67,185 results
Search Results
2. Using Reference Publication Year Spectroscopy (RPYS) to analyze the research and publication culture in immunology
- Author
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Wray, K. Brad, Paludan, Søren R., Bornmann, Lutz, and Haunschild, Robin
- Published
- 2024
- Full Text
- View/download PDF
3. "Auxiliary Test Paper Detection Device" in Patent Application Approval Process (USPTO 20240149265).
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PATENT applications ,UMBILICAL cord clamping ,BASES (Architecture) ,VIRUS isolation ,BLOOD proteins ,VIRAL antigens - Abstract
Jiangsu Bioperfectus Technologies Co. Ltd. has filed a patent application for an auxiliary test paper detection device that aims to improve pathogen detection. The device addresses the limitations of current methods by reducing waiting times, cross-infection risks, and costs associated with hospital treatment. It consists of a reagent cap and a test paper cassette, which form a closed space for sample absorption. The device simplifies the detection process, prevents environmental pollution, and allows for autonomous operation at home. The patent application provides further details and claims. [Extracted from the article]
- Published
- 2024
4. Paper-Based Biosensors for COVID-19: A Review of Innovative Tools for Controlling the Pandemic
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Ana P.M. Tavares, Cristina E. A. Sousa, Rodrigo Martins, Maria Teresa Cruz, Ana C. Marques, Elvira Fortunato, Felismina T.C. Moreira, M. Goreti F. Sales, A. Rita Cardoso, Tomás Pinheiro, Ana Matos, and Universidade do Minho
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Diagnostic methods ,Coronavirus disease 2019 (COVID-19) ,Computer science ,General Chemical Engineering ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Immunology ,02 engineering and technology ,Viral antigen ,Peptides and proteins ,Diagnostic tools ,01 natural sciences ,Biopolymers ,Pandemic ,Medical diagnosis ,Antigens ,QD1-999 ,Science & Technology ,SARS-CoV-2 ,010401 analytical chemistry ,General Chemistry ,Paper based ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,3. Good health ,Chemistry ,Risk analysis (engineering) ,Perspective ,0210 nano-technology - Abstract
The appearance and quick spread of the new severe acute respiratory syndrome coronavirus disease, COVID-19, brought major societal challenges. Importantly, suitable medical diagnosis procedures and smooth clinical management of the disease are an emergent need, which must be anchored on novel diagnostic methods and devices. Novel molecular diagnostic tools relying on nucleic acid amplification testing have emerged globally and are the current gold standard in COVID-19 diagnosis. However, the need for widespread testing methodologies for fast, effective testing in multiple epidemiological scenarios remains a crucial step in the fight against the COVID-19 pandemic. Biosensors have previously shown the potential for cost-effective and accessible diagnostics, finding applications in settings where conventional, laboratorial techniques may not be readily employed. Paper- and cellulose-based biosensors can be particularly relevant in pandemic times, for the renewability, possibility of mass production with sustainable methodologies, and safe environmental disposal. In this review, paper-based devices and platforms targeting SARS-CoV-2 are showcased and discussed, as a means to achieve quick and low-cost PoC diagnosis, including detection methodologies for viral genomic material, viral antigen detection, and serological antibody testing. Devices targeting inflammatory markers relevant for COVID-19 are also discussed, as fast, reliable bedside diagnostic tools for patient treatment and follow-up., The authors acknowledge funding through projects Eco2Covid (POCI-01-02B7-FEDER-068174) and TecniCov (POCI-01-02B7-FEDER-069745), co-funded by FEDER through COMPETE2020 and Lisboa2020. T.P., A.R.C. and A.C.M. acknowledge funding to National Foundation for Science and Technology, I.P., FCT, through their PhD grants, references DFA/BD/8606/2020, SFRH/BD/130107/2017 and SFRH/BD/115173/2016, respectively, info:eu-repo/semantics/publishedVersion
- Published
- 2021
5. Hypersensitivity reactions to chemotherapy: an EAACI Position Paper
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Patrizia Bonadonna, Emilio Alvarez-Cuesta, Adile Berna Dursun, Soledad Sanchez Sanchez, Mariana Castells, Josefina Cernadas, Mauro Pagani, Hamadi Sahar, Anca M. Chiriac, Ricardo Madrigal-Burgaleta, and Sevim Bavbek
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Drug ,medicine.medical_specialty ,Allergy ,media_common.quotation_subject ,medicine.medical_treatment ,Immunology ,Provocation test ,Drug allergy ,Antineoplastic Agents ,Disease ,Drug Hypersensitivity ,Neoplasms ,Humans ,Immunology and Allergy ,Medicine ,Intensive care medicine ,Anaphylaxis ,Skin Tests ,media_common ,Desensitization (medicine) ,business.industry ,medicine.disease ,Desensitization, Immunologic ,Position paper ,business - Abstract
Chemotherapeutic drugs have been widely used in the treatment of cancer disease for about 70 years. The development of new treatments has not hindered their use, and oncologists still prescribe them routinely, alone or in combination with other antineoplastic agents. However, all chemotherapeutic agents can induce hypersensitivity reactions (HSRs), with different incidences depending on the culprit drug. These reactions are the third leading cause of fatal drug-induced anaphylaxis in the United States. In Europe, deaths related to chemotherapy have also been reported. In particular, most reactions are caused by platinum compounds, taxanes, epipodophyllotoxins and asparaginase. Despite their prevalence and relevance, the ideal pathways for diagnosis, treatment and prevention of these reactions are still unclear, and practice remains considerably heterogeneous with vast differences from center to center. Thus, the European Network on Drug Allergy and Drug Allergy Interest Group of the European Academy of Allergy and Clinical Immunology organized a task force to provide data and recommendations regarding the allergological work-up in this field of drug hypersensitivity reactions. This position paper aims to provide consensus on the investigation of HSRs to chemotherapeutic drugs and give practical recommendations for clinicians that treat these patients, such as oncologists, allergologists and internists. Key sections cover risk factors, pathogenesis, symptoms, the role of skin tests, in vitro tests, indications and contraindications of drug provocation tests and desensitization of neoplastic patients with allergic reactions to chemotherapeutic drugs. Statements, recommendations and unmet needs were discussed and proposed at the end of each section.
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- 2021
6. One Health: EAACI Position Paper on coronaviruses at the human‐animal interface, with a specific focus on comparative and zoonotic aspects of SARS‐CoV‐2
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Erika Jensen-Jarolim, Jozef Janda, Anna D. J. Korath, Isabella Pali-Schöll, Wojciech Feleszko, Milena Sokolowska, Eva Untersmayr, Ahmed Adel Seida, Katrin Hartmann, Ioana Agache, University of Zurich, and Pali‐Schöll, Isabella
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Eaaci Position Paper ,Immunology ,coronavirus ,610 Medicine & health ,Disease ,medicine.disease_cause ,Quality of life (healthcare) ,10183 Swiss Institute of Allergy and Asthma Research ,Environmental health ,Pandemic ,medicine ,Animals ,Humans ,Immunology and Allergy ,One Health ,Pandemics ,Coronavirus ,disease transmission ,(reverse) zoonosis ,2403 Immunology ,SARS-CoV-2 ,Transmission (medicine) ,COVID-19 ,Outbreak ,companion animals and pets ,Geography ,2723 Immunology and Allergy ,Quality of Life ,Position paper - Abstract
The latest outbreak of a coronavirus disease in 2019 (COVID‐19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), evolved into a worldwide pandemic with massive effects on health, quality of life, and economy. Given the short period of time since the outbreak, there are several knowledge gaps on the comparative and zoonotic aspects of this new virus. Within the One Health concept, the current EAACI position paper dwells into the current knowledge on SARS‐CoV‐2’s receptors, symptoms, transmission routes for human and animals living in close vicinity to each other, usefulness of animal models to study this disease and management options to avoid intra‐ and interspecies transmission. Similar pandemics might appear unexpectedly and more frequently in the near future due to climate change, consumption of exotic foods and drinks, globe‐trotter travel possibilities, the growing world population, the decreasing production space, declining room for wildlife and free‐ranging animals, and the changed lifestyle including living very close to animals. Therefore, both the society and the health authorities need to be aware and well prepared for similar future situations, and research needs to focus on prevention and fast development of treatment options (medications, vaccines).
- Published
- 2021
7. SOLVING THE ADMINISTRATIVE PROBLEM AS AN EFFECTIVE FORM «OPEN PAPER EXAM»
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Леся / Lesia Мороз-Рекотова / Moroz-Rekotova
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Microbiology (medical) ,Immunology ,Immunology and Allergy - Abstract
The article raises the question of the effectiveness of final control in the conditions of distance learning. A description of the traditional form of the exam (oral answer to questions on the exam ticket) is given, its purpose is revealed. The approaches of modern didactics to the use of methods of oral, written, practical (laboratory) control and self-control of education seekers are disclosed; the types of control are distinguished, which are classified according to the scale of learning goals, learning stages, time orientation, frequency, volume, organizational forms of learning, forms of social mediation, types of educational activities, and methods of control. The need to review the forms of final control in the conditions of distance learning based on the competency approach is substantiated. The necessity of rethinking the purpose of the final control is revealed, which consists in checking not so much the amount of theoretical knowledge, but the level of the formation of competences, provided as a result of studying an educational discipline. A comparison of the competencies laid down in the Standard of Higher Education for the specialty 012 Preschool Education and the competencies from the Professional Standard of the Head of a Preschool Education Institution was carried out. The necessity of training future managers of preschool education to make managerial decisions at the stage of obtaining higher education, taking into account the personal qualities that influence it, has been proven. Special attention is paid to views on the functions that the manager of preschool education should perform. The characteristics of non-traditional forms of examination are given: «closed book exam», «Multiple-choice еxam або Shot-question exam», «open-book exam або open paper exam», «“thinking” exam», «“take-home” exam», «practical exam». The process of organizing and conducting final control in the educational discipline «Management in the system of preschool education» in the form of «open paper exam» is described. Examples of management tasks presented for the exam are presented, the procedure of the exam itself is described. The advantages and disadvantages of using this form of final control are determined. Key words: distance learning, final control, exam, non-traditional exam, «open paper exam».
