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5. Efficacy and safety of pulmonary vein isolation with pulsed field ablation vs. novel cryoballoon ablation system for atrial fibrillation.

Author

Badertscher, Patrick, Weidlich, Simon, Knecht, Sven, Stauffer, Niklas, Krisai, Philipp, Voellmin, Gian, Osswald, Stefan, Sticherling, Christian, and Kühne, Michael

Abstract

Aims Pulsed-field ablation (PFA) has emerged as a novel treatment technology for patients with atrial fibrillation (AF). Cryoballoon (CB) is the most frequently used single shot technology. A direct comparison to a novel CB system is lacking. We aimed to compare pulmonary vein isolation (PVI) using PFA vs. a novel CB system regarding efficiency, safety, myocardial injury, and outcomes. Methods and results One hundred and eighty-one consecutive patients underwent PVI and were included (age 64 ± 9.7 years, ejection fraction 0.58 ± 0.09, left atrial size 40 ± 6.4 mm, paroxysmal AF 64%). 106 patients (59%) underwent PFA (FARAPULSE, Boston Scientific) and 75 patients (41%) underwent CB ablation (PolarX, Boston Scientific). The median procedure time, left atrial dwell time and fluoroscopic time were similar between the PFA and the CB group with 55 [interquartile range (IQR) 43–64] min vs. 58 (IQR 48–69) min (P < 0.087), 38 (30–49) min vs. 37 (31–48) min, (P = 0.871), and 11 (IQR 9.3–14) min vs. 11 (IQR 8.7–16) min, (P < 0.81), respectively. Three procedural complications were observed in the PFA group (two tamponades, one temporary ST elevation) and three complications in the CB group (3× reversible phrenic nerve palsies). During the median follow-up of 404 days (IQR 208–560), AF recurrence was similar in the PFA group and the CB group with 24 vs. 30%, P = 0.406. Conclusion Procedural characteristics were very similar between PFA and CB in regard to procedure duration fluoroscopy time and complications. Atrial fibrillation free survival did not differ between the PFA and CB groups. [ABSTRACT FROM AUTHOR]

Published
2023
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6. Association of bone morphogenetic protein 10 and recurrent atrial fibrillation after catheter ablation.

Author

Hennings, Elisa, Aeschbacher, Stefanie, Coslovsky, Michael, Paladini, Rebecca E, Meyre, Pascal B, Voellmin, Gian, Blum, Livia, Kastner, Peter, Ziegler, André, Conen, David, Zuern, Christine S, Krisai, Philipp, Badertscher, Patrick, Sticherling, Christian, Osswald, Stefan, Knecht, Sven, and Kühne, Michael

Abstract

Aims Atrial remodelling, defined as a change in atrial structure, promotes atrial fibrillation (AF). Bone morphogenetic protein 10 (BMP10) is an atrial-specific biomarker released to blood during atrial development and structural changes. We aimed to validate whether BMP10 is associated with AF recurrence after catheter ablation (CA) in a large cohort of patients. Methods and results We measured baseline BMP10 plasma concentrations in AF patients who underwent a first elective CA in the prospective Swiss-AF-PVI cohort study. The primary outcome was AF recurrence lasting longer than 30 s during a follow-up of 12 months. We constructed multivariable Cox proportional hazard models to determine the association of BMP10 and AF recurrence. A total of 1112 patients with AF (age 61 ± 10 years, 74% male, 60% paroxysmal AF) was included in our analysis. During 12 months of follow-up, 374 patients (34%) experienced AF recurrence. The probability for AF recurrence increased with increasing BMP10 concentration. In an unadjusted Cox proportional hazard model, a per-unit increase in log-transformed BMP10 was associated with a hazard ratio (HR) of 2.28 (95% CI 1.43; 3.62, P < 0.001) for AF recurrence. After multivariable adjustment, the HR of BMP10 for AF recurrence was 1.98 (95% CI 1.14; 3.42, P = 0.01), and there was a linear trend across BMP10 quartiles (P = 0.02 for linear trend). Conclusion The novel atrial-specific biomarker BMP10 was strongly associated with AF recurrence in patients undergoing CA for AF. ClinicalTrials.gov Identifier NCT03718364; https://clinicaltrials.gov/ct2/show/NCT03718364 [ABSTRACT FROM AUTHOR]

