien, Bouattour, Mohamed, Bouctot, Marion, Bouhours-Nouet, Natacha, Bouligand, Jérôme, Bouras, Ahmed, Bourgeron, Thomas, Bourges, Jean-Louis, Bourrat, Emmanuelle, Boursier, Guilaine, Bousquet, Guilhem, Bousquet, Philippe-Jean, Boussion, Simon, Boutaud, Lucile, Boutin, Julian, Bouvagnet, Patrice, Bouvattier, Claire, Boyault, Sandrine, Brac de la Perriere, Aude, Brahmi, Mehdi, Brard, Valentine, Brasseur, Mathilde, Brazzalotto, Nadège, Brémond-Gignac, Dominique, Briand-Suleau, Audrey, Briet, Claire, Bringuier, Pierre-Paul, Bris, Céline, Brischoux-Boucher, Elise, Brochard, Karine, Broly, Martin, Brosseau, Laura, Bruel, Ange-Line, Brunelle, Perrine, Bubien, Virginie, Buecher, Bruno, Buffet, Alexandre, Buisson, Adrien, Burglen, Lydie, Des Roziers, Cyril Burin, Burnichon, Nelly, Busa, Tiffany, Cabart, Mathilde, Cabet, Sara, Caille-Benigni, Charlotte, Caillot, Claire, Calvin, Christophe, Cambon-Thomsen, Anne, Cances, Claude, Cantan, Alexandre, Carausu, Liana, Carbasse, Aurélia, Carbonneil, Cédric, Cariou, Bertrand, Caron, Olivier, Carras, Sylvain, Cartalat, Stéphanie, Cassinari, Kévin, Castelle, Martin, Castéra, Laurent, Castinetti, Frédéric, Catteau, Julie, Caumes, Roseline, Caux, Aurélien, Cavaillé, Mathias, Cavé, Hélène, Caye-Eude, Aurélie, Cazeneuve, Cécile, Celse, Tristan, Celton, Noémie, Cenni, Camille, Cévost, Jasmin, Chaabna, Rania, Chabrol, Brigitte, Challet, Ilyas, Chalumeau, Clélia, Chambon, Pascal, Chansavang, Albain, Chanson, Jean-Baptiste, Chapelant, Sébastien, Charbit-Henrion, Fabienne, Charles, Perrine, Charrière, Sybil, Charron, Philippe, Chassaing, Nicolas, Chatron, Nicolas, Chaumette, Boris, Chaussain, Catherine, Chaussenot, Annabelle, Cheillan, David, Chenavier, Olivier, Chesneau, Bertrand, Chevalier, Louise-Marie, Chomienne, Christine, Chougnet, Cécile, Christin-Maitre, Sophie, Chuet, Marine, Clappier, Emmanuelle, Clet, Johanna, Cloteau, Mélanie, Cluzeau, Thomas, Cogan, Guillaume, Cogné, Benjamin, Cohen, Alicia, Cohen, Camille, Cohen-Haguenauer, Odile, Cohen-Solal, Martine, Colas, Chrystelle, Colin, Estelle, Collet, Corinne, Collin-Chavagnac, Delphine, Colliou, Eloïse, Collonge-Rame, Marie-Agnès, Colmard, Maxime, Coopman, Stéphanie, Coppin, Lucie, Coquan, Elodie, Cormier-Daire, Valérie, Corradini, Nadège, Corsini, Carole, Cossée, Mireille, Coste, Thibault, Cotteret, Sophie, Cottet, Rachel, Coubes, Christine, Coulet, Florence, Couque, Nathalie, Couratier, Philippe, Courbebaisse, Marie, Courbette, Olivier, Courdier, Cécile, Coursimault, Juliette, Courtin, Thomas, Courtois, Lucien, Coury, Fabienne, Coutos-Thévenot, Laure, Coutton, Charles, Creveaux, Isabelle, Crickx, Etienne, Crivelli, Louise, Cuggia, Marc, Cuisset, Laurence, Curcio, Hubert, Curie, Aurore, Cusin, Veronica, Da Costa, Noémie, Da Cruz, Lionel, Dahlen, Eric, Dardenne, Antoine, Dauriat, Benjamin, Dausse, Nell, De Becdelièvre, Alix, De Fraipont, Florence, De La Cruz, Elisa, De la Motte Rouge, Thibault, De Montgolfier, Sandrine, De Pauw, Antoine, De Reyniès, Aurélien, De Sainte Agathe, Jean-Madeleine, De Tayrac, Marie, Defachelles, Anne-Sophie, Degaud, Michaël, Deiller, Caroline, Delabesse, Eric, Delachaux, Leslie, Delahaye-Duriez, Andrée, Deleuze, Jean-François, Delhomelle, Hélène, Delmas, Christelle, Delnatte, Capucine, Delorme, Catherine, Delorme, Richard, Demeer, Bénédicte, Demilly, Caroline, Denizeau, Philippe, Denjoy, Isabelle, Denommé-Pichon, Anne-Sophie, Depienne, Christel, Derive, Nicolas, Dervillé, Flora, Portes, Vincent Des, Desguerre, Isabelle, Desnous, Béatrice, Desseignes, Camille, Devillard, Françoise, Deville, Manjula, Dewulf-Pasz, Nelly, Dhaenens, Claire-Marie, Dietrich, Klaus, Dieux, Anne, Diop, Mody, Disse, Emmanuel, Djaber, Samir, Cao, Christine Do, Dollfus, Hélène, Domenach, Louis, Donadieu, Jean, Donadille, Bruno, Dougé, Aurore, Dreyfus, Hélène, Drunat, Séverine, Dubois-Laforgue, Danièle, Dubourg, Christele, Dubucs, Charlotte, Dubus, Jean-Christophe, Duchmann, Matthieu, Ducray, François, Ducrotverdun, Marion, Duffaud, Florence, Duffourd, Yannis, Dufour, William, Duhil de Bénazé, Gwénaelle, Dulac, Yves, Dunand, Olivier, Dunoyer de Segonzac, Denis, Dupain, Célia, Duployez, Nicolas, Dupré, Anaïs, Dupré, Aurélien, Dupuis-Girod, Sophie, Duquet, Romain, Durand, Alice, Durand, Benjamin, Durand-Zaleski, Isabelle, Durando, Xavier, Durr, Alexandra, Eberst, Lauriane, Edery, Patrick, Egloff, Matthieu, El Chehadeh, Salima, El Khattabi, Laïla, Engel, Camille, Entresangle, Mathilde, Espérou, Hélène, Esselin, Florence, Etancelin, Pascaline, Evrevin, Clémence, Ewenczyk, Claire, Eychene, Alain, Eychenne, Thomas, Ezaru, Andra, Fabry, Vincent, Faivre, Laurence, Faoucher, Marie, Faure, Clémentine, Fauré, Julien, Fauret-Amsellem, Anne-Laure, Feigerlova, Eva, Feillet, François, Fenwarth, Laurène, Férec, Claude, Fergelot, Patricia, Ferrari, Anthony, Ferraro-Peyret, Carole, Feugeas, Jean-Paul, Fieschi, Claire, Fievet, Alice, Fila, Marc, Fillatre, Rémi, Filser, Mathilde, Fin, Bertrand, Fiore, Mathieu, Firmin, Nelly, Flandrin-Gresta, Pascale, Flechon, Aude, Fournier, Benjamin, Fragny, Cécile, Francois-Heude, Marie-Céline, Francou, Bruno, Frébourg, Thierry, Fressart, Véronique, Frétigny, Mathilde, Funalot, Benoit, Fusaro, Mathieu, Gaignard, Pauline, Gandjbakhch, Estelle, Ganne, Benjamin, Garde, Aurore, Gatinois, Vincent, Gaucher, Céline, Gaudillat, Léa, Gaulard, Philippe, Gauthier, Lucas, Gay-Bellile, Mathilde, Geneste, Damien, Geneviève, David, Genin, Emmanuelle, Genoux, Sandrine, Geoerger, Birgit, Geoffroy, Véronique, Georget, Mathieu, Gérard, Bénédicte, Gertych, Witold, Halem, Souad Gherbi, Ghorab, Karima, Gille, Romane, Gillet, Charlène, Gillibert-Yvert, Marion, Gilly, Olivier, Gimenez-Roqueplo, Anne-Paule, Giraud, Sophie, Girerd, Barbara, Girodon, François, Glazunova, Olga, Gobert, Delphine, Goizet, Cyril, Gokce-Samar, Zeynep, Golmard, Lisa, Gomez-Roca, Carlos, Gonzales, Emmanuel, Gorce, Magali, Gorenstein, Marie-Clémence, Gorrichon, Kévin, Gottrand, Frédéric, Gouas, Laetitia, Gourdon, Stéphanie, Gourdy, Pierre, Gouronc, Aurélie, Goursaud, Claire, Gousse, Gaëlle, Gouy, Evan, Goze-Martineau, Odile, Gozlan, Diane, Grabli, David, Gras, Margaux, Grelet, Maude, Gressin, Laetitia, Grivel, Nathalie, Grotto, Sarah, Grouthier, Virginie, Grunenwald, Solange, Grunewald, Olivier, Gueguen, Paul, Guérin, Cécile, Guerrot, Anne-Marie, Guey, Stéphanie, Guffon, Nathalie, Guichet, Agnès, Guièze, Romain, Guillaud-Bataille, Marine, Guillemin, Francis, Guillerm, Erell, Guillermin, Yann, Guillet-Pichon, Virginie, Guillou, Isabelle, Guimbaud, Rosine, Guimier, Anne, Guissart, Claire, Guittet, Eric, Guy, Nathalie, Hadchouel, Alice, Abdallah, Hamza Hadj, Hadj-Rabia, Smail, Hadjadj, Samy, Hage-Sleiman, Mehdi, Haioun, Corinne, Halawi, Sara, Hamza, Abderaouf, Hanau, Perrine, Hanna, Nadine, Harbuz, Radu, Hardy, Gaëlle, Hauspie, Carine, Hayette, Sandrine, Heard, Jean-Michel, Heiblig, Maël, Heide, Solveig, Heidet, Laurence, Henry, Marcia, Hentgen, Véronique, Héron, Bénédicte, Héron, Delphine, Hervé, Dominique, Herzig, Anthony, Hirsch, Pierre, Hommais, Antoine, Honnorat, Jérôme, Horta, Edgar, Houdayer, Claude, Houillier, Pascal, Huet, Sarah, Hugot, Jean-Pierre, Huguenin, Yoann, Humbert, Marc, Humbert-Asensio, Marie-Laure, Huot, Laure, Ifrah, Norbert, Illouz, Frédéric, Imbard, Apolline, Imbert-Bouteille, Marion, Isambert, Nicolas, Isidor, Bertrand, Italiano, Antoine, Itzykson, Raphaël, Jaillard, Sylvie, Jamilloux, Yvan, Janin, Alexandre, Januel, Louis, Javelot-Jacquelin, Cécile, Jeanne, Médéric, Jedraszak, Guillaume, Jéru, Isabelle, Jeunemaitre, Xavier, Jeziorski, Eric, Jobic, Florence, Joly, Philippe, Jonard, Laurence, Jondeau, Guillaume, Jones, Natalie, Jouannic, Jean-Marie, Jouinot, Anne, Jouk, Pierre-Simon, Jourdy, Yohann, Jousselin, Kévin, Jouvenceau, Anne, Jubert, Charlotte, Julia, Sophie, Jurquet, Anne-laure, Juven, Aurélien, Kamal, Maud, Kantapareddy, Pascal, Kaphan, Elsa, Karayan-Tapon, Lucie, Kasper, Edwige, Kerbellec, Lara, Keren, Boris, Khalifa, Emmanuel, Van Kien, Philippe Khau, Kheddouci, Sihem, Kientz, Caroline, Kim, Rathana, Knapke, Antjie, Koenig, Michel, isabelle Kone, Konyukh, Marina, Kormann, Raphaël, Kossorotoff, Manoelle, Kuentz, Paul, Kyndt, Florence, L'Haridon, Anaïs, Labrune, Philippe, Lackmy, Marilyn, Lacombe, Didier, Lacroix, Ludovic, Laffargue, Fanny, Lahlou, Ghizlene, Laizet, Yec'han, Lambert, Laetitia, Lamoril, Jérôme, Lamouroux, Audrey, Landais, Emilie, Landman, Samuel, Landry, Elise, Lapillonne, Hélène, Lapointe, Anne-Sophie, Larcher, Lise, Lardeux, Pierre, Largeaud, Laetitia, Larger, Etienne, Larrouquere, Louis, Lasolle, Hélène, Lasseaux, Eulalie, Latypova, Xenia, Laurens, Tiphany, Laurent, Camille, Laurent-Puig, Pierre, Lautrette, Géraldine, Lauvray, Thomas, Lavallart, Benoît, Lavenu-Bombled, Cécile, Laverdure, Noémie, Le Bris, Yannick, Le Chalony, Catherine, Le