1. Health-related quality of life and burden of fatigue in patients with primary immune thrombocytopenia by phase of disease
- Author
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Annamaria Petrungaro, Sonia Cirrincione, Marco Ruggeri, Fabio Forghieri, Fabio Efficace, Iolanda Vincelli, Nicola Cascavilla, Giovanni Caocci, Franco Mandelli, Paolo Ditonno, Maria Gabriella Mazzucconi, Francesco Cottone, Monica Carpenedo, Alessandra Borchiellini, Laura Scaramucci, Cristina Santoro, Gianluca Gaidano, Paola Fazi, Francesco Rodeghiero, Valeria Di Giacomo, Micaela Bergamaschi, Maria Pina Simula, and Alessandro Rambaldi
- Subjects
medicine.medical_specialty ,education.field_of_study ,business.industry ,Population ,Physical fitness ,Hematology ,Disease ,03 medical and health sciences ,0302 clinical medicine ,Quality of life ,030220 oncology & carcinogenesis ,Internal medicine ,Bayesian multivariate linear regression ,Propensity score matching ,Immunology ,Severity of illness ,Medicine ,Observational study ,business ,education ,030215 immunology - Abstract
The main objective of this study was to compare health-related quality of life (HRQOL) of primary immune thrombocytopenia (pITP) patients with that of general population, overall, and by patient group (i.e., newly diagnosed, persistent, and chronic patients). Fatigue was also investigated as a secondary objective. Overall, 424 adult patients were enrolled in a multicenter observational study and the control group consisted of a representative sample from the general population. Propensity score matching plus further multivariate linear regression adjustment was used to compare HRQOL outcomes between pITP patients and general population. Mean age of patients was 54 years. Of those with HRQOL assessment, 99 patients (23.6%) were newly diagnosed, 53 (12.6%) were persistent, and 268 (63.8%) were chronic pITP patients. Comparison by patient group versus their respective peers in the general population revealed greater impairments in persistent pITP patients. Persistent pITP patients reported clinically meaningful impairments in physical functioning (-15; 95% CI -24.1 to -5.8; P = 0.002), social functioning (-15.3; 95% CI -25.5 to -5.1; P = 0.004), role physical (-28.4; 95% CI -43.1 to -13.7; P
- Published
- 2016