13,412 results
Search Results
2. The Human and the Context Components in the Design of Automatic Sign Language Recognition Systems
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Silva Prietch, Soraia, dos Santos Paim, Polianna, Olmos-Pineda, Ivan, Guerrero García, Josefina, Gonzalez Calleros, Juan Manuel, Barbosa, Simone Diniz Junqueira, Editorial Board Member, Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Kotenko, Igor, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Ruiz, Pablo H., editor, and Agredo-Delgado, Vanessa, editor
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- 2019
- Full Text
- View/download PDF
3. What makes a good reflective paper?
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Walling, Anne, Shapiro, Johanna, and Ast, Terry
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Editorial Policies ,Humans ,Medicine in Literature ,Periodicals as Topic: standards ,Personal Narratives as Topic ,Primary Health Care ,Questionnaires ,Writing: standards ,article ,human ,literature ,primary health care ,publication ,publishing ,questionnaire ,standard ,writing ,Editorial Policies ,Humans ,Medicine in Literature ,Periodicals as Topic ,Personal Narratives as Topic ,Primary Health Care ,Questionnaires ,Writing - Abstract
Reflective papers are increasingly recognized as potentially important contributors to clinical education and practice; however, few quality guidelines are available for potential authors or reviewers. We sought to identify key characteristics of effective reflective papers and to clarify factors that increased or reduced the probability of acceptance for publication.A 10-item survey addressing the definition, purpose, and quality characteristics of reflective papers was developed based on a literature review and analysis of the author instructions of 14 journals that regularly publish reflective papers and are likely to be read by primary care physicians. The survey was sent electronically to the editor or associate editor responsible for reflective papers at each journal.Seven completed surveys were returned. The essential element defining a reflective paper was identified as narration of a specific professional experience that resonated with readers and conveyed deeper meaning. All respondents rated emotional engagement as very important, followed by stimulating reflection in the reader, providing a lesson applicable to patient care, and stimulating discussion with colleagues and/or learners. Reasons for acceptance or rejection of reflective submissions to journals were identified in issues related to writing style, topic selection, and reader reaction.Writing and reviewing reflective papers is strongly dependent on context, personal values, experience, and emotional reaction; nevertheless, core quality features can be identified to guide both writers and editors/reviewers without destroying the unique nature of these papers.
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- 2013
4. Machine Perfusions in Liver Transplantation: The Evidence‐Based Position Paper of the Italian Society of Organ and Tissue Transplantation
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Paolo Muiesan, Massimo Rossi, Damiano Patrono, F. Melandro, Daniele Pezzati, Markus Selzner, Alberto Zanella, Andrea Lauterio, Riccardo De Carlis, Cristiano Quintini, Stefano Baroni, Domenico Bassi, Davide Ghinolfi, Paolo Magistri, Fabio Ferla, Luca Toti, Marinella Zanierato, Matteo Ravaioli, Quirino Lai, Chiara Lazzeri, Wayel Jassem, Patrizia Burra, Daniele Dondossola, Duilio Pagano, Philippe Dutkowski, Umberto Cillo, Erion Rreka, Salvatore Petta, University of Zurich, Ghinolfi, Davide, Ghinolfi, D, Lai, Q, Dondossola, D, De Carlis, R, Zanierato, M, Patrono, D, Baroni, S, Bassi, D, Ferla, F, Lauterio, A, Lazzeri, C, Magistri, P, Melandro, F, Pagano, D, Pezzati, D, Ravaioli, M, Rreka, E, Toti, L, Zanella, A, Burra, P, Petta, S, Rossi, M, Dutkowski, P, Jassem, W, Muiesan, P, Quintini, C, Selzner, M, Cillo, U, Ghinolfi D., Lai Q., Dondossola D., De Carlis R., Zanierato M., Patrono D., Baroni S., Bassi D., Ferla F., Lauterio A., Lazzeri C., Magistri P., Melandro F., Pagano D., Pezzati D., Ravaioli M., Rreka E., Toti L., Zanella A., Burra P., Petta S., Rossi M., Dutkowski P., Jassem W., Muiesan P., Quintini C., Selzner M., and Cillo U.
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medicine.medical_specialty ,Evidence-based practice ,2747 Transplantation ,GRADE ,donor after circulatory death ,donor brain death ,hypothermic machine ,liver transplant ,machine perfusion ,normothermic machine ,normothermic regional perfusion ,position paper ,medicine.medical_treatment ,Delphi method ,MEDLINE ,610 Medicine & health ,liver, perfusion machine ,030230 surgery ,Liver transplantation ,liver ,03 medical and health sciences ,0302 clinical medicine ,Humans ,Medicine ,Medical physics ,10217 Clinic for Visceral and Transplantation Surgery ,HumansItaly ,Transplantation ,Machine perfusion ,Hepatology ,business.industry ,Organ Preservation ,perfusion machine ,Institutional review board ,Liver Transplantation ,2746 Surgery ,Perfusion ,Italy ,Position paper ,2721 Hepatology ,030211 gastroenterology & hepatology ,Surgery ,business ,Human - Abstract
The use of machine perfusion (MP) in liver transplantation (LT) is spreading worldwide. However, its efficacy has not been demonstrated, and its proper clinical use has far to go to be widely implemented. The Società Italiana Trapianti d’Organo (SITO) promoted the development of an evidence-based position paper. A 3-step approach has been adopted to develop this position paper. First, SITO appointed a chair and a cochair who then assembled a working group with specific experience of MP in LT. The Guideline Development Group framed the clinical questions into a patient, intervention, control, and outcome (PICO) format, extracted and analyzed the available literature, ranked the quality of the evidence, and prepared and graded the recommendations. Recommendations were then discussed by all the members of the SITO and were voted on via the Delphi method by an institutional review board. Finally, they were evaluated and scored by a panel of external reviewers. All available literature was analyzed, and its quality was ranked. A total of 18 recommendations regarding the use and the efficacy of ex situ hypothermic and normothermic machine perfusion and sequential normothermic regional perfusion and ex situ MP were prepared and graded according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) method. A critical and scientific approach is required for the safe implementation of this new technology.
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- 2020
5. Human-Computer Cloud for Smart Cities: Tourist Itinerary Planning Case Study
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Smirnov, Alexander, Ponomarev, Andrew, Teslya, Nikolay, Shilov, Nikolay, van der Aalst, Wil M.P., Series editor, Mylopoulos, John, Series editor, Rosemann, Michael, Series editor, Shaw, Michael J., Series editor, Szyperski, Clemens, Series editor, and Abramowicz, Witold, editor
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- 2017
- Full Text
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6. Clinical Genomics for the Diagnosis of Monogenic Forms of Inflammatory Bowel Disease: A Position Paper From the Paediatric IBD Porto Group of European Society of Paediatric Gastroenterology, Hepatology and Nutrition
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Simon Travis, Scott B. Snapper, Tobias Schwerd, Aleixo M. Muise, Dan Turner, Christoph Klein, Fabienne Charbit-Henrion, Caterina Strisciuglio, Frank M. Ruemmele, Richard K Russell, Marina Macchi, Johan L van Limbergen, David C. Wilson, Anne M. Griffiths, Dror S. Shouval, Lissy de Ridder, Daniel Kotlarz, Holm H. Uhlig, Paediatric Gastroenterology, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, APH - Digital Health, APH - Health Behaviors & Chronic Diseases, Pediatrics, Uhlig, H. H., Charbit-Henrion, F., Kotlarz, D., Shouval, D. S., Schwerd, T., Strisciuglio, C., de Ridder, L., van Limbergen, J., Macchi, M., Snapper, S. B., Ruemmele, F. M., Wilson, D. C., Travis, S. P. L., Griffiths, A. M., Turner, D., Klein, C., Muise, A. M., and Russell, R. K.
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medicine.medical_specialty ,very early-onset inflammatory bowel disease ,MEDLINE ,primary immunodeficiency ,digestive system ,Article ,ulcerative coliti ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,Internal medicine ,Medicine ,Humans ,Family history ,Young adult ,Intensive care medicine ,Child ,Exome ,Genetic testing ,medicine.diagnostic_test ,business.industry ,Gastroenterology ,Genomics ,Hepatology ,Colitis ,Inflammatory Bowel Diseases ,digestive system diseases ,Crohn's disease ,Systematic review ,Pediatrics, Perinatology and Child Health ,Genomic ,Position paper ,030211 gastroenterology & hepatology ,genetic ,business ,Child Nutritional Physiological Phenomena ,exome sequencing ,Coliti ,Human - Abstract
BACKGROUND: It is important to identify patients with monogenic IBD as management may differ from classical IBD. In this position statement we formulate recommendations for the use of genomics in evaluating potential monogenic causes of IBD across age groups. METHODS: The consensus included paediatric IBD specialists from the Paediatric IBD Porto group of the European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) and specialists from several monogenic IBD research consortia. We defined key topics and performed a systematic literature review to cover indications, technologies (targeted panel, exome and genome sequencing), gene panel setup, cost-effectiveness of genetic screening, and requirements for the clinical care setting. We developed recommendations that were voted upon by all authors and Porto group members (32 voting specialists). RESULTS: We recommend next-generation DNA-sequencing technologies to diagnose monogenic causes of IBD in routine clinical practice embedded in a setting of multidisciplinary patient care. Routine genetic screening is not recommended for all IBD patients. Genetic testing should be considered depending on age of IBD-onset (infantile IBD, very early-onset IBD, paediatric or young adult IBD), and further criteria, such as family history, relevant comorbidities, and extraintestinal manifestations. Genetic testing is also recommended in advance of hematopoietic stem cell transplantation. We developed a diagnostic algorithm that includes a gene panel of 75 monogenic IBD genes. Considerations are provided also for low resource countries. CONCLUSIONS: Genomic technologies should be considered an integral part of patient care to investigate patients at risk for monogenic forms of IBD.
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- 2021
7. Recent Progress of Computational Fluid Dynamics Modeling of Animal and Human Swimming for Computer Animation
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Matko, Tom, Chang, Jian, Xiao, Zhidong, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Chang, Jian, editor, Zhang, Jian Jun, editor, Magnenat Thalmann, Nadia, editor, Hu, Shi-Min, editor, Tong, Ruofeng, editor, and Wang, Wencheng, editor
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- 2017
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8. Colloquium paper: footprints of nonsentient design inside the human genome.
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Avise, John C
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Humans ,Nucleic Acids ,Gene Expression Regulation ,Genome ,Genome ,Human ,Models ,Biological ,Models ,Genetic ,Philosophy ,Religion ,Selection ,Genetic ,Biological Evolution ,creationism ,evolutionary genetics ,intelligent design ,religion ,theodicy ,Genetics ,Human Genome ,Generic Health Relevance ,Human ,Models ,Biological ,Genetic ,Selection - Abstract
Intelligent design (ID)-the latest incarnation of religious creationism-posits that complex biological features did not accrue gradually via natural evolutionary forces but, instead, were crafted ex nihilo by a cognitive agent. Yet, many complex biological traits are gratuitously complicated, function poorly, and debilitate their bearers. Furthermore, such dysfunctional traits abound not only in the phenotypes but inside the genomes of eukaryotic species. Here, I highlight several outlandish features of the human genome that defy notions of ID by a caring cognitive agent. These range from de novo mutational glitches that collectively kill or maim countless individuals (including embryos and fetuses) to pervasive architectural flaws (including pseudogenes, parasitic mobile elements, and needlessly baroque regulatory pathways) that are endogenous in every human genome. Gross imperfection at the molecular level presents a conundrum for the traditional paradigms of natural theology as well as for recent assertions of ID, but it is consistent with the notion of nonsentient contrivance by evolutionary forces. In this important philosophical sense, the science of evolutionary genetics should rightly be viewed as an ally (not an adversary) of mainstream religions because it helps the latter to escape the profound theological enigmas posed by notions of ID.
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- 2010
9. Colloquium paper: in the light of evolution IV: the human condition.
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Avise, John C and Ayala, Francisco J
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Animals ,Humans ,Biodiversity ,Phylogeny ,Genome ,Genome ,Human ,Paleontology ,Biological Evolution ,Human - Published
- 2010
10. Cardiovascular disease and COVID-19:a consensus paper from the ESC Working Group on Coronary Pathophysiology & Microcirculation, ESC Working Group on Thrombosis and the Association for Acute CardioVascular Care (ACVC), in collaboration with the European Heart Rhythm Association (EHRA)
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Maria Dorobantu, Dirk J. Duncker, Geneviève Derumeaux, Diana A. Gorog, Zorana Vasiljevic-Pokrajcic, Cor de Wit, Marija Vavlukis, Dimitris Tousoulis, Etto C. Eringa, Edina Cenko, Christian Hassager, Davor Miličić, Teresa Padró, Giuseppe De Luca, Gemma Vilahur, Marc J. Claeys, Lina Badimon, Danijela Trifunovic-Zamaklar, Raffaele Bugiardini, Frank R. Heinzel, Olivia Manfrini, Evangelos Oikonomou, Kurt Huber, RS: Carim - H08 Experimental atrial fibrillation, Fysiologie, Physiology, ACS - Diabetes & metabolism, Cenko E., Badimon L., Bugiardini R., Claeys M.J., De Luca G., de Wit C., Derumeaux G., Dorobantu M., Duncker D.J., Eringa E.C., Gorog D.A., Hassager C., Heinzel F.R., Huber K., Manfrini O., Milicic D., Oikonomou E., Padro T., Trifunovic-Zamaklar D., Vasiljevic-Pokrajcic Z., Vavlukis M., Vilahur G., and Tousoulis D.