Du, Nathalie, Le Folgoc, Gaëlle, Le Gac, Gerald, Le Gall, Jessica, Le Guillou, Edouard, Le Guillou, Xavier, Le Guyader, Gwenaël, Le Ray, Maryannick, Le Saux, Olivia, Le Tourneau, Christophe, Lebecque, Benjamin, Lebellec, Loïc, Lebigot, Elise, Leblond, Pierre, Leboulanger, Nicolas, Lebras, Laure, Lebre, Anne-Sophie, Lebreton, Louis, Lecoquierre, François, Lefebvre, Mathilde, Legendre, Marine, Leglise, Camille, Legrand, Clémentine, Lehalle, Daphné, Lejeune, Catherine, Lemaitre, Christine, Leman, Raphaël, Lepage, Mathis, Lermine, Alban, Leroy, Karen, Lesca, Gaëtan, Lesieur-Sebellin, Marion, Letexier, Mélanie, Lethimonnier, Franck, Levaillant, Lucie, Levy, Jonathan, Levy, Yves, Lévy, Pascale, Lhermitte, Ludovic, Linglart, Agnès, Lionnet, Clément, Livon, Doriane, Lode, Laurence, Lodin, Magalie, Lopez, Jonathan, Lopez, Maureen, Lortholary, Alain, Louha, Malek, Louvrier, Camille, Ludwig, Thomas E., Luvet, Auriane, Lyonnet, Stanislas, Makowski, Caroline, Malan, Valérie, Mallaret, Martial, Mallet, Delphine, Mallet, Stéphanie, Malphettes, Marion, Manaud, Nathalie, Mancini, Pierre, Manfredi, Sylvain, Manouvrier, Sylvie, Mansard, Luke, Mansard, Sandrine, Mansour-Hendili, Lamisse, Mansuy, Ludovic, Maquet, Julien, Marçais, Ambroise, Marceau-Renaut, Alice, Marec-Berard, Perrine, Marelli, Cécilia, Marenne, Gaëlle, Marey, Isabelle, Margier, Jennifer, Margot, Henri, Marie, Guillaume, Marin, Victor, Marisa, Laetitia, Marlin, Sandrine, Marquant, Emeline, Marquet, Valentine, Marsili, Luisa, Martin, Amaury, Martinerie, Laetitia, Maruani, Anna, Marzin, Pauline, Massard, Christophe, Masson, Emmanuelle, Mathieu, Flavie, Mathieu, Marion, Mathoulin-Pelissier, Simone, Matthieu, Flore, Mauras, Mathilde, Maureille, Aurélien, Mazel, Benoit, Mazeres, Mary, Leer, Anne Mc, Melki, Isabelle, Menassa, Rita, Méneret, Aurélie, Menjard, Julie, Mercier, Anne, Merieau, Elodie, Merlin, Marie-Sophie, Merlio, Jean-Philippe, Meslier, Cécile, Mesnard, Laurent, Mestre-Godin, Sandrine, Metay, Corinne, Meunier, Sandrine, Meyer, Pierre, Michaud, Vincent, Michel-Calemard, Laurence, Mignot, Cyril, Miguet, Marguerite, Millat, Gilles, Mirault, Tristan, Miron de l'Espinay, Albane, Molac, Clémence, Molin, Arnaud, Mondet, Julie, Monin, Faustine, Monin, Pauline, Monneur, Audrey, Monnot, Sophie, Montani, David, Morel, Elodie, Morel, Godelieve, Morel, Valérie, Moretta, Jessica, Morice-Picard, Fanny, Morillon, Lucie, Morin, Carole, Morin-Meschin, Marie-Emmanuelle, Morlat, Philippe, Moshous, Despina, Mouret-Fourme, Emmanuelle, Moussy, Alice, Moutton, Sébastien, Mouzat, Kévin, Muletier, Romane, Muller, Jean, Muller, Marie, Nadaj-Pakleza, Aleksandra, Nambot, Sophie, Nathan, Nadia, Nava, Caroline, Nectoux, Juliette, Netter, Jeanne, Neumann, Florent, Neveu, Julien, Nevière, Zoé, Nguyen, Laetitia, Niclass, Tanguy, Nicolas, Gaël, Nicolas, Laury, Ningarhari, Massih, Nogues, Catherine, Novello, Cécile, Nowak, Frédérique, Odent, Sylvie, Odou, Marie-Françoise, Olaso, Robert, Otmani, Sarah, Ovaert, Caroline, Pacot, Laurence, Pages, Mélanie, Paillard, Catherine, Palmyre, Aurélien, Panagiotakaki, Eleni, Pannard, Myriam, Paoletti, Anne, Papadopoulou, Maria T., Papathanasiou, Matthildi, Paquis, Véronique, Parfait, Béatrice, Paris, Camille, Paris, Clara, Paris, Françoise, Pasmant, Eric, Pasquet, Marlène, Passet, Marie, Pastoret, Cédric, Patat, Olivier, Patay, Léa, Paul, Antoine, Pebrel-Richard, Céline, Peduto, Cristina, Peffault de Latour, Regis, Pegat, Antoine, Pelletier, Annick, Pelletier, Valérie, Pellisson, Fanny, Pennamen, Perrine, Pereira, Victor, Pernin-Grandjean, Julie, Péron, Julien, Perrier, Alexandre, Perrier, Lionel, Perrin, Laurence, Perthus, Isabelle, Petit, Arnaud, Petit, Audrey, Petit, Florence, Petit, François, Petrov, Yuliya, Peyre, Hugo, Philippe, Christophe, Piard, Juliette, Pierre-Noël, Elise, Pierron, Gaëlle, Pimouguet, Clément, Pingault, Véronique, Pinson, Stéphane, Pion, Emmanuelle, Plaisancié, Julie, Planes, Marc, Planté-Bordeneuve, Pauline, Plas, William, Plutino, Morgane, Poignie, Ludivine, Poinsignon, Vianney, Poirée, Marilyne, Pons, Nicolas, Pontier, Bénédicte, Porquet-Bordes, Valérie, Porteret, Camille, Potier, Delphine, Potier, Louis, Pouessel, Damien, Poujade, Laura, Preau, Marie, Preudhomme, Claude, Prieur, Fabienne, Probst, Vincent, Procaccio, Vincent, Prot-Bertoye, Caroline, Prunier, Delphine, Puechberty, Jacques, Pujalte, Mathilde, Qebibo, Leila, Quemener-Redon, Sylvia, Quérée, Isabelle, Quijano-Roy, Susana, Quirin, Nicolas, Racine, Caroline, Raimbault, Sandra, Raimbourg, Judith, Rajaoba, Marine, Rambaud, Thomas, Ramirez, Carole, Ramond, Francis, Ranguin, Kara, Rausell, Antonio, Ravel, Jean-Marie, Ravelli, Claudia, Raverot, Gerald, Ray-Coquard, Isabelle, Raynal, Caroline, Réant, Patricia, Rebours, Vinciane, Redon, Richard, Réguerre, Yves, Reix, Philippe, Renard, Cécile, Renaud, Mathilde, Rendu, John, Renoux, Céline, Rey, Romain, Reynaud, Rachel, Rhinan, Lucie, Riant, Florence, Riccardi, Florence, Richard, Pascale, Ricou, Agathe, Rigalleau, Vincent, Rio, Marlène, Rivière, Axelle, Robelin, Patrick, Robert, Marion, Robert, Thomas, Rohmer, Barbara, Romanet, Pauline, Romoli, Arnaud, Rondeau, Sophie, Rooryck, Caroline, Roquelaure, Bertrand, Rosain, Jérémie, Rossi, Massimiliano, Rossignol, Sylvie, Rothenbuhler, Anya, Rouel, Nadège, Rouillon, Marine, Roux, Anne-Francoise, Roux-Buisson, Nathalie, Rouzier, Cécile, Roze, Emmanuel, Ruaud, Lyse, Ruault, Valentin, Ruysschaert, Claire, Saada, Esma, Saadi - Ait El Mkadem, Samira, Saandi, Thoueiba, Sabour, Niki, Sacconi, Sabrina, Saffroy, Raphaël, Safraou, Hana, Saillour, Virginie, Pierre, Aude Saint, Saint-Martin, Cécile, Saintigny, Pierre, Salaun, Gaëlle, Salgado, David, Salle, Laurence, Samuel, Didier, Sanlaville, Damien, Sapey-Triomphe, Laure, Sarnacki, Sabine, Sarrazin, Elisabeth, Sarret, Catherine, Satre, Véronique, Saugier-Veber, Pascale, Saultier, Paul, Saumet, Laure, Schaefer, Elise, Scheyer, Nicolas, Schiff, Isabelle, Schleiermacher, Gudrun, Schleinitz, Nicolas, Schluth-Bolard, Caroline, Schneider, Anouck, Schwartz, Bertrand, Sebaoun, Jean-Marc, Serey-Gaut, Margaux, Serrier, Hassan, Servais, Aude, Serveaux-Dancer, Marine, Sevenet, Nicolas, Seyve, Antoine, Sibony-Cohen, Alicia, Sicre de Fontbrune, Flore, Sigaudy, Sabine, Sigaux, François, Simaga, Fatoumata, Simmet, Victor, Simon, Pauline, Simon, Sophie, Sirveaux, François, Smol, Thomas, Solé, Guilhem, Soler, Gwendoline, Solignac, Pauline, Soriani, Marie-Hélène, Soubeyran, Isabelle, Soulier, Jean, Spelle, Laurent, Sperelakis-Beedham, Brian, Spinazzi, Marco, Spodenkiewicz, Marta, Spraul, Anne, Squiban, Barbara, Srikaran, Arunya, Steffann, Julie, Stetco, Anamaria, Stoeva, Radka, Stojkovic, Tanya, Stoppa-Lyonnet, Dominique, Suarez, Felipe, Sujobert, Pierre, Svahn, Juliette, Ta, Minh-Chau, Tabet, Anne-Claude, Tachon, Gaëlle, Tallegas, Matthias, Tallet, Anne, Tambourin, Pierre-Edmond, Tandonnet, Julie, Tardy, Véronique, Tavernier, Emmanuelle, Tchernitchko, Dimitri, Teillon-Berranger, Marie-Hélène, Tenenbaum, Julie, Teoli, Jordan, Tessarech, Marine, Tessoulin, Benoit, Tharreau, Mylène, Thauvin-Robinet, Christel, Theou-Anton, Nathalie, Thevenon, Julien, Thomas, Anne, Thomas, Laure, Thomas, Quentin, Thomas-Teinturier, Cécile, Tieulie, Nathalie, Tinat, Julie, Tlemsani, Camille, Tondeur, Sylvie, Tosca, Lucie, Tosi, Diego, Tougeron, David, Touraine, Phlippe, Tournier-Lasserve, Elisabeth, Toutain, Annick, Mau-Them, Frédéric Tran, Tranchant, Christine, Trédan, Olivier, Trimouille, Aurélien, Trochu, Jean-Noël, Tronel, Vincent, Trouba, Cécile, Truchetet, Marie-Elise, Truffaux, Nathalène, Tsalamlal, Amel, Turlotte, Edouard, Turon, Violette, Tusseau, Maud, Uhrhammer, Nancy, Vaché, Christel, Valence, Stéphanie, Valentin, Thibaud, Valero, René, Valleix, Sophie, Vallet, Marion, Vanacker, Hélène, Vande-Perre, Pierre, Vandenbrouck, Yves, Vanlerberghe, Clémence, Vargas-Poussou, Rosa, Vatier, Camille, Vauchel, Vincent, Vaur, Dominique, Velo-Suarez, Lourdes, Venat, Laurence, Vera, Gabriella, Verebi, Camille, Verley, Célia, Verlingue, Loïc, Verny, Christophe, Veronese, Lauren, Verotte, Nelly, Verret, Benjamin, Vial, Yoann, Vialard, Francois, Viari, Alain, Vidailhet, Marie, Vidaud, Dominique, Vidaud, Michel, Vignes, Stéphane, Vigouroux, Clothilde, Villard, Laurent, Villeneuve, Laurent, Villié, Patricia, Villy, Marie-Charlotte, Vinauger, Lara, Vinceneux, Armelle, Vincenot, Anne, Vinciguerra, Christine, Vitobello, Antonio, Vourc'h, Patrick, Vozy, Aurore, Vuillaume-Winter, Marie-Laure, Vuillaumier-Barrot, Sandrine, Wahbi, Karim, Wallet, Cédrick, Walter, Thomas, Walther-Louvier, Ulrike, Watson, Sarah, Waymel, Anne-Christine, Weinhard, Sara, Wicker, Camille, Willems, Marjolaine, Wourms, Justine, Wyrebski, Antoine, Yauy, Kévin, Zaidan, Mohamad, Zaloszyc, Ariane, Zattara, Hélène, Zawadzki, Christophe, and Ziegler, Alban