Published
2023
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7. Blood Pressure and Brain Lesions in Patients With Atrial Fibrillation

Author

Aeschbacher, Stefanie, primary, Blum, Steffen, additional, Meyre, Pascal B., additional, Coslovsky, Michael, additional, Vischer, Annina S., additional, Sinnecker, Tim, additional, Rodondi, Nicolas, additional, Beer, Jürg H., additional, Moschovitis, Giorgio, additional, Moutzouri, Elisavet, additional, Hunkeler, Christof, additional, Burkard, Thilo, additional, Eken, Ceylan, additional, Roten, Laurent, additional, Zuern, Christine S., additional, Sticherling, Christian, additional, Wuerfel, Jens, additional, Bonati, Leo H., additional, Conen, David, additional, Osswald, Stefan, additional, Kühne, Michael, additional, Auberson, Chloé, additional, Ceylan, Selinda, additional, Doerpfeld, Simone, additional, Girod, Marc, additional, Hennings, Elisa, additional, Krisai, Philipp, additional, Monsch, Andreas U., additional, Müller, Christian, additional, Springer, Anne, additional, Voellmin, Gian, additional, Aujesky, Drahomir, additional, Fischer, Urs, additional, Fuhrer, Juerg, additional, Jung, Simon, additional, Mattle, Heinrich, additional, Adam, Luise, additional, Elodie Aubert, Carole, additional, Feller, Martin, additional, Loewe, Axel, additional, Schneider, Claudio, additional, Flückiger, Tanja, additional, Groen, Cindy, additional, Ehrsam, Lukas, additional, Hellrigl, Sven, additional, Nuoffer, Alexandra, additional, Rakovic, Damiana, additional, Schwab, Nathalie, additional, Wenger, Rylana, additional, Müller, Andreas, additional, Beynon, Christopher, additional, Dillier, Roger, additional, Deubelbeiss, Michèle, additional, Eberli, Franz, additional, Franzini, Christine, additional, Juchli, Isabel, additional, Liedtke, Claudia, additional, Nadler, Jacqueline, additional, Obst, Thayze, additional, Roth, Jasmin, additional, Schlomowitsch, Fiona, additional, Schneider, Xiaoye, additional, Studerus, Katrin, additional, Tynan, Noreen, additional, Weishaupt, Dominik, additional, Fontana, Simone, additional, Kuest, Silke, additional, Scheuch, Karin, additional, Hischier, Denise, additional, Bonetti, Nicole, additional, Grau, Alexandra, additional, Villinger, Jonas, additional, Laube, Eva, additional, Baumgartner, Philipp, additional, Filipovic, Mark, additional, Frick, Marcel, additional, Montrasio, Giulia, additional, Leuenberger, Stefanie, additional, Rutz, Franziska, additional, Moccetti, Tiziano, additional, Auricchio, Angelo, additional, Anesini, Adriana, additional, Camporini, Cristina, additional, Conte, Giulio, additional, Luce Caputo, Maria, additional, Regoli, Francois, additional, Ammann, Peter, additional, Brenner, Roman, additional, Altmann, David, additional, Gemperle, Michaela, additional, Hayoz, Daniel, additional, Firmann, Mathieu, additional, Foucras, Sandrine, additional, Rime, Martine, additional, Kobza, Richard, additional, Berte, Benjamin, additional, Justi, Virgina, additional, Kellner-Weldon, Frauke, additional, Mehmann, Brigitta, additional, Meier, Sonja, additional, Roth, Myriam, additional, Ruckli-Kaeppeli, Andrea, additional, Russi, Ian, additional, Schmidt, Kai, additional, Young, Mabelle, additional, Zbinden, Melanie, additional, Frangi-Kultalahti, Jane, additional, Pin, Anica, additional, Shah, Dipen, additional, Ehret, Georg, additional, Gallet, Hervé, additional, Guillermet, Elise, additional, Lazeyras, Francois, additional, Lovblad, Karl-Olof, additional, Perret, Patrick, additional, Tavel, Philippe, additional, Teres, Cheryl, additional, Schläpfer, Jürg, additional, Lauriers, Nathalie, additional, Méan, Marie, additional, Salzmann, Sandrine, additional, Stephan, Frank-Peter, additional, Grêt, Andrea, additional, Novak, Jan, additional, Vitelli, Sandra, additional, Di Valentino, Marcello, additional, Gallino, Augusto, additional, Witassek, Fabienne, additional, Schwenkglenks, Matthias, additional, Altermatt, Anna, additional, Amann, Michael, additional, Huber, Petra, additional, Ruberte, Esther, additional, Zuber, Vanessa, additional, Benkert, Pascal, additional, Dutilh, Gilles, additional, Markovic, Milica, additional, Neuschwander, Pia, additional, Simon, Patrick, additional, and Schmid, Ramun, additional