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- 2022
8. A novel immunosensor for the monitoring of PSA using binding of biotinylated antibody to the prostate specific antigen based on nano-ink modified flexible paper substrate: efficient method for diagnosis of cancer using biosensing technology
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Fatemeh Farshchi, Arezoo Saadati, and Mohammad Hasanzadeh
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Electrochemistry ,Biomedical engineering ,Cancer research ,Immunology ,Nanotechnology ,Conductive ink ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Prostate cancer is the most significant reason for deaths in men, outside of lung cancer. The clinical examination of cancer proteins or biomarkers is extremely significant in early examination and monitoring of recurrence of disease after treatment. Biomarkers have expanded great clinical significance owing to their extensive spectra in the identification, elimination, early diagnosis and cure of cancer. In this work, novel, ultrasensitive sandwich-type portable bio device based on citrate-capped silver nanoparticles (Citrate-AgNPs) modified graphene quantum dots (GQDs) nano ink for detection of Prostate specific antigen (PSA) was fabricated. Functionalized cysteamine with gold nanoparticles (Cys-AuNPs) was also utilized to amplify the signal. It provides a good and high external area for the immobilization biotinylated antibody of PSA in the large amount. For the first time, citrate-AgNPs-GQDs nano ink was directly written on the cellulose paper surface (ivory sheet and photographic paper) and modified by Cys-AuNPs. So, final structure of the immunodevices was completed after including of Ab1 and PSA (antigen). The immunosensors were used for the recognition of PSA by using DPVs (differential pulse voltammetry) technique. The obtained low limit of quantification (LLOQ) of the first immunodevice (ivory sheet/Citrate AgNPs-GQDs nano-ink/CysA-Au NPs/Ab1/BSA/PSA/Ab2) was 0.07 μg/L and the linear range for the calibration plot was from 0.07 to 60 μg/L. Also, the achieved LLOQ of the second immunodevice (photographic paper/Citrate AgNPs-GQDs nano-ink/Cys-Au NPs/Ab1/BSA/PSA/Ab2) was 0.05 μg/L with the linear range of 10 to 0.05 μg/L. It is noteworthy that, proposed immunoassay was effectively utilized to the monitoring of PSA glycoprotein in unprocessed human plasma sample. Obtained results show that the constructed immunosensor is able to apply as portable bio device for the clinical analysis of PSA in human plasma samples.
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- 2020
- Full Text
- View/download PDF
9. Biologicals in atopic disease in pregnancy: An EAACI position paper
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Adam Chaker, Zsolt Szépfalusi, Juan José Yepes-Nuñez, Onur Boyman, A. Vultaggio, Alexia Chatzipetrou, Oscar Palomares, Cezmi A. Akdis, Marek Jutel, Eva Untersmayr, Andrea Matucci, Mohammad Alsalamah, Alanna Marson, Sevim Bavbek, Paula Kauppi, Birgit Pfaller, Barbara Rogala, Antonios G.A. Kolios, Sarah Bendien, Susan Chan, Ioana Agache, Thomas Eiwegger, Carmen Li, Apostolos Bossios, George Du Toit, HUS Inflammation Center, Department of Dermatology, Allergology and Venereology, Helsinki University Hospital Area, University of Helsinki, University of Zurich, and Eiwegger, Thomas
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0301 basic medicine ,Allergy ,Omalizumab ,GUIDELINES ,Inflammatory bowel disease ,Biological Factors ,0302 clinical medicine ,10183 Swiss Institute of Allergy and Asthma Research ,Multicenter Studies as Topic ,Immunology and Allergy ,atopic dermatitis ,10177 Dermatology Clinic ,Atopic dermatitis ,CROHNS-DISEASE ,3. Good health ,biologicals ,2723 Immunology and Allergy ,Female ,Rituximab ,pregnancy ,medicine.drug ,medicine.medical_specialty ,1ST TRIMESTER ,Immunology ,610 Medicine & health ,OMALIZUMAB USE ,Dermatitis, Atopic ,03 medical and health sciences ,MANAGEMENT ,medicine ,Humans ,RITUXIMAB ,REGULATORY T-CELLS ,Intensive care medicine ,Asthma ,Biological Products ,2403 Immunology ,Pregnancy ,business.industry ,Infant, Newborn ,asthma ,medicine.disease ,body regions ,030104 developmental biology ,030228 respiratory system ,3121 General medicine, internal medicine and other clinical medicine ,10033 Clinic for Immunology ,MODIFYING ANTIRHEUMATIC DRUGS ,Position paper ,business ,INFLAMMATORY-BOWEL-DISEASE - Abstract
Biologicals have transformed the management of severe disease phenotypes in asthma, atopic dermatitis, and chronic spontaneous urticaria. As a result, the number of approved biologicals for the treatment of atopic diseases is continuously increasing. Although atopic diseases are among the most common diseases in the reproductive age, investigations, and information on half-life, pharmacokinetics defining the neonatal Fc receptors (FcRn) and most important safety of biologicals in pregnancy are lacking. Given the complex sequence of immunological events that regulate conception, fetal development, and the intrauterine and postnatal maturation of the immune system, this information is of utmost importance. We conducted a systematic review on biologicals in pregnancy for indications of atopic diseases. Evidence in this field is scare and mainly reserved to reports on the usage of omalizumab. This lack of evidence demands the establishment of a multidisciplinary approach for the management of pregnant women who receive biologicals and multicenter registries for long-term follow-up, drug trial designs suitable for women in the reproductive age, and better experimental models that represent the human situation. Due to the very long half-life of biologicals, pre-conception counseling, and health care provider education is crucial to offer the best care for mother and fetus. This position paper integrates available data on safety of biologicals during pregnancy in atopic diseases via a systematic review with a detailed review on immunological considerations how inhibition of different pathways may impact pregnancy.
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- 2021
10. European Academy of Allergy and Clinical Immunology position paper on endoscopic scoring of nasal polyposis
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Philippe Gevaert, Jarno De Craemer, Claus Bachert, Manon Blauwblomme, Adam Chaker, Cemal Cingi, Peter W. Hellings, Claire Hopkins, Valérie Hox, Wytske J. Fokkens, Ludger Klimek, Valerie Lund, Ralph Mösges, Joaquim Mullol, Oliver Pfaar, Glenis Scadding, Peter Valentin Tomazic, Thibaut Van Zele, Stephan Vlaminck, Martin Wagenmann, Sanna Toppila‐Salmi, Isam Alobid, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, and UCL - (SLuc) Service d'oto-rhino-laryngologie
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Immunology ,Immunology and Allergy - Published
- 2023
11. A Study of Tibetan Paper Money
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Jung-Huan Lee
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Microbiology (medical) ,Immunology ,Immunology and Allergy - Published
- 2023
12. EFFECT OF FLOCCULINANTS ON STABILITY OF PAPER MATERIALS
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E. Egamberdiev, R. Kholdarov, R. Masharipov, O. Muratkulov, G. Akmalova, Yo. Ergashev, and M. Mirzakhmedova
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Microbiology (medical) ,Immunology ,Immunology and Allergy - Published
- 2023
13. OBTAINING CELLULOSE NANOCRYSTALS AND THEIR USE IN PAPER PRODUCTION
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Sh.A. Rashidov, E. A. Egamberdiev, and S. M. Turabdjanov
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Microbiology (medical) ,Immunology ,Immunology and Allergy - Published
- 2023
14. Chinese ministry investigates duplications in papers by university president
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Silver, Andrew
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- 2019
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15. Recommendations for psoriatic arthritis management: A joint position paper of the Taiwan Rheumatology Association and the Taiwanese Association for Psoriasis and Skin Immunology
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Kai-Jieh Yeo, Tsen-Fang Tsai, Wen-Chan Tsai, Shang-Hung Lin, Woan-Ruoh Lee, Chih-Hung Lee, Yu-Huei Huang, Hsin-Hua Chen, Deng-Ho Yang, Chung-Tei Chou, Nan-Lin Wu, Chun-Hsiung Chen, Hsien-Tzung Liao, Jui-Cheng Tseng, Skin Immunology, Yi-Ju Chen, Rosaline Chung-Yee Hui, Hsien-Yi Chiu, Hung-An Chen, James Cheng-Chung Wei, Hwa Chang Liu, Ting-Shun Wang, Lin-Fen Hsieh, Po-Ju Lai, Tsu-Yi Hsieh, Ching-Chi Chi, Ying-Chou Chen, Ji-Chen Ho, and Chin-Hsiu Liu
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medicine.medical_specialty ,medicine.medical_treatment ,Taiwan ,Dactylitis ,03 medical and health sciences ,Psoriatic arthritis ,0302 clinical medicine ,Internal medicine ,Psoriasis ,Medicine ,lcsh:R5-920 ,Rehabilitation ,business.industry ,Incidence (epidemiology) ,Enthesitis ,General Medicine ,medicine.disease ,Rheumatology ,030220 oncology & carcinogenesis ,Immunology ,Position paper ,030211 gastroenterology & hepatology ,Rheumatologists ,medicine.symptom ,lcsh:Medicine (General) ,business ,Dermatologists - Abstract
In Taiwan, the incidence and prevalence of psoriatic arthritis (PsA) have risen significantly in recent years. Moreover, data from the Taiwan National Health Insurance Research Database (NHIRD) show that more than 85% of PsA patients are treated with just non-steroidal anti-inflammatory drugs (NSAIDs) and/or conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs). Taiwanese clinicians have also expressed concerns regarding uncertainties in the diagnosis of PsA and the delayed, interrupted, and/or tapered use of biologics, as well as differences in therapeutic preferences between and within dermatologists and rheumatologists. To address these issues, the Taiwan Rheumatology Association and the Taiwanese Association for Psoriasis and Skin Immunology jointly convened a committee of 28 clinicians from the fields of rheumatology, dermatology, orthopedics, and rehabilitation, to develop evidence-based consensus recommendations for the practical management of PsA in Taiwan. A total of six overarching principles and 13 recommendations were developed and approved, as well as a treatment algorithm with four separate tracks for axial PsA, peripheral PsA, enthesitis, and dactylitis. Psoriasis (PsO) management was not discussed here, as the Taiwanese Dermatological Association has recently published a comprehensive consensus statement on the management of PsO. Together, these recommendations provide an up-to-date, evidence-based framework for PsA care in Taiwan.