Published
2025
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3. Systematic analysis of drug-associated myocarditis reported in the World Health Organization pharmacovigilance database.

Author

Nguyen, Lee, Cooper, Leslie, Kerneis, Mathieu, Funck-Brentano, Christian, Silvain, Johanne, Brechot, Nicolas, Hekimian, Guillaume, Ammirati, Enrico, Ben MBarek, Badr, Redheuil, Alban, Gandjbakhch, Estelle, Bihan, Kevin, Lebrun-Vignes, Bénédicte, Ederhy, Stephane, Dolladille, Charles, Moslehi, Javid, and Salem, Joe-Elie

Subjects
Adverse Drug Reaction Reporting Systems, Antineoplastic Agents, Antipsychotic Agents, Bayes Theorem, Cross-Sectional Studies, Data Management, Databases, Factual, Humans, Immunotherapy, Myocarditis, Pharmaceutical Preparations, Pharmacovigilance, Systems Analysis, World Health Organization
Abstract

While multiple pharmacological drugs have been associated with myocarditis, temporal trends and overall mortality have not been reported. Here we report the spectrum and main features of 5108 reports of drug-induced myocarditis, in a worldwide pharmacovigilance analysis, comprising more than 21 million individual-case-safety reports from 1967 to 2020. Significant association between myocarditis and a suspected drug is assessed using disproportionality analyses, which use Bayesian information component estimates. Overall, we identify 62 drugs associated with myocarditis, 41 of which are categorized into 5 main pharmacological classes: antipsychotics (n = 3108 reports), salicylates (n = 340), antineoplastic-cytotoxics (n = 190), antineoplastic-immunotherapies (n = 538), and vaccines (n = 790). Thirty-eight (61.3%) drugs were not previously reported associated with myocarditis. Antipsychotic was the first (1979) and most reported class (n = 3018). In 2019, the two most reported classes were antipsychotics (54.7%) and immunotherapies (29.5%). Time-to-onset between treatment start and myocarditis is 15 [interquartile range: 10; 23] days. Subsequent mortality is 10.3% and differs between drug classes with immunotherapies the highest, 32.5% and salicylates the lowest, 2.6%. These elements highlight the diversity of presentations of myocarditis depending on drug class, and show the emerging role of antineoplastic drugs in the field of drug-induced myocarditis.

Published
2022

4. Long-Term Arrhythmic Follow-Up and Risk Stratification of Patients With Desmoplakin-Associated Arrhythmogenic Right Ventricular Cardiomyopathy

Author

Gasperetti, Alessio, Carrick, Richard, Protonotarios, Alexandros, Laredo, Mikael, van der Schaaf, Iris, Syrris, Petros, Murray, Brittney, Tichnell, Crystal, Cappelletto, Chiara, Gigli, Marta, Medo, Kristen, Crabtree, Peter, Saguner, Ardan M., Duru, Firat, Hylind, Robyn, Abrams, Dominic, Lakdawala, Neal K., Massie, Charles, Cadrin-Tourigny, Julia, Targetti, Mattia, Olivotto, Iacopo, Graziosi, Maddalena, Cox, Moniek, Biagini, Elena, Charron, Philippe, Casella, Michela, Tondo, Claudio, Yazdani, Momina, Ware, James S., Prasad, Sanjay, Calò, Leonardo, Smith, Eric, Helms, Adam, Hespe, Sophie, Ingles, Jodie, Tandri, Harikrishna, Ader, Flavie, Mestroni, Luisa, Wilde, Arthur, Merlo, Marco, Gandjbakhch, Estelle, Calkins, Hugh, te Riele, Anneline S.J.M., Peter van Tintelen, J., Elliot, Perry, and James, Cynthia A.

Published
2024
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6. Position paper on sustainability in cardiac pacing and electrophysiology from the Working Group of Cardiac Pacing and Electrophysiology of the French Society of Cardiology

Author

Sacher, Frédéric, Bacquelin, Raoul, Bessiere, Francis, Ditac, Geoffroy, Duchateau, Josselin, Ait-Said, Mina, Boveda, Serge, Extramiana, Fabrice, Delsarte, Laura, Fauchier, Laurent, Gandjbakhch, Estelle, Garcia, Rodrigue, Klug, Didier, Lellouche, Nicolas, Marijon, Eloi, Martins, Raphael, Maury, Philipe, Mette, Carole, Piot, Olivier, Taieb, Jerome, and Defaye, Pascal

Published
2024
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7. Rationale and design of the ARAMIS trial: Anakinra versus placebo, a double blind randomized controlled trial for the treatment of acute myocarditis

Author

Kerneis, Mathieu, Cohen, Fleur, Combes, Alain, Amoura, Zahir, Pare, Carine, Brugier, Delphine, Puymirat, Etienne, Abtan, Jeremie, Lattuca, Benoit, Dillinger, Jean-Guillaume, Hauguel-Moreau, Marie, Silvain, Johanne, Salem, Joe-Elie, Gandjbakhch, Estelle, Hekimian, Guillaume, Redheuil, Alban, Vicaut, Eric, and Montalescot, Gilles

Published
2023
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9. Androgenic Effects on Ventricular Repolarization: A Translational Study From the International Pharmacovigilance Database to iPSC-Cardiomyocytes.

Author

Salem, Joe-Elie, Yang, Tao, Moslehi, Javid, Waintraub, Xavier, Gandjbakhch, Estelle, Bachelot, Anne, Hidden-Lucet, Francoise, Hulot, Jean-Sebastien, Knollmann, Bjorn, Lebrun-Vignes, Benedicte, Funck-Brentano, Christian, Glazer, Andrew, and Roden, Dan

Subjects
androgen antagonists, hypogonadism, long QT syndrome, testosterone, torsades de pointes, Androgens, Antineoplastic Agents, Benzamides, Cell Differentiation, Cells, Cultured, Databases, Factual, Humans, Hypogonadism, Induced Pluripotent Stem Cells, International Cooperation, Long QT Syndrome, Male, Myocytes, Cardiac, Nitriles, Pharmacovigilance, Phenylthiohydantoin, Risk, Torsades de Pointes, Translational Research, Biomedical
Abstract

BACKGROUND: Male hypogonadism, arising from a range of etiologies including androgen-deprivation therapies (ADTs), has been reported as a risk factor for acquired long-QT syndrome (aLQTS) and torsades de pointes (TdP). A full description of the clinical features of aLQTS associated with ADT and of underlying mechanisms is lacking. METHODS: We searched the international pharmacovigilance database VigiBase for men (n=6 560 565 individual case safety reports) presenting with aLQTS, TdP, or sudden death associated with ADT. In cardiomyocytes derived from induced pluripotent stem cells from men, we studied electrophysiological effects of ADT and dihydrotestosterone. RESULTS: Among subjects receiving ADT in VigiBase, we identified 184 cases of aLQTS (n=168) and/or TdP (n=68; 11% fatal), and 99 with sudden death. Of the 10 ADT drugs examined, 7 had a disproportional association (reporting odds ratio=1.4-4.7; P

Published
2019

10. Sex Differences in Outcomes of Tetralogy of Fallot Patients With Implantable Cardioverter-Defibrillators

Author

Akret, Chrystelle, Albenque, Jean-Paul, Algalarrondo, Vincent, Alonso, Christine, Amet, Denis, Ansselme, Frédéric, Asselin, Anouk, Audinet, Caroline, Badenco, Nicolas, Bader, Hugues, Badoz, Marc, Baudinaud, Pierre, Behar, Nathalie, Ben Kilani, Mouna, Bernard, Yvette, Bertaux, Géraldine, Bertrand, Cathy, Bessiere, Francis, Blangy, Hughes, Bonnet, Damien, Bordchar, Pierre, Bouzeman, Abdeslam, Boveda, Serge, Bru, Paul, Bun, Sok Sithikun, Carabelli, Adrien, Cardin, Christèle, Cauchemez, Bruno, Chalbia, Tej, Champ-Rigot, Laure, Chastre, Thomas, Chevallier, Philippe, Clementy, Nicolas, Clerici, Gaël, Combes, Nicolas, Combes, Stéphane, Da Costa, Antoine, De Chillou, Christian, De Guillebon, Maxime, Defaye, Pascal, Degand, Bruno, Deharo, Jean-Claude, Derval, Nicolas, Di Filippo, Sylvie, Domain, Guillaume, Dompnier, Antoine, Dulac, Arnaud, Duparc, Alexandre, Duplantier, D Cécile, Duthoit, Guillaume, El Bouazzaoui, Rim, Elbaz, Nathalie, Enache, Bogdan, Eschalier, Romain, Extramiana, Fabrice, Fauchier, Laurent, Fiorello, Pierre, Frey, Pierre, Freysz, Luc, Galand, Vincent, Gandjbakhch, Estelle, Garcia, Rodrigue, Gardey, Kevin, Geoffroy, Olivier, Godin, Bénédicte, Gourraud, Jean-Baptiste, Goussot, Samuel, Grimard, Caroline, Guenancia, Charles, Guichard, Jean-Baptiste, Guy-Moyat, Benoit, Haissaguerre, Michel, Halimi, Franck, Hamon, David, Hascoet, Sébastien, Hasni, Karim, Hermida, Alexis, Hermida, Jean-Sylvain, Hidden-Lucet, Françoise, Hocini, Mélèze, Hourdain, Jérome, Irles, Didier, Iserin, Laurence, Jacon, Peggy, Jauvert, Gaël, Jean, Frédéric, Johnson, Nicolas, Jourda, François, Khattar, Pierre, Khoueiry, Ziad, Koutbi, Rita, Labombarda, Fabien, Laborie, Guillaume, Lactu, Gabriel, Ladouceur, Magalie, Lagrange, Philippe, Lallemand, Pierre-Marc, Laredo, Mikael, Laurent, Gabriel, Lavergne, Thomas, Lazarus, Arnaud, Le Gloan, Laurianne, Leclercq, Christophe, Leenhardt, Antoine, Lellouche, Nicolas, Loose, Christophe, Mabo, Philippe, Maltret, Alice, Mandel, Franck, Mansourati, Jacques, Marijon, Eloi, Marquie, Christelle, Martins, Raphaël, Mathiron, Amel, Maupain, Carole, Maury, Philippe, Messali, Anne, Milhelm, Antoine, Milliez, Paul, Mirolo, Adrian, Mondoly, Pierre, Moubarak, Ghassan, Mourot, Stéphane, Nguyen, Cédric, Ollitrault, Jacky, Ollitrault, Pierre, Otmani, Akli, Pasquie, Jean-Luc, Pavin, Dominique, Perier, Marie-Cécile, Philibert, Séverinne, Poindron, Damien, Potelle, Charlotte, Probst, Vincent, Puie, Paul, Pujadas, Penelope, Rollin, Anne, Romeyer-Bouchard, Cécile, Sacher, Frédéric, Sadoul, Nicolas, Sagnard, Audrey, Sagnol, Pascal, Savoure, Arnaud, Scarlatti, Didier, Sellal, Jean Marc, Sharifzadehgan, Ardalan, Squara, Fabien, Tanese, Nikita, Thambo, Jean Benoit, Thomas, Olivier, Varlet, Emie, Venier, Sandrine, Stephanopoli, Quentin Voglimacci, Waintraub, Xavier, Waldmann, Victor, Walton, Camille, Wiart, Françoise, Winum, Pierre, Zakine, Cyril, Zhao, Alexandre, Zouaghi, Amir, Koutbi, Linda, Bessière, Francis, Marquié, Christelle, Bordachar, Pierre, Al Arnaout, Alain, Anselme, Frédéric, Chassignolle, Morgane, de Guillebon, Maxime, Massoulié, Grégoire, Narayanan, Kumar, Ninni, Sandro, Pierre, Bertrand, Pasquié, Jean-Luc, Thambo, Jean-Benoit, and Jouven, Xavier