Published
2021
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8. Relationships of Overt and Silent Brain Lesions With Cognitive Function in Patients With Atrial Fibrillation

Author

Conen, David, primary, Rodondi, Nicolas, additional, Müller, Andreas, additional, Beer, Juerg H., additional, Ammann, Peter, additional, Moschovitis, Giorgio, additional, Auricchio, Angelo, additional, Hayoz, Daniel, additional, Kobza, Richard, additional, Shah, Dipen, additional, Novak, Jan, additional, Schläpfer, Jürg, additional, Di Valentino, Marcello, additional, Aeschbacher, Stefanie, additional, Blum, Steffen, additional, Meyre, Pascal, additional, Sticherling, Christian, additional, Bonati, Leo H., additional, Ehret, Georg, additional, Moutzouri, Elisavet, additional, Fischer, Urs, additional, Monsch, Andreas U., additional, Stippich, Christoph, additional, Wuerfel, Jens, additional, Sinnecker, Tim, additional, Coslovsky, Michael, additional, Schwenkglenks, Matthias, additional, Kühne, Michael, additional, Osswald, Stefan, additional, Berger, Sebastian, additional, Bernasconi, Raffaele, additional, Fröhlich, Lorin, additional, Göldi, Tobias, additional, Gugganig, Rebecca, additional, Kofler, Thomas, additional, Krisai, Philipp, additional, Mongiat, Michel, additional, Pudenz, Christiane, additional, Repilado, Javier Ruperti, additional, Schweizer, Aleksandra, additional, Springer, Anne, additional, Stempfel, Samuel, additional, Szucs, Thomas, additional, van der Stouwe, Jan, additional, Voellmin, Gian, additional, Zwimpfer, Leon, additional, Aujesky, Drahomir, additional, Fuhrer, Juerg, additional, Roten, Laurent, additional, Jung, Simon, additional, Mattle, Heinrich, additional, Adam, Luise, additional, Aubert, Carole Elodie, additional, Feller, Martin, additional, Schneider, Claudio, additional, Loewe, Axel, additional, Flückiger, Tanja, additional, Groen, Cindy, additional, Schwab, Nathalie, additional, Beynon, Christopher, additional, Dillier, Roger, additional, Eberli, Franz, additional, Fontana, Simone, additional, Franzini, Christine, additional, Juchli, Isabel, additional, Liedtke, Claudia, additional, Nadler, Jacqueline, additional, Obst, Thayze, additional, Schneider, Xiaoye, additional, Studerus, Katrin, additional, Weishaupt, Dominik, additional, Kuest, Silke, additional, Scheuch, Karin, additional, Hischier, Denise, additional, Bonetti, Nicole, additional, Bello, Corina, additional, Isberg, Henriette, additional, Grau, Alexandra, additional, Villinger, Jonas, additional, Papaux, Mary-Monica, additional, Baumgartner, Philipp, additional, Filipovic, Mark, additional, Frick, Marcel, additional, Anesini, Adriana, additional, Camporini, Cristina, additional, Conte, Giulio, additional, Caputo, Maria Luce, additional, Regoli, Francois, additional, Moccetti, Tiziano, additional, Brenner, Roman, additional, Altmann, David, additional, Forrer, Manuela, additional, Gemperle, Michaela, additional, Firmann, Mathieu, additional, Foucras, Sandrine, additional, Berte, Benjamin, additional, Kaeppeli, Andrea, additional, Mehmann, Brigitta, additional, Pfeiffer, Markus, additional, Russi, Ian, additional, Schmidt, Kai, additional, Weberndoerfer, Vanessa, additional, Young, Mabelle, additional, Zbinden, Melanie, additional, Vicari, Luisa, additional, Frangi, Jane, additional, Terrot, Tatiana, additional, Gallet, Hervé, additional, Guillermet, Elise, additional, Lazeyras, Francois, additional, Lovblad, Karl-Olof, additional, Perret, Patrick, additional, Teres, Cheryl, additional, Lauriers, Nathalie, additional, Méan, Marie, additional, Salzmann, Sandrine, additional, Arenja, Nisha, additional, Grêt, Andrea, additional, Vitelli, Sandra, additional, Gallino, Augusto, additional, Schoenenberger-Berzins, Renate, additional, Witassek, Fabienne, additional, Radue, Ernst-Wilhelm, additional, Benkert, Pascal, additional, Fabbro, Thomas, additional, Simon, Patrick, additional, and Schmid, Ramun, additional