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Physiology ,Disease ,Review ,CORONAVIRUS ,030204 cardiovascular system & hematology ,Bioinformatics ,endothelial dysfunction ,0302 clinical medicine ,cytokine ,Cardiometabolic Risk Factor ,thrombosi ,AcademicSubjects/MED00200 ,030212 general & internal medicine ,Endothelial dysfunction ,CARDIOLOGY ,Clinical Trials as Topic ,Sex Characteristics ,post-acute COVID-19 ,THROMBOEMBOLISM FOLLOWING HOSPITALIZATION ,Inflammation/complications ,Cardiovascular disease ,Thrombosis ,Pathophysiology ,3. Good health ,Cardiovascular Diseases ,Myocardial injury ,Cardiovascular Diseases/enzymology ,COVID-19/complications ,Angiotensin-Converting Enzyme 2 ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,Infection ,Viral load ,POSITION PAPER ,Human ,ANGIOTENSIN-CONVERTING ENZYME ,EXPRESSION ,SEX-DIFFERENCES ,microcirculation ,Inflammation ,Angiotensin-Converting Enzyme 2/metabolism ,03 medical and health sciences ,Post-Acute COVID-19 Syndrome ,SDG 3 - Good Health and Well-being ,Physiology (medical) ,medicine ,Humans ,thrombosis ,business.industry ,SARS-CoV-2 ,INFLAMMATORY RESPONSE ,Cardiometabolic Risk Factors ,COVID-19 ,medicine.disease ,CARDIAC ARREST SYNDROME ,cytokines ,inflammation ,Cardiovascular Injury ,Myocardial fibrosis ,Human medicine ,business - Abstract
The cardiovascular system is significantly affected in coronavirus disease-19 (COVID-19). Microvascular injury, endothelial dysfunction, and thrombosis resulting from viral infection or indirectly related to the intense systemic inflammatory and immune responses are characteristic features of severe COVID-19. Pre-existing cardiovascular disease and viral load are linked to myocardial injury and worse outcomes. The vascular response to cytokine production and the interaction between severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and angiotensin-converting enzyme 2 receptor may lead to a significant reduction in cardiac contractility and subsequent myocardial dysfunction. In addition, a considerable proportion of patients who have been infected with SARS-CoV-2 do not fully recover and continue to experience a large number of symptoms and post-acute complications in the absence of a detectable viral infection. This conditions often referred to as ‘post-acute COVID-19’ may have multiple causes. Viral reservoirs or lingering fragments of viral RNA or proteins contribute to the condition. Systemic inflammatory response to COVID-19 has the potential to increase myocardial fibrosis which in turn may impair cardiac remodelling. Here, we summarize the current knowledge of cardiovascular injury and post-acute sequelae of COVID-19. As the pandemic continues and new variants emerge, we can advance our knowledge of the underlying mechanisms only by integrating our understanding of the pathophysiology with the corresponding clinical findings. Identification of new biomarkers of cardiovascular complications, and development of effective treatments for COVID-19 infection are of crucial importance., Graphical Abstract Graphical Abstract
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- 2021
11. Recommendations For Metrics For Multidrug-Resistant Organisms In Healthcare Settings: SHEA/HICPAC Position Paper
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Cohen, Adam L, Calfee, David, Fridkin, Scott K, Huang, Susan S, Jernigan, John A, Lautenbach, Ebbing, Oriola, Shannon, Ramsey, Keith M, Salgado, Cassandra D, and Weinstein, Robert A
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Biodefense ,Prevention ,Clinical Research ,Vaccine Related ,Antimicrobial Resistance ,Health Services ,Emerging Infectious Diseases ,Infectious Diseases ,Comparative Effectiveness Research ,Infection ,Good Health and Well Being ,Carrier State ,Cross Infection ,Drug Resistance ,Multiple ,Bacterial ,Enterococcus ,Gram-Negative Bacteria ,Gram-Negative Bacterial Infections ,Gram-Positive Bacterial Infections ,Humans ,Incidence ,Methicillin Resistance ,Population Surveillance ,Prevalence ,Staphylococcal Infections ,Staphylococcus aureus ,Vancomycin Resistance ,Society for Healthcare Epidemiology of America and the Healthcare Infection Control Practices Advisory Committee ,meticillin ,vancomycin ,anamnesis ,antibiotic resistance ,Gram negative bacterium ,health care personnel ,health service ,health survey ,hospital infection ,human ,infection ,methicillin resistant Staphylococcus aureus ,microbial colonization ,multidrug resistance ,prevalence ,review ,vancomycin resistant Enterococcus ,Medical and Health Sciences ,Epidemiology - Abstract
The assessment of MDRO infection and colonization should include the identification of known carriers, the detection of hospital-specific and healthcare-associated acquisition, an estimation of the burden of serious infection, an understanding of the reservoir affecting the transmission of MDROs, and an evaluation of the effect of intervention. Several strategies can be used to obtain data that aid in this assessment. We have defined and categorized the recommended metrics for each of these aspects of measuring MDRO infection and colonization, for use by healthcare facilities. © 2008 by The Society for Healthcare Epidemiology of America. All rights reserved.
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- 2008
12. Treatment of children with COVID-19: update of the Italian Society of Pediatric Infectious Diseases position paper
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Elisabetta Venturini, Carlotta Montagnani, Silvia Garazzino, Daniele Donà, Luca Pierantoni, Andrea Lo Vecchio, Andrzej Krzysztofiak, Giangiacomo Nicolini, Sonia Bianchini, Luisa Galli, Alberto Villani, Guido Castelli Gattinara, the Italian SITIP-SIP SARS-Cov-2 pediatric infection study group, Venturini, E., Montagnani, C., Garazzino, S., Dona, D., Pierantoni, L., Lo Vecchio, A., Krzysztofiak, A., Nicolini, G., Bianchini, S., Galli, L., Villani, A., and Gattinara, G. C.
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Male ,2019-20 coronavirus outbreak ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,MEDLINE ,Pediatrics ,RJ1-570 ,Medical ,medicine ,Humans ,Disease management (health) ,Child ,Intensive care medicine ,Letter to the Editor ,book ,Societies, Medical ,Infectious Disease Medicine ,SARS-CoV-2 ,business.industry ,COVID-19 ,Disease Management ,Settore MED/38 ,Italy ,Practice Guidelines as Topic ,Pediatric Infectious Disease ,Position paper ,book.journal ,Female ,Periodicals as Topic ,Societies ,business ,Human - Published
- 2021
13. The tumor-agnostic treatment for patients with solid tumors: a position paper on behalf of the AIOM- SIAPEC/IAP-SIBioC-SIF Italian Scientific Societies
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Stefania Gori, Carmine Pinto, Antonio Russo, Rita Chiari, Laura Cortesi, Antonio Marchetti, Umberto Malapelle, Romano Danesi, Ettore Capoluongo, Nicola Silvestris, Dario Sangiolo, Bruno Vincenzi, Marzia Del Re, Giovanni Tallini, Pierosandro Tagliaferri, Saverio Cinieri, Giordano D. Beretta, Ada Maria Florena, Nicola Normanno, Gabriella Fontanini, Lorena Incorvaia, Russo A., Incorvaia L., Malapelle U., Del Re M., Capoluongo E., Vincenzi B., Chiari R., Cortesi L., Danesi R., Florena A.M., Fontanini G., Gori S., Marchetti A., Normanno N., Pinto C., Sangiolo D., Silvestris N., Tagliaferri P., Tallini G., Cinieri S., Beretta G.D., Russo, A., Incorvaia, L., Malapelle, U., Del Re, M., Capoluongo, E., Vincenzi, B., Chiari, R., Cortesi, L., Danesi, R., Florena, A. M., Fontanini, G., Gori, S., Marchetti, A., Normanno, N., Pinto, C., Sangiolo, D., Silvestris, N., Tagliaferri, P., Tallini, G., Cinieri, S., and Beretta, G. D.
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Societies, Scientific ,Genomic profiling ,Druggability ,NTRK-Fusions ,Medical Oncology ,Neoplasms ,Medicine ,Humans ,Agnostic biomarkers ,Precision Medicine ,Histology-agnostic ,Tumor histology ,business.industry ,Agnostic drugs ,Homologous recombination deficiency ,Microsatellite instability ,Mismatch repair deficiency ,Precision oncology ,Italy ,Scientific ,Hematology ,Precision medicine ,Data science ,Oncology ,Economic sustainability ,Agnostic biomarker ,Position paper ,Neoplasm ,Identification (biology) ,Personalized medicine ,Agnostic drug ,NTRK-Fusion ,business ,Societies ,Human - Abstract
The personalized medicine is in a rapidly evolving scenario. The identification of actionable mutations is revolutionizing the therapeutic landscape of tumors. The morphological and histological tumor features are enriched by the extensive genomic profiling, and the first tumor-agnostic drugs have been approved regardless of tumor histology, guided by predictive and druggable genetic alterations. This new paradigm of "mutational oncology", presents a great potential to change the oncologic therapeutic scenario, but also some critical aspects need to be underlined. A process governance is mandatory to ensure the genomic testing accuracy and homogeneity, the economic sustainability, and the regulatory issues, ultimately granting the possibility of translating this model in the "real world". In this position paper, based on experts' opinion, the AIOM-SIAPEC-IAP-SIBIOC-SIF Italian Scientific Societies revised the new agnostic biomarkers, the diagnostic technologies available, the current availability of agnostic drugs and their present indication.
- Published
- 2021
14. Spatial neglect in the digital age: Influence of presentation format on patients' test behavior.
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Rosenzopf, Hannah, Sperber, Christoph, Wortha, Franz, Wiesen, Daniel, Muth, Annika, Klein, Elise, Möller, Korbinian, and Karnath, Hans-Otto
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UNILATERAL neglect ,DIGITAL technology ,ELECTRONIC paper ,STROKE patients ,SEARCHING behavior - Abstract
Objective: Computerized neglect tests could significantly deepen our disorder-specific knowledge by effortlessly providing additional behavioral markers that are hardly or not extractable from existing paper-and-pencil versions. This study investigated how testing format (paper versus digital), and screen size (small, medium, large) affect the Center of cancelation (CoC) in right-hemispheric stroke patients in the Letters and the Bells cancelation task. Our second objective was to determine whether a machine learning approach could reliably classify patients with and without neglect based on their search speed, search distance, and search strategy. Method: We compared the CoC measure of right hemisphere stroke patients with neglect in two cancelation tasks across different formats and display sizes. In addition, we evaluated whether three additional parameters of search behavior that became available through digitization are neglect-specific behavioral markers. Results: Patients' CoC was not affected by test format or screen size. Additional search parameters demonstrated lower search speed, increased search distance, and a more strategic search for neglect patients than for control patients without neglect. Conclusion: The CoC seems robust to both test digitization and display size adaptations. Machine learning classification based on the additional variables derived from computerized tests succeeded in distinguishing stroke patients with spatial neglect from those without. The investigated additional variables have the potential to aid in neglect diagnosis, in particular when the CoC cannot be validly assessed (e.g., when the test is not performed to completion). [ABSTRACT FROM AUTHOR]
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- 2023
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15. Environmental risks related to organic compounds from the combustion of paper briquettes in domestic boilers
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Marek Kucbel, Michal Šafář, Helena Raclavská, Pavel Kantor, Fabrizio Scala, Jana Růžičková, Konstantin Raclavský, Dagmar Juchelková, Barbora Švédová, Ruzickova, J., Raclavska, H., Safar, M., Kucbel, M., Svedova, B., Raclavsky, K., Juchelkova, D., Scala, F., and Kantor, P.
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Briquette ,Flue gas ,Environmental Engineering ,Health, Toxicology and Mutagenesis ,0211 other engineering and technologies ,Biomass ,02 engineering and technology ,010501 environmental sciences ,Raw material ,Combustion ,01 natural sciences ,Gas Chromatography-Mass Spectrometry ,Wastepaper analysi ,Bioma ,Paper additive ,Environmental Chemistry ,Humans ,Organic Chemicals ,Wastepaper combustion ,Waste Management and Disposal ,Flue ,0105 earth and related environmental sciences ,021110 strategic, defence & security studies ,cardboard ,Pulp and paper industry ,Py-GC/MS ,Pollution ,visual_art ,Phthalate ,visual_art.visual_art_medium ,Environmental science ,Pyrolysis ,Human - Abstract
Environmental risks connected with the combustion of paper/cardboard briquettes are still not sufficiently known. This paper aims to bring attention to the risks related to the utilisation of paper briquettes in local boilers and to characterise these risks by means of the identification of organic compounds in deposits from exhaust flues. The identification of the chemical compounds was performed by pyrolysis gas chromatography with mass spectrometric detection. Paper/cardboard briquettes contain 119 compounds of biogenic origin derived from major biomass components and 53 additives. Additives are used both for improving the properties of paper and in printing inks. By burning the paper briquettes, the same 53 compounds from the additive group were caught in the deposits from the flue gas pathway, occurring in the range of 1–10% of the concentration of individual compounds (additives) contained in the input fuel. Compounds that are very stable during the combustion process have an enrichment factor (EF) > 30, which corresponded to approximately 3% of the additive capture in deposits. The highest values were found for plasticisers (phthalates). Many of the primary organic compounds contained in the input raw material do not decompose during combustion and can have adverse effects on human health.
- Published
- 2021
16. The molecular profiling of solid tumors by liquid biopsy: a position paper of the AIOM–SIAPEC-IAP–SIBioC–SIC–SIF Italian Scientific Societies
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A. Russo, Umberto Malapelle, Pierosandro Tagliaferri, Saverio Cinieri, Daniele Santini, M. Del Re, Nicola Silvestris, Antonio Marchetti, Carmine Pinto, Giuseppe Giuffrè, Ettore Capoluongo, Giancarlo Troncone, Romano Danesi, Giulio Rossi, Stefania Gori, Nicola Normanno, Matteo Fassan, Valerio Gristina, Andrea Sartore-Bianchi, Giordano D. Beretta, Lorena Incorvaia, Marta Castiglia, Russo A., Incorvaia L., Del Re M., Malapelle U., Capoluongo E., Gristina V., Castiglia M., Danesi R., Fassan M., Giuffre G., Gori S., Marchetti A., Normanno N., Pinto C., Rossi G., Santini D., Sartore-Bianchi A., Silvestris N., Tagliaferri P., Troncone G., Cinieri S., Beretta G.D., Russo, A., Incorvaia, L., Del Re, M., Malapelle, U., Capoluongo, E., Gristina, V., Castiglia, M., Danesi, R., Fassan, M., Giuffre, G., Gori, S., Marchetti, A., Normanno, N., Pinto, C., Rossi, G., Santini, D., Sartore-Bianchi, A., Silvestris, N., Tagliaferri, P., Troncone, G., Cinieri, S., and Beretta, G. D.
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Societies, Scientific ,Cancer Research ,Context (language use) ,Review ,Neoplastic Cells ,Bioinformatics ,Circulating tumor cell ,Circulating ,Biomarkers, Tumor ,Medicine ,Humans ,Digital polymerase chain reaction ,Liquid biopsy ,cfDNA ,circulating tumor DNA ,circulating cell-free DNA ,ctDNA ,digital PCR ,liquid biopsy ,next-generation sequencing ,real-time PCR ,Tumor ,Circulating Neoplastic Cells ,business.industry ,Scientific ,Neoplastic Cells, Circulating ,Circulating Cell-Free DNA ,Italy ,Liquid Biopsy ,Oncology ,Circulating tumor DNA ,Position paper ,Societies ,business ,Biomarkers ,Human - Abstract
The term liquid biopsy (LB) refers to the use of various biological fluids as a surrogate for neoplastic tissue to achieve information for diagnostic, prognostic and predictive purposes. In the current clinical practice, LB is used for the identification of driver mutations in circulating tumor DNA derived from both tumor tissue and circulating neoplastic cells. As suggested by a growing body of evidence, however, there are several clinical settings where biological samples other than tissue could be used in the routine practice to identify potentially predictive biomarkers of either response or resistance to targeted treatments. New applications are emerging as useful clinical tools, and other blood derivatives, such as circulating tumor cells, circulating tumor RNA, microRNAs, platelets, extracellular vesicles, as well as other biofluids such as urine and cerebrospinal fluid, may be adopted in the near future. Despite the evident advantages compared with tissue biopsy, LB still presents some limitations due to both biological and technological issues. In this context, the absence of harmonized procedures corresponds to an unmet clinical need, ultimately affecting the rapid implementation of LB in clinical practice. In this position paper, based on experts’ opinions, the AIOM–SIAPEC-IAP–SIBIOC–SIF Italian Scientific Societies critically discuss the most relevant technical issues of LB, the current and emerging evidences, with the aim to optimizing the applications of LB in the clinical setting., Highlights • In the current clinical practice LB is used for the identification of driver mutations in circulating tumor DNA (ctDNA). • New applications in tumors other than non-small-cell lung cancer (NSCLC) are emerging as useful clinical tools. • Other blood derivatives, together with other biofluids, are an active field of research and may be adopted in the near future. • Despite the evident advantages, liquid biopsy still presents limitations due to both biological and technological issues. • Standardization of the procedures needs to be addressed to ensure widespread implementation in clinical practice.
- Published
- 2021
17. Paper-Based Lateral Flow Device for the Sustainable Measurement of Human Plasma Fibrinogen in Low-Resource Settings
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Anthony J. Killard, Stefano Cinti, Jennifer E. May, Jerro Saidykhan, Laura Selevic, Saidykhan, J., Selevic, L., Cinti, S., May, J. E., and Killard, A. J.