- Published
- 2021
16. Management of patients with chronic rhinosinusitis during the COVID‐19 pandemic—An EAACI position paper
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Jean Bousquet, Adam Chaker, Cezmi A. Akdis, Claus Bachert, Peter Valentin Tomazic, Marek Jutel, Sanna Toppila-Salmi, Valérie Hox, Wytske Fokkens, Carmen Rondon, Barbara Wollenberg, Banu Bozkurt, Jan Hagemann, Aspasia Karavelia, U Förster-Ruhrmann, Ralph Mösges, Cemal Cingi, Tilman Huppertz, Philippe Gevaert, Ioana Agache, Sven Becker, Ludger Klimek, HUS Inflammation Center, Department of Dermatology, Allergology and Venereology, University of Helsinki, and Helsinki University Hospital Area
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0301 basic medicine ,medicine.medical_specialty ,education ,Immunology ,MEDLINE ,Cochrane Library ,03 medical and health sciences ,Nasal Polyps ,0302 clinical medicine ,Adrenal Cortex Hormones ,Pandemic ,medicine ,Humans ,Immunology and Allergy ,biologics ,Nasal polyps ,Sinusitis ,Risk factor ,Intensive care medicine ,Rhinitis ,Biological Products ,SARS-CoV-2 ,business.industry ,chronic rhinosinusitis ,Standard treatment ,COVID-19 ,CRSwNP ,medicine.disease ,Dupilumab ,Asthma ,3. Good health ,030104 developmental biology ,030228 respiratory system ,3121 General medicine, internal medicine and other clinical medicine ,Chronic Disease ,Position paper ,business - Abstract
BackgroundChronic rhinosinusitis is regarded as a chronic airway disease. According to WHO recommendations, it may be a risk factor for COVID-19 patients. In most CRSwNP cases, the inflammatory changes affecting the nasal and paranasal mucous membranes are type-2 (T2) inflammation endotypes. MethodsThe current knowledge on COVID-19 and on treatment options for CRS was analyzed by a literature search in Medline, Pubmed, international guidelines, the Cochrane Library and the Internet. ResultsBased on international literature, on current recommendations by WHO and other international organizations as well as on previous experience, a panel of experts from EAACI and ARIA provided recommendations for the treatment of CRS during the COVID-19 pandemic. ConclusionIntranasal corticosteroids remain the standard treatment for CRS in patients with SARS-CoV-2 infection. Surgical treatments should be reduced to a minimum and surgery preserved for patients with local complications and for those with no other treatment options. Systemic corticosteroids should be avoided. Treatment with biologics can be continued with careful monitoring in noninfected patients and should be temporarily interrupted during the course of the COVID-19 infection.
- Published
- 2021
17. Tracking Religious Moderation Discourse Content on Student’s Final Paper in Indonesian Islamic Higher Education
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Abdul Gaffar, Abdul Muiz Amir, and Akbar Akbar
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Microbiology (medical) ,Immunology ,Immunology and Allergy - Abstract
Albeit research into religious moderation at Indonesian Islamic Higher Education (PTKIN) has been widely undertaken, little empirical research reports on tracing students’ final works as critical research to examine the alignment of PTKIN’s vision in support of government programs to build an inclusive and moderate discourse on religious understanding distribution. This study employs Tracing of Research Studies in three steps, taxonomy analysis, citation analysis, and statistical analysis of diversity. The analysis was conducted on Qur’an and Hadith theses and dissertations published by five institutions. The findings indicate that the religious moderation discourse established in PTKIN’s dissertation and thesis truly conveys the ambiguity of its concept. The ideas employed in the research obscured the government's concepts in establishing religious moderation in the Indonesian setting. This research proposes that mainstreaming religious moderation in PTKIN be implemented more thoroughly, particularly in compiling students’ final papers. Abstrak Meski telah banyak penelitian terkait moderasi beragama di Perguruan Tinggi Keagamaan Islam Negeri (PTKIN), penelitian empiris yang menelusuri karya akhir mahasiswa masih terbatas, khususnya kajian kritis untuk mengeksplorasi keselarasan perwujudan visi dan misi PTKIN dalam mendukung program pemerintah untuk menciptakan paham keagamaan yang bersifat inklusif dan moderat. Penelitian ini menerapkan Tracing of Research Studies dengan tiga langkah analisis yaitu analisis taksonomi, analisis kutipan, dan analisis statistik keragaman. Analisis tersebut dilakukan terhadap tesis dan disertasi Al-Qur’an dan Hadis yang diterbitkan oleh 5 PTKIN. Hasil penelitian menunjukkan bahwa diskursus yang dikembangkan dalam tesis dan disertasi PTKIN justru mengesankan ambiguitas gagasan moderasi beragama. Gagasan yang digunakan dalam penelitian mengaburkan konsep yang telah dikonsep oleh pemerintah sebagai pedoman untuk mencapai moderasi beragama dalam konteks keIndonesiaan. Penelitian ini menyarankan agar strategi pengarusutamaan moderasi beragama di PTKIN dilakukan secara lebih komprehensif khususnya dalam produksi karya tulis akhir mahasiswa.
- Published
- 2022
18. Broussonetia papyrifera (paper mulberry) pollen is an important cause of allergic rhinitis in Southwest China
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Zihan Jiang, Hao Xiao, Hongting Zhang, Qiaoru Jia, Hang Lin, Li Zhang, Jonas Lidholm, Magnus P. Borres, Juan Meng, and Lianglu Wang
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Immunology ,Immunology and Allergy - Published
- 2022
19. Diagnosis and management of allergy and respiratory disorders in sport: An EAACI task force position paper.
- Author
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Price, Oliver J., Walsted, Emil S., Bonini, Matteo, Brannan, John D., Bougault, Valérie, Carlsen, Kai‐Håkon, Couto, Mariana, Kippelen, Pascale, Moreira, André, Pite, Helena, Rukhadze, Maia, and Hull, James H.
- Subjects
- *
RESPIRATORY allergy , *TASK forces , *SPORTS physicians , *ALLERGIES , *DIAGNOSIS , *SPORTS injuries , *ALLERGIC conjunctivitis - Abstract
Allergy and respiratory disorders are common in young athletic individuals. In the context of elite sport, it is essential to secure an accurate diagnosis in order to optimize health and performance. It is also important, however, to consider the potential impact or consequences of these disorders, in recreationally active individuals engaging in structured exercise and/or physical activity to maintain health and well‐being across the lifespan. This EAACI Task Force was therefore established, to develop an up‐to‐date, research‐informed position paper, detailing the optimal approach to the diagnosis and management of common exercise‐related allergic and respiratory conditions. The recommendations are informed by a multidisciplinary panel of experts including allergists, pulmonologists, physiologists and sports physicians. The report is structured as a concise, practically focussed document, incorporating diagnostic and treatment algorithms, to provide a source of reference to aid clinical decision‐making. Throughout, we signpost relevant learning resources to consolidate knowledge and understanding and conclude by highlighting future research priorities and unmet needs. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
20. Considerations for immune effector cell therapy collections: a white paper from the American Society for Apheresis
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Hien D. Liu, Leon Su, Jeffrey L. Winters, Suzanne R. Thibodeaux, Yara A. Park, YanYun Wu, Joseph Schwartz, Abba C. Zubair, Jennifer Schneiderman, Gaurav K. Gupta, Sharanya Ramakrishnan, and Nicole A. Aqui
- Subjects
Adult ,Cancer Research ,Transplantation ,Consensus ,Immunology ,Cell- and Tissue-Based Therapy ,Cell Biology ,Tissue Donors ,United States ,Oncology ,Blood Component Removal ,Humans ,Immunology and Allergy ,Leukapheresis ,Child ,Genetics (clinical) - Abstract
This white paper was developed to provide leukapheresis guidance for the collection of mononuclear cells from adult and pediatric patients who are destined for immune effector cell (IEC) therapies for commercial and research applications. Currently, there is considerable variability in leukapheresis processes and limited published information regarding best practices relevant to new cellular therapies, especially IECs. Herein the authors address critical leukapheresis questions in five domains to help guide consistent collection processes and ensure high-quality products. The first four domains are onboarding, pre-collection, collection and post-collection, with protocol feasibility, preparation, care and follow-up of the patient/donor at each step, respectively, and technical considerations during collection. The fifth domain of quality assurance focuses on ensuring product potency, purity, safety and auditing.The American Society for Apheresis (ASFA) Clinical Applications Committee (IEC Therapy Subcommittee) was charged by the society's board of directors with working collaboratively with other ASFA committees and organizations, including the Foundation for the Accreditation of Cellular Therapy, Association for the Advancement of Blood and Biotherapies, American Society for Transplantation and Cellular Therapy, National Marrow Donor Program and International Society for CellGene Therapy, to develop guidelines regarding leukapheresis collection of cells destined for the manufacture of IEC therapies. After a review of the literature and discussion with members of the involved committees and various institutions, a draft guidance was created and circulated for comment and revision.Critical aspects of apheresis that could affect the quality and quantity of the leukapheresis product were identified. These areas were then discussed and reviewed. After consensus, the best practice guidelines were proposed and accepted.In the current era of rapid growth of IEC therapies, it is important to address critical leukapheresis steps to provide high-quality products and more consistent practices and to eliminate redundant efforts.