Published
2019
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11. Insulin-like growth factor-binding protein 7 and risk of congestive heart failure hospitalization in patients with atrial fibrillation

Author

Steffen Blum, Stefanie Aeschbacher, Pascal Meyre, Michael Kühne, Nicolas Rodondi, Jürg H. Beer, Peter Ammann, Giorgio Moschovitis, Leo H. Bonati, Manuel R. Blum, Peter Kastner, Fiona Baguley, Christian Sticherling, Stefan Osswald, David Conen, Chloé Auberson, Leo Bonati, Selinda Ceylan, Simone Doerpfeld, Ceylan Eken, Marc Girod, Peter Hämmerle, Philipp Krisai, Christine Meyer-Zürn, Andreas U. Monsch, Christian Müller, Anne Springer, Thomas Szucs, Gian Voellmin, Leon Zwimpfer, Drahomir Aujesky, Urs Fischer, Juerg Fuhrer, Laurent Roten, Simon Jung, Heinrich Mattle, Luise Adam, Carole Elodie Aubert, Martin Feller, Axel Loewe, Elisavet Moutzouri, Claudio Schneider, Tanja Flückiger, Cindy Groen, Lukas Ehrsam, Sven Hellrigl, Alexandra Nuoffer, Damiana Rakovic, Nathalie Schwab, Rylana Wenger, Christopher Beynon, Roger Dillier, Michèle Deubelbeiss, Franz Eberli, Christine Franzini, Isabel Juchli, Claudia Liedtke, Jacqueline Nadler, Thayze Obst, Jasmin Roth, Fiona Schlomowitsch, Xiaoye Schneider, Katrin Studerus, Noreen Tynan, Dominik Weishaupt, Andreas Müller, Simone Fontana, Silke Kuest, Karin Scheuch, Denise Hischier, Nicole Bonetti, Alexandra Grau, Jonas Villinger, Eva Laube, Philipp Baumgartner, Mark Filipovic, Marcel Frick, Giulia Montrasio, Stefanie Leuenberger, Franziska Rutz, Jürg-Hans Beer, Angelo Auricchio, Adriana Anesini, Cristina Camporini, Giulio Conte, Maria Luce Caputo, Francois Regoli, Tiziano Moccetti, Roman Brenner, David Altmann, Michaela Gemperle, Mathieu Firmann, Sandrine Foucras, Martine Rime, Daniel Hayoz, Benjamin Berte, Virgina Justi, Frauke Kellner-Weldon, Brigitta Mehmann, Sonja Meier, Myriam Roth, Andrea Ruckli-Kaeppeli, Ian Russi, Kai Schmidt, Mabelle Young, Melanie Zbinden, Richard Kobza, Jane Frangi-Kultalahti, Anica Pin, Luisa Vicari, Georg Ehret, Hervé Gallet, Elise Guillermet, Francois Lazeyras, Karl-Olof Lovblad, Patrick Perret, Philippe Tavel, Cheryl Teres, Dipen Shah, Nathalie Lauriers, Marie Méan, Sandrine Salzmann, Jürg Schläpfer, Andrea Grêt, Jan Novak, Sandra Vitelli, Frank-Peter Stephan, Augusto Gallino, Marcello Di Valentino, Fabienne Witassek, Matthias Schwenkglenks, Jens Würfel, Anna Altermatt, Michael Amann, Petra