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9. Twelve-month follow-up effects of cognitive training after heart valve surgery on cognitive functions and health-related quality of life: a randomised clinical trial

Author

Butz, Marius, primary, Gerriets, Tibo, additional, Sammer, Gebhard, additional, El-Shazly, Jasmin, additional, Tschernatsch, Marlene, additional, Braun, Tobias, additional, Meyer, Rolf, additional, Schramm, Patrick, additional, Doeppner, Thorsten R, additional, Böning, Andreas, additional, Mengden, Thomas, additional, Choi, Yeong-Hoon, additional, Schönburg, Markus, additional, and Juenemann, Martin, additional

Published
2023
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11. Neuroprotective mechanisms of erythropoietin in a rat stroke model

Author

Juenemann Martin, Braun Tobias, Schleicher Nadine, Yeniguen Mesut, Schramm Patrick, Gerriets Tibo, Ritschel Nouha, Bachmann Georg, Obert Martin, Schoenburg Markus, Kaps Manfred, and Tschernatsch Marlene

Subjects
neuroprotection, rat, recombinant human erythropoietin, transient focal cerebral ischemia, vascular disorders, craniectomy, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

This study was designed to investigate the indirect neuroprotective properties of recombinant human erythropoietin (rhEPO) pretreatment in a rat model of transient middle cerebral artery occlusion (MCAO).

Published
2020
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20. The impact of postoperative cognitive training on health‐related quality of life and cognitive failures in daily living after heart valve surgery: A randomized clinical trial

Author

Butz, Marius, primary, Gerriets, Tibo, additional, Sammer, Gebhard, additional, El‐Shazly, Jasmin, additional, Tschernatsch, Marlene, additional, Schramm, Patrick, additional, Doeppner, Thorsten R., additional, Braun, Tobias, additional, Boening, Andreas, additional, Mengden, Thomas, additional, Choi, Yeong‐Hoon, additional, Schoenburg, Markus, additional, and Juenemann, Martin, additional

Published
2023
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21. Increasing preoperative cognitive reserve to prevent postoperative delirium and postoperative cognitive decline in cardiac surgical patients (INCORE): Study protocol for a randomized clinical trial on cognitive training

Author

Butz, Marius, primary, Meyer, Rolf, additional, Gerriets, Tibo, additional, Sammer, Gebhard, additional, Doerr, Johanna M., additional, El-Shazly, Jasmin, additional, Doeppner, Thorsten R., additional, Choi, Yeong-Hoon, additional, Schoenburg, Markus, additional, and Juenemann, Martin, additional

Published
2022
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23. Comprehensive Geriatric Care in Older Adults: Walking Ability after an Acute Fracture.

Author

Niemöller, Ulrich, Arnold, Andreas, Stein, Thomas, Juenemann, Martin, Erkapic, Damir, Rosenbauer, Josef, Kostev, Karel, Meyer, Marco, and Tanislav, Christian

Subjects
OLDER people, OLDER patients, GERIATRIC assessment, BARTHEL Index, COMBINED modality therapy, HOSPITAL patients, GERIATRIC nursing, GERIATRIC care units
Abstract

Background/Objectives: Comprehensive Geriatric Care (CGC) is a specific multimodal treatment for older patients. In the current study, we aimed to investigate walking performance after CGC in medically ill patients versus those with fractures. Methods: The timed up and go test (TuG), a 5-grade scale assessment (1 = no walking impairment to 5 = no walking ability at all) for evaluating individual walking ability was performed in all patients who underwent CGC prior to and after treatment. Factors associated with improvement in walking ability were analyzed in the subgroup of patients with fractures. Results: Out of 1263 hospitalized patients, 1099 underwent CGC (median age: 83.1 years (IQR 79.0–87.8 years); 64.1% were female). Patients with fractures (n = 300) were older than those without (n = 799), (median 85.6 versus 82.4 years, p = 0.001). Improvement in TuG after CGC was found in 54.2% of the fracture patients compared to just 45.9% of those without fractures. In fracture group patients, TuG improved from median 5 on admission to median 3 on discharge (p = 0.001). In fracture patients, improvement in walking ability was associated with higher Barthel index values on admission (median 45 (IQR: 35–55) versus 35 (IQR: 20–50): p = 0.001) and Tinetti assessment scores (median 9 (IQR: 4–14.25) versus 5 (IQR: 0–13); p = 0.001) and was negatively associated with the diagnosis of dementia (21.4% versus 31.5%; p = 0.058). Conclusion: CGC improved walking ability in more than half of all patients examined. Older patients in particular might benefit from undergoing the procedure after an acute fracture. A better initial functional status favors a positive result following the treatment. [ABSTRACT FROM AUTHOR]

