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3. High-content synaptic phenotyping in human cellular models reveals a role for BET proteins in synapse assembly

Author

Berryer, Martin H, primary, Rizki, Gizem, additional, Nathanson, Anna, additional, Klein, Jenny A, additional, Trendafilova, Darina, additional, Susco, Sara G, additional, Lam, Daisy, additional, Messana, Angelica, additional, Holton, Kristina M, additional, Karhohs, Kyle W, additional, Cimini, Beth A, additional, Pfaff, Kathleen, additional, Carpenter, Anne E, additional, Rubin, Lee L, additional, and Barrett, Lindy E, additional

Published
2023
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7. Head Start Planned Variation Program.

Author

Klein, Jenny

Abstract

There is little agreement concerning which methods of preschool intervention are most effective. In order to evaluate several approaches to early childhood education, Project Head Start, in conjunction with Project Follow Through, has initiated the Planned Variation program. This year only a pilot project is underway with eight schools participating. These are (1) University of Kansas, where Bushell uses a behavior analysis approach; (2) University of Illinois, where Becker and Engelmann use a structured, academic approach; (3) Bank Street College, where Gilkeson presents a developmental approach with emphasis on self-direction; (4) University of Arizona, where Henderson stresses behavioral skills and attitudes; (5) Ypsilanti, where Weikart relies on Piaget's cognitive theories; (6) University of Florida, where Gordon uses the concept of the parent-educator; (7) Far West Lab, where Nimnicht relies on the autotelic discovery approach; and (8) Education Development Center, where Armington follows on action-oriented approach. Evaluation will involve comparison of the development of children participating in the above programs with that of children attending regular Head Start programs within the same community or in a similar community. (MH)

Published
1969

9. Society Records and Activities

Author

Yochelson, Ellis L., Ladd, Harry Stephen, Rose, Kenneth D., Gingerich, Philip D., Sweet, Walter C., Bergström, Stig M., Klein, Jenny Lyn, Collinson, James W., Kaesler, Roger L., Feldmann, Rodney M., Coogan, Alan H., Hopson, James A., Kauffman, Erle G., Robeson, R. A., and Rowell, A. J.

Published
1982

10. Asynchronous excitatory neuron development in an isogenic cortical spheroid model of Down syndrome.

Author

Zhen Li, Klein, Jenny A., Rampam, Sanjeev, Kurzion, Ronni, Baker Campbell, Natalie, Patel, Yesha, Haydar, Tarik F., and Zeldich, Ella

Subjects
NEURON development, DOWN syndrome, PLURIPOTENT stem cells, CELL populations, CELL analysis, NEURAL stem cells, OLIGODENDROGLIA
Abstract

The intellectual disability (ID) in Down syndrome (DS) is thought to result from a variety of developmental deficits such as alterations in neural progenitor division, neurogenesis, gliogenesis, cortical architecture, and reduced cortical volume. However, the molecular processes underlying these neurodevelopmental changes are still elusive, preventing an understanding of the mechanistic basis of ID in DS. In this study, we used a pair of isogenic (trisomic and euploid) induced pluripotent stem cell (iPSC) lines to generate cortical spheroids (CS) that model the impact of trisomy 21 on brain development. Cortical spheroids contain neurons, astrocytes, and oligodendrocytes and they are widely used to approximate early neurodevelopment. Using single cell RNA sequencing (scRNA-seq), we uncovered cell type-specific transcriptomic changes in the trisomic CS. In particular, we found that excitatory neuron populations were most affected and that a specific population of cells with a transcriptomic profile resembling layer IV cortical neurons displayed the most profound divergence in developmental trajectory between trisomic and euploid genotypes. We also identified candidate genes potentially driving the developmental asynchrony between trisomic and euploid excitatory neurons. Direct comparison between the current isogenic CS scRNA-seq data and previously published datasets revealed several recurring differentially expressed genes between DS and control samples. Altogether, our study highlights the power and importance of cell type-specific analyses within a defined genetic background, coupled with broader examination of mixed samples, to comprehensively evaluate cellular phenotypes in the context of DS. [ABSTRACT FROM AUTHOR]

Published
2022
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11. DNA templates with blocked long 3ʹ end single-stranded overhangs (BL3SSO) promote bona fide Cas9-stimulated homology-directed repair of long transgenes into endogenous gene loci

Author

Bandyopadhyay, Saptaparni, primary, Douglass, Joseph, additional, Kapell, Sebastian, additional, Khan, Nazimuddin, additional, Feitosa-Suntheimer, Fabiana, additional, Klein, Jenny A, additional, Temple, Jasmine, additional, Brown-Culbertson, Jayce, additional, Tavares, Alexander H, additional, Saeed, Mohsan, additional, and Lau, Nelson C, additional

Published
2021
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16. Toward Competency in Child Care.

Author

Klein, Jenny W.

Subjects
CHILD care services, OUTCOME-based education, CHILD development, NEED (Psychology) in children, TEACHER training, CHILD rearing, DAY care centers, UNITED States education system, ASSOCIATIONS, institutions, etc.
Abstract

The article talks about the competency of child care services in the U.S. The need to provide quality programs for children, which will facilitate and support the potential of the child for growth and development and will meet the emotional, intellectual, social and physical needs of preschool children, is offered. The Office of Child development created the Child Development Association (CDA) program for the training of child care staff. The goals and competencies of the program and the training programs and the assessment and credentialing of the staff are discussed.

Published
1973

17. Head Start: Intervention for What?

Author

Klein, Jenny W.

Subjects
HEAD Start programs, PRESCHOOL education, CHILD welfare, PUBLIC welfare, EDUCATION, CHILD development, CHILD psychology, POOR children
Abstract

The article reports on the Project Head Start. Project Head Start was a comprehensive program designed to address itself to the educational, emotional and physical needs of the child while dealing with the problems of the family, needs and resources of the community. The first program launched by Head Start focuses on the preparation of the children to enter the first grade of public school that showed positive results. Moreover, it discusses the experimental program sponsored by Head Start called Planned Variation which focuses on the effects of approaches to preschool education and others.

Published
1971

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