Published
2022
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14. Position paper concerning the competence, performance and environment required for the practice of ablation in children and in congenital heart disease

Author

Maury, Philippe, Thambo, Jean Benoit, Maltret, Alice, Combes, Nicolas, Hascoet, Sébastien, Derval, Nicolas, Ladouceur, Magalie, Acar, Philippe, Amedro, Pascal, Anselm, Frederic, Bajolle, Fanny, Basquin, Adeline, Belli, Emre, Bordachar, Pierre, Duthoit, Guillaume, Di Filippo, Sylvie, Fauchier, Laurent, Gandjbakhch, Estelle, Gras, Daniel, Gronier, Celine, Karsenty, Clement, Klug, Didier, Koutbi, Linda, Lacotte, Jérôme, Laurent, Gabriel, Laux, Daniela, Mansourati, Jacques, Marijon, Eloi, Ovaert, Caroline, Sacher, Frederic, Sadoul, Nicolas, Taieb, Jérôme, Waldmann, Victor, Warinfresse, Karine, Defaye, Pascal, Piot, Olivier, and Boveda, Serge

Published
2020
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15. Joint Position Paper of the Working Group of Pacing and Electrophysiology of the French Society of Cardiology and the French Society of Diagnostic and Interventional Cardiac and Vascular Imaging on magnetic resonance imaging in patients with cardiac electronic implantable devices

Author

Gandjbakhch, Estelle, Dacher, Jean-Nicolas, Taieb, Jerome, Chauvin, Michel, Anselme, Frederic, Bartoli, Axel, Boyer, Louis, Cassagnes, Lucie, Cochet, Hubert, Defaye, Pascal, Deharo, Jean-Claude, Dubourg, Benjamin, Fauchier, Laurent, Gras, Daniel, Klug, Didier, Laurent, Gabriel, Mansourati, Jacques, Marijon, Eloi, Maury, Philippe, Piot, Olivier, Pontana, François, Sacher, Frederic, Sadoul, Nicolas, Jacquier, Alexis, and Boveda, Serge

Published
2020
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16. Clinical differences between drug‐induced type 1 Brugada pattern and syndrome

Author

Sabbag, Avi, primary, Amoroso, Gisella, additional, Tomer, Orr, additional, Conte, Giulio, additional, Beinart, Roy, additional, Nof, Eyal, additional, Özkartal, Tardu, additional, Ollitrault, Pierre, additional, Laredo, Mikael, additional, Tovia‐Brodie, Oholi, additional, Gandjbakhch, Estelle, additional, de Benedictis, Michele, additional, ter Bekke, Rachel M. A., additional, and Milman, Anat, additional

Published
2024
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17. Clinical impact of post-mortem genetic testing in cardiac death and cardiomyopathy

Author

Marey Isabelle, Fressart Véronique, Rambaud Caroline, Fornes Paul, Martin Laurent, Grotto Sarah, Alembik Yves, Gorka Hervé, Millat Gilles, Gandjbakhch Estelle, Bordet Céline, Grandmaison Geoffroy Lorin de la, Richard Pascale, and Charron Philippe

Subjects
sudden death, cardiac death, cardiomyopathy, post-mortem, genetic testing, Medicine
Abstract

Post-mortem genetic analyses may help to elucidate the cause of cardiac death. The added value is however unclear when a cardiac disease is already suspected or affirmed. Our aim was to study the feasibility and medical impact of post-mortem genetic analyses in suspected cardiomyopathy. We studied 35 patients with cardiac death and suspected cardiomyopathy based on autopsy or clinical data. After targeted sequencing, we identified 15 causal variants in 15 patients (yield 43%) in sarcomeric (n = 8), desmosomal (n = 3), lamin A/C (n = 3) and transthyretin (n = 1) genes. The results had various impacts on families, i.e. allowed predictive genetic testing in relatives (15 families), planned early therapeutics based on the specific underlying gene (5 families), rectified the suspected cardiomyopathy subtype (2 families), assessed the genetic origin of cardiomyopathy that usually has an acquired cause (1 family), assessed the diagnosis in a patient with uncertain borderline cardiomyopathy (1 family), reassured the siblings because of a de novo mutation (2 families) and allowed prenatal testing (1 family). Our findings suggest that post-mortem molecular testing should be included in the strategy of family care after cardiac death and suspected cardiomyopathy, since genetic findings provide additional information useful for relatives, which are beyond conventional autopsy.

Published
2020
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18. Safety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study

Author

Ekanem, Emmanuel, Neuzil, Petr, Reichlin, Tobias, Kautzner, Joseph, van der Voort, Pepijn, Jais, Pierre, Chierchia, Gian Battista, Bulava, Alan, Blaauw, Yuri, Skala, Tomas, Fiala, Martin, Duytschaever, Mattias, Szeplaki, Gabor, Schmidt, Boris, Massoullie, Grégoire, Neven, Kars, Thomas, Olivier, Vijgen, Johan, Gandjbakhch, Estelle, Scherr, Daniel, Johannessen, Arne, Keane, David, Boveda, Serge, Maury, Philippe, García-Bolao, Ignacio, Anic, Ante, Hansen, Peter Steen, Raczka, Franck, Lepillier, Antoine, Guyomar, Yves, Gupta, Dhiraj, Van Opstal, Jurren, Defaye, Pascal, Sticherling, Christian, Sommer, Philipp, Kucera, Pavel, Osca, Joaquin, Tabrizi, Fariborz, Roux, Antoine, Gramlich, Michael, Bianchi, Stefano, Adragão, Pedro, Solimene, Francesco, Tondo, Claudio, Russo, Antonio Dello, Schreieck, Jürgen, Luik, Armin, Rana, Obaida, Frommeyer, Gerrit, Anselme, Frédéric, Kreis, Ingo, Rosso, Raphael, Metzner, Andreas, Geller, Laszlo, Baldinger, Samuel H., Ferrero, Angel, Willems, Stephan, Goette, Andreas, Mellor, Greg, Mathew, Shibu, Szumowski, Lukasz, Tilz, Roland, Iacopino, Saverio, Jacobsen, Peter Karl, George, Andrikopoulos, Osmancik, Pavel, Spitzer, Stefan, Balasubramaniam, Richard, Parwani, Abdul Shokor, Deneke, Thomas, Glowniak, Andrzej, Rossillo, Antonio, Pürerfellner, Helmut, Duncker, David, Reil, Peter, Arentz, Thomas, Steven, Daniel, Olalla, Juan José, de Jong, Jonas S.S.G., Wakili, Reza, Abbey, Selim, Timo, Gottschling, Asso, Antonio, Wong, Tom, Pierre, Bertrand, Ewertsen, Niels Christian, Bergau, Leonard, Lozano-Granero, Cristina, Rivero, Maximo, Breitenstein, Alexander, Inkovaara, Jaakko, Fareh, Samir, Latcu, Decebal Gabriel, Linz, Dominik, Müller, Patrick, Ramos-Maqueda, Javier, Beiert, Thomas, Themistoclakis, Sakis, Meininghaus, Dirk Grosse, Stix, Günter, Tzeis, Stylianos, Baran, Jakub, Almroth, Henrik, Munoz, Daniel Rodriguez, de Sousa, João, Efremidis, Michalis, Balsam, Pawel, Petru, Jan, Küffer, Thomas, Peichl, Petr, Dekker, Lukas, Della Rocca, Domenico G., Moravec, Ondrej, Funasako, Moritoshi, Knecht, Sebastien, Jauvert, Gael, Chun, Julian, Eschalier, Romain, Füting, Anna, Zhao, Alexandre, Koopman, Pieter, Laredo, Mikael, Manninger, Martin, Hansen, Jim, O’Hare, Daniel, Rollin, Anne, Jurisic, Zrinka, Fink, Thomas, Chaumont, Corentin, Rillig, Andreas, Gunawerdene, Melanie, Martin, Claire, Kirstein, Bettina, Nentwich, Karin, Lehrmann, Heiko, Sultan, Arian, Bohnen, Jan, Turagam, Mohit K., Reddy, Vivek Y., Ekanem, Emmanuel, Neuzil, Petr, Reichlin, Tobias, Kautzner, Joseph, van der Voort, Pepijn, Jais, Pierre, Chierchia, Gian Battista, Bulava, Alan, Blaauw, Yuri, Skala, Tomas, Fiala, Martin, Duytschaever, Mattias, Szeplaki, Gabor, Schmidt, Boris, Massoullie, Grégoire, Neven, Kars, Thomas, Olivier, Vijgen, Johan, Gandjbakhch, Estelle, Scherr, Daniel, Johannessen, Arne, Keane, David, Boveda, Serge, Maury, Philippe, García-Bolao, Ignacio, Anic, Ante, Hansen, Peter Steen, Raczka, Franck, Lepillier, Antoine, Guyomar, Yves, Gupta, Dhiraj, Van Opstal, Jurren, Defaye, Pascal, Sticherling, Christian, Sommer, Philipp, Kucera, Pavel, Osca, Joaquin, Tabrizi, Fariborz, Roux, Antoine, Gramlich, Michael, Bianchi, Stefano, Adragão, Pedro, Solimene, Francesco, Tondo, Claudio, Russo, Antonio Dello, Schreieck, Jürgen, Luik, Armin, Rana, Obaida, Frommeyer, Gerrit, Anselme, Frédéric, Kreis, Ingo, Rosso, Raphael, Metzner, Andreas, Geller, Laszlo, Baldinger, Samuel H., Ferrero, Angel, Willems, Stephan, Goette, Andreas, Mellor, Greg, Mathew, Shibu, Szumowski, Lukasz, Tilz, Roland, Iacopino, Saverio, Jacobsen, Peter Karl, George, Andrikopoulos, Osmancik, Pavel, Spitzer, Stefan, Balasubramaniam, Richard, Parwani, Abdul Shokor, Deneke, Thomas, Glowniak, Andrzej, Rossillo, Antonio, Pürerfellner, Helmut, Duncker, David, Reil, Peter, Arentz, Thomas, Steven, Daniel, Olalla, Juan José, de Jong, Jonas S.S.G., Wakili, Reza, Abbey, Selim, Timo, Gottschling, Asso, Antonio, Wong, Tom, Pierre, Bertrand, Ewertsen, Niels Christian, Bergau, Leonard, Lozano-Granero, Cristina, Rivero, Maximo, Breitenstein, Alexander, Inkovaara, Jaakko, Fareh, Samir, Latcu, Decebal Gabriel, Linz, Dominik, Müller, Patrick, Ramos-Maqueda, Javier, Beiert, Thomas, Themistoclakis, Sakis, Meininghaus, Dirk Grosse, Stix, Günter, Tzeis, Stylianos, Baran, Jakub, Almroth, Henrik, Munoz, Daniel Rodriguez, de Sousa, João, Efremidis, Michalis, Balsam, Pawel, Petru, Jan, Küffer, Thomas, Peichl, Petr, Dekker, Lukas, Della Rocca, Domenico G., Moravec, Ondrej, Funasako, Moritoshi, Knecht, Sebastien, Jauvert, Gael, Chun, Julian, Eschalier, Romain, Füting, Anna, Zhao, Alexandre, Koopman, Pieter, Laredo, Mikael, Manninger, Martin, Hansen, Jim, O’Hare, Daniel, Rollin, Anne, Jurisic, Zrinka, Fink, Thomas, Chaumont, Corentin, Rillig, Andreas, Gunawerdene, Melanie, Martin, Claire, Kirstein, Bettina, Nentwich, Karin, Lehrmann, Heiko, Sultan, Arian, Bohnen, Jan, Turagam, Mohit K., and Reddy, Vivek Y.