Published
2023
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24. Effects of postoperative cognitive training on neurocognitive decline after heart surgery: a randomized clinical trial

Author

Butz, Marius, primary, Gerriets, Tibo, additional, Sammer, Gebhard, additional, El-Shazly, Jasmin, additional, Tschernatsch, Marlene, additional, Huttner, Hagen B, additional, Braun, Tobias, additional, Boening, Andreas, additional, Mengden, Thomas, additional, Choi, Yeong-Hoon, additional, Schoenburg, Markus, additional, and Juenemann, Martin, additional

Published
2022
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25. Case Report: Take a Second Look: Covid-19 Vaccination-Related Cerebral Venous Thrombosis and Thrombotic Thrombocytopenia Syndrome

Author

Braun, Tobias, Viard, Maxime, Juenemann, Martin, Struffert, Tobias, Schwarm, Frank, Huttner, Hagen B., and Roessler, Florian C.

Subjects
Neurology, Covid-19-vaccination, ChAdOx1 nCoV-19 vaccine, Case Report, cerebral venous thrombosis, Neurology (clinical), vaccine-induced thrombotic thrombocytopenia, Neurology. Diseases of the nervous system, RC346-429, thrombotic thrombocytopenia syndrome
Abstract

We present two cases of ChAdOx1 nCov-19 (AstraZeneca)-associated thrombotic thrombocytopenia syndrome (TTS) and cerebral venous sinus thrombosis (CVST). At the time of emergency room presentation due to persistent headache, blood serum levels revealed reduced platelet counts. Yet, 1 or 4 days after the onset of the symptom, the first MR-angiography provided no evidence of CVST. Follow-up imaging, performed upon headache refractory to nonsteroidal pain medication verified CVST 2–10 days after initial negative MRI. Both the patients received combined treatment with intravenous immunoglobulins and parenteral anticoagulation leading to an increase of platelet concentration in both the individuals and resolution of the occluded cerebral sinus in one patient.

Published
2021

27. Neuroprotective effects of dynamic bubble trap use in patients undergoing pulmonary endarterectomy: a two-arm randomized controlled trial

Author

El Shazly, Jasmin, primary, Gerriets, Tibo, additional, Hennig, Juergen, additional, Butz, Marius, additional, Kastaun, Sabrina, additional, Wiedenroth, Christoph B., additional, Schoenburg, Markus, additional, Wollenschlaeger, Marc, additional, Bachmann, Georg, additional, Guth, Stefan, additional, and Juenemann, Martin, additional

Published
2021
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28. Case Report: A Well-Hidden Cause for Myelopathy

Author

Braun, Tobias, Schulz, Eva, Viard, Maxime, AlhajOmar, Omar, Struffert, Tobias, Gattenlöhner, Stefan, Yenigün, Mesut, Juenemann, Martin, and Justus Liebig University Giessen

Subjects
spinal cord syndrome, ddc:610, neurosarcoidosis, myelopathy, bone marrow sarcoidosis, case report, Neurology. Diseases of the nervous system, RC346-429
Abstract

Introduction: Sarcoidosis is a rare, systemic inflammatory disease and can involve multiple organs, especially the lungs and lymph nodes. The nervous system is affected in

Published
2021

29. Microbubble-mediated sonothrombolysis with BR38 of a venous full blood thrombus in a rat embolic stroke model

Author

Braun, Tobias, primary, Sünner, Laura, additional, Hachenberger, Maaike, additional, Müller, Clemens, additional, Wietelmann, Astrid, additional, Juenemann, Martin, additional, Pons-Kühnemann, Jörn, additional, Kaps, Manfred, additional, Gerriets, Tibo, additional, Tschernatsch, Marlene, additional, Roth, Joachim, additional, and Yenigün, Mesut, additional