- Published
- 2022
21. Diagnosis and management of allergy and respiratory disorders in sport: An EAACI task force position paper
- Author
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Oliver J. Price, Emil S. Walsted, Matteo Bonini, John D. Brannan, Valérie Bougault, Kai‐Håkon Carlsen, Mariana Couto, Pascale Kippelen, André Moreira, Helena Pite, Maia Rukhadze, and James H. Hull
- Subjects
exercise ,Advisory Committees ,Respiratory Tract Diseases ,Immunology ,Respiration Disorders ,allergy ,immunology ,physiology ,Hypersensitivity ,Humans ,Immunology and Allergy ,sport ,Exercise ,Sports - Abstract
Copyright © 2022 Allergy and respiratory disorders are common in young athletic individuals. In the context of elite sport, it is essential to secure an accurate diagnosis in order to optimize health and performance. It is also important, however, to consider the potential impact or consequences of these disorders, in recreationally active individuals engaging in structured exercise and/or physical activity to maintain health and well-being across the lifespan. This EAACI Task Force was therefore established, to develop an up-to-date, research-informed position paper, detailing the optimal approach to the diagnosis and management of common exercise-related allergic and respiratory conditions. The recommendations are informed by a multidisciplinary panel of experts including allergists, pulmonologists, physiologists and sports physicians. The report is structured as a concise, practically focussed document, incorporating diagnostic and treatment algorithms, to provide a source of reference to aid clinical decision-making. Throughout, we signpost relevant learning resources to consolidate knowledge and understanding and conclude by highlighting future research priorities and unmet needs. European Academy of Allergy and Clinical Immunology
- Published
- 2022
22. Paper-based ELISA diagnosis technology for human brucellosis based on a multiepitope fusion protein
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Han Li, Hai Jiang, Mingjun Sun, Qiongqiong Bai, Dehui Yin, Jingpeng Zhang, Xiling Wu, and Jihong Shao
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Bacterial Diseases ,Serum Proteins ,B Cells ,RC955-962 ,Disease ,Pathology and Laboratory Medicine ,Biochemistry ,Epitope ,Cell Fusion ,Epitopes ,White Blood Cells ,Medical Conditions ,Filter Paper ,Animal Cells ,Zoonoses ,Arctic medicine. Tropical medicine ,Medicine and Health Sciences ,Enzyme-Linked Immunoassays ,biology ,Bacterial Pathogens ,Laboratory Equipment ,medicine.anatomical_structure ,Infectious Diseases ,Medical Microbiology ,Engineering and Technology ,Pathogens ,Cellular Types ,Public aspects of medicine ,RA1-1270 ,Bacterial Outer Membrane Proteins ,Research Article ,Neglected Tropical Diseases ,China ,Cell Physiology ,Immune Cells ,Immunology ,Equipment ,Enzyme-Linked Immunosorbent Assay ,Brucella ,Research and Analysis Methods ,Sensitivity and Specificity ,Microbiology ,Brucellosis ,Antigen ,Diagnostic Medicine ,medicine ,Humans ,Immunoassays ,Antibody-Producing Cells ,Microbial Pathogens ,B cell ,Antigens, Bacterial ,Blood Cells ,Bacteria ,business.industry ,Public Health, Environmental and Occupational Health ,Organisms ,Biology and Life Sciences ,Proteins ,Cell Biology ,medicine.disease ,biology.organism_classification ,Tropical Diseases ,Fusion protein ,Virology ,Infectious disease (medical specialty) ,Immunologic Techniques ,business - Abstract
Background Brucellosis, as a serious zoonotic infectious disease, has been recognized as a re-emerging disease in the developing countries worldwide. In china, the incidence of brucellosis is increasing each year, seriously threatening the health of humans as well as animal populations. Despite a quite number of diagnostic methods currently being used for brucellosis, innovative technologies are still needed for its rapid and accurate diagnosis, especially in area where traditional diagnostic is unavailable. Methodology/Principal findings In this study, a total of 22 B cell linear epitopes were predicted from five Brucella outer membrane proteins (OMPs) using an immunoinformatic approach. These epitopes were then chemically synthesized, and with the method of indirect ELISA (iELISA), each of them displayed a certain degree of capability in identifying human brucellosis positive sera. Subsequently, a fusion protein consisting of the 22 predicted epitopes was prokaryotically expressed and used as diagnostic antigen in a newly established brucellosis testing method, nano-ZnO modified paper-based ELISA (nano-p-ELISA). According to the verifying test using a collection of sera collected from brucellosis and non-brucellosis patients, the sensitivity and specificity of multiepitope based nano-p-ELISA were 92.38% and 98.35% respectively. The positive predictive value was 98.26% and the negative predictive value was 91.67%. The multiepitope based fusion protein also displayed significantly higher specificity than Brucella lipopolysaccharide (LPS) antigen. Conclusions B cell epitopes are important candidates for serologically testing brucellosis. Multiepitope fusion protein based nano-p-ELISA displayed significantly sensitivity and specificity compared to Brucella LPS antigen. The strategy applied in this study will be helpful to develop rapid and accurate diagnostic method for brucellosis in human as well as animal populations., Author summary Brucellosis is one of the most important zoonosis in the world and has caused tremendous economic losses in agriculture and animal husbandry in many countries. Developing rapid, sensitive and specific diagnostic methods is very important for early detection and treatment of brucellosis patients. In this study, a novel diagnostic technique, nano-ZnO modified paper ELISA, was established. The antigen used in this technique was a fusion protein containing multiple B cell epitopes, which were predicted from Brucella major outer membrane proteins such as Bp26, Omp31, Omp16, Omp2b and Omp25. Comparing to traditional LPS antigen, this multiepitope based antigen displayed considerably higher sensitivity and higher specificity in laboratory. With the strategy described in this paper, more efficient epitopes and protein antigen can be identified in the future. Currently, LPS antigen is only prepared from live Brucella, while protein antigen can be produced in large quantities in prokaryotic expression system. In addition to nano-p-ELISA, this protein antigen can also be used for development other methods such as fluorescent polarization assay (FPA) and immunochromatographic assay (ICA) to meet the varied demand for brucellosis testing.
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- 2021
23. COVID-19 vaccination and allergen immunotherapy (AIT) - A position paper of the German Society for Applied Allergology (AeDA) and the German Society for Allergology and Clinical Immunology (DGAKI)
- Author
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Martin Wagenmann, Eckard Hamelmann, Randolf Brehler, Christian Taube, Thomas Werfel, Norbert Mülleneisen, Jörg Kleine-Tebbe, Sven Becker, Oliver Pfaar, Natalija Novak, Margitta Worm, and Ludger Klimek
- Subjects
Allergy ,Allergen immunotherapy ,allergic rhinitis ,business.industry ,SARS-CoV-2 ,General Engineering ,COVID-19 ,Disease ,asthma ,medicine.disease ,Vaccination ,Immune system ,Food allergy ,Immunology ,medicine ,allergen immunotherapy ,General Earth and Planetary Sciences ,Position paper ,Position Paper ,business ,General Environmental Science ,Asthma - Abstract
Background Vaccinations against severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) are intended to induce an immune response to protect against infection/disease. Allergen immunotherapy (AIT) is thought to induce a (different) immune response, e.g., to induce tolerance to allergens. In this position paper we clarify how to use AIT in temporal relation to COVID-19 vaccination. Four SARS-CoV-2 vaccines are currently approved in the EU, and their possible immunological interactions with AIT are described together with practical recommendations for use. Materials and methods Based on the internationally published literature, this position paper provides specific recommendations for the use of AIT in temporal relation to a SARS-CoV-2 vaccination. Results AIT is used in 1) allergic rhinitis, 2) allergic bronchial asthma, 3) insect venom allergy, 4) food allergy (peanut). Conclusion For the continuation of an ongoing AIT, we recommend an interval of 1 week before and after vaccination for subcutaneous immunotherapy (SCIT). For sublingual immunotherapy (SLIT) and oral immunotherapy (OIT), we recommend taking them up to the day before vaccination and a break of 2 - 7 days after vaccination. Initiation of a new SCIT, SLIT, or OIT should be delayed until 1 week after the day of the second vaccination. For SCIT, we generally recommend an interval of ~ 1 week to COVID-19 vaccination.