Abstract

Pulsed field ablation (PFA) is an emerging technology for the treatment of atrial fibrillation (AF), for which pre-clinical and early-stage clinical data are suggestive of some degree of preferentiality to myocardial tissue ablation without damage to adjacent structures. Here in the MANIFEST-17K study we assessed the safety of PFA by studying the post-approval use of this treatment modality. Of the 116 centers performing post-approval PFA with a pentaspline catheter, data were received from 106 centers (91.4% participation) regarding 17,642 patients undergoing PFA (mean age 64, 34.7% female, 57.8% paroxysmal AF and 35.2% persistent AF). No esophageal complications, pulmonary vein stenosis or persistent phrenic palsy was reported (transient palsy was reported in 0.06% of patients; 11 of 17,642). Major complications, reported for ~1% of patients (173 of 17,642), were pericardial tamponade (0.36%; 63 of 17,642) and vascular events (0.30%; 53 of 17,642). Stroke was rare (0.12%; 22 of 17,642) and death was even rarer (0.03%; 5 of 17,642). Unexpected complications of PFA were coronary arterial spasm in 0.14% of patients (25 of 17,642) and hemolysis-related acute renal failure necessitating hemodialysis in 0.03% of patients (5 of 17,642). Taken together, these data indicate that PFA demonstrates a favorable safety profile by avoiding much of the collateral damage seen with conventional thermal ablation. PFA has the potential to be transformative for the management of patients with AF.

Published
2024

19. Proposed diagnostic criteria for arrhythmogenic cardiomyopathy:European Task Force consensus report

Author

Corrado, Domenico, Anastasakis, Aris, Basso, Cristina, Bauce, Barbara, Blomström-Lundqvist, Carina, Bucciarelli-Ducci, Chiara, Cipriani, Alberto, De Asmundis, Carlo, Gandjbakhch, Estelle, Jiménez-Jáimez, Juan, Kharlap, Maria, McKenna, William J., Monserrat, Lorenzo, Moon, James, Pantazis, Antonis, Pelliccia, Antonio, Perazzolo Marra, Martina, Pillichou, Kalliopi, Schulz-Menger, Jeanette, Jurcut, Ruxandra, Seferovic, Petar, Sharma, Sanjay, Tfelt-Hansen, Jacob, Thiene, Gaetano, Wichter, Thomas, Wilde, Arthur, Zorzi, Alessandro, Corrado, Domenico, Anastasakis, Aris, Basso, Cristina, Bauce, Barbara, Blomström-Lundqvist, Carina, Bucciarelli-Ducci, Chiara, Cipriani, Alberto, De Asmundis, Carlo, Gandjbakhch, Estelle, Jiménez-Jáimez, Juan, Kharlap, Maria, McKenna, William J., Monserrat, Lorenzo, Moon, James, Pantazis, Antonis, Pelliccia, Antonio, Perazzolo Marra, Martina, Pillichou, Kalliopi, Schulz-Menger, Jeanette, Jurcut, Ruxandra, Seferovic, Petar, Sharma, Sanjay, Tfelt-Hansen, Jacob, Thiene, Gaetano, Wichter, Thomas, Wilde, Arthur, and Zorzi, Alessandro

Abstract

Arrhythmogenic cardiomyopathy (ACM) is a heart muscle disease characterized by prominent “non-ischemic” myocardial scarring predisposing to ventricular electrical instability. Diagnostic criteria for the original phenotype, arrhythmogenic right ventricular cardiomyopathy (ARVC), were first proposed in 1994 and revised in 2010 by an international Task Force (TF). A 2019 International Expert report appraised these previous criteria, finding good accuracy for diagnosis of ARVC but a lack of sensitivity for identification of the expanding phenotypic disease spectrum, which includes left-sided variants, i.e., biventricular (ABVC) and arrhythmogenic left ventricular cardiomyopathy (ALVC). The ARVC phenotype together with these left-sided variants are now more appropriately named ACM. The lack of diagnostic criteria for the left ventricular (LV) phenotype has resulted in clinical under-recognition of ACM patients over the 4 decades since the disease discovery. In 2020, the “Padua criteria” were proposed for both right- and left-sided ACM phenotypes. The presently proposed criteria represent a refinement of the 2020 Padua criteria and have been developed by an expert European TF to improve the diagnosis of ACM with upgraded and internationally recognized criteria. The growing recognition of the diagnostic role of CMR has led to the incorporation of myocardial tissue characterization findings for detection of myocardial scar using the late‑gadolinium enhancement (LGE) technique to more fully characterize right, biventricular and left disease variants, whether genetic or acquired (phenocopies), and to exclude other “non-scarring” myocardial disease. The “ring-like’ pattern of myocardial LGE/scar is now a recognized diagnostic hallmark of ALVC. Additional diagnostic criteria regarding LV depolarization and repolarization ECG abnormalities and ventricular arrhythmias of LV origin are also provided. These proposed upgrading of diagnostic criteria represents a working framewor

Published
2024

20. A novel tool for arrhythmic risk stratification in desmoplakin gene variant carriers

Author

Electrofysiologie, Genetica Sectie Genoomdiagnostiek, Circulatory Health, Genetica Groep Van Tintelen, Child Health, Team Medisch, Carrick, Richard T, Gasperetti, Alessio, Protonotarios, Alexandros, Murray, Brittney, Laredo, Mikael, van der Schaaf, Iris, Dooijes, Dennis, Syrris, Petros, Cannie, Douglas, Tichnell, Crystal, Gilotra, Nisha A, Cappelletto, Chiara, Medo, Kristen, Saguner, Ardan M, Duru, Firat, Hylind, Robyn J, Abrams, Dominic J, Lakdawala, Neal K, Cadrin-Tourigny, Julia, Targetti, Mattia, Olivotto, Iacopo, Graziosi, Maddalena, Cox, Moniek, Biagini, Elena, Charron, Philippe, Compagnucci, Paolo, Casella, Michela, Conte, Giulio, Tondo, Claudio, Yazdani, Momina, Ware, James S, Prasad, Sanjay K, Calò, Leonardo, Smith, Eric D, Helms, Adam S, Hespe, Sophie, Ingles, Jodie, Tandri, Harikrishna, Ader, Flavie, Peretto, Giovanni, Peters, Stacey, Horton, Ari, Yao, Jessica, Schulze-Bahr, Eric, Dittman, Sven, Carruth, Eric D, Young, Katelyn, Qureshi, Maria, Haggerty, Chris, Parikh, Victoria N, Taylor, Matthew, Mestroni, Luisa, Wilde, Arthur, Sinagra, Gianfranco, Merlo, Marco, Gandjbakhch, Estelle, van Tintelen, J Peter, Te Riele, Anneline S J M, Elliot, Perry, Calkins, Hugh, Wu, Katherine C, James, Cynthia A, Electrofysiologie, Genetica Sectie Genoomdiagnostiek, Circulatory Health, Genetica Groep Van Tintelen, Child Health, Team Medisch, Carrick, Richard T, Gasperetti, Alessio, Protonotarios, Alexandros, Murray, Brittney, Laredo, Mikael, van der Schaaf, Iris, Dooijes, Dennis, Syrris, Petros, Cannie, Douglas, Tichnell, Crystal, Gilotra, Nisha A, Cappelletto, Chiara, Medo, Kristen, Saguner, Ardan M, Duru, Firat, Hylind, Robyn J, Abrams, Dominic J, Lakdawala, Neal K, Cadrin-Tourigny, Julia, Targetti, Mattia, Olivotto, Iacopo, Graziosi, Maddalena, Cox, Moniek, Biagini, Elena, Charron, Philippe, Compagnucci, Paolo, Casella, Michela, Conte, Giulio, Tondo, Claudio, Yazdani, Momina, Ware, James S, Prasad, Sanjay K, Calò, Leonardo, Smith, Eric D, Helms, Adam S, Hespe, Sophie, Ingles, Jodie, Tandri, Harikrishna, Ader, Flavie, Peretto, Giovanni, Peters, Stacey, Horton, Ari, Yao, Jessica, Schulze-Bahr, Eric, Dittman, Sven, Carruth, Eric D, Young, Katelyn, Qureshi, Maria, Haggerty, Chris, Parikh, Victoria N, Taylor, Matthew, Mestroni, Luisa, Wilde, Arthur, Sinagra, Gianfranco, Merlo, Marco, Gandjbakhch, Estelle, van Tintelen, J Peter, Te Riele, Anneline S J M, Elliot, Perry, Calkins, Hugh, Wu, Katherine C, and James, Cynthia A

Published
2024

21. Proposed diagnostic criteria for arrhythmogenic cardiomyopathy : European Task Force consensus report

Author

Corrado, Domenico, Anastasakis, Aris, Basso, Cristina, Bauce, Barbara, Blomström-Lundqvist, Carina, Bucciarelli-Ducci, Chiara, Cipriani, Alberto, De Asmundis, Carlo, Gandjbakhch, Estelle, Jimenez-Jaimez, Juan, Kharlap, Maria, Mckenna, William J., Monserrat, Lorenzo, Moon, James, Pantazis, Antonis, Pelliccia, Antonio, Marra, Martina Perazzolo, Pillichou, Kalliopi, Schulz-Menger, Jeanette, Jurcut, Ruxandra, Seferovic, Petar, Sharma, Sanjay, Tfelt-Hansen, Jacob, Thiene, Gaetano, Wichter, Thomas, Wilde, Arthur, Zorzi, Alessandro, Corrado, Domenico, Anastasakis, Aris, Basso, Cristina, Bauce, Barbara, Blomström-Lundqvist, Carina, Bucciarelli-Ducci, Chiara, Cipriani, Alberto, De Asmundis, Carlo, Gandjbakhch, Estelle, Jimenez-Jaimez, Juan, Kharlap, Maria, Mckenna, William J., Monserrat, Lorenzo, Moon, James, Pantazis, Antonis, Pelliccia, Antonio, Marra, Martina Perazzolo, Pillichou, Kalliopi, Schulz-Menger, Jeanette, Jurcut, Ruxandra, Seferovic, Petar, Sharma, Sanjay, Tfelt-Hansen, Jacob, Thiene, Gaetano, Wichter, Thomas, Wilde, Arthur, and Zorzi, Alessandro

Abstract

Arrhythmogenic cardiomyopathy (ACM) is a heart muscle disease characterized by prominent "non-ischemic" myocardial scarring predisposing to ventricular electrical instability. Diagnostic criteria for the original phenotype, arrhythmogenic right ventricular cardiomyopathy (ARVC), were first proposed in 1994 and revised in 2010 by an international Task Force (TF). A 2019 International Expert report appraised these previous criteria, finding good accuracy for diagnosis of ARVC but a lack of sensitivity for identification of the expanding phenotypic disease spectrum, which includes left-sided variants, i.e., biventricular (ABVC) and arrhythmogenic left ventricular cardiomyopathy (ALVC). The ARVC phenotype together with these left-sided variants are now more appropriately named ACM. The lack of diagnostic criteria for the left ventricular (LV) phenotype has resulted in clinical under-recognition of ACM patients over the 4 decades since the disease discovery. In 2020, the "Padua criteria" were proposed for both right-and left-sided ACM phenotypes. The presently proposed criteria represent a refinement of the 2020 Padua criteria and have been developed by an expert European TF to improve the diagnosis of ACM with upgraded and internationally recognized criteria. The growing recognition of the diagnostic role of CMR has led to the incorporation of myocardial tissue characterization findings for detection of myocardial scar using the late-gadolinium enhancement (LGE) technique to more fully characterize right, biventricular and left disease variants, whether genetic or acquired (phenocopies), and to exclude other "non-scarring" myocardial disease. The "ring-like' pattern of myocardial LGE/scar is now a recognized diagnostic hallmark of ALVC. Additional diagnostic criteria regarding LV depolarization and repolarization ECG abnor-malities and ventricular arrhythmias of LV origin are also provided. These proposed upgrading of diagnostic criteria represents a working framework t, Funding agency:European Union-next generation EU-PNRRM6 C2-Investement 2.1 PNRR-MR1-2022-12376614