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Low resource ,Fibrinogen ,Article ,Fibrin ,Analytical Chemistry ,Fibrinogen Measurement ,Plasma ,Blood plasma ,medicine ,Animals ,Humans ,biology ,Plasma samples ,Chemistry ,Animal ,Thrombin ,Paper based ,Blood Coagulation Test ,Human plasma ,biology.protein ,Cattle ,Female ,Blood Coagulation Tests ,Biomedical engineering ,medicine.drug ,Human - Abstract
Fibrinogen concentration is a major determinant of both clotting and bleeding risk. Clotting and bleeding disorders cause extensive morbidity and mortality, particularly in resource-poor and emergency settings. This is exacerbated by a lack of timely intervention informed by measurement of fibrinogen levels under conditions such as thrombosis or postpartum haemorrhage. There is an absence of simple, rapid, low-cost, and sustainable diagnostic devices for fibrinogen measurement that can be deployed in such environments. Paper-based analytical devices are of significant interest due to their potential for low-cost production, ease of use, and environmental sustainability. In this work, a device for measuring blood plasma fibrinogen using chromatography paper was developed. Wax printing was used to create hydrophobic structures to define the test channel and sample application zone. Test strips were modified with bovine thrombin. Plasma samples (22 μL) were applied, and the flow rate was monitored over 5 min. As the sample traversed the strip, clotting was induced by the conversion of soluble fibrinogen to insoluble fibrin. The flow rate and distance travelled by the sample were dependent on fibrinogen concentration. The device was able to measure fibrinogen concentration in the range of 0.5–7.0 ± 0.3 mg/mL (p < 0.05, n = 24) and had excellent correlation with laboratory coagulometry in artificial samples (r2 = 0.9582, n = 60). Devices were also stable at 4–6 °C for up to 3 weeks.
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- 2021
18. The Italian law on body donation: A position paper of the Italian College of Anatomists
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Raffaele De Caro, Rafael, Boscolo-Berto, Marco, Artico, Eugenio, Bertelli, Mario, Cannas, Francesco, Cappello, Guido, Carpino, Sergio, Castorina, Amelia, Cataldi, Guido Angelo Cavaletti, Saverio, Cinti, Lucio Ildebrando Cocco, Ottavio, Cremona, Enrico, Crivellato, Antonio De Luca, Mirella, Falconi, Giuseppe, Familiari, Gianluca, Ferri, Francesco, Fornai, Marco, Gesi, Stefano, Geuna, Daniele Maria Gibelli, Antonio, Giordano, Pietro, Gobbi, Germano, Guerra, Massimo, Gulisano, Veronica, Macchi, Guido, Macchiarelli, Lucia, Manzoli, Fabrizio, Michetti, Sebastiano, Miscia, Stefania, Montagnani, Andrea, Costantino, Mario, Montella, Sergio, Morini, Paolo, Onori, Carla, Palumbo, Michele, Papa, Andrea, Porzionato, Daniela Elena Quacci, Mario, Raspanti, Rende, Mario, Rita, Rezzani, Domenico, Ribatti, Maurizio, Ripani, Luigi Fabrizio Rodella, Pellegrino, Rossi, Andrea, Sbarbati, Paola, Secchiero, Chiarella, Sforza, Carla, Stecco, Roberto, Toni, Alessandro, Vercelli, Marco, Vitale, Carlo, Zancanaro, Giorgio, Zauli, Sandra, Zecchi, Giuseppe Pio Anastasi, Eugenio, Gaudio, De Caro, R., Boscolo-Berto, R., Artico, M., Bertelli, E., Cannas, M., Cappello, F., Carpino, G., Castorina, S., Cataldi, A., Cavaletti, G. A., Cinti, S., Cocco, L. I., Cremona, O., Crivellato, E., De Luca, A., Falconi, M., Familiari, G., Ferri, G. L., Fornai, F., Gesi, M., Geuna, S., Gibelli, D. M., Giordano, A., Gobbi, P., Guerra, G., Gulisano, M., Macchi, V., Macchiarelli, G., Manzoli, L., Michetti, F., Miscia, S., Montagnani, S., Montella, A. C. M., Morini, S., Onori, P., Palumbo, C., Papa, M., Porzionato, A., Quacci, D. E., Raspanti, M., Rende, M., Rezzani, R., Ribatti, D., Ripani, M., Rodella, L. F., Rossi, P., Sbarbati, A., Secchiero, P., Sforza, C., Stecco, C., Toni, R., Vercelli, A., Vitale, M., Zancanaro, C., Zauli, G., Zecchi, S., Anastasi, G. P., Gaudio, E., De Caro, R, Boscolo-Berto, R, Artico, M, Bertelli, E, Cannas, M, Cappello, F, Carpino, G, Castorina, S, Cataldi, A, Cavaletti, G, Cinti, S, Cocco, L, Cremona, O, Crivellato, E, De Luca, A, Falconi, M, Familiari, G, Ferri, G, Fornai, F, Gesi, M, Geuna, S, Gibelli, D, Giordano, A, Gobbi, P, Guerra, G, Gulisano, M, Macchi, V, Macchiarelli, G, Manzoli, L, Michetti, F, Miscia, S, Montagnani, S, Montella, A, Morini, S, Onori, P, Palumbo, C, Papa, M, Porzionato, A, Quacci, D, Raspanti, M, Rende, M, Rezzani, R, Ribatti, D, Ripani, M, Rodella, L, Rossi, P, Sbarbati, A, Secchiero, P, Sforza, C, Stecco, C, Toni, R, Vercelli, A, Vitale, M, Zancanaro, C, Zauli, G, Zecchi, S, Anastasi, G, Gaudio, E, De Caro R., Boscolo-Berto R., Artico M., Bertelli E., Cannas M., Cappello F., Carpino G., Castorina S., Cataldi A., Cavaletti G.A., Cinti S., Cocco L.I., Cremona O., Crivellato E., De Luca A., Falconi M., Familiari G., Ferri G.L., Fornai F., Gesi M., Geuna S., Gibelli D.M., Giordano A., Gobbi P., Guerra G., Gulisano M., Macchi V., Macchiarelli G., Manzoli L., Michetti F., Miscia S., Montagnani S., Montella A.C.M., Morini S., Onori P., Palumbo C., Papa M., Porzionato A., Quacci D.E., Raspanti M., Rende M., Rezzani R., Ribatti D., Ripani M., Rodella L.F., Rossi P., Sbarbati A., Secchiero P., Sforza C., Stecco C., Toni R., Vercelli A., Vitale M., Zancanaro C., Zauli G., Zecchi S., Anastasi G.P., and Gaudio E.
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0301 basic medicine ,Students, Medical ,Tissue and Organ Procurement ,education ,Tissue Donor ,Legislation ,Body donation programme, Law Regulation, Cadaver lab, Education ,Cadaver lab ,NO ,Education ,03 medical and health sciences ,Body donation ,Anatomist ,Body donation programme Law Regulation Cadaver lab Education ,Political science ,Medical ,Cadaver ,Humans ,Anatomists ,Students ,Implementation ,Settore BIO/16 ,Body donation programme ,Settore BIO/16 - Anatomia Umana ,General Medicine ,Tissue Donors ,Transplantation ,Subordination (finance) ,030104 developmental biology ,Italy ,Law ,Donation ,Regulation ,Position paper ,030101 anatomy & morphology ,Anatomy ,Inefficiency ,Developmental Biology ,Human - Abstract
In Italy, recent legislation (Law No. 10/2020) has tuned regulations concerning the donation of one's postmortem body and tissues for study, training, and scientific research purposes. This study discusses several specific issues to optimise the applicability and effectiveness of such an important, novel regulatory setting. Some of these unsolved issues may involve the grantees of teaching and training activities, the role of academic anatomical institutes, the role of family members in the donation process, the universal time limit indicated for any donation, the handling of corpses, and the limited body donation and its subordination to the donation of organs and tissues. Critical issues arise concerning the learners, the type of training and teaching activities that can be planned, the position of academic anatomy institutes, the role of family members in the donation process, the time frame of the donation process, the eligibility of partial donation, or the simultaneous donation of organs and tissues to patients awaiting transplantation. In particular, a universal time limit for donations (i.e., one year) makes it impossible to plan the long-term use of specific body parts, which could be effectively preserved for the advanced teaching and training of medical students and surgeons. The abovementioned conditions lead to the limited use of corpses, thus resulting in the inefficiency of the whole system of body donation. Overall, the donors' scope for the donation of their body could be best honoured by a more flexible and tuneable approach that can be used on a case-by-case basis. Furthermore, it is deemed necessary to closely monitor the events scheduled for corpses in public nonacademic institutions or private enterprises. This paper presents useful insights from Italian anatomists with the hope of providing inspiration for drafting the regulations. In conclusion, this paper focuses on the critical issues derived from the recently introduced Italian law on the donation and use of the body after death and provides suggestions to lawmakers for future implementations.
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- 2021
19. The concept, importance and values of support during childbearing and breastfeeding – A discourse paper
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Caroline A. Bäckström, Stina Thorstensson, and Anette Ekström-Bergström
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Value (ethics) ,Parents ,family ,breastfeeding ,Emotions ,Breastfeeding ,RT1-120 ,Reproduktionsmedicin och gynekologi ,fathers ,Nursing ,labour ,child parent relation ,birth ,professional support ,Obstetrics, Gynecology and Reproductive Medicine ,Health care ,father ,Childbirth ,Humans ,human ,professional issues ,theory ,Beneficial effects ,Discursive Articles ,General Nursing ,Medical education ,healthcare organizations ,Parenting ,business.industry ,adult ,Omvårdnad ,mother ,article ,Professional support ,theoretical study ,clinical practice ,Clinical Practice ,childbearing ,mothers ,female ,Breast Feeding ,breast feeding ,Female ,pregnancy ,partners ,business ,Psychology ,Discursive Article - Abstract
Background: Professional support in childbearing has beneficial effects on childbirth experience, interactions within the family, breastfeeding and medical outcomes. However, more knowledge is needed about prerequisites for professional support to be valuable and satisfactory during childbearing. Aim: The aim of this discourse paper is to describe and explore prerequisites for professional support that are of value for women and their families during childbearing as well as how healthcare organizations can be formed to facilitate these prerequisites. Design: Discourse paper. Methods: This discourse paper is based on our own experiences and is supported by literature and theory. Results: Well-functioning structures and processes facilitate professional support that leads to safe, secure, calm and prepared parents with the ability to handle the challenges of childbearing and parenting. When organizing care in childbearing, prerequisites for support needs must also be considered. CC BY 4.0© 2021 The Authors. Nursing Open published by John Wiley & Sons Ltd.First published: 06 November 2021CorrespondenceAnette Ekström-Bergström, Department of Health Sciences, University West, SE-461 86 Trollhättan, Sweden.Email: anette.ekstrom-bergstrom@hv.se
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- 2021
20. Diagnosis and management of food allergy‐associated gastroesophageal reflux disease in young children— <scp>EAACI</scp> position paper
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Rosan Meyer, Yvan Vandenplas, Adriana Chebar Lozinsky, Mario C. Vieira, Roberto Berni Canani, Christophe Dupont, Pinar Uysal, Ozlem Cavkaytar, Rebecca Knibb, David M. Fleischer, Anna Nowak‐Wegrzyn, Carina Venter, Brussels Heritage Lab, Clinical sciences, Growth and Development, Pediatrics, Meyer, Rosan, Vandenplas, Yvan, Lozinsky, Adriana Chebar, Vieira, Mario C, Canani, Roberto Berni, Dupont, Christophe, Uysal, Pinar, Cavkaytar, Ozlem, Knibb, Rebecca, Fleischer, David M, Nowak-Wegrzyn, Anna, and Venter, Carina
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Nutrition and Dietetics ,Child, preschool ,Turkey ,extensively hydrolysed formula ,Immunology ,cow milk allergy ,Infant ,gastroenterology ,Europe ,amino acid formula ,Gastroesophageal Reflux/diagnosis ,Food Hypersensitivity/diagnosis ,non-IgE mediated food allergy ,Pediatrics, Perinatology and Child Health ,Gastroesophageal Reflux ,Humans ,Immunology and Allergy ,Pediatrics, Perinatology, and Child Health ,Child ,Food Hypersensitivity ,Brazil ,Human - Abstract
Gastro-oesophageal reflux (GOR) and food allergy (FA) are common conditions, especially during the first 12 months of life. When GOR leads to troublesome symptoms, that affect the daily functioning of the infant and family, it is referred to as GOR disease (GORD). The role of food allergens as a cause of GORD remains controversial. This European Academy of Allergy and Clinical Immunology (EAACI) position paper aims to review the evidence for FA-associated GORD in young children and translate this into clinical practice that guides healthcare professionals through the diagnosis of suspected FA-associated GORD and medical and dietary management. The task force (TF) on non-IgE mediated allergy consists of EAACI experts in paediatric gastroenterology, allergy, dietetics and psychology from Europe, United Kingdom, United States, Turkey and Brazil. Six clinical questions were formulated, amended and approved by the TF to guide this publication. A systematic literature search using PubMed, Cochrane and EMBASE databases (until June 2021) using predefined inclusion criteria based on the 6 questions was used. The TF also gained access to the database from the European Society of Paediatric Gastroenterology and Hepatology working group, who published guidelines on GORD and ensured that all publications used within that position paper were included. For each of the 6 questions, practice points were formulated, followed by a modified Delphi method consisting of anonymous web-based voting that was repeated with modified practice points where required, until at least 80% consensus for each practice point was achieved. This TF position paper shares the process, the discussion and consensus on all practice points on FA-associated GORD.
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- 2022
21. Roles and competencies in the nutritional domain for the management of the metabolic diseases and in the hospital setting: A position paper of the Italian College of Academic Nutritionists, MED-49 (ICAN-49)
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Lucia Frittitta, Tiziana Montalcini, Marisa Porrini, Angela A. Rivellese, Mauro Serafini, Arturo Pujia, Patrizia Riso, Lorenzo M. Donini, Andrea Natali, Anna Tagliabue, Antonino De Lorenzo, Fabio Galvano, Loris Pironi, Giovanni Scapagnini, Diego Russo, Pujia A., Montalcini T., Donini L.M., Frittitta L., Galvano F., Natali A., Pironi L., Porrini M., Riso P., Rivellese A.A., Russo D., Scapagnini G., Serafini M., Tagliabue A., and De Lorenzo A.
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Hospital setting ,Nutritional Sciences ,Endocrinology, Diabetes and Metabolism ,Nutrition Education ,Medicine (miscellaneous) ,Metabolic disease ,Dietary factors ,Settore MED/49 ,Health care ,Epidemiology ,Medical Staff ,Medicine ,Nutrition and Dietetics ,Skills ,Non-communicable disease ,Academic training ,Competencies ,Medical education ,Metabolic diseases ,Non-communicable diseases ,Physicians clinical nutrition ,Registered dietitian ,Hospitalization ,Treatment Outcome ,Competencie ,Clinical Competence ,Nutrition Therapy ,Cardiology and Cardiovascular Medicine ,Human ,Specialization ,medicine.medical_specialty ,Consensus ,Humans ,Medical Staff, Hospital ,Metabolic Diseases ,Nutritionists ,Education, Medical, Graduate ,Nutritional Status ,Consensu ,Clinical nutrition ,Education ,Hospital ,Nutritional Science ,Educational leadership ,Medical ,Graduate ,business.industry ,Family medicine ,Position paper ,Skill ,business ,Nutritionist - Abstract
Epidemiological evidence has confirmed the potential causal relationship between specific dietary factors and non-communicable diseases. However, currently nutrition was shown to be insufficiently integrated into medical education, regardless of the country. Without an adequate nutrition education, it is reasonable to assume that future physicians, as well as other health care professionals, will be not able to provide the highest quality care to patients in preventing and treating non-communicable diseases. Furthermore, the insufficient availability of physicians with specializations in nutrition has posed the basis for the development of non-medical careers in the field of nutrition. The present document was drafting by the Italian College of Academic Nutritionists, MED-49 (ICAN-49), with the aim to provide an overview on the nutritional competency standards covered by several health care professionals (Physicians Clinical Nutrition Specialists, Clinical Dietitians, Professional Clinical Nutrition Specialists, etc) for the prevention of diseases and/or support of pharmacological therapies. The aim of the ICAN 49 is to suggest a major shift in practice opportunities and roles for many nutritionists, especially for the management of the metabolic diseases, and promote a paradigm change: a clinical and educational leadership role for Physician Clinical Nutrition Specialists in the hospital setting.
