1. Familial Clustering of Classic Kaposi Sarcoma.
- Author
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Guttman-Yassky, Emma, Cohen, Adina, Kra-Oz, Zippi, Friedman-Birnbaum, Rachel, Sprecher, Elli, Zaltzman, Neli, Friedman, Eitan, Silbermann, Michael, Rubin, Dinna, Linn, Shai, Whitby, Dennis, Gideoni, Osnat, Pollack, Shimon, Bergman, Reuven, and Sarid, Ronit
- Subjects
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KAPOSI'S sarcoma , *HERPESVIRUS diseases , *MEDICAL genetics , *GENETIC disorders , *GENETIC polymorphisms , *GENETICS of disease susceptibility - Abstract
It is widely accepted that there is a causal association between Kaposi sarcomaassociated herpesvirus (KSHV) and Kaposi sarcoma (KS). However, the majority of individuals infected with KSHV never develop KS. Here, we present a unique familial case of classic KS, in which the disease occurs in 4 siblings who have no recognized underlying immunodeficiency. We examine risk factors that could play a role in this condition, including KSHV infection, KSHV DNA load, genetic variants of KSHV, infection with additional viruses, interleukin-6promoter polymorphism, and HLA genotype. We hypothesize that a genetic susceptibility to KS, in combination with KSHV infection, may play an important role in the presented familial case. [ABSTRACT FROM AUTHOR]
- Published
- 2004
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