Published
2021
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30. Case Report: Neuropsychological Findings in IgLON5 Antibody Disorder

Author

El Shazly, Jasmin, Juenemann, Martin, Gerriets, Tibo, and Tschernatsch, Marlene

Subjects
neuropsychological findings, cognitive deficits, Neurology, autoimmune encephalopathy, Case Report, IgLON5, sleep disorder
Abstract

IgLON5 antibody encephalopathy is a rare but increasingly recognized disorder with a variety of clinical signs. Typical symptoms are sleep disorder, gait disturbances, signs of bulbar dysfunction and a variety of neurological symptoms like oculomotor abnormalities and movement disorders. In addition, cognitive decline can be a prominent symptom. So far, there are only a few studies that have dealt with the course and possible treatment options of IgLON5 antibody encephalopathy. In this study the clinical case of a female patient with IgLON5 antibody disease and the response to treatment is described. Here we report on the case of a 67-year-old female patient who showed cognitive deterioration, gait difficulties, and chronic obstructive sleep disorder. The diagnostic course showed a positive anti-IgLON5 serum and anti-IgLON5 IgG antibodies in cerebrospinal fluid. The patient was subsequently treated with high dosage i.v. methylprednisolone, i.v. immunoglobulins and plasmapheresis. Neuropsychological tests showed cognitive deficits in different domains, including verbal and visual memory. Both, neuropsychological deficits and antibody titer, showed an improvement after plasmapheresis. The presented case shows that IgLON5 disease can present with rapidly progressing cognitive deterioration as the prominent symptom, adding to the variety of clinical signs in this disorder. Testing for IgLON5-antibodies should be considered in patients with progressing cognitive decline, especially if accompanied by sleep disorders or neurological symptoms like oculomotor abnormalities, dysautonomia or bulbar signs.

Published
2021

32. Hereditary transthyretin-related amyloidosis is frequent in polyneuropathy and cardiomyopathy of no obvious aetiology

Author

Skrahina, Volha, primary, Grittner, Ulrike, additional, Beetz, Christian, additional, Skripuletz, Thomas, additional, Juenemann, Martin, additional, Krämer, Heidrun H., additional, Hahn, Katrin, additional, Rieth, Andreas, additional, Schaechinger, Volker, additional, Patten, Monica, additional, Tanislav, Christian, additional, Achenbach, Stephan, additional, Assmus, Birgit, additional, Knebel, Fabian, additional, Gingele, Stefan, additional, Skrahin, Aliaksandr, additional, Hartkamp, Jörg, additional, Förster, Toni M., additional, Roesner, Sabine, additional, Pereira, Catarina, additional, and Rolfs, Arndt, additional

Published
2021
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33. MOESM1 of Adjustment of oral diet based on flexible endoscopic evaluation of swallowing (FEES) in acute stroke patients: a cross-sectional hospital-based registry study

Author

Braun, Tobias, Juenemann, Martin, Viard, Maxime, Meyer, Marco, Reuter, Iris, Prosiegel, Mario, Kaps, Manfred, and Tanislav, Christian

Subjects
cardiovascular diseases
Abstract

Additional file 1: Table S1. Differences in baseline characteristics between patients with normal swallowing function versus those with clinically relevant dysphagia in the subgroup of patients with ischemic stroke. Table S2. Differences in baseline characteristics between stroke patients with and without change in oral diet in the subgroup of patients with ischemic stroke. Table S3. Binaryl logistic regression analysis for pneumonia in ischemic stroke patients. Table S4. Binary logistic regression analysis for intubation in ischemic stroke patients.

Published
2019
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34. MOESM1 of Decreasing postoperative cognitive deficits after heart surgery: protocol for a randomized controlled trial on cognitive training

Author

Butz, Marius, Shazly, Jasmin El, Sammer, Gebhard, Tschernatsch, Marlene, Kastaun, Sabrina, Yenigün, Mesut, Braun, Tobias, Kaps, Manfred, Böning, Andreas, Puvogel, Ulrike, Bachmann, Georg, Mengden, Thomas, Schönburg, Markus, Tibo Gerriets, and Juenemann, Martin

Abstract

Additional file 1. SPIRIT 2013 Checklist: recommended items to address in a clinical trial protocol and related documents.