- Published
- 2021
24. A novel method for precise detection of allergen‐specific IgE via immobilizing His‐tagged allergens to paper‐based device
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Zhiqiang Xu, Xisi Han, Bicong Zhou, Shuangxi Wang, Chengwu Zhang, Changmin Yu, Lin Li, Chen Lu, Yu-Jie Wang, Mengda Cao, and Ji-Fu Wei
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biology ,Chemistry ,Immunology ,biology.protein ,Humans ,Immunology and Allergy ,Enzyme-Linked Immunosorbent Assay ,Paper based ,Allergens ,Immunoglobulin E ,Allergen specific IgE - Published
- 2020
25. Diagnosis and management of the drug hypersensitivity reactions in Coronavirus disease 19: An EAACI Position Paper
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Antonino Romano, Knut Brockow, Cristobalina Mayorga, María José Torres, Gülfem Çelik, Aslı Gelincik, Marina Atanaskovic-Markovic, Annick Barbaud, Ozge Soyer, and Inmaculada Doña
- Subjects
Drug ,medicine.medical_specialty ,SARS‐CoV2 ,medicine.medical_treatment ,media_common.quotation_subject ,Immunology ,desensitization ,Review Article ,Disease ,medicine.disease_cause ,Asymptomatic ,Drug Hypersensitivity ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,COVID‐19 ,Pandemic ,medicine ,Humans ,Immunology and Allergy ,drug hypersensitivity reactions ,Intensive care medicine ,Pandemics ,Review Articles ,Coronavirus ,Desensitization (medicine) ,media_common ,SARS-CoV-2 ,business.industry ,Academies and Institutes ,COVID-19 ,3. Good health ,Europe ,030228 respiratory system ,Position paper ,Differential diagnosis ,medicine.symptom ,business - Abstract
Coronavirus disease 2019 (COVID‐19), a respiratory tract infection caused by a novel human coronavirus, the severe acute respiratory syndrome coronavirus 2, leads to a wide spectrum of clinical manifestations ranging from asymptomatic cases to patients with mild and severe symptoms, with or without pneumonia. Given the huge influence caused by the overwhelming COVID‐19 pandemic affecting over three million people worldwide, a wide spectrum of drugs is considered for the treatment in the concept of repurposing and off‐label use. There is no knowledge about the diagnosis and clinical management of the drug hypersensitivity reactions that can potentially occur during the disease. This review brings togetherall the published information about the diagnosis and management of drug hypersensitivity reactions due to current and candidate off‐label drugs andhighlights relevant recommendations. Furthermore, it gathers all the dermatologic manifestations reported during the disease for guiding the clinicians to establish a better differential diagnosis of drug hypersensitivity reactionsin the course of the disease.
- Published
- 2020
26. PRODUCTION OF ABO ANTI-SERA AND A SLIDE AND FILTER PAPER- BASE TECHNIQUE FOR ABO BLOOD GROUPING USING REJECTED BLOOD
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Ngum Lesley Ngum, Palmer Masumbe Netongo, Stephane Herve Mpopo, Jean Paul Chedjou, and Wilfred Mbacham
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Filter paper ,business.industry ,ABO blood group system ,Immunology ,Medicine ,General Medicine ,business ,Base (exponentiation) - Published
- 2020
27. Allergen immunotherapy in the current COVID-19 pandemic: A position paper of AeDA, ARIA, EAACI, DGAKI and GPA
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Martin Wagenmann, Wolfgang Pohl, P. V. Tomazic, Hans F. Merk, Wolfgang Wehrmann, Rudolf Valenta, Torsten Zuberbier, A. Chaker, Thomas Werfel, Karin Hoffmann-Sommergruber, Klaus Rabe, Isabella Pali-Schöll, Christian Taube, Katja Nemat, Stefan Wöhrl, Jeroen Buters, Karl-Christian Bergmann, Michael Gerstlauer, Marcus Maurer, Wofgang Czech, Joachim Saloga, Regina Roller-Wirnsberger, Randolf Brehler, Thomas Fuchs, Jean-Pierre Michel, Petra Stute, Uta Rabe, Peter Schmid-Grendelmeier, Werner Aberer, Friedrich Horak, Jean Bousquet, Otto Spranger, Thomas Keil, Thilo Jakob, Laurent P. Nicod, Eckard Hamelmann, Christian Vogelberg, Marek Jutel, Norbert Mülleneisen, Johannes Ring, Petra Staubach, Tilo Biedermann, Thomas Bieber, Holger Wrede, Wolfgang Schlenter, Roland Buhl, François Spertini, Jörg Kleine-Tebbe, Cezmi A. Akdis, Mübecell Akdis, Ralph Mösges, Verena Niederberger-Leppin, Susanne Lau, P. M. Matricardi, Kirsten Jung, Sven Becker, Antje Fink-Wagner, Claus Vogelmeier, Ulf Darsow, Ludger Klimek, Margitta Worm, N. Khaltaev, and O. Pfaar
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Allergen immunotherapy ,Allergy ,Coronavirus disease 2019 (COVID-19) ,business.industry ,General Engineering ,COVID-19 ,antiviral immunity ,SLIT ,Immunology ,Pandemic ,General Earth and Planetary Sciences ,Position paper ,Medicine ,Current (fluid) ,SCIT ,business ,Research Article ,General Environmental Science - Abstract
No abstract available.
- Published
- 2020
28. Commentary on the 1988 paper by Slichter, Weiden, Kane, and Storb
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Moritz Stolla
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Immunology ,Immunology and Allergy ,Hematology - Published
- 2022
29. Role of dietary fiber in promoting immune health—An <scp>EAACI</scp> position paper
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Carina Venter, Rosan W. Meyer, Matthew Greenhawt, Isabella Pali‐Schöll, Bright Nwaru, Caroline Roduit, Eva Untersmayr, Karine Adel‐Patient, Ioana Agache, Carlo Agostoni, Cezmi A. Akdis, Mary Feeney, Karin Hoffmann‐Sommergruber, Nonhlanhla Lunjani, Kate Grimshaw, Imke Reese, Peter K. Smith, Milena Sokolowska, Emilia Vassilopoulou, Berber Vlieg‐Boerstra, Shriya Amara, Jens Walter, Liam O'Mahony, Médicaments et Technologies pour la Santé (MTS), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
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Dietary Fiber ,Prebiotics ,allergy, diet, fiber, nutrition, prebiotics ,Immunology ,[SDV.IMM]Life Sciences [q-bio]/Immunology ,Humans ,Immunology and Allergy ,prebiotics ,fiber ,allergy ,diet ,nutrition ,Rhinitis, Allergic ,Dermatitis, Atopic ,Gastrointestinal Microbiome - Abstract
Microbial metabolism of specific dietary components, such as fiber, contributes to the sophisticated inter-kingdom dialogue in the gut that maintains a stable environment with important beneficial physiological, metabolic, and immunological effects on the host. Historical changes in fiber intake may be contributing to the increase of allergic and hypersensitivity disorders as fiber-derived metabolites are evolutionarily hardwired into the molecular circuitry governing immune cell decision-making processes. In this review, we highlight the importance of fiber as a dietary ingredient, its effects on the microbiome, its effects on immune regulation, the importance of appropriate timing of intervention to target any potential window of opportunity, and potential mechanisms for dietary fibers in the prevention and management of allergic diseases. In addition, we review the human studies examining fiber or prebiotic interventions on asthma and respiratory outcomes, allergic rhinitis, atopic dermatitis, and overall risk of atopic disorders. While exposures, interventions, and outcomes were too heterogeneous for meta-analysis, there is significant potential for using fiber in targeted manipulations of the gut microbiome and its metabolic functions in promoting immune health.