Published
2024
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22. Long-Term Arrhythmic Follow-Up and Risk Stratification of Patients With Desmoplakin-Associated Arrhythmogenic Right Ventricular Cardiomyopathy

Author

Team Onderzoek, Circulatory Health, Genetica, Genetica Groep Van Tintelen, Cancer, Child Health, Gasperetti, Alessio, Carrick, Richard, Protonotarios, Alexandros, Laredo, Mikael, van der Schaaf, Iris, Syrris, Petros, Murray, Brittney, Tichnell, Crystal, Cappelletto, Chiara, Gigli, Marta, Medo, Kristen, Crabtree, Peter, Saguner, Ardan M., Duru, Firat, Hylind, Robyn, Abrams, Dominic, Lakdawala, Neal K., Massie, Charles, Cadrin-Tourigny, Julia, Targetti, Mattia, Olivotto, Iacopo, Graziosi, Maddalena, Cox, Moniek, Biagini, Elena, Charron, Philippe, Casella, Michela, Tondo, Claudio, Yazdani, Momina, Ware, James S., Prasad, Sanjay, Calò, Leonardo, Smith, Eric, Helms, Adam, Hespe, Sophie, Ingles, Jodie, Tandri, Harikrishna, Ader, Flavie, Mestroni, Luisa, Wilde, Arthur, Merlo, Marco, Gandjbakhch, Estelle, Calkins, Hugh, te Riele, Anneline S.J.M., Peter van Tintelen, J., Elliot, Perry, James, Cynthia A., Team Onderzoek, Circulatory Health, Genetica, Genetica Groep Van Tintelen, Cancer, Child Health, Gasperetti, Alessio, Carrick, Richard, Protonotarios, Alexandros, Laredo, Mikael, van der Schaaf, Iris, Syrris, Petros, Murray, Brittney, Tichnell, Crystal, Cappelletto, Chiara, Gigli, Marta, Medo, Kristen, Crabtree, Peter, Saguner, Ardan M., Duru, Firat, Hylind, Robyn, Abrams, Dominic, Lakdawala, Neal K., Massie, Charles, Cadrin-Tourigny, Julia, Targetti, Mattia, Olivotto, Iacopo, Graziosi, Maddalena, Cox, Moniek, Biagini, Elena, Charron, Philippe, Casella, Michela, Tondo, Claudio, Yazdani, Momina, Ware, James S., Prasad, Sanjay, Calò, Leonardo, Smith, Eric, Helms, Adam, Hespe, Sophie, Ingles, Jodie, Tandri, Harikrishna, Ader, Flavie, Mestroni, Luisa, Wilde, Arthur, Merlo, Marco, Gandjbakhch, Estelle, Calkins, Hugh, te Riele, Anneline S.J.M., Peter van Tintelen, J., Elliot, Perry, and James, Cynthia A.

Published
2024

26. NEXN Gene in Cardiomyopathies and Sudden Cardiac Deaths: Prevalence, Phenotypic Expression, and Prognosis

Author

Hermida, Alexis, primary, Ader, Flavie, additional, Millat, Gilles, additional, Jedraszak, Guillaume, additional, Maury, Phillipe, additional, Cador, Romain, additional, Catalan, Pierre-Antoine, additional, Clerici, Gaël, additional, Combes, Nicolas, additional, De Groote, Pascal, additional, Dupin-Deguine, Delphine, additional, Eschalier, Romain, additional, Faivre, Laurence, additional, Garcia, Patricia, additional, Guillon, Benoit, additional, Janin, Alexandre, additional, Kugener, Beatrice, additional, Lackmy, Marylin, additional, Laredo, Mikael, additional, Le Guillou, Xavier, additional, Lesaffre, François, additional, Lucron, Hugues, additional, Milhem, Antoine, additional, Nadeau, Gwenaël, additional, Nguyen, Karine, additional, Palmyre, Aurélien, additional, Perdreau, Elodie, additional, Picard, François, additional, Rebotier, Nicolas, additional, Richard, Pascale, additional, Rooryck, Caroline, additional, Seitz, Julien, additional, Verloes, Alain, additional, Vernier, Agathe, additional, Winum, Pierre, additional, Yabeta, Grace-A-Dieu, additional, Bouchot, Océane, additional, Chevalier, Philippe, additional, Charron, Philippe, additional, and Gandjbakhch, Estelle, additional

Published
2024
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27. Prevalence and Significance of Rare Genetic Variants in AKAP9 in Inherited Cardiac Diseases

Author

Hermida, Alexis, primary, Ader, Flavie, additional, Jedraszak, Guillaume, additional, Viboud, Guillaume, additional, Fressart, Véronique, additional, Bréhin, Anne Claire, additional, Gérard, Marion, additional, Khraiche, Diala, additional, Palmyre, Asurélien, additional, Paziaud, Olivier, additional, Popescu, Elena, additional, Proukhnitzky, Julie, additional, Laredo, Mikael, additional, Richard, Pascale, additional, Vedrenne, Geraldine, additional, Vernier, Agathe, additional, Charron, Philippe, additional, and Gandjbakhch, Estelle, additional

Published
2024
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34. Pre‐emptive treatment of heart failure exacerbations in patients managed with the HeartLogic™ algorithm.

Author

Garcia, Rodrigue, Gras, Daniel, Mansourati, Jacques, Defaye, Pascal, Bisson, Arnaud, Boveda, Serge, Gandjbakhch, Estelle, Gras, Matthieu, Gueffet, Jean‐Pierre, Himbert, Caroline, Jacon, Peggy, Khattar, Pierre, Lequeux, Benoit, Li, Anthony, Mansourati, Vincent, Minois, Damien, Marijon, Eloi, Pierre, Bertrand, Probst, Vincent, and Degand, Bruno

Subjects
VENTRICULAR ejection fraction, HEART failure patients, TREATMENT failure, ATRIAL arrhythmias, VENTRICULAR arrhythmia, ARTIFICIAL implants
Abstract

Aims: Heart failure (HF) is a chronic disease affecting 64 million people worldwide and places a severe burden on society because of its mortality, numerous re‐hospitalizations and associated costs. HeartLogic™ is an algorithm programmed into implanted devices incorporating several biometric parameters which aims to predict HF episodes. It provides an index which can be monitored remotely, allowing pre‐emptive treatment of congestion to prevent acute decompensation. We aim to assess the impact and security of pre‐emptive HF management, guided by the HeartLogic™ index. Methods and results: The HeartLogic™ France Cohort Study is an investigator‐initiated, prospective, multi‐centre, non‐randomized study. Three hundred ten patients with a history of HF (left ventricular ejection fraction ≤40%; or at least one episode of clinical HF with elevated NT‐proBNP ≥450 ng/L) and implanted with a cardioverter defibrillator enabling HeartLogic™ index calculation will be included across 10 French centres. The HeartLogic™ index will be monitored remotely for 12 months and in the event of a HeartLogic™ index ≥16, the local investigator will contact the patient for assessment and adjust HF treatment as necessary. The primary endpoint is unscheduled hospitalization for HF. Secondary endpoints are all‐cause mortality, cardiovascular death, HF‐related death, unscheduled hospitalizations for ventricular or atrial arrhythmia and HeartLogic™ index evolution over time. Blood samples will be collected for biobanking, and quality of life will be assessed. Finally, the safety of a HeartLogic™‐triggered strategy for initiating or increasing diuretic therapy will be assessed. A blind and independent committee will adjudicate the events. Conclusions: The HeartLogic™ France Cohort Study will provide robust real‐world data in a cohort of HF patients managed with the HeartLogic™ algorithm allowing pre‐emptive treatment of heart failure exacerbations. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Effectiveness of Deep Sedation for Patients With Intractable Electrical Storm Refractory to Antiarrhythmic Drugs

Author

Martins, Raphaël P., Urien, Jean-Marie, Barbarot, Nicolas, Rieul, Guillaume, Sellal, Jean-Marc, Borella, Lionel, Clementy, Nicolas, Bisson, Arnaud, Guenancia, Charles, Sagnard, Audrey, Schumacher, Stéphane, Gandjbakhch, Estelle, Duchateau, Josselin, Tixier, Romain, Goepp, Angélique, Hamon, David, Lellouche, Nicolas, Champ-Rigot, Laure, Milliez, Paul, Marijon, Eloi, Varlet, Emilie, Garcia, Rodrigue, Degand, Bruno, Bouju, Pierre, Mabo, Philippe, Leclercq, Christophe, Behar, Nathalie, Pavin, Dominique, de Chillou, Christian, Sacher, Frédéric, and Galand, Vincent

Published
2020
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36. EHRA consensus on prevention and management of interference due to medical procedures in patients with cardiac implantable electronic devices

Author

Gandjbakhch, Estelle, Stuehlinger, Markus, Burri, Haran, Vernooy, Kevin, Garcia, Rodrigue, Lenarczyk, Radoslaw, Sultan, Arian, Brunner, Michael, Sabbag, Avi, Özcan, Emin Evren, Ramos, Jorge Toquero, Di Stolfo, Giuseppe, Suleiman, Mahmoud, Tinhofer, Florian, Aristizabal, Julian Miguel, Cakulev, Ivan, Eidelman, Gabriel, Yeo, Wee Tiong, Lau, Dennis H., Mulpuru, Silva K., Nielsen, Jens Cosedis, Heinzel, Frank, Prabhu, Mukundaprabhu, Rinaldi, Christopher Aldo, Sacher, Frederic, Guillen, Raul, De Pooter, Jan, Sheldon, Seth, Prenner, Guenther, Mason, Pamela K., Fichtner, Stephanie, Nitta, Takashi, Cardiologie, MUMC+: MA Med Staf Spec Cardiologie (9), RS: Carim - H01 Clinical atrial fibrillation, and RS: Carim - H06 Electro mechanics

Subjects
Pacemaker, Artificial, PERIOPERATIVE MANAGEMENT, Consensus, SHOCK-WAVE LITHOTRIPSY, Electrosurgery, Magnet mode, ELECTRICAL NERVE-STIMULATION, Defibrillator, Magnetic resonance imaging, Physiology (medical), Therapeutic radiation, Humans, ELECTROMAGNETIC-INTERFERENCE, MUSCLE STIMULATION, PERMANENT PACEMAKER, ICD, Heart, Electrocautery, ATRIOVENTRICULAR NODE ABLATION, Defibrillators, Implantable, Pacemaker, CARDIOVERTER-DEFIBRILLATOR THERAPY, ATRIAL-FIBRILLATION, Electronics, Cardiology and Cardiovascular Medicine, NONCARDIAC SURGERY, CIED
Published
2022
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38. A worldwide survey on incidence, management and prognosis of oesophageal fistula formation following atrial fibrillation catheter ablation: The POTTER-AF study