Published
2019
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36. Sonothrombolysis with BR38 Microbubbles Improves Microvascular Patency in a Rat Model of Stroke

Author

Schleicher, Nadine, primary, Tomkins, Amelia J., additional, Kampschulte, Marian, additional, Hyvelin, Jean-Marc, additional, Botteron, Catherine, additional, Juenemann, Martin, additional, Yeniguen, Mesut, additional, Krombach, Gabriele A., additional, Kaps, Manfred, additional, Spratt, Neil J., additional, Gerriets, Tibo, additional, and Nedelmann, Max, additional

Published
2016
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40. Impact of bubble size in a rat model of cerebral air microembolization

Author

Juenemann, Martin, primary, Yeniguen, Mesut, additional, Schleicher, Nadine, additional, Blumenstein, Johannes, additional, Nedelmann, Max, additional, Tschernatsch, Marlene, additional, Bachmann, Georg, additional, Kaps, Manfred, additional, Urbanek, Petr, additional, Schoenburg, Markus, additional, and Gerriets, Tibo, additional

Published
2013
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41. Patient-Reported Postoperative Neuropsychological Deterioration After Heart Valve Replacement and Coronary Artery Bypass Grafting.

Author

Butz M, El-Shazly J, Gerriets T, Meyer R, Tschernatsch M, Braun T, Schramm P, Doeppner TR, Gerner ST, Boening A, Choi YH, Schoenburg M, and Juenemann M

Abstract

Background: Postoperative cognitive decline (POCD) after cardiosurgical interventions are well described through objective psychometric tests. However, a patient's subjective perception is essential to clinical assessment and quality of life. This study systematically evaluated patient-reported POCD between subjects undergoing coronary artery bypass grafting and heart valve replacement., Methods: This study was a multicentre, prospective questionnaire survey conducted at the cardiac surgery departments at the Kerckhoff Clinic in Bad Nauheim and the University Hospital in Giessen, Germany. We included patients undergoing elective coronary artery bypass grafting (CABG), aortic valve replacement (AVR), mitral valve replacement or reconstruction (MVR), and combined surgery (CABG + valve replacement [VR]) with extracorporeal circulation. The Hospital Anxiety and Depression Scale, the Cognitive Failures Questionnaire (CFQ) for Self-assessment (CFQ-S), and the external assessment (CFQ-foreign [F]) were completed preoperatively, as well as at 3 and 12 months postoperatively., Results: A total of 491 patients were available for analyses (CABG = 182, AVR = 134, MVR = 93, CABG + VR = 82). POCD and postoperative depression increase (PODI) were observed for each surgical procedure. (At the 3-month follow-up: CFQ-S [CABG = 7.1%, AVR = 3.7%, MVR = 9.7%, CABG + VR = 9.8%]; CFQ-F [CABG = 9.9%, AVR = 9.7%, MVR = 9.7%, CABG + VR = 15.9%]; PODI [CABG = 7.7%, AVR = 9.7%, MVR = 6.5%, CABG + VR = 8.5%]. At the 12-month follow-up: CFQ-S [CABG = 6.6%, AVR = 7.5%, MVR = 15.1%, CABG + VR = 7.3%]; CFQ-F [CABG = 7.1%, AVR = 14.9%, MVR = 10.8%, CABG + VR = 9.8%]; PODI [CABG = 10.4%, AVR = 11.2%, MVR = 6.5%, CABG + VR = 4.9%]). No significant between-group effects were observed for the CFQ-S, CFQ-F, or the Hospital Anxiety and Depression Scale., Conclusions: For clinicians, paying attention to patients' self-reported experiences of reduced cognitive function and symptoms of depression following cardiac surgery is important. Such reporting is an indication that interventions such as cognitive training or psychotherapy should be considered., (© 2023 The Authors.)

Published
2023
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