Huber, Esther Ruberte, Tim Sinnecker, Vanessa Zuber, Michael Coslovsky, Pascal Benkert, Gilles Dutilh, Milica Markovic, Patrick Simon, Ramun Schmid, Clinical sciences, Auberson, Chloé, Bonati, Leo, Ceylan, Selinda, Doerpfeld, Simone, Eken, Ceylan, Girod, Marc, Hämmerle, Peter, Krisai, Philipp, Meyer-Zürn, Christine, Monsch, Andreas U., Müller, Christian, Springer, Anne, Szucs, Thomas, Voellmin, Gian, Zwimpfer, Leon, Aujesky, Drahomir, Fischer, Urs, Fuhrer, Juerg, Roten, Laurent, Jung, Simon, Mattle, Heinrich, Adam, Luise, Aubert, Carole Elodie, Feller, Martin, Loewe, Axel, Moutzouri, Elisavet, Schneider, Claudio, Flückiger, Tanja, Groen, Cindy, Ehrsam, Lukas, Hellrigl, Sven, Nuoffer, Alexandra, Rakovic, Damiana, Schwab, Nathalie, Wenger, Rylana, Beynon, Christopher, Dillier, Roger, Deubelbeiss, Michèle, Eberli, Franz, Franzini, Christine, Juchli, Isabel, Liedtke, Claudia, Nadler, Jacqueline, Obst, Thayze, Roth, Jasmin, Schlomowitsch, Fiona, Schneider, Xiaoye, Studerus, Katrin, Tynan, Noreen, Weishaupt, Dominik, Müller, Andreas, Fontana, Simone, Kuest, Silke, Scheuch, Karin, Hischier, Denise, Bonetti, Nicole, Grau, Alexandra, Villinger, Jonas, Laube, Eva, Baumgartner, Philipp, Filipovic, Mark, Frick, Marcel, Montrasio, Giulia, Leuenberger, Stefanie, Rutz, Franziska, Auricchio, Angelo, Anesini, Adriana, Camporini, Cristina, Conte, Giulio, Caputo, Maria Luce, Regoli, Francois, Moccetti, Tiziano, Brenner, Roman, Altmann, David, Gemperle, Michaela, Firmann, Mathieu, Foucras, Sandrine, Rime, Martine, Hayoz, Daniel, Berte, Benjamin, Justi, Virgina, Kellner-Weldon, Frauke, Mehmann, Brigitta, Meier, Sonja, Roth, Myriam, Ruckli-Kaeppeli, Andrea, Russi, Ian, Schmidt, Kai, Young, Mabelle, Zbinden, Melanie, Kobza, Richard, Frangi-Kultalahti, Jane, Pin, Anica, Vicari, Luisa, Ehret, Georg Benedikt, Gallet, Hervé, Guillermet, Elise, Lazeyras, François, Lövblad, Karl-Olof, Perret, Patrick, Tavel, Philippe, Teres Castillo, Cheryl, Shah, Dipen, Lauriers, Nathalie, Méan, Marie, Salzmann, Sandrine, Schläpfer, Jürg, Grêt, Andrea, Novak, Jan, Vitelli, Sandra, Stephan, Frank-Peter, Gallino, Augusto, Di Valentino, Marcello, Witassek, Fabienne, Schwenkglenks, Matthias, Würfel, Jens, Altermatt, Anna, Amann, Michael, Huber, Petra, Ruberte, Esther, Sinnecker, Tim, Zuber, Vanessa, Coslovsky, Michael, Benkert, Pascal, Dutilh, Gilles, Markovic, Milica, Simon, Patrick, and Schmid, Ramun

