150 results on '"Obeng, Esther A."'
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2. Proteasome inhibition targets the KMT2A transcriptional complex in acute lymphoblastic leukemia
3. Author Correction: Proteasome inhibition targets the KMT2A transcriptional complex in acute lymphoblastic leukemia
4. SF3B1 mutation and ATM deletion codrive leukemogenesis via centromeric R-loop dysregulation
5. Engineering naturally occurring CD7− T cells for the immunotherapy of hematological malignancies
6. Splicing factor deficits render hematopoietic stem and progenitor cells sensitive to STAT3 inhibition
7. Preferential expansion of CD8+ CD19-CAR T cells postinfusion and the role of disease burden on outcome in pediatric B-ALL
8. A Murine Model of Chronic Lymphocytic Leukemia Based on B Cell-Restricted Expression of Sf3b1 Mutation and Atm Deletion
9. Murine fetal bone marrow does not support functional hematopoietic stem and progenitor cells until birth
10. Clones assemble! The clonal complexity of blood during ontogeny and disease
11. SF3B1 mutation and ATM deletion co-drive leukemogenesis via centromeric R-loop dysregulation
12. Congenital macrothrombocytopenia with focal myelofibrosis due to mutations in human G6b-B is rescued in humanized mice
13. 3211 – SF3B1/DNMT3A CO-MUTATIONS MITIGATES DNMT3A PHENOTYPE IN HEMATOPOIETIC STEM AND PROGENITOR CELLS
14. 3138 – EPIGENETIC REGULATORS TET2 AND POLYCOMB REPRESSIVE COMPLEX 2 (PRC2) COORDINATE GENE EXPRESSION IN MYELODYSPLASTIC SYNDROME (MDS)
15. A Murine Model Harboring Cooperating DNMT3A and SF3B1 Mutations Phenocopies SF3B1 Driven Myelodysplastic Syndrome
16. Mutant SF3B1 splices a more leukemogenic EVI1
17. CD45RA Depleted T-Cell Addback and Prophylactic Blinatumomab Administration Following Tcrαβ/CD19-Depleted Haploidentical Transplantation in Pediatric Patients with High Risk Acute Leukemia
18. CD45RA-Depleted Haploidentical Transplantation Combined with NK Cell Addback Results in Promising Long-Term Outcomes in Pediatric Patients with High-Risk Hematologic Malignancies
19. Venetoclax-Based Combination Therapy As a Bridge to Allogeneic Hematopoietic Stem Cell Transplant in Children with Relapsed/Refractory AML
20. 3220 – SF3B1/DNMT3A CO-MUTATION MIMICS FEATURES OF SOLE SF3B1 OR DNMT3A MUTATION DEPENDING ON STRESS CONDITIONS
21. 3137 – A MODIFIED ACTIVIN RECEPTOR TYPE IIB LIGAND TRAP (RAP-536) IMPROVES ANEMIA IN SF3B1K700E MICE BY PROMOTING EARLY-STAGE ERYTHROPOIESIS AND IMPROVING ALTERNATIVE SPLICING
22. CD45RA-Depleted Haploidentical Transplantation Combined with NK Cell Addback Results in Promising Long-Term Outcomes in Pediatric Patients with High-Risk Hematologic Malignancies
23. CD45RO+ T-Cell Add Back and Prophylactic Blinatumomab Administration Post Tcrαβ/CD19-Depleted Haploidentical Transplantation in Pediatric Patients with High Risk Acute Leukemia
24. Selective Targeting of Splicing Factor Mutant Hematopoietic Stem and Progenitor Cells Via STAT3 Inhibition
25. Integrative Genomic Analysis of Pediatric Myeloid-Related Acute Leukemias Identifies Novel Subtypes and Prognostic Indicators
26. 3116 – SELECTIVE TARGETING OF SPLICING FACTOR MUTANT HEMATOPOIETIC STEM AND PROGENITOR CELLS VIA STAT3 INHIBITION
27. Nonsense-Mediated RNA Decay Is a Unique Vulnerability of Cancer Cells Harboring SF3B1 or U2AF1 Mutations
28. Engineering naturally occurring CD7−T cells for the immunotherapy of hematological malignancies
29. Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells
30. 3123 – STAT3 INHIBITION IS A SYNTHETIC LETHAL VULNERABILITY FOR SPLICING FACTOR-MUTATED HEMATOPOIETIC STEM CELLS
31. 148 - Venetoclax-Based Combination Therapy As a Bridge to Allogeneic Hematopoietic Stem Cell Transplant in Children with Relapsed/Refractory AML
32. 128 - CD45RA-Depleted Haploidentical Transplantation Combined with NK Cell Addback Results in Promising Long-Term Outcomes in Pediatric Patients with High-Risk Hematologic Malignancies
33. 41 - CD45RA Depleted T-Cell Addback and Prophylactic Blinatumomab Administration Following Tcrαβ/CD19-Depleted Haploidentical Transplantation in Pediatric Patients with High Risk Acute Leukemia
34. STAT3 INHIBITION IS A SYNTHETIC LETHAL VULNERABILITY FOR SF3B1-MUTATED HEMATOPOIETIC STEM CELLS
35. Impaired human hematopoiesis due to a cryptic intronic GATA1 splicing mutation
36. Splicing Control in Normal and Aberrant Erythropoiesis
37. Integrated Genomic and Proteomic Analysis of Murine CLL-like Cells Reveals SF3B1 Mutation to Impact DNA Damage Response and BCR Signaling
38. A Cryptic Intronic GATA1 Splicing Mutation Provides Insights Into Human Hematopoietic Differentiation
39. Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations
40. BIOL-04. INTEGRATED COPY-NUMBER AND CANCER DEPENDENCY ANALYSIS REVEALS ALTERED SPLICEOSOME STOICHIOMETRY AS A NOVEL VULNERABILITY IN GENOMICALLY DISRUPTED CANCERS
41. Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability
42. Synthetic Lethal Interactions of MDS-Associated Spliceosomal Gene Mutations Identifies the Basis for Their Mutual Exclusivity
43. Hematopoietic Stem Cells from Mice and Individuals with Sickle Cell Disease Display Premature Senescence and Loss of Function That Is Targetable By Senolytic Therapy
44. Regulation of Alternative Splicing in B-Cell ALL By DYRK1A
45. SF3B1 K700EAlters the Splicing of Metabolism and Stress Response Genes, Attenuating the Effect of DNMT3A Mutations in MDS
46. Physiologic Expression of Sf3b1 K700E Causes Impaired Erythropoiesis, Aberrant Splicing, and Sensitivity to Therapeutic Spliceosome Modulation
47. Heterozygous Hotspot SF3B1 Mutations Found in Myelodysplastic Syndromes Downregulate Genes Involved in Differentiation of Erythroid Cells
48. Expressionof Sf3b1- K700Ein Murine B Cells Causes Pre-mRNA Splicing and Altered B Cell Differentiation and Function
49. Abstract B125: Mutant SF3B1 downregulates proteins involved in differentiation, including ABCB7
50. 3000 - A Cryptic Intronic GATA1 Splicing Mutation Provides Insights Into Human Hematopoietic Differentiation
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