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- 2021
22. Cardiovascular risk management in type 2 diabetes mellitus: A joint position paper of the Italian Cardiology (SIC) and Italian Diabetes (SID) Societies
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Roberto Pedrinelli, Agostino Consoli, Gianfranco Sinagra, Angelo Avogaro, Pasquale Perrone Filardi, Franco Cavalot, Francesco Purrello, Ciro Indolfi, F. Barilla, Gianluca Perseghin, Carmen Spaccarotella, Stefania Paolillo, Massimo Mancone, Roberto Scicali, Massimo Federici, Avogaro, A, Barillà, F, Cavalot, F, Consoli, A, Federici, M, Mancone, M, Paolillo, S, Pedrinelli, R, Perseghin, G, Filardi, P, Scicali, R, Sinagra, G, Spaccarotella, C, Indolfi, C, Purrello, F, Avogaro, A., Barilla, F., Cavalot, F., Consoli, A., Federici, M., Mancone, M., Paolillo, S., Pedrinelli, R., Perseghin, G., Perrone Filardi, P., Scicali, R., Sinagra, G., Spaccarotella, C., Indolfi, C., and Purrello, F.
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Endocrinology, Diabetes and Metabolism ,Medicine (miscellaneous) ,Type 2 diabetes ,030204 cardiovascular system & hematology ,Vitality ,Type 2 diabete ,Settore MED/11 ,0302 clinical medicine ,Cardiovascular Disease ,Prevalence ,Risk management ,Hypolipidemic Agents ,Hypolipidemic Agent ,Nutrition and Dietetics ,Heart Disease Risk Factor ,Antihypertensive Agent ,Treatment Outcome ,Cardiovascular Diseases ,Hypertension ,Cardiology ,Platelet aggregation inhibitor ,Cardiology and Cardiovascular Medicine ,Psychology ,Risk assessment ,Type 2 ,Human ,medicine.medical_specialty ,030209 endocrinology & metabolism ,Heart failure ,Risk Assessment ,03 medical and health sciences ,Type 2 diabetes, Cardiovascular risk, Heart failure ,Internal medicine ,Diabetes mellitus ,medicine ,Diabetes Mellitus ,Humans ,Hypoglycemic Agents ,Cardiovascular risk ,Antihypertensive Agents ,Diabetes Mellitus, Type 2 ,Dyslipidemias ,Heart Disease Risk Factors ,Platelet Aggregation Inhibitors ,MED/13 - ENDOCRINOLOGIA ,Hypoglycemic Agent ,business.industry ,Platelet Aggregation Inhibitor ,Type 2 Diabetes Mellitus ,medicine.disease ,Dyslipidemia ,Position paper ,business - Abstract
Aim This review represents a joint effort of the Italian Societies of Cardiology (SIC) and Diabetes (SID) to define the state of the art in a field of great clinical and scientific interest which is experiencing a moment of major cultural advancements, the cardiovascular risk management in type 2 diabetes mellitus. Data synthesis Consists of six chapters that examine various aspects of pathophysiology, diagnosis and therapy which in recent months have seen numerous scientific innovations and several clinical studies that require extensive sharing. Conclusions The continuous evolution of our knowledge in this field confirms the great cultural vitality of these two cultural spheres, which requires, under the leadership of the scientific Societies, an ever greater and effective collaboration.
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- 2021
23. Therapeutic strategies for severe COVID-19: a position paper from the Italian Society of Infectious and Tropical Diseases (SIMIT)
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Silvia Nozza, Cristina Mussini, Giampiero Carosi, Antonio Cascio, Francesco Mazzotta, Nicola Petrosillo, Marco Falcone, Roberto Parrella, Paolo Grossi, Antonio Chirianni, Carmelo Iacobello, Evangelista Sagnelli, Claudio Maria Mastroianni, Massimo Galli, Marco Tinelli, Marianna Meschiari, Marcello Tavio, Massimo Andreoni, Giovanni Di Perri, V. Portelli, Chiara Iaria, Orlando Armignacco, Caterina Sagnelli, Mussini, C., Falcone, M., Nozza, S., Sagnelli, C., Parrella, R., Meschiari, M., Petrosillo, N., Mastroianni, C., Cascio, A., Iaria, C., Galli, M., Chirianni, A., Sagnelli, E., Iacobello, C., Di Perri, G., Mazzotta, F., Carosi, G., Tinelli, M., Grossi, P., Armignacco, O., Portelli, V., Andreoni, M., Tavio, M., Mussini C., Falcone M., Nozza S., Sagnelli C., Parrella R., Meschiari M., Petrosillo N., Mastroianni C., Cascio A., Iaria C., Galli M., Chirianni A., Sagnelli E., Iacobello C., Di Perri G., Mazzotta F., Carosi G., Tinelli M., Grossi P., Armignacco O., Portelli V., Andreoni M., and Tavio M.
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0301 basic medicine ,Microbiology (medical) ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,030106 microbiology ,Coronaviru ,practice guidelines as topic ,coronavirus ,randomized controlled trials as topic ,Guidelines ,medicine.disease_cause ,medical ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,societies ,Randomized controlled trial ,law ,Pandemic ,italy ,medicine ,pneumonia ,030212 general & internal medicine ,Intensive care medicine ,humans ,Societies, Medical ,Coronavirus ,therapy ,SARS-CoV-2 ,business.industry ,COVID-19 ,Pneumonia ,Therapy ,Standard treatment ,General Medicine ,covid-19 ,sars-cov-2 ,societies, medical ,standard of care ,COVID-19 Drug Treatment ,Clinical trial ,Infectious Diseases ,Position paper ,Observational study ,business ,Human - Abstract
Scope Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has become pandemic, reaching almost one million death worldwide. At present standard treatment for coronavirus disease 2019 (COVID-19) is not well defined because the evidence, either from randomized or observational studies, with conflicting results, has led to rapid changes in treatment guidelines. Our aim was to narratively summarize the available literature on the management of COVID-19 in order to combine current evidence and interpretation of the data by experts who are treating patients in the frontline setting. Methods The panel conducted a detailed review of the literature and eventual press releases from randomized clinical trials for each possible available treatment. Inductive PubMed search waws performed for publications relevant to the topic, including all clinical trials conducted. The result was a flowchart with treatment indications for patients with COVID-19. Implications After 6 months of a pandemic situation and before a possible second coronavirus wave descends on Europe, it is important to evaluate which drugs proved to be effective while also considering that results from many randomized clinical trials are still awaited. Indeed, among treatments for COVID-19, only glucocorticoids have resulted in an association with a significant decrease in mortality in published randomized controlled trials. New therapeutic strategies are urgently needed.
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- 2021
24. Critical concepts and management recommendations for cutaneous T-cell lymphoma: A consensus-based position paper from the Italian Group of Cutaneous Lymphoma
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Nicola Pimpinelli, Pier Luigi Zinzani, Gaia Goteri, Maria Cantonetti, Francesco Onida, Silvia Alberti Violetti, Marco Paulli, Serena Rupoli, Pietro Quaglino, Giovanni Barosi, Zinzani P.L., Quaglino P., Violetti S.A., Cantonetti M., Goteri G., Onida F., Paulli M., Rupoli S., Barosi G., and Pimpinelli N.
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mycosis fungoide ,recommendation ,Adult ,Cancer Research ,medicine.medical_specialty ,Consensus ,diagnosis ,Consensu ,Scientific literature ,Cutaneous lymphoma ,03 medical and health sciences ,0302 clinical medicine ,Histological diagnosis ,cutaneous T-cell lymphomas ,mycosis fungoides ,recommendations ,Sèzary syndrome ,treatment ,medicine ,Biomarkers, Tumor ,Humans ,Medical physics ,cutaneous T-cell lymphoma ,Mycosis fungoides ,business.industry ,Cutaneous T-cell lymphoma ,Hematology ,General Medicine ,medicine.disease ,Lymphoma, T-Cell, Cutaneous ,Clinical Practice ,diagnosi ,Group discussion ,Oncology ,Italy ,030220 oncology & carcinogenesis ,Position paper ,Female ,business ,030215 immunology ,Human - Abstract
In this paper, we present a review of critical concepts, and produce recommendations on management issues in cutaneous T-cell lymphomas (CTCLs) of adults. A panel of nine experts was selected for their expertise in research and clinical practice of CTCLs. During an initial meeting, the areas of major concern in the management of CTCLs were selected by generating and rank-ordering clinical key questions using the criterion of clinical relevance, through group discussion. Recommendations were achieved by multiple-step formalized procedures to reach a consensus after a comprehensive analysis of the scientific literature. The panel produced recommendations on how to facilitate the clinical suspicion of CTCL; indication of cutaneous biopsy; optimal histological diagnosis, immunohistochemistry and genetic markers; and staging pathway and up-to-date therapeutics (with particular focus on new treatments). The critical concept of integration of the different medical expertise in the management of the patients with CTCL was thoroughly examined. These recommendations are intended for use not only by expert centers but above all by "not experienced" dermatologists and hematologists as well as general practitioners.
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- 2020
25. Experimental Comparison in Sensing Breast Cancer Mutations by Signal ON and Signal OFF Paper-Based Electroanalytical Strips
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Emily P. Nguyen, Fabiana Arduini, Claudio Parolo, Giulia Cinotti, Danila Moscone, Stefano Cinti, Arben Merkoçi, Veronica Caratelli, Cinti, S., Cinotti, G., Parolo, C., Nguyen, E. P., Caratelli, V., Moscone, D., Arduini, F., and Merkoci, A.
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Paper ,DNA, Single-Stranded ,Breast Neoplasms ,STRIPS ,Biosensing Techniques ,010402 general chemistry ,computer.software_genre ,01 natural sciences ,Signal ,Field (computer science) ,Analytical Chemistry ,law.invention ,Biosensing Technique ,DNA-based biosensors ,Breast cancer ,Settore CHIM/01 ,Design and Development ,law ,Experimental comparison ,Detection methods ,medicine ,Humans ,Liquid biopsy ,Protocol (science) ,Electrochemical Technique ,Chemistry ,010401 analytical chemistry ,Analytical performance ,Electrochemical Techniques ,medicine.disease ,Signal on ,0104 chemical sciences ,Emerging technologies ,Mutation ,Single strand DNA ,Female ,Data mining ,Detection protocols ,Biosensor ,computer ,Breast Neoplasm ,Human - Abstract
Altres ajuts: the ICN2 is funded by the CERCA Programme/Generalitat de Catalunya. The development of paper-based electroanalytical strips as powerful diagnostic tools has gained a lot of attention within the sensor community. In particular, the detection of nucleic acids in complex matrices represents a trending topic, especially when focused toward the development of emerging technologies, such as liquid biopsy. DNA-based biosensors have been largely applied in this direction, and currently, there are two main approaches based on target/probe hybridization reported in the literature, namely Signal ON and Signal OFF. In this technical note, the two approaches are evaluated in combination with paper-based electrodes, using a single strand DNA relative to H1047R (A3140G) missense mutation in exon 20 in breast cancer as the model target. A detailed comparison among the analytical performances, detection protocol, and cost associated with the two systems is provided, highlighting the advantages and drawbacks depending on the application. The present work is aimed to a wide audience, particularly for those in the field of point-of-care, and it is intended to provide the know-how to manage with the design and development stages, and to optimize the platform for the sensing of nucleic acids using a paper-based detection method.
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- 2019
26. Management of paediatric IBD after the peak of COVID-19 pandemic in Italy: A position paper on behalf of the SIGENP IBD working group
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Federica Mario, Federica Nuti, Chiara Moretti, Claudia Banzato, Lorenzo Norsa, Stefano Martelossi, Claudio Romano, Caterina Strisciuglio, Sara Renzo, Antonio Corsello, Maurizio Fuoti, Massimo Martinelli, Anna Dilillo, Zeno Giusti, Paolo Lionetti, Simona Gatti, Valeria Dipasquale, Fortunata Civitelli, Erminia Romeo, A. Marseglia, Enrico Felici, Matteo Bramuzzo, Roberto Panceri, Stefania Rampado, Serena Arrigo, Patrizia Alvisi, Daniela Knafelz, Giulia D'Arcangelo, Arrigo, Serena, Alvisi, Patrizia, Banzato, Claudia, Bramuzzo, Matteo, Civitelli, Fortunata, Corsello, Antonio, D'Arcangelo, Giulia, Dilillo, Anna, Dipasquale, Valeria, Felici, Enrico, Fuoti, Maurizio, Gatti, Simona, Giusti, Zeno, Knafelz, Daniela, Lionetti, Paolo, Mario, Federica, Marseglia, Antonio, Martelossi, Stefano, Moretti, Chiara, Norsa, Lorenzo, Nuti, Federica, Panceri, Roberto, Rampado, Stefania, Renzo, Sara, Romano, Claudio, Romeo, Erminia, Strisciuglio, Caterina, Martinelli, Massimo, Arrigo, S., Alvisi, P., Banzato, C., Bramuzzo, M., Civitelli, F., Corsello, A., D'Arcangelo, G., Dilillo, A., Dipasquale, V., Felici, E., Fuoti, M., Gatti, S., Giusti, Z., Knafelz, D., Lionetti, P., Mario, F., Marseglia, A., Martelossi, S., Moretti, C., Norsa, L., Nuti, F., Panceri, R., Rampado, S., Renzo, S., Romano, C., Romeo, E., Strisciuglio, C., and Martinelli, M.
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2019-20 coronavirus outbreak ,medicine.medical_specialty ,COVID-19, Inflammatory bowel disease, Paediatrics ,SARS-CoV2 ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Guidelines ,Inflammatory bowel disease ,Pediatrics ,Disease course ,03 medical and health sciences ,0302 clinical medicine ,Pandemic ,Medicine ,Humans ,Intensive care medicine ,Child ,Hepatology ,business.industry ,SARS-CoV-2 ,Gastroenterology ,Outbreak ,COVID-19 ,Paediatrics ,medicine.disease ,Inflammatory Bowel Diseases ,Organizational Innovation ,Italy ,Paediatric ,030220 oncology & carcinogenesis ,Communicable Disease Control ,Position paper ,030211 gastroenterology & hepatology ,Risk Adjustment ,business ,Human - Abstract
Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2, spreading in Italy during the first months of 2020, abruptly changed the way of practicing medicine in this country. As a consequence of the lockdown, the diagnostic and therapeutic management of paediatric chronic conditions, such as inflammatory bowel disease (IBD) has been affected. During the peak of COVID-19 pandemic, elective visits, endoscopies and infusions have been postponed, with potential clinical and psychological impact on disease course and a high likelihood of increasing waiting lists. While slowly moving back towards normality, clinicians need to recognize the best ways to care for patients with IBD, carefully avoiding risk factors for new potential epidemic outbreaks. In this uncertain scenario until the development and spread of COVID-19 vaccine, it is necessary to continue to operate with caution. Hereby we provide useful indications for a safer and gradual restarting of routine clinical activities after COVID-19 peak in Italy.