Subjects
Male, medicine.medical_specialty, medicine.drug_class, Epidemiology, Heart failure, 030204 cardiovascular system & hematology, ddc:616.0757, 03 medical and health sciences, 0302 clinical medicine, Insulin-Like Growth Factor Binding Proteins/blood, Physiology (medical), Internal medicine, Atrial Fibrillation, Clinical endpoint, Natriuretic peptide, medicine, Heart Failure/blood, Humans, 030212 general & internal medicine, cardiovascular diseases, Hospitalization/statistics & numerical data, Aged, Retrospective Studies, ddc:616, Heart Failure, Proportional hazards model, business.industry, Insulin-like growth factor-binding protein 7, Hazard ratio, Atrial fibrillation, Middle Aged, medicine.disease, Prognosis, Confidence interval, Hospitalization, Insulin-Like Growth Factor Binding Proteins, Atrial Fibrillation/blood, Cardiology, Disease Progression, Female, business, Cardiology and Cardiovascular Medicine, Biomarkers/blood, Biomarkers, Cohort study, Follow-Up Studies
Abstract

BACKGROUND: The occurrence of congestive heart failure (CHF) hospitalization among patients with atrial fibrillation (AF) is a poor prognostic marker. OBJECTIVE: The purpose of this study was to assess whether insulin-like growth factor-binding protein 7 (IGFBP-7), a marker of myocardial damage, identifies AF patients at high risk for this complication. METHODS: We analyzed 2 prospective multicenter observational cohort studies that included 3691 AF patients. Levels of IGFBP-7 and N-terminal pro-brain natriuretic peptide (NT-proBNP) were measured from frozen plasma samples at baseline. The primary endpoint was hospitalization for CHF. Multivariable adjusted Cox regression analyses were constructed. RESULTS: Mean patient age was 69 ± 12 years, 1028 (28%) were female, and 879 (24%) had a history of CHF. The incidence per 1000 patient-years across increasing IGFBP-7 quartiles was 7, 10, 32, and 85. The corresponding multivariable adjusted hazard ratios (aHRs) (95% confidence interval [CI]) were 1.0, 1.05 (0.63-1.77), 2.38 (1.50-3.79), and 4.37 (2.72-7.04) (P for trend

