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Start Over Author "Xu, Zuqiang" Search Limiters Peer Reviewed Topic cancer treatment

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1 results on '"Xu, Zuqiang"'

1. Bifunctional supramolecular prodrug vesicles constructed from a camptothecin derivative with a water-soluble pillar[5]arene for cancer diagnosis and therapy.

Author

Sun, Guangping, He, Zhimei, Hao, Min, Xu, Zuqiang, Hu, Xiao-Yu, Zhu, Jun-Jie, and Wang, Leyong

Subjects
*CANCER diagnosis, *CANCER treatment, *CANCER cells, *FLUORESCENCE
Abstract

Bifunctional supramolecular prodrug vesicles have been successfully constructed based on the complexation between a glutathione (GSH)-responsive prodrug guest molecule (DNS-CPT) and a water-soluble pillar[5]arene (WP5) for cancer diagnosis and therapy. Under the microenvironment of cancer cells with high GSH concentration, 7-ethyl-10-hydroxycamptothecin (SN-38) with strong yellow fluorescence can be efficiently released from the prodrug DNS-CPT for drug location and cancer therapy. [ABSTRACT FROM AUTHOR]

Published
2019
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