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- 2020
27. How Relevant Are Chess Composition Conventions?
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Iqbal, Azlan, Cazenave, Tristan, editor, Winands, Mark H.M., editor, and Iida, Hiroyuki, editor
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- 2014
- Full Text
- View/download PDF
28. Position paper of the Italian Society of Cardiology: The renin-angiotensin-aldosterone system blockade in heart failure patients - Part II: Mechanistic effects of sacubitril/valsartan, placement in current guidelines and use in clinical practice [Position paper della Società Italiana di Cardiologia: Il blocco del sistema renina-angiotensina-aldosterone nel paziente con scompenso cardiaco – Parte II: Effetti meccanicistici di sacubitril/valsartan, posizionamento nelle linee guida ed utilizzo nella pratica clinica]
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Filardi, Pasquale Perrone, Indolfi, Ciro, Paolillo, Stefania, Agostoni, Piergiuseppe, Basso, Cristina, Barillà, Francesco, Correale, Michele, Curcio, Antonio, Mancone, Massimo, Merlo, Marco, Metra, Marco, Muscoli, Saverio, Nodari, Savina, Palazzuoli, Alberto, Pedrinelli, Roberto, Pontremoli, Roberto, Senni, Michele, Volpe, Massimo, Sinagra, Gianfranco, Filardi, P, Indolfi, C, Paolillo, S, Agostoni, P, Basso, C, Barilla, F, Correale, M, Curcio, A, Mancone, M, Merlo, M, Metra, M, Muscoli, S, Nodari, S, Palazzuoli, A, Pedrinelli, R, Pontremoli, R, Senni, M, Volpe, M, and Sinagra, G
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Heart Failure ,Aminobutyrates ,Biphenyl Compounds ,Aminobutyrate ,Angiotensin Receptor Antagonist ,Cardiology ,Angiotensin Receptor Antagonists ,Humans ,Renin-Angiotensin System ,Tetrazoles ,Valsartan ,Scompenso cardiaco a frazione di eiezione ridotta ,Guidelines ,Linee guida ,Sacubitrilvalsartan ,Angiotensin receptor-neprilysin inhibitors ,Heart failure ,Heart failure with re-duced ejection fraction ,Scompenso cardiaco ,Biphenyl Compound ,Inibitori del recettore dell’angiotensina e della neprilisina ,Sacubitril/valsartan ,Tetrazole ,Human - Abstract
Il trattamento con sacubitril/valsartan ha assunto un ruolo di primo piano nelle ultime linee guida sia europee che americane, ed è attualmente raccomandato in classe I per il trattamento dei pazienti con ridotta frazione di eiezione. Accanto ai ben noti effetti sulla mortalità, sacubitril/valsartan agisce positivamente sulla riduzione dei valori di NT-proBNP e su parametri di rimodellamento ventricolare sinistro, determinando un rimodellamento inverso riconosciuto come uno degli effetti meccanicistici del farmaco atto a spiegare in parte il suo effetto favorevole sulla prognosi. Un’attenta valutazione del profilo di ogni singolo paziente consente un utilizzo più mirato e meglio tollerato del farmaco, garantendo anche in ambito di insufficienza cardiaca la strada della medicina di precisione. La seconda parte di questo position paper esplora gli effetti meccanicistici degli inibitori del recettore dell’angiotensina e della neprilisina e il loro posizionamento nelle linee guida, proponendo in ultima analisi un uso di sacubitril/valsartan in specifici contesti clinici. The use of sacubitril/valsartan has been fully recognized in the most recent European and American guidelines that recommend in class I the prescription of this drug in heart failure patients with reduced systolic function. Besides the effects on cardiovascular mortality and heart failure hospitalization, sacubitril/valsartan significantly reduces NT-proBNP levels and improves cardiac remodeling, recognized as one of the mechanistic effects of the drug that is linked to favorable prognostic effects. A careful evaluation of the patients' clinical profile is needed to implement the use of sacubitril/valsartan into clinical practice and to make the treatment successful. This second part of the position paper focuses on the mechanistic effects of angiotensin receptor-neprilysin inhibitors and on its placement in current guidelines, also suggesting the use of sacubitril/valsartan in specific clinical settings.
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- 2022
29. Position paper of the Italian Society of Cardiology: The renin-angiotensin-aldosterone system (RAAS) blockade in heart failure patients - Part I: From RAAS identification to clinical trials [Position paper della Società Italiana di Cardiologia: Il blocco del sistema renina-angiotensina-aldosterone (RAAS) nel paziente con scompenso cardiaco – Parte I: Dalla scoperta del RAAS ai trial clinici]
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Filardi P. P., Paolillo S., Indolfi C., Agostoni P., Basso C., Barilla F., Correale M., Curcio A., Mancone M., Merlo M., Metra M., Muscoli S., Nodari S., Palazzuoli A., Pedrinelli R., Pontremoli R., Senni M., Volpe M., Sinagra G., Filardi, P, Paolillo, S, Indolfi, C, Agostoni, P, Basso, C, Barilla, F, Correale, M, Curcio, A, Mancone, M, Merlo, M, Metra, M, Muscoli, S, Nodari, S, Palazzuoli, A, Pedrinelli, R, Pontremoli, R, Senni, M, Volpe, M, and Sinagra, G
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Heart Failure ,Renin-Angiotensin System ,Aminobutyrate ,Angiotensin Receptor Antagonist ,Scompenso cardiaco ,Biphenyl Compound ,Cardiology ,Inibitori del recettore dell’angiotensina e della neprilisina ,Sacubitril/valsartan ,Scompenso cardiaco a frazione di eiezione ridotta ,Linee guida ,Tetrazole ,Human - Abstract
L’inibizione del sistema renina-angiotensina-aldosterone (RAAS) rappresenta un caposaldo del trattamento farmacologico dello scompenso cardiaco a ridotta frazione di eiezione ed è stato potenziato dall’arrivo degli inibitori del recettore dell’angiotensina e della neprilisina (ARNI) che combinano l’inibizione del RAAS con l’inibizione della neprilisina responsabile di un incremento delle attività favorevoli dei peptidi natriuretici. Sacubitril/valsartan ha dimostrato nello studio PARADIGM-HF un netto vantaggio rispetto ad enalapril in termini di riduzione di mortalità ed ospedalizzazioni per insufficienza cardiaca e numerosi altri trial randomizzati e studi clinici ne hanno testato l’efficacia in differenti contesti. Dai risultati di questi studi è derivata la raccomandazione di classe I per l’utilizzo del farmaco in pazienti con frazione di eiezione ridotta. La prima parte di questo position paper esplora la storia dell’inibizione del RAAS per passare poi ad una dettagliata analisi dei risultati ottenuti negli studi clinici con gli ARNI che ne supportano le raccomandazioni delle più recenti linee guida. Renin-angiotensin-aldosterone (RAAS) system inhibition is a mainstay of the pharmacological treatment of heart failure with reduced ejection fraction and has been implemented by the introduction of angiotensin receptor-neprilysin inhibitors (ARNI), that combine RAAS inhibition with the inhibition of neprilysin, enhancing the favorable effects of natriuretic peptides. The PARADIGM-HF trial demonstrated a favorable effect of sacubitril/valsartan over enalapril in terms of mortality and heart failure hospitalization rate reduction. Then several randomized clinical trials and observational studies confirmed the favorable role of ARNI in different clinical scenarios, supporting the guideline class I recommendation for the use of sacubitrilvalsartan in patients with reduced systolic function. The first part of this position paper summarizes the history of RAAS inhibition and reports the results of ARNI trials that support the recommendations of the most recent guidelines.
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- 2022
30. Considerations for the management of home parenteral nutrition during the SARS-CoV-2 pandemic: A position paper from the Home Artificial Nutrition and Chronic Intestinal Failure Special Interest Group of ESPEN
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Simon Lal, Geert J. A. Wanten, Federico Bozzetti, Manpreet S. Mundi, Cristina Cuerda, Carolyn Wheatley, Kinga Szczepanek, Georg Lamprecht, Francisca Joly, Michael Staun, Loris Pironi, André Van Gossum, Lal S., Van Gossum A., Joly F., Bozzetti F., Cuerda C., Lamprecht G., Mundi M.S., Staun M., Szczepanek K., Wanten G., Wheatley C., and Pironi L.
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0301 basic medicine ,medicine.medical_specialty ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Coronaviru ,Pneumonia, Viral ,030209 endocrinology & metabolism ,Clinical nutrition ,Critical Care and Intensive Care Medicine ,Article ,03 medical and health sciences ,Betacoronavirus ,0302 clinical medicine ,All institutes and research themes of the Radboud University Medical Center ,Ambulatory care ,Pandemic ,medicine ,Humans ,Intensive care medicine ,Pandemics ,Home parenteral nutrition ,Intestinal Disease ,030109 nutrition & dietetics ,Nutrition and Dietetics ,Betacoronaviru ,Coronavirus Infection ,business.industry ,SARS-CoV-2 ,COVID-19 ,Chronic intestinal failure ,Special Interest Group ,Coronavirus ,Hospitalization ,Intestinal Diseases ,Parenteral nutrition ,lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4] ,Chronic Disease ,Practice Guidelines as Topic ,Position paper ,business ,Coronavirus Infections ,Parenteral Nutrition, Home ,Human - Abstract
Summary The management of patients with chronic intestinal failure requiring home parenteral nutrition has been and will continue to be impaired during the SARS-CoV-2 pandemic. Multidisciplinary intestinal failure teams may have to adapt their clinical approaches to home care, outpatient care as well as hospital admission and discharge in order to keep this vulnerable group of patients as safe and well as possible during the unprecedented challenges that countries are facing during the pandemic. Equally, it is important that expert advice from intestinal failure teams is available when home parenteral nutrition (HPN)-dependent patients require admission with SARS-CoV-2 infection. The Home Artificial Nutrition & Chronic Intestinal Failure Special Interest Group of the European Society for Clinical Nutrition and Metabolism (ESPEN) has developed a position paper to outline areas for intestinal failure teams to consider when managing patients with chronic intestinal failure during the SARS-CoV-2 pandemic.
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- 2020
31. Guidance for the Management of Patients with Vascular Disease or Cardiovascular Risk Factors and COVID-19: Position Paper from VAS-European Independent Foundation in Angiology/Vascular Medicine
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Gerotziafas G. T., Catalano M., Colgan M. -P., Pecsvarady Z., Wautrecht J. C., Fazeli B., Olinic D. -M., Farkas K., Elalamy I., Falanga A., Fareed J., Papageorgiou C., Arellano R. S., Agathagelou P., Antic D., Auad L., Banfic L., Bartolomew J. R., Benczur B., Bernardo M. B., Boccardo F., Cifkova R., Cosmi B., De Marchi S., Dimakakos E., Dimopoulos M. A., Dimitrov G., Durand-Zaleski I., Edmonds M., El Nazar E. A., Erer D., Esponda O. L., Gresele P., Gschwandtner M., Gu Y., Heinzmann M., Hamburg N. M., Hamade A., Jatoi N. -A., Karahan O., Karetova D., Karplus T., Klein-Weigel P., Kolossvary E., Kozak M., Lefkou E., Lessiani G., Liew A., Marcoccia A., Marshang P., Marakomichelakis G., Matuska J., Moraglia L., Pillon S., Poredos P., Prior M., Salvador D. R. K., Schlager O., Schernthaner G., Sieron A., Spaak J., Spyropoulos A., Sprynger M., Suput D., Stanek A., Stvrtinova V., Szuba A., Tafur A., Vandreden P., Vardas P. E., Vasic D., Vikkula M., Wennberg P., Zhai Z., Bikdeli B., Guo Y., Harenberg J., Hu Y., Lip G. Y. H., Roldan V., Gerotziafas, G, Catalano, M, Colgan, M, Pecsvarady, Z, Wautrecht, J, Fazeli, B, Olinic, D, Farkas, K, Elalamy, I, Falanga, A, Fareed, J, Papageorgiou, C, Arellano, R, Agathagelou, P, Antic, D, Auad, L, Banfic, L, Bartolomew, J, Benczur, B, Bernardo, M, Boccardo, F, Cifkova, R, Cosmi, B, De Marchi, S, Dimakakos, E, Dimopoulos, M, Dimitrov, G, Durand-Zaleski, I, Edmonds, M, El Nazar, E, Erer, D, Esponda, O, Gresele, P, Gschwandtner, M, Gu, Y, Heinzmann, M, Hamburg, N, Hamade, A, Jatoi, N, Karahan, O, Karetova, D, Karplus, T, Klein-Weigel, P, Kolossvary, E, Kozak, M, Lefkou, E, Lessiani, G, Liew, A, Marcoccia, A, Marshang, P, Marakomichelakis, G, Matuska, J, Moraglia, L, Pillon, S, Poredos, P, Prior, M, Salvador, D, Schlager, O, Schernthaner, G, Sieron, A, Spaak, J, Spyropoulos, A, Sprynger, M, Suput, D, Stanek, A, Stvrtinova, V, Szuba, A, Tafur, A, Vandreden, P, Vardas, P, Vasic, D, Vikkula, M, Wennberg, P, Zhai, Z, Bikdeli, B, Guo, Y, Harenberg, J, Hu, Y, Lip, G, Roldan, V, Centre de Recherche Saint-Antoine (CR Saint-Antoine), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Trinity College Dublin, Hôpital Erasme [Bruxelles] (ULB), Faculté de Médecine [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB), Mashhad University of Medical Sciences, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Gerotziafas G.T., Catalano M., Colgan M.-P., Pecsvarady Z., Wautrecht J.C., Fazeli B., Olinic D.-M., Farkas K., Elalamy I., Falanga A., Fareed J., Papageorgiou C., Arellano R.S., Agathagelou P., Antic D., Auad L., Banfic L., Bartolomew J.R., Benczur B., Bernardo M.B., Boccardo F., Cifkova R., Cosmi B., De Marchi S., Dimakakos E., Dimopoulos M.A., Dimitrov G., Durand-Zaleski I., Edmonds M., El Nazar E.A., Erer D., Esponda O.L., Gresele P., Gschwandtner M., Gu Y., Heinzmann M., Hamburg N.M., Hamade A., Jatoi N.-A., Karahan O., Karetova D., Karplus T., Klein-Weigel P., Kolossvary E., Kozak M., Lefkou E., Lessiani G., Liew A., Marcoccia A., Marshang P., Marakomichelakis G., Matuska J., Moraglia L., Pillon S., Poredos P., Prior M., Salvador D.R.K., Schlager O., Schernthaner G., Sieron A., Spaak J., Spyropoulos A., Sprynger M., Suput D., Stanek A., Stvrtinova V., Szuba A., Tafur A., Vandreden P., Vardas P.E., Vasic D., Vikkula M., Wennberg P., Zhai Z., Bikdeli B., Guo Y., Harenberg J., Hu Y., Lip G.Y.H., Roldan V., and UCL - SSS/DDUV/GEHU - Génétique
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030204 cardiovascular system & hematology ,antithrombotic ,antiplatelet ,chemistry.chemical_compound ,0302 clinical medicine ,Rivaroxaban ,Risk Factors ,cardiovascular disease ,Thrombophilia ,030212 general & internal medicine ,antiplatelets ,low-molecular-weight heparin ,Societies, Medical ,Low-Molecular-Weight ,Hematology ,3. Good health ,Europe ,Cardiovascular Diseases ,Thrombosi ,Practice Guidelines as Topic ,Position Paper ,Risk assessment ,medicine.drug ,Human ,medicine.medical_specialty ,anticoagulants ,medicine.drug_class ,DOAC ,Cardiology ,Low molecular weight heparin ,peripheral artery disease ,deep vein thrombosis ,03 medical and health sciences ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Medical ,medicine ,Humans ,COVID-19 - cardiovascular disease - peripheral artery disease - deep vein thrombosis - antithrombotic - antiplatelets - anticoagulants - low-molecular-weight heparin - DOAC ,Intensive care medicine ,Contraindication ,Angiology ,Inflammation ,Vascular disease ,business.industry ,Heparin ,SARS-CoV-2 ,Risk Factor ,anticoagulant ,deep vein thrombosi ,COVID-19 ,Thrombosis ,Heparin, Low-Molecular-Weight ,medicine.disease ,COVID-19 Drug Treatment ,chemistry ,Betrixaban ,business ,Societies - Abstract
COVID-19 is also manifested with hypercoagulability, pulmonary intravascular coagulation, microangiopathy, and venous thromboembolism (VTE) or arterial thrombosis. Predisposing risk factors to severe COVID-19 are male sex, underlying cardiovascular disease, or cardiovascular risk factors including noncontrolled diabetes mellitus or arterial hypertension, obesity, and advanced age. The VAS-European Independent Foundation in Angiology/Vascular Medicine draws attention to patients with vascular disease (VD) and presents an integral strategy for the management of patients with VD or cardiovascular risk factors (VD-CVR) and COVID-19. VAS recommends (1) a COVID-19-oriented primary health care network for patients with VD-CVR for identification of patients with VD-CVR in the community and patients' education for disease symptoms, use of eHealth technology, adherence to the antithrombotic and vascular regulating treatments, and (2) close medical follow-up for efficacious control of VD progression and prompt application of physical and social distancing measures in case of new epidemic waves. For patients with VD-CVR who receive home treatment for COVID-19, VAS recommends assessment for (1) disease worsening risk and prioritized hospitalization of those at high risk and (2) VTE risk assessment and thromboprophylaxis with rivaroxaban, betrixaban, or low-molecular-weight heparin (LMWH) for those at high risk. For hospitalized patients with VD-CVR and COVID-19, VAS recommends (1) routine thromboprophylaxis with weight-adjusted intermediate doses of LMWH (unless contraindication); (2) LMWH as the drug of choice over unfractionated heparin or direct oral anticoagulants for the treatment of VTE or hypercoagulability; (3) careful evaluation of the risk for disease worsening and prompt application of targeted antiviral or convalescence treatments; (4) monitoring of D-dimer for optimization of the antithrombotic treatment; and (5) evaluation of the risk of VTE before hospital discharge using the IMPROVE-D-dimer score and prolonged post-discharge thromboprophylaxis with rivaroxaban, betrixaban, or LMWH.