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- 2022
30. Placebo effects in allergen immunotherapy-An EAACI Task Force Position Paper
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Oliver Pfaar, Mohamed H. Shamji, Glenis Scadding, Ludger Klimek, Stefan Vieths, Ronald van Ree, Antonella Muraro, Jörg Kleine-Tebbe, Bettina Wedi, Karl Christian Bergmann, Anthony J. Frew, Philippe Devillier, Gunter J. Sturm, Carsten Bindslev-Jensen, Roy Gerth van Wijk, Carmen Vidal, Marek Jutel, Peter S. Creticos, Jean Bousquet, Lars Jacobsen, Nikolaos G. Papadopoulos, Stephen R. Durham, Winfried Rief, Ioana Agache, S. Kaul, Manfred Schedlowski, Peter Hellings, APH - Personalized Medicine, AII - Inflammatory diseases, APH - Global Health, Experimental Immunology, Ear, Nose and Throat, and Internal Medicine
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Allergy ,medicine.medical_specialty ,Allergen immunotherapy ,Blinding ,business.industry ,Advisory Committees ,Immunology ,Medizin ,Disease ,Placebo Effect ,Placebo ,medicine.disease ,law.invention ,Clinical trial ,Treatment Outcome ,Double-Blind Method ,Randomized controlled trial ,Desensitization, Immunologic ,law ,Physical therapy ,Humans ,Immunology and Allergy ,Medicine ,Position paper ,business - Abstract
The placebo (Latin "I will please") effect commonly occurs in clinical trials. The psychological and physiological factors associated with patients' expectations about a treatment's positive and negative effects have yet to be well characterized, although a functional prefrontal cortex and intense bidirectional communication between the central nervous system and the immune system appear to be prerequisites for a placebo effect. The use of placebo raises certain ethical issues, especially if patients in a placebo group are denied an effective treatment for a long period of time. The placebo effect appears to be relatively large (up to 77%, relative to pretreatment scores) in controlled clinical trials of allergen immunotherapy (AIT), such as the pivotal, double-blind, placebo-controlled (DBPC) randomized clinical trials currently required by regulatory authorities worldwide. The European Academy of Allergy and Clinical Immunology (EAACI) therefore initiated a Task Force, in order to better understand the placebo effect in AIT and its specific role in comorbidities, blinding issues, adherence, measurement time points, variability and the natural course of the disease. In this Position Paper, the EAACI Task Force highlights several important topics regarding the placebo effect in AIT such as a) regulatory aspects, b) neuroimmunological and psychological mechanisms, c) placebo effect sizes in AIT trials, d) methodological limitations in AIT trial design and e) potential solutions in future AIT trial design. In conclusion, this Position Paper aims to examine the methodological problem of placebo in AIT from different aspects and also to highlight unmet needs and possible solutions for future trials. ispartof: ALLERGY vol:76 issue:3 pages:629-647 ispartof: location:Denmark status: published
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- 2021
31. Manufacture of Banana-Based Paper
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William Cabezas, Daniel Davila, Carlos Freire, Steven Hernandez, and Alexander Morales
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Microbiology (medical) ,Immunology ,Immunology and Allergy - Abstract
The paper is one of the most used elements in modern society, despite the fact that its invention dates back to ancient times. The paper is used for different domestic, labor and industrial purposes. Its manufacture is made from cellulose pulp and vegetable fibers, which have had a significant environmental impact in recent years. This work proposes the analysis of the production of paper from the use of residues of the banana plant, which could offer a better use of natural resources and a lower impact on nature. In addition, the natural fiber of bananas is resistant and is easily obtained in Latin American countries such as Ecuador, which has a high production of it. The results found show that it is possible to make paper with fiber from banana residues and that it is possible to commercialize and make good use of resources. Keywords: Organic paper, banana waste, environmental protection. References [1]A. Herrera, «ELABORACIÓN DEL PAPEL ORGÁNICO A BASE DE PSEUDOTALLO DE BANANO, CANTÓN SANTA ROSA, PROVINCIA DE EL ORO, ECUADOR,» Guayaquil, 2019. [2]R. d. León, «Fabrican papel con desechos de plátano,» CIENCIAMX, 1 julio 2016. [En línea]. Available: http://www.cienciamx.com/index.php/tecnologia/biotecnologia/8476-generacion-de-celulosa-a-partir-de-desechos-de-la-planta-del-platano. [3]A. Cortéz, «ELABORACIÓN DE PAPEL A BASE DE RESIDUOS DE BANANO,» Guayaquil, 2014. [4]M. Dávalos and S. Zurita, «Organic paper, banana waste, environmental protection,» Universidad Politécnica del Litoral, Chile, 2004. [5]G. Castillo-Tumaille and W. Espinoza- Espinoza, «Análisis de aceptación del papel a base de pinzote de banano como alternativa de,» Ingeniería Industrial. Actualidad y Nuevas Tendencias, vol. V, nº 18, pp. 59-70, 2017. [6]M. Mazzeo, L. León, L. Mejía, L. Guerrero and J. Botero, «APROVECHAMIENTO INDUSTRIAL DE RESIDUOS DE COSECHA Y POSCOSECHA DEL PLÁTANO EN EL DEPARTAMENTO DE CALDAS,» Educación en Ingeniería, vol. junio de 2010, nº 9, pp. 128-139, 2010. [7]M. Arzola and A. Mejías, «Modelo conceptual para gestionar la innovación en las empresas del sector servicios,» Revista Venezolana de Gerencia, vol. 12, nº 37, pp. 80-98, 2007. [8]I. Azman and S. Yusrizal, «Service quality as a predictor of satisfaction and customer loyalty.,» Scientific Journal of Logistics. , vol. 12, nº 4, pp. 269-283, 2016.
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- 2022
32. AllergoOncology: Microbiota in allergy and cancer—A European Academy for Allergy and Clinical Immunology position paper
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Debra H. Josephs, Karin Hartmann, Manuel L. Penichet, Erika Jensen-Jarolim, Luca Vangelista, Sophia N. Karagiannis, Liam O'Mahony, Rodolfo Bianchini, Hannah J. Gould, Eva Untersmayr, Francesca Levi-Schaffer, Heather J. Bax, Christoph Bergmann, Michelle C. Turner, Franziska Roth-Walter, Wendy Cozen, Frank A. Redegeld, Aurélie Poli, Afd Pharmacology, and Pharmacology
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0301 basic medicine ,Male ,Allergy ,Disease ,hygiene hypothesis ,Epithelium ,Immune tolerance ,0302 clinical medicine ,oncoimmunology ,Neoplasms ,Immunology and Allergy ,Medicine ,Micronutrients ,Child ,Phylogeny ,Cancer ,Immunity, Cellular ,Microbiota ,3. Good health ,Child, Preschool ,Female ,Oncoimmunology ,Position Paper ,Immunology ,03 medical and health sciences ,Immune system ,Hygiene hypothesis ,Immunity ,microbiota ,cancer ,Animals ,Humans ,Microbiome ,Mucous Membrane ,Bacteria ,Host Microbial Interactions ,business.industry ,Infant ,biochemical phenomena, metabolism, and nutrition ,medicine.disease ,allergy ,Asthma ,Diet ,Gastrointestinal Microbiome ,030104 developmental biology ,030228 respiratory system ,Hygience hypothesis ,bacteria ,business - Abstract
The microbiota can play important roles in the development of human immunity and the establishment of immune homeostasis. Lifestyle factors including diet, hygiene, and exposure to viruses or bacteria, and medical interventions with antibiotics or anti‐ulcer medications, regulate phylogenetic variability and the quality of cross talk between innate and adaptive immune cells via mucosal and skin epithelia. More recently, microbiota and their composition have been linked to protective effects for health. Imbalance, however, has been linked to immune‐related diseases such as allergy and cancer, characterized by impaired, or exaggerated immune tolerance, respectively. In this AllergoOncology position paper, we focus on the increasing evidence defining the microbiota composition as a key determinant of immunity and immune tolerance, linked to the risk for the development of allergic and malignant diseases. We discuss novel insights into the role of microbiota in disease and patient responses to treatments in cancer and in allergy. These may highlight opportunities to improve patient outcomes with medical interventions supported through a restored microbiome.
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- 2019
33. Hypersensitivity reactions to biologicals: An EAACI position paper
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Alessandra Vultaggio, Soledad Sanchez-Sanchez, Mauro Pagani, Ricardo Madrigal-Burgaleta, Mariana Castells, Emilio Alvarez-Cuesta, Adile Berna Dursun, Sevim Bavbek, and Sahar Hamadi
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medicine.medical_specialty ,Biological Products ,High prevalence ,business.industry ,Immunology ,Treatment options ,Antineoplastic Agents ,Precision medicine ,Optimal management ,Unmet needs ,Clinical Practice ,Drug Hypersensitivity ,Desensitization, Immunologic ,Immunology and Allergy ,Medicine ,Position paper ,Humans ,Precision Medicine ,business ,Intensive care medicine - Abstract
Biologicals are crucial targeted therapeutic agents in oncological, immunological, and inflammatory diseases, and their use in clinical practice is broadening. In recent years, the spread of Personalized Precision Medicine has facilitated a proliferation of new treatment options, especially biologicals. Consequently, biologicals are now among the drugs that most frequently cause hypersensitivity reactions (HSRs). Patients can develop HSRs to these agents during the first-lifetime exposure or after repeated exposure, and these HSRs can be potentially life-threatening or limit therapeutic options. Despite the relatively high prevalence, the underlying mechanisms of these HSRs remain obscure, and the optimal management pathways are still a matter of discussion. In this Position Paper, the authors will provide evidence-based recommendations for diagnosing and managing HSRs to biologicals. Additionally, the document defines unmet needs as an opportunity to shape future research.