Author

Tilz, Roland Richard, Schmidt, Vanessa, Pürerfellner, Helmut, Maury, Philippe, Chun, Kr Julian, Martinek, Martin, Sohns, Christian, Schmidt, Boris, Mandel, Franck, Gandjbakhch, Estelle, Laredo, Mikael, Gunawardene, Melanie Anuscha, Willems, Stephan, Beiert, Thomas, Borlich, Martin, Iden, Leon, Füting, Anna, Spittler, Raphael, Gaspar, Thomas, Richter, Sergio, Schade, Anja, Kuniss, Malte, Neumann, Thomas, Francke, Alexander, Wunderlich, Carsten, Shin, Dong-In, Grosse Meininghaus, Dirk, Foresti, Mike, Bonsels, Marc, Reek, David, Wiegand, Uwe, Bauer, Alexander, Metzner, Andreas, Eckardt, Lars, Popescu, Sorin Ștefan, Krahnefeld, Olaf, Sticherling, Christian, Kühne, Michael, Nguyen, Dinh Quang, Roten, Laurent, Saguner, Ardan M, Linz, Dominik, van der Voort, Pepijn, Mulder, Bart A, Vijgen, Johan, Almorad, Alexandre, Guenancia, Charles, Fauchier, Laurent, Boveda, Serge, De Greef, Y, Da Costa, Antoine, Jais, Pierre, Derval, Nicolas, Milhem, Antoine, Jesel, Laurence, Garcia, Rodrigue, Poty, Hervé, Khoueiry, Ziad, Seitz, Julien, Laborderie, Julien, Mechulan, Alexis, Brigadeau, Francois, Zhao, Alexandre, Saludas, Yannick, Piot, Olivier, Ahluwalia, Nikhil, Martin, Claire, Chen, Jian, Antolic, Bor, Leventopoulos, Georgios, Özcan, Emin Evren, Yorgun, Hikmet, Cay, Serkan, Yalin, Kivanc, Botros, Maichel Sobhy, Mahmoud, Ahmed Taher, Jędrzejczyk-Patej, Ewa, Inaba, Osamu, Okumura, Ken, Ejima, Koichiro, Khakpour, Houman, Boyle, Noel, Catanzaro, J N, Reddy, Vivek, Mohanty, Sanghamitra, Natale, Andrea, Blessberger, Hermann, Yang, Bing, Stevens, Irene, Sommer, Philipp, Veltmann, Christian, Steven, Daniel, Vogler, Julia, Kuck, Karl-Heinz, Merino, José Luis, Keelani, Ahmad, and Heeger, Christian-H

Subjects
610 Medicine & health, ddc:610, Cardiology and Cardiovascular Medicine
Abstract

Aims Oesophageal fistula represents a rare but dreadful complication of atrial fibrillation catheter ablation. Data on its incidence, management, and outcome are sparse. Methods and results This international multicentre registry investigates the characteristics of oesophageal fistulae after treatment of atrial fibrillation by catheter ablation. A total of 553 729 catheter ablation procedures (radiofrequency: 62.9%, cryoballoon: 36.2%, other modalities: 0.9%) were performed, at 214 centres in 35 countries. In 78 centres 138 patients [0.025%, radiofrequency: 0.038%, cryoballoon: 0.0015% (P < 0.0001)] were diagnosed with an oesophageal fistula. Peri-procedural data were available for 118 patients (85.5%). Following catheter ablation, the median time to symptoms and the median time to diagnosis were 18 (7.75, 25; range: 0–60) days and 21 (15, 29.5; range: 2–63) days, respectively. The median time from symptom onset to oesophageal fistula diagnosis was 3 (1, 9; range: 0–42) days. The most common initial symptom was fever (59.3%). The diagnosis was established by chest computed tomography in 80.2% of patients. Oesophageal surgery was performed in 47.4% and direct endoscopic treatment in 19.8% and conservative treatment in 32.8% of patients. The overall mortality was 65.8%. Mortality following surgical (51.9%) or endoscopic treatment (56.5%) was significantly lower as compared to conservative management (89.5%) [odds ratio 7.463 (2.414, 23.072) P < 0.001]. Conclusion Oesophageal fistula after catheter ablation of atrial fibrillation is rare and occurs mostly with the use of radiofrequency energy rather than cryoenergy. Mortality without surgical or endoscopic intervention is exceedingly high.

Published
2023
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39. Development and Validation of a New Risk Prediction Score for Life-Threatening Ventricular Tachyarrhythmias in Laminopathies

Author

Wahbi, Karim, Ben Yaou, Rabah, Gandjbakhch, Estelle, Anselme, Frédéric, Gossios, Thomas, Lakdawala, Neal K., Stalens, Caroline, Sacher, Frédéric, Babuty, Dominique, Trochu, Jean-Noel, Moubarak, Ghassan, Savvatis, Kostantinos, Porcher, Raphaël, Laforêt, Pascal, Fayssoil, Abdallah, Marijon, Eloi, Stojkovic, Tanya, Béhin, Anthony, Leonard-Louis, Sarah, Sole, Guilhem, Labombarda, Fabien, Richard, Pascale, Metay, Corinne, Quijano-Roy, Susana, Dabaj, Ivana, Klug, Didier, Vantyghem, Marie-Christine, Chevalier, Philippe, Ambrosi, Pierre, Salort, Emmanuelle, Sadoul, Nicolas, Waintraub, Xavier, Chikhaoui, Khadija, Mabo, Philippe, Combes, Nicolas, Maury, Philippe, Sellal, Jean-Marc, Tedrow, Usha B., Kalman, Jonathan M., Vohra, Jitendra, Androulakis, Alexander F.A., Zeppenfeld, Katja, Thompson, Tina, Barnerias, Christine, Bécane, Henri-Marc, Bieth, Eric, Boccara, Franck, Bonnet, Damien, Bouhour, Françoise, Boulé, Stéphane, Brehin, Anne-Claire, Chapon, Françoise, Cintas, Pascal, Cuisset, Jean-Marie, Davy, Jean-Marc, De Sandre-Giovannoli, Annachiara, Demurger, Florence, Desguerre, Isabelle, Dieterich, Klaus, Durigneux, Julien, Echaniz-Laguna, Andoni, Eschalier, Romain, Ferreiro, Ana, Ferrer, Xavier, Francannet, Christine, Fradin, Mélanie, Gaborit, Bénédicte, Gay, Arnaud, Hagège, Albert, Isapof, Arnaud, Jeru, Isabelle, Juntas Morales, Raul, Lagrue, Emmanuelle, Lamblin, Nicolas, Lascols, Olivier, Laugel, Vincent, Lazarus, Arnaud, Leturcq, France, Levy, Nicolas, Magot, Armelle, Manel, Véronique, Martins, Raphaël, Mayer, Michèle, Mercier, Sandra, Meune, Christophe, Michaud, Maud, Minot-Myhié, Marie-Christine, Muchir, Antoine, Nadaj-Pakleza, Aleksandra, Péréon, Yann, Petiot, Philippe, Petit, Florence, Praline, Julien, Rollin, Anne, Sabouraud, Pascal, Sarret, Catherine, Schaeffer, Stéphane, Taithe, Frederic, Tard, Céline, Tiffreau, Vincent, Toutain, Annick, Vatier, Camille, Walther-Louvier, Ulrike, Eymard, Bruno, Charron, Philippe, Vigouroux, Corinne, Bonne, Gisèle, Kumar, Saurabh, Elliott, Perry, and Duboc, Denis

Published
2019
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40. Electrocardiographic findings in patients with arrhythmogenic cardiomyopathy and right bundle branch block ventricular tachycardia.

Author

Laredo, Mikael, Tovia-Brodie, Oholi, Milman, Anat, Michowitz, Yoav, Roudijk, Rob RW, Peretto, Giovanni, Badenco, Nicolas, Te Riele, Anneline ASJM, Sala, Simone, Duthoit, Guillaume, Arbelo, Elena, Ninni, Sandro, Gasperetti, Alessio, van Tintelen, Peter JP, Paglino, Gabriele, Waintraub, Xavier, Andorin, Antoine, Peichl, Petr, Bosman, Laurens P, Calo, Leonardo, Giustetto, Carla, Radinovic, Andrea, Jorda, Paloma, Casado Arroyo, Ruben, Zorio, Esther, Bermúdez-Jiménez, Francisco FJ, Behr, Elijah Raphael, Havranek, Stepan, Tfelt-Hansen, Jacob, Sacher, Frédéric, Hermida, Jean-Sylvain, Nof, Eyal, Casella, Michela, Kautzner, Josef, Lacroix, Dominique, Brugada, Josep, Duru, Firat, Bella, Paolo Della, Gandjbakhch, Estelle, Hauer, Richard, Belhassen, Bernard, Laredo, Mikael, Tovia-Brodie, Oholi, Milman, Anat, Michowitz, Yoav, Roudijk, Rob RW, Peretto, Giovanni, Badenco, Nicolas, Te Riele, Anneline ASJM, Sala, Simone, Duthoit, Guillaume, Arbelo, Elena, Ninni, Sandro, Gasperetti, Alessio, van Tintelen, Peter JP, Paglino, Gabriele, Waintraub, Xavier, Andorin, Antoine, Peichl, Petr, Bosman, Laurens P, Calo, Leonardo, Giustetto, Carla, Radinovic, Andrea, Jorda, Paloma, Casado Arroyo, Ruben, Zorio, Esther, Bermúdez-Jiménez, Francisco FJ, Behr, Elijah Raphael, Havranek, Stepan, Tfelt-Hansen, Jacob, Sacher, Frédéric, Hermida, Jean-Sylvain, Nof, Eyal, Casella, Michela, Kautzner, Josef, Lacroix, Dominique, Brugada, Josep, Duru, Firat, Bella, Paolo Della, Gandjbakhch, Estelle, Hauer, Richard, and Belhassen, Bernard

Abstract

Little is known about patients with right bundle branch block (RBBB)-ventricular tachycardia (VT) and arrhythmogenic cardiomyopathy (ACM). Our aims were: (i) to describe electrocardiogram (ECG) characteristics of sinus rhythm (SR) and VT; (ii) to correlate SR with RBBB-VT ECGs; and (iii) to compare VT ECGs with electro-anatomic mapping (EAM) data., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2023

41. Electrocardiographic findings in patients with arrhythmogenic cardiomyopathy and right bundle branch block ventricular tachycardia

Author

Arts Assistenten Cardiologie, Onderzoek Precision medicine, Circulatory Health, Genetica, Cancer, Child Health, Team Medisch, Laredo, Mikael, Tovia-Brodie, Oholi, Milman, Anat, Michowitz, Yoav, Roudijk, Rob W, Peretto, Giovanni, Badenco, Nicolas, Te Riele, Anneline S J M, Sala, Simone, Duthoit, Guillaume, Arbelo, Elena, Ninni, Sandro, Gasperetti, Alessio, van Tintelen, J Peter, Paglino, Gabriele, Waintraub, Xavier, Andorin, Antoine, Peichl, Petr, Bosman, Laurens P, Calo, Leonardo, Giustetto, Carla, Radinovic, Andrea, Jorda, Paloma, Casado-Arroyo, Ruben, Zorio, Esther, Bermúdez-Jiménez, Francisco J, Behr, Elijah R, Havranek, Stepan, Tfelt-Hansen, Jacob, Sacher, Frederic, Hermida, Jean-Sylvain, Nof, Eyal, Casella, Michela, Kautzner, Josef, Lacroix, Dominique, Brugada, Josep, Duru, Firat, Bella, Paolo Della, Gandjbakhch, Estelle, Hauer, Richard, Belhassen, Bernard, Arts Assistenten Cardiologie, Onderzoek Precision medicine, Circulatory Health, Genetica, Cancer, Child Health, Team Medisch, Laredo, Mikael, Tovia-Brodie, Oholi, Milman, Anat, Michowitz, Yoav, Roudijk, Rob W, Peretto, Giovanni, Badenco, Nicolas, Te Riele, Anneline S J M, Sala, Simone, Duthoit, Guillaume, Arbelo, Elena, Ninni, Sandro, Gasperetti, Alessio, van Tintelen, J Peter, Paglino, Gabriele, Waintraub, Xavier, Andorin, Antoine, Peichl, Petr, Bosman, Laurens P, Calo, Leonardo, Giustetto, Carla, Radinovic, Andrea, Jorda, Paloma, Casado-Arroyo, Ruben, Zorio, Esther, Bermúdez-Jiménez, Francisco J, Behr, Elijah R, Havranek, Stepan, Tfelt-Hansen, Jacob, Sacher, Frederic, Hermida, Jean-Sylvain, Nof, Eyal, Casella, Michela, Kautzner, Josef, Lacroix, Dominique, Brugada, Josep, Duru, Firat, Bella, Paolo Della, Gandjbakhch, Estelle, Hauer, Richard, and Belhassen, Bernard

Published
2023

42. A worldwide survey on incidence, management, and prognosis of oesophageal fistula formation following atrial fibrillation catheter ablation: the POTTER-AF study