Published
2020

12. Blood Pressure and Brain Lesions in Patients With Atrial Fibrillation

Author

Aeschbacher, Stefanie, Blum, Steffen, Meyre, Pascal B., Coslovsky, Michael, Vischer, Annina S., Sinnecker, Tim, Rodondi, Nicolas, Beer, Jürg H., Moschovitis, Giorgio, Moutzouri, Elisavet, Hunkeler, Christof, Burkard, Thilo, Eken, Ceylan, Roten, Laurent, Zuern, Christine S., Sticherling, Christian, Wuerfel, Jens, Bonati, Leo H., Conen, David, Osswald, Stefan, Kühne, Michael, Swiss-AF Investigators, Auberson, Chloé, Ceylan, Selinda, Doerpfeld, Simone, Girod, Marc, Hennings, Elisa, Krisai, Philipp, Monsch, Andreas U., Müller, Christian, Springer, Anne, Voellmin, Gian, Aujesky, Drahomir, Fischer, Urs, Fuhrer, Juerg, Jung, Simon, Mattle, Heinrich, Adam, Luise, Elodie Aubert, Carole, Feller, Martin, Loewe, Axel, Schneider, Claudio, Flückiger, Tanja, Groen, Cindy, Ehrsam, Lukas, Hellrigl, Sven, Nuoffer, Alexandra, Rakovic, Damiana, Schwab, Nathalie, Wenger, Rylana, Müller, Andreas, Beynon, Christopher, Dillier, Roger, Deubelbeiss, Michèle, Eberli, Franz, Franzini, Christine, Juchli, Isabel, Liedtke, Claudia, Nadler, Jacqueline, Obst, Thayze, Roth, Jasmin, Schlomowitsch, Fiona, Schneider, Xiaoye, Studerus, Katrin, Tynan, Noreen, Weishaupt, Dominik, Fontana, Simone, Kuest, Silke, Scheuch, Karin, Hischier, Denise, Bonetti, Nicole, Grau, Alexandra, Villinger, Jonas, Laube, Eva, Baumgartner, Philipp, Filipovic, Mark, Frick, Marcel, Montrasio, Giulia, Leuenberger, Stefanie, Rutz, Franziska, Moccetti, Tiziano, Auricchio, Angelo, Anesini, Adriana, Camporini, Cristina, Conte, Giulio, Luce Caputo, Maria, Regoli, Francois, Ammann, Peter, Brenner, Roman, Altmann, David, Gemperle, Michaela, Hayoz, Daniel, Firmann, Mathieu, Foucras, Sandrine, Rime, Martine, Kobza, Richard, Berte, Benjamin, Justi, Virgina, Kellner-Weldon, Frauke, Mehmann, Brigitta, Meier, Sonja, Roth, Myriam, Ruckli-Kaeppeli, Andrea, Russi, Ian, Schmidt, Kai, Young, Mabelle, Zbinden, Melanie, Frangi-Kultalahti, Jane, Pin, Anica, Shah, Dipen, Ehret, Georg Benedikt, Gallet, Hervé, Guillermet, Elise, Lazeyras, François, Lövblad, Karl-Olof, Perret, Patrick, Tavel, Philippe, Teres Castillo, Cheryl, Schläpfer, Jürg, Lauriers, Nathalie, Méan, Marie, Salzmann, Sandrine, Stephan, Frank-Peter, Grêt, Andrea, Novak, Jan, Vitelli, Sandra, Di Valentino, Marcello, Gallino, Augusto, Witassek, Fabienne, Schwenkglenks, Matthias, Altermatt, Anna, Amann, Michael, Huber, Petra, Ruberte, Esther, Zuber, Vanessa, Benkert, Pascal, Dutilh, Gilles, Markovic, Milica, Neuschwander, Pia, Simon, Patrick, and Schmid, Ramun

Subjects
Brain Infarction, Male, brain, ddc:616.0757, White Matter Lesions, Magnetic resonance imaging, Atrial Fibrillation, Humans, Aged, Aged, 80 and over, ddc:616, White matter, blood pressure, Brain, Original Articles, Middle Aged, Magnetic Resonance Imaging, White Matter, Atrial fibrillation, Cross-Sectional Studies, Hypertension, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Blood pressure, Female
Abstract

Supplemental Digital Content is available in the text., The association of blood pressure (BP) and hypertension with the presence of different types of brain lesions in patients with atrial fibrillation is unclear. BP values were obtained in a multicenter cohort of patients with atrial fibrillation. Systolic and diastolic BP was categorized in predefined groups. All patients underwent brain magnetic resonance imaging and neurocognitive testing. Brain lesions were classified as large noncortical or cortical infarcts, small noncortical infarcts, microbleeds, or white matter lesions. White matter lesions were graded according to the Fazekas scale. Overall, 1738 patients with atrial fibrillation were enrolled in this cross-sectional analysis (mean age, 73 years, 73% males). Mean BP was 135/79 mm Hg, and 67% of participants were taking BP-lowering treatment. White matter lesions Fazekas ≥2 were found in 54%, large noncortical or cortical infarcts in 22%, small noncortical infarcts in 21%, and microbleeds in 22% of patients, respectively. Compared with patients with systolic BP