- Published
- 2021
34. A practical toolbox for the effective transition of adolescents and young adults with asthma and allergies - an EAACI Position paper
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Marta Vazquez‐Ortiz, Claudia Gore, Cherry Alviani, Elizabeth Angier, Katharina Blumchen, Pasquale Comberiati, Bettina Duca, Audrey DunnGalvin, Teresa Garriga‐Baraut, M. Hazel Gowland, Britt Egmose, Rebecca Knibb, Ekaterina Khaleva, Charlotte G. Mortz, Oliver Pfaar, Helena Pite, Marcia Podesta, Alexandra F. Santos, Silvia Sanchez‐Garcia, Frans Timmermans, Graham Roberts, NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), Centro de Estudos de Doenças Crónicas (CEDOC), and iNOVA4Health - pólo NMS
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Adolescent ,Health Personnel ,Immunology ,transition ,asthma ,allergy ,Asthma ,Europe ,Young Adult ,Caregivers ,adolescent ,Humans ,Immunology and Allergy ,young adult - Abstract
Introduction: adolescence is a critical stage of rapid biological, emotional and social change and development. Adolescents and young adults (AYA) with asthma and allergies need to develop the knowledge and skills to self-manage their health independently. Healthcare professionals (HCP), parents and their wider network play an essential role in supporting AYA in this process. Previous work showed significant limitations in transition care across Europe. In 2020, the first evidence-based guideline on effective transition for AYA with asthma and allergies was published by EAACI.Aim: we herein summarize practical resources to support this guideline's implementation in clinical practice.Methods: for this purpose, multi-stakeholder Task Force members searched for resources in peer review journals and grey literature. These resources were included if relevant and of good quality and were pragmatically rated for their evidence-basis and user friendliness.Results: resources identified covered a range of topics and targeted healthcare professionals, AYA, parents/carers, schools, workplace and wider community. Most resources were in English, web-based and had limited evidence-basis.Conclusions: this position paper provides a valuable selection of practical resources for all stakeholders to support effective transitional care for AYA with asthma and allergies. Future research should focus on developing validated, patient-centred tools to further assist evidence-based transition care.
- Published
- 2023
35. Paper-based biosensor for the detection of sepsis murine using MMP9 and a9ß6, integrons RI Class1 and R2 Class 2 peptides
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J Popp, D May, Nuha Alekhmimi, and Mohammed Zourob
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ARDS ,biology ,business.industry ,Integrin ,MMP9 ,medicine.disease ,Sepsis ,Paper based biosensor ,Immune system ,Immunology ,biology.protein ,Medicine ,Biomarker (medicine) ,Multiplex ,business - Abstract
Sepsis is an inflammatory and immune response to microbial invasion that produces organs injury developed to systemic inflammatory respon seyndrome due to organs dysfunction. Sepsis is the indirect risk factor which can developed to ARDS. The most critical point for best prognosis is to diagnose the infection at its early stage, therefore, we need a novel sensitive and rapid method for screening is necessary for sepsis detection. In this study we designed a paper-based sensing platform for the detection of a number of expecting sepsis biomarkers such as, MMP9, α9β6 integrins, integrons RI Class1 and R2 Class 2 secreted during treated mice with FIP for 1h, 2h, 4h, and 20h (early /severe sepsis). Later on, we developed a multiplexing paper-based biosensor after adding BAL collected from septic mice on it, in order to target sepsis biomarker by cleavage of the four multiplex paper based peptides with comparison blood cultures of septic mice samples.
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- 2021
36. The role of mobile health technologies in allergy care: An EAACI position paper
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Jean Bousquet, Jean-Christoph Roger J-P Caubet, James Gardner, Ralph Mösges, Simon Blank, Dermot Ryan, Alla Nakonechna, Daniel Perez-Formigo, Markus Ollert, Ignacio Esteban-Gorgojo, Ileana Ghiordanescu, Darío Antolín-Amérigo, Giovanni Battista Pajno, Jörn Wittmann, Jeroen Buters, Elisa Boni, Constantinos Pitsios, Karin Hoffmann-Sommergruber, Knut Brockow, Philippe Gevaert, Uwe Berger, Harmieke van Os-Medendorp, Matteo Bonini, Tania Elliott, Peter Hellings, Jennifer Shih, Marina Atanaskovic-Markovic, Salvatore Tripodi, Michael S. Blaiss, Stephanie Dramburg, A. Fusun Kalpaklioglu, Ioana Agache, Oliver Pfaar, Lauri-Ann Van der Poel, João Fonseca, Christian Apfelbacher, Ozlem Cavkaytar, Gilda Varricchi, Jose Oteros, S. Sanchez-Garcia, Farid Marmouz, Alberto Alvarez-Perea, Victoria Cardona, Ángela Meijide Calderón, Paolo Maria Matricardi, Michael Rudenko, Catalina Panaitescu, Margitta Worm, KKÜ, Ear, Nose and Throat, Kırıkkale Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kalpaklıoğlu, A. Fusun, Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Hospital General Universitario 'Gregorio Marañón' [Madrid], Hospital Universitario Ramón y Cajal [Madrid], Universidad de Alcalá - University of Alcalá (UAH), University of Regensburg, University of Belgrade [Belgrade], Medizinische Universität Wien = Medical University of Vienna, Augusta University - Medical College of Georgia, University System of Georgia (USG), Center of Allergy & Environment (CK-CARE, ZAUM), Helmholtz-Zentrum München (HZM), German Research Center for Environmental Health - Helmholtz Center München (GmbH), Royal Brompton Hospital, Fondazione 'Policlinico Universitario A. Gemelli' [Rome], Università cattolica del Sacro Cuore [Roma] (Unicatt), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Technical University of Munich (TUM), Vall d'Hebron University Hospital [Barcelona], Geneva University Hospital (HUG), Istanbul Medeniyet University [Istanbul, Turquie] (IMU), New York University Langone Medical Center (NYU Langone Medical Center), NYU System (NYU), General Hospital of Villalba [Madrid], Center of Research in Health Technologies and Information Systems (CINTESIS), Universidade do Porto, Department of Hygiene and Epidemiology, University of Porto Medical School, Porto, Great North Children's Hospital, Partenaires INRAE, Newcastle University [Newcastle], Ghent University Hospital, Emergency University Hospital Elias, European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA), Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), University of Kirikkale, Hopital Réné Dubos, University of Vigo [ Pontevedra], University Hospital of Cologne [Cologne], Clinical Research International Ltd., Royal Liverpool and Broadgreen University Hospital NHS Trust, Liverpool Hope University, Luxembourg Institute of Health (LIH), University of Southern Denmark (SDU), University of Messina, Romanian Primary Care Respiratory Group (RespiRo), Hospital Universitario de Torrejón, Univ Politecn Madrid, Ctr Tecnol Biomed, Pozuelo De Alarcon 28223, Madrid, Spain, Philipps Universität Marburg, University of Cyprus (UCY), Centre Harley Street Allergy Clinic, Centre of Medical Informatics [Edinburgh, UK] (Usher Institute of Population Health Sciences and Informatics), University of Edinburgh, Hospital Infantil Universitario Niño Jesús [Madrid, Spain] (HIUNJ), Institute of Health Carlos III, Emory University School of Medicine, Emory University [Atlanta, GA], Policlinico Casilino (Ospedale Policlinico Casilino), Medical Physics Department,Guy's and St Thomas'NHS Foundation Trust, London, UK, Medical Physics Department, London, UK, Medical Physics Department, Guy's and St Thomas'NHS Foundation Trust-Medical Physics Department, Guy's and St Thomas'NHS Foundation Trust, University Medical Center [Utrecht], 'Federico II' University of Naples Medical School, Transilvania University of Brasov, Helmholtz Zentrum München = German Research Center for Environmental Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] (Unicatt), Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), Universidade do Porto = University of Porto, Philipps Universität Marburg = Philipps University of Marburg, University of Cyprus [Nicosia] (UCY), Hospital Infantil Universitario Niño Jesús (HIUNJ), Salvy-Córdoba, Nathalie, Matricardi, Paolo Maria, Dramburg, Stephanie, Alvarez-Perea, Alberto, Antolín-Amérigo, Darío, Apfelbacher, Christian, Atanaskovic-Markovic, Marina, Berger, Uwe, Blaiss, Michael S, Blank, Simon, Boni, Elisa, Bonini, Matteo, Bousquet, Jean, Brockow, Knut, Buters, Jeroen, Cardona, Victoria, Caubet, Jean-Christoph, Cavkaytar, Özlem, Elliott, Tania, Esteban-Gorgojo, Ignacio, Fonseca, Joao A, Gardner, Jame, Gevaert, Philippe, Ghiordanescu, Ileana, Hellings, Peter, Hoffmann-Sommergruber, Karin, Kalpaklioglu, A Fusun, Marmouz, Farid, Meijide Calderón, Ángela, Mösges, Ralph, Nakonechna, Alla, Ollert, Marku, Oteros, José, Pajno, Giovanni, Panaitescu, Catalina, Perez-Formigo, Daniel, Pfaar, Oliver, Pitsios, Constantino, Rudenko, Michael, Ryan, Dermot, Sánchez-García, Silvia, Shih, Jennifer, Tripodi, Salvatore, Van der Poel, Lauri-Ann, van Os-Medendorp, Harmieke, Varricchi, Gilda, Wittmann, Jörn, Worm, Margitta, Agache, Ioana, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), and Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)