Author

Tilz, Roland Richard; https://orcid.org/0000-0002-0122-7130, Schmidt, Vanessa, Pürerfellner, Helmut, Maury, Philippe; https://orcid.org/0000-0002-4800-1841, Chun, K R Julian, Martinek, Martin; https://orcid.org/0000-0002-8895-8488, Sohns, Christian; https://orcid.org/0000-0003-0490-5862, Schmidt, Boris; https://orcid.org/0000-0001-5347-9906, Mandel, Franck, Gandjbakhch, Estelle; https://orcid.org/0000-0002-4846-5021, Laredo, Mikael; https://orcid.org/0000-0002-7326-2656, Gunawardene, Melanie Anuscha, Willems, Stephan; https://orcid.org/0000-0002-8890-5749, Beiert, Thomas, Borlich, Martin, Iden, Leon, Füting, Anna, Spittler, Raphael, Gaspar, Thomas, Richter, Sergio, Schade, Anja, Kuniss, Malte; https://orcid.org/0000-0002-1593-9657, Neumann, Thomas, Francke, Alexander, Wunderlich, Carsten, Shin, Dong-In, Meininghaus, Dirk Grosse; https://orcid.org/0000-0003-1532-1934, Foresti, Mike, Bonsels, Marc, Reek, David, et al, Saguner, Ardan M; https://orcid.org/0000-0003-1896-0803, Tilz, Roland Richard; https://orcid.org/0000-0002-0122-7130, Schmidt, Vanessa, Pürerfellner, Helmut, Maury, Philippe; https://orcid.org/0000-0002-4800-1841, Chun, K R Julian, Martinek, Martin; https://orcid.org/0000-0002-8895-8488, Sohns, Christian; https://orcid.org/0000-0003-0490-5862, Schmidt, Boris; https://orcid.org/0000-0001-5347-9906, Mandel, Franck, Gandjbakhch, Estelle; https://orcid.org/0000-0002-4846-5021, Laredo, Mikael; https://orcid.org/0000-0002-7326-2656, Gunawardene, Melanie Anuscha, Willems, Stephan; https://orcid.org/0000-0002-8890-5749, Beiert, Thomas, Borlich, Martin, Iden, Leon, Füting, Anna, Spittler, Raphael, Gaspar, Thomas, Richter, Sergio, Schade, Anja, Kuniss, Malte; https://orcid.org/0000-0002-1593-9657, Neumann, Thomas, Francke, Alexander, Wunderlich, Carsten, Shin, Dong-In, Meininghaus, Dirk Grosse; https://orcid.org/0000-0003-1532-1934, Foresti, Mike, Bonsels, Marc, Reek, David, et al, and Saguner, Ardan M; https://orcid.org/0000-0003-1896-0803

Abstract

AIMS Oesophageal fistula represents a rare but dreadful complication of atrial fibrillation catheter ablation. Data on its incidence, management, and outcome are sparse. METHODS AND RESULTS This international multicentre registry investigates the characteristics of oesophageal fistulae after treatment of atrial fibrillation by catheter ablation. A total of 553 729 catheter ablation procedures (radiofrequency: 62.9%, cryoballoon: 36.2%, other modalities: 0.9%) were performed, at 214 centres in 35 countries. In 78 centres 138 patients [0.025%, radiofrequency: 0.038%, cryoballoon: 0.0015% (P < 0.0001)] were diagnosed with an oesophageal fistula. Peri-procedural data were available for 118 patients (85.5%). Following catheter ablation, the median time to symptoms and the median time to diagnosis were 18 (7.75, 25; range: 0-60) days and 21 (15, 29.5; range: 2-63) days, respectively. The median time from symptom onset to oesophageal fistula diagnosis was 3 (1, 9; range: 0-42) days. The most common initial symptom was fever (59.3%). The diagnosis was established by chest computed tomography in 80.2% of patients. Oesophageal surgery was performed in 47.4% and direct endoscopic treatment in 19.8% and conservative treatment in 32.8% of patients. The overall mortality was 65.8%. Mortality following surgical (51.9%) or endoscopic treatment (56.5%) was significantly lower as compared to conservative management (89.5%) [odds ratio 7.463 (2.414, 23.072) P < 0.001]. CONCLUSION Oesophageal fistula after catheter ablation of atrial fibrillation is rare and occurs mostly with the use of radiofrequency energy rather than cryoenergy. Mortality without surgical or endoscopic intervention is exceedingly high.

Published
2023

43. A worldwide survey on incidence, management, and prognosis of oesophageal fistula formation following atrial fibrillation catheter ablation: the POTTER-AF study

Author

Tilz, Roland Richard, primary, Schmidt, Vanessa, additional, Pürerfellner, Helmut, additional, Maury, Philippe, additional, Chun, K R J ulian, additional, Martinek, Martin, additional, Sohns, Christian, additional, Schmidt, Boris, additional, Mandel, Franck, additional, Gandjbakhch, Estelle, additional, Laredo, Mikael, additional, Gunawardene, Melanie Anuscha, additional, Willems, Stephan, additional, Beiert, Thomas, additional, Borlich, Martin, additional, Iden, Leon, additional, Füting, Anna, additional, Spittler, Raphael, additional, Gaspar, Thomas, additional, Richter, Sergio, additional, Schade, Anja, additional, Kuniss, Malte, additional, Neumann, Thomas, additional, Francke, Alexander, additional, Wunderlich, Carsten, additional, Shin, Dong-In, additional, Meininghaus, Dirk Grosse, additional, Foresti, Mike, additional, Bonsels, Marc, additional, Reek, David, additional, Wiegand, Uwe, additional, Bauer, Alexander, additional, Metzner, Andreas, additional, Eckardt, Lars, additional, Popescu, Sorin Ștefan, additional, Krahnefeld, Olaf, additional, Sticherling, Christian, additional, Kühne, Michael, additional, Nguyen, Dinh Quang, additional, Roten, Laurent, additional, Saguner, Ardan M, additional, Linz, Dominik, additional, van der Voort, Pepijn, additional, Mulder, Bart A, additional, Vijgen, Johan, additional, Almorad, Alexandre, additional, Guenancia, Charles, additional, Fauchier, Laurent, additional, Boveda, Serge, additional, Greef, Y De, additional, Da Costa, Antoine, additional, Jais, Pierre, additional, Derval, Nicolas, additional, Milhem, Antoine, additional, Jesel, Laurence, additional, Garcia, Rodrigue, additional, Poty, Hervé, additional, Khoueiry, Ziad, additional, Seitz, Julien, additional, Laborderie, Julien, additional, Mechulan, Alexis, additional, Brigadeau, Francois, additional, Zhao, Alexandre, additional, Saludas, Yannick, additional, Piot, Olivier, additional, Ahluwalia, Nikhil, additional, Martin, Claire, additional, Chen, Jian, additional, Antolic, Bor, additional, Leventopoulos, Georgios, additional, Özcan, Emin Evren, additional, Yorgun, Hikmet, additional, Cay, Serkan, additional, Yalin, Kivanc, additional, Botros, Maichel Sobhy, additional, Mahmoud, Ahmed Taher, additional, Jędrzejczyk-Patej, Ewa, additional, Inaba, Osamu, additional, Okumura, Ken, additional, Ejima, Koichiro, additional, Khakpour, Houman, additional, Boyle, Noel, additional, Catanzaro, John N, additional, Reddy, Vivek, additional, Mohanty, Sanghamitra, additional, Natale, Andrea, additional, Blessberger, Hermann, additional, Yang, Bing, additional, Stevens, Irene, additional, Sommer, Philipp, additional, Veltmann, Christian, additional, Steven, Daniel, additional, Vogler, Julia, additional, Kuck, Karl-Heinz, additional, Merino, José Luis, additional, Keelani, Ahmad, additional, and Heeger, Christian-H, additional

Published
2023
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44. Impact of peri-procedural management of direct oral anticoagulants on pocket haematoma after cardiac electronic device implantation: the StimAOD multicentre prospective study

Author

Martin, Anne-Céline, primary, Weizman, Orianne, additional, Sellal, Jean-Marc, additional, Algalarrondo, Vincent, additional, Amara, Walid, additional, Bouzeman, Abdeslam, additional, Gandjbakhch, Estelle, additional, Lellouche, Nicolas, additional, Louembe, Jules, additional, Menet, Aymeric, additional, Roumegou, Pierre, additional, Treguer, Frederic, additional, Godier, Anne, additional, Boveda, Serge, additional, Garcia, Rodrigue, additional, and Marijon, Eloi, additional

Published
2023
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45. Feasibility of a New Regional Myocardial Strain Parameter for the Detection of Wall Motion Abnormalities in Arrhythmogenic Right Ventricular Cardiomyopathy

Author

Laredo, Mikael, primary, Lamy, Jérôme, additional, Bouazizi-Verdier, Khaoula, additional, Gueda, Moussa, additional, Giron, Alain, additional, Gallo, Antonio, additional, Cluzel, Philippe, additional, Gandjbakhch, Estelle, additional, Redheuil, Alban, additional, and Kachenoura, Nadjia, additional

Published
2023
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46. Abnormal Cellular Phenotypes Induced by Three TMPO/LAP2 Variants Identified in Men with Cardiomyopathies

Author

Vadrot, Nathalie, primary, Ader, Flavie, additional, Moulin, Maryline, additional, Merlant, Marie, additional, Chapon, Françoise, additional, Gandjbakhch, Estelle, additional, Labombarda, Fabien, additional, Maragnes, Pascale, additional, Réant, Patricia, additional, Rooryck, Caroline, additional, Probst, Vincent, additional, Donal, Erwan, additional, Richard, Pascale, additional, Ferreiro, Ana, additional, and Buendia, Brigitte, additional

Published
2023
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47. Electrocardiographic findings in patients with arrhythmogenic cardiomyopathy and right bundle branch block ventricular tachycardia

Author

Laredo, Mikael, primary, Tovia-Brodie, Oholi, additional, Milman, Anat, additional, Michowitz, Yoav, additional, Roudijk, Rob W, additional, Peretto, Giovanni, additional, Badenco, Nicolas, additional, te Riele, Anneline S J M, additional, Sala, Simone, additional, Duthoit, Guillaume, additional, Arbelo, Elena, additional, Ninni, Sandro, additional, Gasperetti, Alessio, additional, van Tintelen, J Peter, additional, Paglino, Gabriele, additional, Waintraub, Xavier, additional, Andorin, Antoine, additional, Peichl, Petr, additional, Bosman, Laurens P, additional, Calo, Leonardo, additional, Giustetto, Carla, additional, Radinovic, Andrea, additional, Jorda, Paloma, additional, Casado-Arroyo, Ruben, additional, Zorio, Esther, additional, Bermúdez-Jiménez, Francisco J, additional, Behr, Elijah R, additional, Havranek, Stepan, additional, Tfelt-Hansen, Jacob, additional, Sacher, Frederic, additional, Hermida, Jean-Sylvain, additional, Nof, Eyal, additional, Casella, Michela, additional, Kautzner, Josef, additional, Lacroix, Dominique, additional, Brugada, Josep, additional, Duru, Firat, additional, Bella, Paolo Della, additional, Gandjbakhch, Estelle, additional, Hauer, Richard, additional, and Belhassen, Bernard, additional

Published
2023
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49. Hypogonadism as a Reversible Cause of Torsades de Pointes in Men

Author

Salem, Joe-Elie, Waintraub, Xavier, Courtillot, Carine, Shaffer, Christian M., Gandjbakhch, Estelle, Maupain, Carole, Moslehi, Javid J., Badilini, Fabio, Haroche, Julien, Gougis, Paul, Fressart, Veronique, Glazer, Andrew M., Hidden-Lucet, Francoise, Touraine, Philippe, Lebrun-Vignes, Benedicte, Roden, Dan M., Bachelot, Anne, Funck-Brentano, Christian, Bretagne, Marie, Dureau, Pauline, Saqué, Valentin, Zarhrate-Ghoul, Aida, Bourguignon, Clément, Leban, Monique, Grouthier, Virginie, and Vaglio, Martino

Published
2018
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