Published
2020

13. Association of bone morphogenetic protein 10 and recurrent atrial fibrillation after catheter ablation.

Author

Hennings E, Aeschbacher S, Coslovsky M, Paladini RE, Meyre PB, Voellmin G, Blum L, Kastner P, Ziegler A, Conen D, Zuern CS, Krisai P, Badertscher P, Sticherling C, Osswald S, Knecht S, and Kühne M

Subjects
Humans, Male, Middle Aged, Aged, Female, Cohort Studies, Prospective Studies, Bone Morphogenetic Proteins, Atrial Fibrillation diagnosis, Atrial Fibrillation surgery, Catheter Ablation adverse effects
Abstract

Aims: Atrial remodelling, defined as a change in atrial structure, promotes atrial fibrillation (AF). Bone morphogenetic protein 10 (BMP10) is an atrial-specific biomarker released to blood during atrial development and structural changes. We aimed to validate whether BMP10 is associated with AF recurrence after catheter ablation (CA) in a large cohort of patients., Methods and Results: We measured baseline BMP10 plasma concentrations in AF patients who underwent a first elective CA in the prospective Swiss-AF-PVI cohort study. The primary outcome was AF recurrence lasting longer than 30 s during a follow-up of 12 months. We constructed multivariable Cox proportional hazard models to determine the association of BMP10 and AF recurrence. A total of 1112 patients with AF (age 61 ± 10 years, 74% male, 60% paroxysmal AF) was included in our analysis. During 12 months of follow-up, 374 patients (34%) experienced AF recurrence. The probability for AF recurrence increased with increasing BMP10 concentration. In an unadjusted Cox proportional hazard model, a per-unit increase in log-transformed BMP10 was associated with a hazard ratio (HR) of 2.28 (95% CI 1.43; 3.62, P < 0.001) for AF recurrence. After multivariable adjustment, the HR of BMP10 for AF recurrence was 1.98 (95% CI 1.14; 3.42, P = 0.01), and there was a linear trend across BMP10 quartiles (P = 0.02 for linear trend)., Conclusion: The novel atrial-specific biomarker BMP10 was strongly associated with AF recurrence in patients undergoing CA for AF., Clinicaltrials.gov Identifier: NCT03718364; https://clinicaltrials.gov/ct2/show/NCT03718364., Competing Interests: Conflict of interest: P.B. received research funding from the University of Basel, the ‘Stiftung für Herzschrittmacher und Elektrophysiologie’, the ‘Freiwillige Akademische Gesellschaft Basel’, and the Swiss Heart Foundation and Johnson&Johnson, all outside the submitted work, and reports personal fees from Abbott, Boston Scientific, and Pfizer BMS. D.C. received consultancy fees from Roche Diagnostics and Trimedics and speaker fees from Servier and BMS/Pfizer. S.K. received funding from the ‘Stiftung für Herzschrittmacher und Elektrophysiologie’. M.K. received personal fees from Daiichi Sankyo and grants from the Swiss National Science Foundation, Swiss Heart Foundation, Foundation for CardioVascular Research Basel, Bayer, Pfizer, Boston Scientific, BMS, Biotronik, and Daiichi Sankyo. S.O. received research grants from the Swiss National Science Foundation and Swiss Heart Foundation, Foundation for CardioVascular Research Basel, and F. Hoffmann-La Roche Ltd and educational and speaker grants from F. Hoffmann-La Roche Ltd, Bayer, Novartis, Sanofi, AstraZeneca, Daiichi Sankyo, and Pfizer. C.S. is a member of the Advisory Board of Medtronic Europe and Advisory Board of Boston Scientific Europe and has received educational grants from Biosense Webster and Biotronik, research grants from the European Union’s FP7 program and Biosense Webster, and lecture and consulting fees from Abbott, Medtronic, Biosense Webster, Boston Scientific, Micro-Port, and Biotronik. All remaining authors have declared no conflicts of interest., (© The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology.)

Published
2023
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