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- 2020
32. Treatment of children with COVID-19: position paper of the Italian Society of Pediatric Infectious Disease
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Elisabetta Venturini, Carlotta Montagnani, Silvia Garazzino, Daniele Donà, Luca Pierantoni, Andrea Lo Vecchio, Giangiacomo Nicolini, Sonia Bianchini, Andrzej Krzysztofiak, Luisa Galli, Alberto Villani, Guido Castelli-Gattinara, for the Italian SITIP-SIP SARS-Cov-2 pediatric infection study group, Venturini, E., Montagnani, C., Garazzino, S., Dona, D., Pierantoni, L., Lo Vecchio, A., Nicolini, G., Bianchini, S., Krzysztofiak, A., Galli, L., Villani, A., and Castelli-Gattinara, G.
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medicine.medical_specialty ,2019-20 coronavirus outbreak ,Consensus ,Coronavirus disease 2019 (COVID-19) ,Adolescent ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Pneumonia, Viral ,SARS CoV-2 ,Consensu ,Review ,030204 cardiovascular system & hematology ,03 medical and health sciences ,Betacoronavirus ,0302 clinical medicine ,Children ,COVID-19 ,Treatment ,Pandemic ,medicine ,Humans ,Age Factor ,030212 general & internal medicine ,Child ,book ,Pandemics ,Societies, Medical ,Coronavirus Infection ,business.industry ,Maternal and child health ,SARS-CoV-2 ,Age Factors ,lcsh:RJ1-570 ,Infant ,lcsh:Pediatrics ,Settore MED/38 ,Italy ,Family medicine ,Child, Preschool ,Pediatric Infectious Disease ,book.journal ,Position paper ,Treatment strategy ,business ,Coronavirus Infections ,Human - Abstract
A statement of consensus was formulated after reviewing available literature on pediatric treatment strategies for COVID-19 by the Steering and Scientific Committee of the Italian Society of Infectious Pediatric Diseases in connection with the Italian Society of Paediatrics.
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- 2020
33. Incidental Findings and How to Manage Them: Testis- A WFUMB Position Paper
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M. Jêdrzejczyk, Andrzej Lewicki, Yi Dong, Christoph F. Dietrich, Simon Freeman, Jakub Dobruch, Michele Bertolotto, Lewicki, Andrzej, Freeman, Simon, Jędrzejczyk, Maciej, Dobruch, Jakub, Dong, Yi, Bertolotto, Michele, and Dietrich, Christoph F
- Subjects
Position statement ,Male ,medicine.medical_specialty ,Acoustics and Ultrasonics ,Biophysics ,Neuroimaging ,Malignancy ,Asymptomatic ,Follow-up ,Incidental findings ,Testis ,Ultrasound ,Humans ,Ultrasonography ,Incidental Findings ,Incidental Finding ,medicine ,Radiology, Nuclear Medicine and imaging ,Radiological and Ultrasound Technology ,business.industry ,Incidentaloma ,medicine.disease ,Ultrasound techniques ,Testi ,Position paper ,Radiology ,medicine.symptom ,business ,Human - Abstract
Testicular incidentalomas are non-palpable, asymptomatic lesions, most frequently detected on ultrasound examinations. Each incidentaloma should undergo a standardized diagnostic workup to exclude malignancy and recognize other potentially significant non-malignant conditions that may first present with an incidental finding on scrotal ultrasound. This position statement of the World Federation of Ultrasound in Medicine and Biology (WFUMB) summarizes the available evidence on management of testicular incidentalomas and describes efficient management strategies with particular reference to the role of ultrasound techniques. (C) 2021 World Federation for Ultrasound in Medicine & Biology. All rights reserved.
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- 2020
34. Reply to Dr. Capovilla on 'Reply to the article 'Management of status epilepticus in adults. Position paper of the Italian League Against Epilepsy'
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Stefano Meletti, Roberto Michelucci, Massimo Mastrangelo, Monica Ferlisi, Paolo Tinuper, Nicola Specchio, Oriano Mecarelli, Fabio Minicucci, Stefano Sartori, Umberto Aguglia, Francesco Brigo, Minicucci F., Ferlisi M., Brigo F., Mecarelli O., Meletti S., Aguglia U., Michelucci R., Mastrangelo M., Specchio N., Sartori S., and Tinuper P.
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Adult ,medicine.medical_specialty ,Midazolam ,Diazepam ,Status epilepticus ,Humans ,Italy ,Epilepsy ,Status Epilepticus ,League ,Behavioral Neuroscience ,medicine ,Psychiatry ,business.industry ,Status epilepticu ,medicine.disease ,Neurology ,Position paper ,Neurology (clinical) ,medicine.symptom ,business ,Human ,medicine.drug - Abstract
n.a.
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- 2020
35. Massive Multiplayer Human Computation for Fun, Money, and Survival
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Biewald, Lukas, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Harth, Andreas, editor, and Koch, Nora, editor
- Published
- 2012
- Full Text
- View/download PDF
36. A 96-well wax printed Prussian Blue paper for the visual determination of cholinesterase activity in human serum
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Fabiana Arduini, Danila Moscone, Renato Massoud, Mohammad Saraji, Stefano Cinti, Neda Bagheri, Veronica Caratelli, Bagheri, N., Cinti, S., Caratelli, V., Massoud, R., Saraji, M., Moscone, D., and Arduini, F.
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Paper ,Computer science ,Biomedical Engineering ,Biophysics ,Biosensing Techniques ,02 engineering and technology ,01 natural sciences ,Biosensing Technique ,chemistry.chemical_compound ,Limit of Detection ,Activity detection ,Electrochemistry ,Humans ,Settore CHIM/01 - Chimica Analitica ,Paper-based assay, Colorimetric detection, Multiplexed measurement, Butyrylcholinesterase, Chromatography paper ,Waxe ,Coloring Agent ,Coloring Agents ,Chromatography paper ,Detection limit ,Prussian blue ,Chromatography ,Paper-based assay ,010401 analytical chemistry ,Equipment Design ,General Medicine ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,Thiocholine ,chemistry ,Waxes ,Butyrylcholinesterase ,Printing, Three-Dimensional ,Colorimetry ,0210 nano-technology ,Multiplexed measurement ,Ferrocyanide ,Colorimetric detection ,Human ,Ferrocyanides ,Biotechnology - Abstract
In the last decades, there is a growing search for analytical strategies to ensure clinical analysis without the need of laboratory set-up and skilled personnel. Indeed, user-friendly and low-cost devices are highly valued in the era of sustainability for their capability to be applied in low-resource contexts, such as developing countries. To address this issue, herein we report a 96-well paper-based and laboratory setup-free optical platform for the detection of butyrylcholinesterase enzyme (BChE) activity in human serum. We used chromatographic paper to realize a novel analytical tool exploiting its porous structure for reagentless synthesize Prussian Blue Nanoparticles (the sensing element), as well to load all the reagents required for the measurement. The principle of BChE activity detection relies on the reaction between the enzymatic product thiocholine and Prussian Blue, giving the Prussian White with subsequently Prussian Blue's fading, detected by a common office scanner supported by ImageJ software. Using this novel paper-based optical platform, BChE activity was linearly detected in the 2–15 U/mL range with a detection limit down to 0.8 U/mL. The accuracy was successfully demonstrated by recovery study with spiked serum and by comparing the data with the gold standard method.
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- 2019
37. Origami multiple paper-based electrochemical biosensors for pesticide detection
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Luca Amendola, Stefano Cinti, Danila Moscone, Fabiana Arduini, Veronica Caratelli, Giuseppe Palleschi, Arduini, F., Cinti, S., Caratelli, V., Amendola, L., Palleschi, G., and Moscone, D.
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Paper ,Insecticides ,Biomedical Engineering ,Biophysics ,02 engineering and technology ,Biosensing Techniques ,Standard solution ,Butyrylcholinesterase Alkaline phosphatase Tyrosinase Paraoxon 2,4-dichlorophenoxyacetic acid Atrazine ,01 natural sciences ,Paraoxon ,chemistry.chemical_compound ,Organophosphorus Compounds ,Rivers ,Limit of Detection ,Alkaline phosphatase ,Electrochemistry ,medicine ,Humans ,Settore CHIM/01 - Chimica Analitica ,Atrazine ,Pesticides ,Insecticide ,River ,Prussian blue ,Chromatography ,2,4-dichlorophenoxyacetic acid ,Filter paper ,010401 analytical chemistry ,Water ,General Medicine ,Pesticide ,021001 nanoscience & nanotechnology ,Potentiostat ,0104 chemical sciences ,chemistry ,Butyrylcholinesterase ,Tyrosinase ,Organophosphorus Compound ,0210 nano-technology ,Biosensor ,Butyrylcholinesterase Alkaline phosphatase Tyrosinase Paraoxon 2 ,4-dichlorophenoxyacetic acid Atrazine ,Water Pollutants, Chemical ,Biotechnology ,medicine.drug ,Human - Abstract
Herein, we propose the first three-dimensional origami paper-based device for the detection of several classes of pesticides by combining different enzyme-inhibition biosensors. This device was developed by integrating two different office paper-based screen-printed electrodes and multiple filter paper-based pads to load enzymes and enzymatic substrates. The versatile analysis of different pesticides was carried by folding and unfolding the filter paper-based structure, without any addition of reagents and any sample treatment (i.e. dilution, filtration, pH adjustment). The paper-based platform was employed to detect paraoxon, 2,4-dichlorophenoxyacetic acid, and atrazine by exploiting the capability of these different types of pesticides (i.e. organophosphorus insecticides, phenoxy-acid herbicides, and triazine herbicide) to inhibit butyrylcholinesterase, alkaline phosphatase, and tyrosinase, respectively. The degree of inhibition correlating to the quantity of pesticides was evaluated by chronoamperometrically monitoring the enzymatic activity in the absence and in the presence of pesticides by using a portable potentiostat. To improve the sensitivity, the paper-based electrodes were modified with carbon black alone in the case of platforms for 2,4-dichlorophenoxyacetic acid and atrazine detection, or decorated with Prussian blue nanoparticles for the detection of paraoxon. The paper-based device was applied for the detection of paraoxon, 2,4-dichlorophenoxyacetic acid, and atrazine at ppb level in both standard solutions and river water sample. The accuracy of this origami multiple paper-based electrochemical biosensor was evaluated in river water by recovery studies, obtaining satisfactory values (e.g. for paraoxon 90 ± 1% and 88 ± 2%, for 10 and 20 ppb, respectively). The proposed three-dimensional origami paper device allows for rapid, cost-effective and accurate pesticide detection in surface water as a result of combining filter and office papers, screen-printing, wax-printing and nanomaterial technology.
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- 2019
38. Position paper of the GMA Committee Interprofessional Education in the Health Professions - current status and outlook
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Kaap-Fröhlich, S, Ulrich, G, Wershofen, B, Ahles, J, Behrend, R, Handgraaf, M, Herinek, D, Mitzkat, A, Oberhauser, H, Scherer, T, Schlicker, A, Straub, C, Waury Eichler, R, Wesselborg, B, Witti, M, Huber, M, and Bode, SF
- Subjects
competencies ,Competency ,Interprofessional education ,Pandemic ,COVID-19 ,interprofessionelle Zusammenarbeit ,Network ,interprofessionelles Lernen ,Interprofessional learning ,610: Medizin und Gesundheit ,ddc: 610 ,networks ,Interprofessional collaborative practice ,Health occupation ,Netzwerke ,Curriculum ,Kompetenzen ,Evaluation ,inteprofessionelle Ausbildung ,Human - Abstract
In the wake of local initiatives and developmental funding programs, interprofessionality is now included in national curricula in the German-speaking countries. Based on the 3P model (presage, process, product), this position paper presents the development of interprofessional education in recent years in Germany, Austria and Switzerland and places it in an international context. Core aspects as legal frameworks, including amendments to occupational regulations as well as the formation of networks and faculty development are basic requirements for interprofessional education. New topics and educational settings take shape in the process of interprofessional education: patient perspectives and teaching formats, such as online courses, become more important or are newly established. The influence of the COVID-19 pandemic on interprofessional education is explored as well. Among many new interprofessional courses, particularly the implementation of interprofessional training wards in Germany and Switzerland are positive examples of successful interprofessional education. The objective of interprofessional education continues to be the acquisition of interprofessional competencies. The main focus is now centered on evaluating this educational format and testing for the corresponding competencies. In the future, more capacities will be required for interprofessional continuing education and post-graduate education. Structured research programs are essential to ascertain the effects of interprofessional education in the German-speaking countries.In this position paper the GMA committee on interprofessional education encourages further advancement of this topic and expresses the aim to continue cooperating with other networks to strengthen and intensify interprofessional education and collaboration in healthcare. Das Thema der Interprofessionalität in den deutschsprachigen Ländern hat nach lokalen Initiativen und Förderprogrammen in nationale Ausbildungspläne Einzug erhalten. Angelehnt an das 3P Modell ("Presage, Process, Product"; dt. in etwa: Rahmenbedingungen, Prozess, Produkt/Ergebnis) zeigt das nun neu vorliegende Positionspapier die Entwicklung interprofessioneller Ausbildung der letzten Jahre in Deutschland, in Österreich und in der Schweiz auf und setzt diese in einen internationalen Kontext. Neben rechtlichen Aspekten wie Veränderungen in den Berufsgesetzen zählen Netzwerkbildung und Fakultätsentwicklung zu den identifizierten Rahmenbedingungen. Im Prozess der interprofessionellen Ausbildung kristallisieren sich neue Themenfelder und Bildungssettings heraus, die Perspektive der Patient*innen und didaktische Formate wie Online-Angebote nehmen eine wichtigere Rolle ein bzw. wurden neu etabliert. In einem Exkurs werden darüber hinaus die Einflüsse der COVID-19-Pandemie auf interprofessionelle Ausbildung beleuchtet. Neben vielen neuen interprofessionellen Lernangeboten ist die Schaffung interprofessioneller Ausbildungsstationen in Deutschland und der Schweiz als Positivbeispiel für gelungene interprofessionelle Ausbildung hervorzuheben. Das Ziel interprofessioneller Ausbildung ist weiterhin der Erwerb interprofessioneller Kompetenzen. Im Fokus stehen dabei nun die Evaluation und Bewertung dieser Ausbildungsform sowie das (Über-)Prüfen entsprechender Kompetenzen. Zukünftig wird mehr Raum für die interprofessionelle Fort- und Weiterbildung nötig sein. Strukturierte Forschungsprogramme sind essenziell, um die Effekte von interprofessioneller Ausbildung im DACH-Raum nachweisen zu können.In diesem Positionspapier regt der GMA Ausschuss für Interprofessionelle Ausbildung an, dieses Thema weiter voranzubringen und möchte gemeinsam mit anderen entstandenen Netzwerken weiterhin für eine Stärkung und Intensivierung von interprofessioneller Ausbildung und Zusammenarbeit im Gesundheitswesen sorgen.
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- 2022
39. Are we prepared to educate the next generation of bachelor nursing students? : A discussion paper
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Edith Roth Gjevjon, Cecilia Olsson, and Espen Gade Rolland
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article ,General Medicine ,bachelor nursing students ,clinical assessment ,peer learning ,Hälsovetenskaper ,clinical skills ,nursing student ,learning outcomes ,human experiment ,generation ,Health Sciences ,ComputingMilieux_COMPUTERSANDEDUCATION ,human ,skill ,educational model ,learning style ,expectation - Abstract
This paper answers a call from Nordic colleagues for new strategies in education to meet the needs of a new generation of bachelor nursing students regarding the development of clinical skills. We, as they, believe that educational models targeting the development of clinical skills must be customised to meet the learning style of the current and future generations of bachelor nursing students. In this paper we put forward that using a comprehensive, collaborative, student-centred approach will assist younger generations’ learning processes. We describe a pedagogical model of peer learning that combines collaboration, reflection and assessment aligned with learning outcomes. Such an approach, we believe, is likely to be in line with expectations, needs and preconditions of the current and future generations of nursing students.
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- 2022
40. Position Paper on Asbestos of the Italian Society of Occupational Medicine
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Apostoli P., Boffetta P., Bovenzi M., Cocco P. L., Consonni D., Cristaudo A., Discalzi G., Farioli A., Manno M., Mattioli S., Pira E., Soleo L., Taino G., Violante F. S., Zocchetti C., Apostoli P., Boffetta P., Bovenzi M., Cocco P.L., Consonni D., Cristaudo A., Discalzi G., Farioli A., Manno M., Mattioli S., Pira E., Soleo L., Taino G., Violante F.S., and Zocchetti C.
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Amianto ,Mesothelioma ,Asbestos, Position Paper, SIML ,Occupational Medicine ,Lung Neoplasms ,Pleural Neoplasms ,SIML ,Asbestosi ,Asbesto ,Asbestos ,NO ,Lung Neoplasm ,Italy ,Retrospective Studie ,Amianto, Position Paper, SIML ,Occupational Exposure ,Asbestosis ,Position Paper ,Humans ,Retrospective Studies ,Human - Abstract
The Position Paper (PP) on asbestos of the Italian Society of Occupational Medicine (SIML) aims at providing a tool to the occupational physician to address current diagnostic criteria and results of epidemiological studies, and their consequences in terms of preventive and evaluation actions for insurance, compensation and litigation. The PP was based on an extensive review of the scientific literature and was compiled by a Working Group comprising researchers who have contributed to the international literature on asbestos-related diseases, as well as occupational physicians with extensive experience in the evaluation of risks and the medical surveillance of workers currently and formerly exposed to asbestos. The PP was drafted and reviewed between 2017 and 2018; its final version was prepared according to the guidelines of AGREE Reporting Checklist. All the members of the Working Group subscribed to the document, which was eventually approved by SIML’s Executive Committee. The first section addresses industrial hygiene issues, such as methods for environmental monitoring, advantages and limitations of different microscopy techniques, the potential role of microfibers and approaches for retrospective assessment of exposure, in particular in epidemiological studies. The second section reviews the biological effects of asbestos with particular attention to the diagnostic aspects of asbestosis, pleural changes, mesothelioma and lung cancer. In the following section the criteria of causal attribution are discussed, together with different hypotheses on the form of the risk functions, with a comparison of the opinions prevalent in the literature. In particular, the models of the risk function for mesothelioma were examined, in the light of the hypothesis of an acceleration or anticipation of the events in relation to the dose. The last section discusses topics of immediate relevance for the occupational physician, such as health surveillance of former exposed and of workers currently exposed in remediation activities.
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- 2019
41. Developing a woman-centered, inclusive definition of positive childbirth experiences: A discussion paper
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Leinweber, Julia, Fontein‐Kuipers, Yvonne, Karlsdottir, Sigfridur Inga, Ekström‐Bergström, Anette, Nilsson, Christina, Stramrood, Claire, Thomson, Gillian, and Obstetrics and Gynaecology
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Maternal and child health ,Childbirth experience, definition, positive childbirth, provider interactions, subjective, woman-centred ,woman centered ,Reproduktionsmedicin och gynekologi ,childbirth ,provider interactions ,B720 ,Maternal and Child Health and Wellbeing Research Group ,human experiment ,Obstetrics, Gynecology and Reproductive Medicine ,definition ,human ,postpartum ,Other Health Sciences ,clinical article ,education ,adult ,consumer ,article ,face validity ,Obstetrics and Gynecology ,childbirth experience ,positive childbirth ,AI and Technologies ,Annan hälsovetenskap ,female ,social well-being ,Health ,Human medicine ,mental health ,subjective - Abstract
Introduction A positive childbirth experience promotes women’s health, both during and beyond the perinatal period. Understanding what constitutes a positive childbirth experience is thus critical to providing high-quality maternity care. Currently, there is no clear, inclusive, woman-centered definition of a positive childbirth experience to guide practice, education, and research. Aim To formulate an inclusive woman-centered definition of a positive childbirth experience. Methods A six-step process was undertaken: (a) Key concepts associated with a positive childbirth were derived from a rapid literature review; (b) The key concepts were used by interdisciplinary experts in the author group to create a draft definition; (c) The draft definition was presented to clinicians and researchers during a European research meeting on perinatal mental health; (d) The authors integrated the expert feedback to refine the working definition; (e) A revised definition was shared with women from consumer groups in six countries to confirm its face validity; and (f) A final definition was formulated based on the women’s feedback (n = 42). Results The following definition was formulated: “A positive childbirth experience refers to a woman’s experience of interactions and events directly related to childbirth that made her feel supported, in control, safe, and respected; a positive childbirth can make women feel joy, confident, and/or accomplished and may have short and/or long-term positive impacts on a woman’s psychosocial well-being.” Conclusions This inclusive, woman-centered definition highlights the importance of provider interactions for facilitating a positive childbirth experience. Feeling supported and having a sense of control, safety, and respect are central tenets. This definition could help to identify and validate positive childbirth experience(s), and to inform practice, education, research, advocacy, and policy-making. CC BY-NC-ND 4.0Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)© 2022 The Authors. Birth published by Wiley Periodicals LLC.First published: 05 July 2022Correspondence Julia Leinweber, PhD, RM, Institute of Midwifery, Charité - University Medicine Berlin, Oudenarder Strasse 16, 13347 Berlin, Germany. Email: julia.leinweber@charite.de
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- 2022
42. Management of adverse events associated with idelalisib treatment in chronic lymphocytic leukemia and follicular lymphoma: A multidisciplinary position paper
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Pier Luigi Zinzani, Stefano Fagiuoli, Paolo Ghia, Antonio Cuneo, Giovanni Barosi, Alfredo Marzano, Romano Danesi, Pierluigi Viale, Marco Montillo, Venerino Poletti, Cuneo, Antonio, Barosi, Giovanni, Danesi, Romano, Fagiuoli, Stefano, Ghia, Paolo, Marzano, Alfredo, Montillo, Marco, Poletti, Venerino, Viale, Pierluigi, Zinzani, Pier Luigi, Cuneo, A, Barosi, G, Danesi, R, Fagiuoli, S, Ghia, P, Marzano, A, Montillo, M, Poletti, V, Viale, P, and Zinzani, P
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Oncology ,Cancer Research ,Adverse events ,chronic lymphocytic leukemia ,follicular lymphoma ,idelalisib ,Chronic lymphocytic leukemia ,adverse event ,Follicular lymphoma ,Review ,Antineoplastic Agent ,0302 clinical medicine ,hemic and lymphatic diseases ,Antineoplastic Combined Chemotherapy Protocols ,Cytochrome P-450 CYP3A ,Drug Interactions ,Disease management (health) ,Lymphoma, Follicular ,Disease Management ,Hematology ,General Medicine ,Colitis ,Algorithm ,Aldehyde Oxidase ,Drug Interaction ,030220 oncology & carcinogenesis ,Idelalisib ,Algorithms ,Human ,Diarrhea ,medicine.medical_specialty ,Reviews ,Antineoplastic Agents ,Quinazolinone ,NO ,03 medical and health sciences ,Internal medicine ,medicine ,Animals ,Humans ,Clinical significance ,Adverse effect ,Purine ,Quinazolinones ,Pneumonitis ,adverse events ,Antineoplastic Combined Chemotherapy Protocol ,Animal ,business.industry ,medicine.disease ,Leukemia, Lymphocytic, Chronic, B-Cell ,Purines ,Position paper ,business ,Coliti ,030215 immunology - Abstract
The introduction of new therapeutic agents in chronic lymphocytic leukemia (CLL) and follicular lymphoma (FL), including the new kinase inhibitor idelalisib, has changed the therapeutic landscape of these diseases. However, the use of idelalisib is associated with a peculiar profile of side effects, which require an optimization of the current approach to prophylaxis and supportive treatment. Moving from the recognition that the abovementioned issue represents an unmet need in CLL and FL, a multidisciplinary panel of experts was convened to produce a consensus document aiming to provide practical recommendations for the management of the side effects during idelalisib therapy for CLL and FL. The present publication represents a consensus document from a series of meetings held during 2017. The Panel generated clinical key questions using the criterion of clinical relevance through a Delphi process and explored 4 domains, ie, diarrhea/colitis, transaminitis, pneumonitis, and infectious complications. Using the consensus method, the Panel was able to shape recommendations which may assist hematologist to minimize adverse events and guarantee adherence to treatment in patients with CLL and FL candidate to receive idelalisib.
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- 2019
43. Complementary feeding in preterm infants: a position paper by Italian neonatal, paediatric and paediatric gastroenterology joint societies
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Baldassarre, Maria Elisabetta, Panza, Raffaella, Cresi, Francesco, Salvatori, Guglielmo, Corvaglia, Luigi, Aceti, Arianna, Giannì, Maria Lorella, Liotto, Nadia, Ilardi, Laura, Laforgia, Nicola, Maggio, Luca, Lionetti, Paolo, Agostoni, Carlo, Orfeo, Luigi, Di Mauro, Antonio, Staiano, Annamaria, Mosca, Fabio, Baldassarre, Maria Elisabetta, Panza, Raffaella, Cresi, Francesco, Salvatori, Guglielmo, Corvaglia, Luigi, Aceti, Arianna, Giannì, Maria Lorella, Liotto, Nadia, Ilardi, Laura, Laforgia, Nicola, Maggio, Luca, Lionetti, Paolo, Agostoni, Carlo, Orfeo, Luigi, Di Mauro, Antonio, Staiano, Annamaria, and Mosca, Fabio
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Weaning [Mesh] ,Fortification ,Gestational Age ,Complementary feeding ,Premature [Mesh] ,Births [Mesh] ,Preterm ,Humans ,Preterm, Births [Mesh] ,Infant Nutritional Physiological Phenomena ,Child ,Premature ,Infant, Premature [Mesh] ,Nutrition ,Settore MED/38 - Pediatria Generale e Specialistica ,Milk, Human ,Infant, Newborn ,Gastroenterology ,Infant ,General Medicine ,Breast milk [Mesh] ,Breastfeeding [Mesh] ,Newborn ,Breast Feeding ,Milk ,Female ,Infant, Premature ,Human - Abstract
Nutrition in the first 1000 days of life is essential to ensure appropriate growth rates, prevent adverse short- and long-term outcomes, and allow physiologic neurocognitive development. Appropriate management of early nutritional needs is particularly crucial for preterm infants. Although the impact of early nutrition on health outcomes in preterm infants is well established, evidence-based recommendations on complementary feeding for preterm neonates and especially extremely low birth weight and extremely low gestational age neonates are still lacking. In the present position paper we performed a narrative review to summarize current evidence regarding complementary feeding in preterm neonates and draw recommendation shared by joint societies (SIP, SIN and SIGENP) for paediatricians, healthcare providers and families with the final aim to reduce the variability of attitude and timing among professionals.
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- 2022
44. Diagnosis and management of rare cardiomyopathies in adult and paediatric patients. a position paper of the italian society of cardiology (sic) and italian society of paediatric cardiology (sicp)
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Giuseppe Limongelli, Rachele Adorisio, Chiara Baggio, Barbara Bauce, Elena Biagini, Silvia Castelletti, Silvia Favilli, Massimo Imazio, Michele Lioncino, Marco Merlo, Emanuele Monda, Iacopo Olivotto, Vanda Parisi, Francesco Pelliccia, Cristina Basso, Gianfranco Sinagra, Ciro Indolfi, Camillo Autore, Limongelli, G., Adorisio, R., Baggio, C., Bauce, B., Biagini, E., Castelletti, S., Favilli, S., Imazio, M., Lioncino, M., Merlo, M., Monda, E., Olivotto, I., Parisi, V., Pelliccia, F., Basso, C., Sinagra, G., Indolfi, C., Autore, C., Limongelli, Giuseppe, Adorisio, Rachele, Baggio, Chiara, Bauce, Barbara, Biagini, Elena, Castelletti, Silvia, Favilli, Silvia, Imazio, Massimo, Lioncino, Michele, Merlo, Marco, Monda, Emanuele, Olivotto, Iacopo, Parisi, Vanda, Pelliccia, Francesco, Basso, Cristina, Sinagra, Gianfranco, Indolfi, Ciro, and Autore, Camillo
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Heart Defects, Congenital ,Consensus ,Cardiomyopathy ,diagnosis ,Cardiology ,Consensu ,Cardiovascular System ,Management ,Congenital ,rare cardiovascular disease ,Humans ,Diagnosis ,Rare cardiovascular disease ,Child ,Cardiomyopathies ,cardiomyopathy ,management ,Cardiology and Cardiovascular Medicine ,Heart Defects ,Diagnosi ,Human ,Cardiomyopathie - Abstract
Cardiomyopathies (CMPs) are myocardial diseases in which the heart muscle is structurally and functionally abnormal in the absence of coronary artery disease, hypertension, valvular disease and congenital heart disease sufficient to cause the observed myocardial abnormality. Thought for a long time to be rare diseases, it is now clear that most of the CMPs can be easily observed in clinical practice. However, there is a group of specific heart muscle diseases that are rare in nature whose clinical/echocardiographic phenotypes resemble those of the four classical morphological subgroups of hypertrophic, dilated, restrictive, arrhythmogenic CMPs. These rare CMPs, often but not solely diagnosed in infants and paediatric patients, should be more properly labelled as specific CMPs. Emerging consensus exists that these conditions require tailored investigation and management. Indeed, an appropriate understanding of these conditions is mandatory for early treatment and counselling. At present, however, the multisystemic and heterogeneous presentation of these entities is a challenge for clinicians, and time delay in diagnosis is a significant concern. The aim of this paper is to define practical recommendations for diagnosis and management of the rare CMPs in paediatric or adult age. A modified Delphi method was adopted to grade the recommendations proposed by each member of the writing committee.
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- 2022
45. Position paper of the Italian Society of Cardiology: The renin-angiotensin-aldosterone system (RAAS) blockade in heart failure patients - Part I: From RAAS identification to clinical trials
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Filardi P. P., Paolillo S., Indolfi C., Agostoni P., Basso C., Barilla F., Correale M., Curcio A., Mancone M., Merlo M., Metra M., Muscoli S., Nodari S., Palazzuoli A., Pedrinelli R., Pontremoli R., Senni M., Volpe M., Sinagra G., Filardi, P. P., Paolillo, S., Indolfi, C., Agostoni, P., Basso, C., Barilla, F., Correale, M., Curcio, A., Mancone, M., Merlo, M., Metra, M., Muscoli, S., Nodari, S., Palazzuoli, A., Pedrinelli, R., Pontremoli, R., Senni, M., Volpe, M., and Sinagra, G.
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Renin-Angiotensin System ,Heart Failure ,Clinical Trials as Topic ,Aminobutyrate ,Angiotensin Receptor Antagonist ,Biphenyl Compound ,Cardiology ,Tetrazole ,Human - Abstract
Renin-angiotensin-aldosterone (RAAS) system inhibition is a mainstay of the pharmacological treatment of heart failure with reduced ejection fraction and has been implemented by the introduction of angiotensin receptor-neprilysin inhibitors (ARNI), that combine RAAS inhibition with the inhibition of neprilysin, enhancing the favorable effects of natriuretic peptides. The PARADIGM-HF trial demonstrated a favorable effect of sacubitril/valsartan over enalapril in terms of mortality and heart failure hospitalization rate reduction. Then several randomized clinical trials and observational studies confirmed the favorable role of ARNI in different clinical scenarios, supporting the guideline class I recommendation for the use of sacubitril/valsartan in patients with reduced systolic function. The first part of this position paper summarizes the history of RAAS inhibition and reports the results of ARNI trials that support the recommendations of the most recent guidelines.
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- 2022
46. Position paper of the Italian Society of Cardiology: The renin-angiotensin-aldosterone system blockade in heart failure patients - Part II: Mechanistic effects of sacubitril/valsartan, placement in current guidelines and use in clinical practice
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Filardi P. P., Indolfi C., Paolillo S., Agostoni P., Basso C., Barilla F., Correale M., Curcio A., Mancone M., Merlo M., Metra M., Muscoli S., Nodari S., Palazzuoli A., Pedrinelli R., Pontremoli R., Senni M., Volpe M., Sinagra G., Filardi, P. P., Indolfi, C., Paolillo, S., Agostoni, P., Basso, C., Barilla, F., Correale, M., Curcio, A., Mancone, M., Merlo, M., Metra, M., Muscoli, S., Nodari, S., Palazzuoli, A., Pedrinelli, R., Pontremoli, R., Senni, M., Volpe, M., and Sinagra, G.
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Renin-Angiotensin System ,Heart Failure ,Aminobutyrate ,Angiotensin Receptor Antagonist ,Biphenyl Compound ,Cardiology ,Valsartan ,Tetrazole ,Human - Abstract
The use of sacubitril/valsartan has been fully recognized in the most recent European and American guidelines that recommend in class I the prescription of this drug in heart failure patients with reduced systolic function. Besides the effects on cardiovascular mortality and heart failure hospitalization, sacubitril/valsartan significantly reduces NT-proBNP levels and improves cardiac remodeling, recognized as one of the mechanistic effects of the drug that is linked to favorable prognostic effects. A careful evaluation of the patients' clinical profile is needed to implement the use of sacubitril/valsartan into clinical practice and to make the treatment successful. This second part of the position paper focuses on the mechanistic effects of angiotensin receptor-neprilysin inhibitors and on its placement in current guidelines, also suggesting the use of sacubitril/valsartan in specific clinical settings.
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- 2022
47. Considerations on antimicrobial prophylaxis in patients with lymphoproliferative diseases: A SEIFEM group position paper
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Elena De Carolis, Michele Malagola, Livio Pagano, Angelica Spolzino, Monica Piedimonte, Angela Maria Quinto, Roma Rosa Fanci, Eleonora Ceresoli, Francesca Farina, Ilaria Del Principe, Fabio Trastulli, Francesco Marchesi, Marco Picardi, Maria Chiara Tisi, Patrizia Zappasodi, Mario Delia, Anna Candoni, Mario Tumbarello, Lucia Prezioso, Marianna Criscuolo, Gianpaolo Nadali, Chiara Cattaneo, Roberta Della Pepa, Alessandro Busca, Claudia Giordano, Enrico Maria Trecarichi, Massimo Offidani, Nicola Stefano Fracchiolla, Busca, A., Cattaneo, C., De Carolis, E., Nadali, G., Offidani, M., Picardi, M., Candoni, A., Ceresoli, E., Criscuolo, M., Delia, M., Della Pepa, R., Del Principe, I., Fanci, R. R., Farina, F., Fracchiolla, N., Giordano, C., Malagola, M., Marchesi, F., Piedimonte, M., Prezioso, L., Quinto, A. M., Spolzino, A., Tisi, M. C., Trastulli, F., Trecarichi, E. M., Zappasodi, P., Tumbarello, M., and Pagano, L.
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Anti-Infective Agent ,Lymphoproliferative disorders ,0301 basic medicine ,medicine.medical_specialty ,Antimicrobial prophylaxis ,Antimicrobial stewardship ,Bacterial ,Fungal and viral infections ,03 medical and health sciences ,0302 clinical medicine ,Fungal and viral infection ,Anti-Infective Agents ,Anti-Bacterial Agent ,medicine ,Humans ,Antimicrobial prophylaxi ,Antibiotic prophylaxis ,Intensive care medicine ,Antiinfective agent ,business.industry ,Anti-Bacterial Agents ,Lymphoproliferative Disorders ,Hematology ,Settore MED/15 ,Antimicrobial ,medicine.disease ,Multiple drug resistance ,Settore MED/15 - MALATTIE DEL SANGUE ,030104 developmental biology ,Lymphoproliferative disorder ,Oncology ,030220 oncology & carcinogenesis ,Position paper ,business ,Human - Abstract
The therapeutic armamentarium for the treatment of patients with lymphoproliferative diseases has grown considerably over the most recent years, including a large use of new immunotherapeutic agents. As a consequence, the epidemiology of infectious complications in this group of patients is poorly documented, and even more importantly, the potential benefit of antimicrobial prophylaxis remains a matter of debate when considering the harmful effect from the emergence of multidrug resistant pathogens. The present position paper is addressed to all hematologists treating patients affected by lymphoproliferative malignancies with the aim to provide clinicians with a useful tool for the prevention of bacterial, fungal and viral infections.
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- 2021
48. A practical algorithmic approach to mature aggressive B cell lymphoma diagnosis in the double/triple hit era. Selecting cases, matching clinical benefit. A position paper from the Italian Group of Haematopathology (G.I.E.)
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Maurilio Ponzoni, Fabio Facchetti, Claudio Tripodo, Maria Raffaella Ambrosio, Alberto Zamo, Stefano Lazzi, Arianna Di Napoli, Domenico Novero, Marco Lucioni, Marco Paulli, Claudio Agostinelli, Elena Sabattini, Alessia Carbone, Stefano Ascani, Stefano Pileri, Luigi Ruco, Lorenzo Leoncini, D. Remotti, Di Napoli, A., Remotti, D., Agostinelli, C., Ambrosio, M. R., Ascani, S., Carbone, A., Facchetti, F., Lazzi, S., Leoncini, L., Lucioni, M., Novero, D., Pileri, S., Ponzoni, M., Sabattini, E., Tripodo, C., Zamo, A., Paulli, M., Ruco, L., Di Napoli A., Remotti D., Agostinelli C., Ambrosio M.R., Ascani S., Carbone A., Facchetti F., Lazzi S., Leoncini L., Lucioni M., Novero D., Pileri S., Ponzoni M., Sabattini E., Tripodo C., Zamo A., Paulli M., and Ruco L.
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0301 basic medicine ,medicine.medical_specialty ,Matching (statistics) ,Lymphoma, B-Cell ,Lymphoma ,double hit ,Computer science ,MYC ,Double hit ,Fluorescence ,Pathology and Forensic Medicine ,Immunophenotyping ,03 medical and health sciences ,0302 clinical medicine ,FISH ,Diagnosis ,medicine ,Practical algorithm ,Humans ,Intensive care medicine ,B-cell lymphoma ,Molecular Biology ,In Situ Hybridization ,In Situ Hybridization, Fluorescence ,HGBL ,Brief Report ,B-Cell ,Treatment options ,Correction ,DLBCL ,Algorithms ,Cell Biology ,General Medicine ,Diagnosis, DLBCL, Double hit, FISH, HGBL, MYC ,medicine.disease ,Optimal management ,Molecular analysis ,030104 developmental biology ,030220 oncology & carcinogenesis ,Position paper ,Proper treatment ,Diagnosi ,Human - Abstract
An accurate diagnosis of clinically distinct subgroups of aggressive mature B cell lymphomas is crucial for the choice of proper treatment. Presently, precise recognition of these disorders relies on the combination of morphological, immunophenotypical, and cytogenetic/molecular features. The diagnostic workup in such situations implies the application of costly and time-consuming analyses, which are not always required, since an intensified treatment option is reasonably reserved to fit patients. The Italian Group of Haematopathology proposes herein a practical algorithm for the diagnosis of aggressive mature B cell lymphomas based on a stepwise approach, aimed to select cases deserving molecular analysis, in order to optimize time and resources still assuring the optimal management for any patient.
- Published
- 2019
49. Critically appraised paper: Task-oriented exercise improved disability, pain and quality of life compared with general physiotherapy for surgically treated proximal humeral fractures [synopsis]
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Jane Chalmers and Chalmers, Jane
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exercise ,Rehabilitation ,Pain ,Physical Therapy, Sports Therapy and Rehabilitation ,RM1-950 ,Proximal humeral fractures ,shoulder fracture ,quality of life ,Quality of Life ,Shoulder Fractures ,Humans ,Surgery ,pain ,Therapeutics. Pharmacology ,human ,Task-oriented exercises ,Exercise ,Physical Therapy Modalities ,physiotherapy ,Research Article - Abstract
Background General physiotherapy is a common means of rehabilitation after surgery for proximal humeral fracture (PHF). Better-targeted exercises seem worthy of investigation and the aim of this study was to assess the efficacy of a rehabilitation program including task-oriented exercises in improving disability, pain, and quality of life in patients after a PHF. Methods By means of a randomized controlled trial with one-year follow-up, 70 working patients (mean age of 49 ± 11 years; 41 females), who were selected for open reduction and internal fixation with plates caused by PHF, were randomized to be included in an experimental (n = 35) or control group (n = 35). There was a permuted-block randomization plan, and a list of program codes was previously created; subsequently, an automatic assignment system was used to conceal the allocation. The first group underwent a supervised rehabilitation program of task-oriented exercises based on patients’ specific job activities, and occupational therapy. The second group underwent general physiotherapy, including supervised mobility, strengthening and stretching exercises. Both groups individually followed programs of 60-min session three times per week for 12 weeks in the outpatient setting. The Disability Arm Shoulder Hand questionnaire (DASH; scores range from 0 to 100; primary outcome), a Pain intensity Numerical Rating Scale (scores range 0 to 10; secondary outcomes), and the Short-Form Health Survey (scores range from 0 to 100; secondary outcomes) assessed the interventions. Participants were evaluated before surgery, before and after rehabilitation (primary endpoint), and at the one-year follow-up (secondary endpoint). A linear mixed model analysis for repeated measures was carried out for each outcome measure (p
- Published
- 2022
50. The challenge of the Molecular Tumor Board empowerment in clinical oncology practice: A Position Paper on behalf of the AIOM- SIAPEC/IAP-SIBioC-SIC-SIF-SIGU-SIRM Italian Scientific Societies
- Author
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Antonio Russo, Lorena Incorvaia, Ettore Capoluongo, Pierosandro Tagliaferri, Antonio Galvano, Marzia Del Re, Umberto Malapelle, Rita Chiari, Pierfranco Conte, Romano Danesi, Matteo Fassan, Roberto Ferrara, Maurizio Genuardi, Paola Ghiorzo, Stefania Gori, Fiorella Guadagni, Antonio Marchetti, Paolo Marchetti, Massimo Midiri, Nicola Normanno, Francesco Passiglia, Carmine Pinto, Nicola Silvestris, Giovanni Tallini, Simona Vatrano, Bruno Vincenzi, Saverio Cinieri, Giordano Beretta, Russo, Antonio, Incorvaia, Lorena, Capoluongo, Ettore, Tagliaferri, Pierosandro, Galvano, Antonio, Del Re, Marzia, Malapelle, Umberto, Chiari, Rita, Conte, Pierfranco, Danesi, Romano, Fassan, Matteo, Ferrara, Roberto, Genuardi, Maurizio, Ghiorzo, Paola, Gori, Stefania, Guadagni, Fiorella, Marchetti, Antonio, Marchetti, Paolo, Midiri, Massimo, Normanno, Nicola, Passiglia, Francesco, Pinto, Carmine, Silvestris, Nicola, Tallini, Giovanni, Vatrano, Simona, Vincenzi, Bruno, Cinieri, Saverio, Beretta, Giordano, Russo, A., Incorvaia, L., Capoluongo, E., Tagliaferri, P., Galvano, A., Del Re, M., Malapelle, U., Chiari, R., Conte, P., Danesi, R., Fassan, M., Ferrara, R., Genuardi, M., Ghiorzo, P., Gori, S., Guadagni, F., Marchetti, A., Marchetti, P., Midiri, M., Normanno, N., Passiglia, F., Pinto, C., Silvestris, N., Tallini, G., Vatrano, S., Vincenzi, B., Cinieri, S., Beretta, G., Russo A., Incorvaia L., Capoluongo E., Tagliaferri P., Galvano A., Del Re M., Malapelle U., Chiari R., Conte P., Danesi R., Fassan M., Ferrara R., Genuardi M., Ghiorzo P., Gori S., Guadagni F., Marchetti A., Marchetti P., Midiri M., Normanno N., Passiglia F., Pinto C., Silvestris N., Tallini G., Vatrano S., Vincenzi B., Cinieri S., and Beretta G.
- Subjects
Societies, Scientific ,Molecular ,Scientific ,Precision oncology ,Hematology ,Genomics ,Molecular profiling ,Molecular tumor board ,Mutational oncology ,Settore MED/03 - GENETICA MEDICA ,Medical Oncology ,Oncology ,Italy ,Neoplasms ,Humans ,Genomic ,Neoplasm ,Societies ,Human - Abstract
The development of innovative technologies and the advances in the genetics and genomics, have offered new opportunities for personalized treatment in oncology. Although the selection of the patient based on the molecular characteristics of the neoplasm has the potential to revolutionize the therapeutic scenario of oncology, this approach is extremely challenging. The access, homogeneity, and economic sustainability of the required genomic tests should be warranted in the clinical practice, as well as the specific scientific and clinical expertise for the choice of medical therapies. All these elements make essential the collaboration of different specialists within the Molecular Tumor Boards (MTBs). In this position paper, based on experts' opinion, the AIOM-SIAPEC/IAP-SIBioC-SIC-SIF-SIGU-SIRM Italian Scientific Societies critically discuss the available molecular profiling technologies, the proposed criteria for the selection of patients candidate for evaluation by the MTB, the criteria for the selection and analysis of biological samples, and the regulatory and pharmaco-economic issues.
- Published
- 2021
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