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0301 basic medicine ,MESH: Drug Hypersensitivity ,MESH: Asthma ,Allergy ,MESH: Chronic Urticaria ,[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,immunoglobulin E ,0302 clinical medicine ,Immunology and Allergy ,Chronic Urticaria ,Position paper ,Disease management (health) ,MESH: Desensitization, Immunologic ,[SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology ,mHealth ,Self-management ,ddc:618 ,Health technology ,Disease Management ,allergen-immunotherapy ,Mobile Applications ,Telemedicine ,EAACI ,allergy ,digital health ,mobile health technology ,position paper ,3. Good health ,Dermatitis, Allergic Contact ,biomarker ,MESH: Mobile Applications ,Psychology ,allergic rhiniti ,Digital health ,Food Hypersensitivity ,[SDV.IMM.ALL] Life Sciences [q-bio]/Immunology/Allergology ,allergen ,molecular allergology ,Immunology ,Internet privacy ,component-resolved-diagnosi ,Context (language use) ,Mobile health technology ,MESH: Disease Management ,Dermatitis, Atopic ,Drug Hypersensitivity ,03 medical and health sciences ,[SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics ,MESH: Dermatitis, Allergic Contact ,IgE test ,MESH: Dermatitis, Atopic ,Humans ,Mobile technology ,Anaphylaxis ,Physician-Patient Relations ,[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics ,MESH: Humans ,business.industry ,Rhinitis, Allergic, Seasonal ,MESH: Rhinitis, Allergic, Seasonal ,asthma ,molecular spreading ,[SDV.MHEP.DERM] Life Sciences [q-bio]/Human health and pathology/Dermatology ,diagnostic algorithm ,MESH: Anaphylaxis ,030104 developmental biology ,030228 respiratory system ,Desensitization, Immunologic ,Digital Health ,Eaaci ,Mobile Health Technology ,Position Paper ,MESH: Telemedicine ,MESH: Food Hypersensitivity ,[SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,MESH: Physician-Patient Relations ,business ,[SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology - Abstract
Oteros, Jose/0000-0002-9369-8633; Fonseca, Joao Almeida/0000-0002-0887-8796; Alvarez-Perea, Alberto/0000-0001-7417-7309; Oteros, Jose/0000-0002-9369-8633; Gevaert, Philippe/0000-0002-1629-8468; Antolin, Dario/0000-0001-5699-4022; Apfelbacher, Christian/0000-0003-3805-8219; Buters, Jeroen/0000-0003-3581-5472; Berger, Uwe E./0000-0002-9265-2131; Blank, Simon/0000-0002-5649-1078; Cardona, Victoria/0000-0003-2197-9767; Dramburg, Stephanie/0000-0002-9303-3260 WOS: 000486665800001 PubMed: 31230373 Mobile health (mHealth) uses mobile communication devices such as smartphones and tablet computers to support and improve health-related services, data and information flow, patient self-management, surveillance, and disease management from the moment of first diagnosis to an optimized treatment. The European Academy of Allergy and Clinical Immunology created a task force to assess the state of the art and future potential of mHealth in allergology. The task force endorsed the "Be He@lthy, Be Mobile" WHO initiative and debated the quality, usability, efficiency, advantages, limitations, and risks of mobile solutions for allergic diseases. The results are summarized in this position paper, analyzing also the regulatory background with regard to the "General Data Protection Regulation" and Medical Directives of the European Community. The task force assessed the design, user engagement, content, potential of inducing behavioral change, credibility/accountability, and privacy policies of mHealth products. The perspectives of healthcare professionals and allergic patients are discussed, underlining the need of thorough investigation for an effective design of mHealth technologies as auxiliary tools to improve quality of care. Within the context of precision medicine, these could facilitate the change in perspective from clinician- to patient-centered care. The current and future potential of mHealth is then examined for specific areas of allergology, including allergic rhinitis, aerobiology, allergen immunotherapy, asthma, dermatological diseases, food allergies, anaphylaxis, insect venom, and drug allergy. The impact of mobile technologies and associated big data sets are outlined. Facts and recommendations for future mHealth initiatives within EAACI are listed.
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- 2020
37. Diagnosis and management of food allergy‐associated gastroesophageal reflux disease in young children— <scp>EAACI</scp> position paper
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Rosan Meyer, Yvan Vandenplas, Adriana Chebar Lozinsky, Mario C. Vieira, Roberto Berni Canani, Christophe Dupont, Pinar Uysal, Ozlem Cavkaytar, Rebecca Knibb, David M. Fleischer, Anna Nowak‐Wegrzyn, Carina Venter, Brussels Heritage Lab, Clinical sciences, Growth and Development, Pediatrics, Meyer, Rosan, Vandenplas, Yvan, Lozinsky, Adriana Chebar, Vieira, Mario C, Canani, Roberto Berni, Dupont, Christophe, Uysal, Pinar, Cavkaytar, Ozlem, Knibb, Rebecca, Fleischer, David M, Nowak-Wegrzyn, Anna, and Venter, Carina
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Nutrition and Dietetics ,Child, preschool ,Turkey ,extensively hydrolysed formula ,Immunology ,cow milk allergy ,Infant ,gastroenterology ,Europe ,amino acid formula ,Gastroesophageal Reflux/diagnosis ,Food Hypersensitivity/diagnosis ,non-IgE mediated food allergy ,Pediatrics, Perinatology and Child Health ,Gastroesophageal Reflux ,Humans ,Immunology and Allergy ,Pediatrics, Perinatology, and Child Health ,Child ,Food Hypersensitivity ,Brazil ,Human - Abstract
Gastro-oesophageal reflux (GOR) and food allergy (FA) are common conditions, especially during the first 12 months of life. When GOR leads to troublesome symptoms, that affect the daily functioning of the infant and family, it is referred to as GOR disease (GORD). The role of food allergens as a cause of GORD remains controversial. This European Academy of Allergy and Clinical Immunology (EAACI) position paper aims to review the evidence for FA-associated GORD in young children and translate this into clinical practice that guides healthcare professionals through the diagnosis of suspected FA-associated GORD and medical and dietary management. The task force (TF) on non-IgE mediated allergy consists of EAACI experts in paediatric gastroenterology, allergy, dietetics and psychology from Europe, United Kingdom, United States, Turkey and Brazil. Six clinical questions were formulated, amended and approved by the TF to guide this publication. A systematic literature search using PubMed, Cochrane and EMBASE databases (until June 2021) using predefined inclusion criteria based on the 6 questions was used. The TF also gained access to the database from the European Society of Paediatric Gastroenterology and Hepatology working group, who published guidelines on GORD and ensured that all publications used within that position paper were included. For each of the 6 questions, practice points were formulated, followed by a modified Delphi method consisting of anonymous web-based voting that was repeated with modified practice points where required, until at least 80% consensus for each practice point was achieved. This TF position paper shares the process, the discussion and consensus on all practice points on FA-associated GORD.
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- 2022
38. The need for Pan-European automatic pollen and fungal spore monitoring: A stakeholder workshop position paper
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Oliver Pfaar, Bernard Clot, Vladimir Kendrovski, Christophe Jacob, Martin Hicke, Fiona Tummon, Branko Šikoparija, William McCairns, Lucas Alados Arboledas, Benjamin Guinot, Maira Bonini, Vincent-Henri Peuch, Eric Petermann, Michaël Sicard, Laboratoire d'aérologie (LAERO), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, Universitat Politècnica de Catalunya. Departament de Teoria del Senyal i Comunicacions, and Universitat Politècnica de Catalunya. RSLAB - Grup de Recerca en Teledetecció
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Pulmonary and Respiratory Medicine ,High temporal resolution ,medicine.medical_specialty ,Al·lèrgia ,010504 meteorology & atmospheric sciences ,Allergy ,Monitoring ,Immunology ,010501 environmental sciences ,Pollen -- Measurement ,medicine.disease_cause ,01 natural sciences ,end‐user needs ,Stakeholders ,Pollen ,near real‐time ,Fungal spores ,medicine ,Immunology and Allergy ,Environmental planning ,0105 earth and related environmental sciences ,End-user needs ,business.industry ,End user ,Public health ,Research ,Stakeholder ,Pol·len -- Mesurament ,Fongs -- Espores ,RC581-607 ,Enginyeria de la telecomunicació::Processament del senyal [Àrees temàtiques de la UPC] ,Agriculture ,Fungi -- Spores ,Temporal resolution ,[SDE]Environmental Sciences ,Position paper ,Near real-time ,Immunologic diseases. Allergy ,business - Abstract
This paper is a contribution to the EUMETNET AutoPollen Programme, which is developing a prototype automatic pollen monitoring network in Europe covering all aspects of the information chain from measurements through to communicating information to the public., Background: Information about airborne pollen concentrations is required by a range of end users, particularly from the health sector who use both observations and forecasts to diagnose and treat allergic patients. Manual methods are the standard for such measurements but, despite the range of pollen taxa that can be identified, these techniques suffer from a range of drawbacks. This includes being available at low temporal resolution (usually daily averages) and with a delay (usually 3–9 days from the measurement). Recent technological developments have made possible automatic pollen measurements, which are available at high temporal resolution and in real time, although currently only scattered in a few locations across Europe. Materials & Methods: To promote the development of an extensive network across Europe and to ensure that this network will respond to end user needs, a stakeholder workshop was organised under the auspices of the EUMETNET AutoPollen Programme. Participants discussed requirements for the groups they represented, ranging from the need for information at various spatial scales, at high temporal resolution, and for targeted services to be developed. Results: The provision of real-time information is likely to lead to a notable decrease in the direct and indirect health costs associated with allergy in Europe, currently estimated between €50–150 billion/year.. Discussion & Conclusion: A European measurement network to meet end user requirements would thus more than pay for itself in terms of potential annual savings and provide significant impetus to research across a range of disciplines from climate science and public health to agriculture and environmental management.
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- 2021
39. Pathogenesis, immunology, and immune-targeted management of the multisystem inflammatory syndrome in children (MIS-C) or pediatric inflammatory multisystem syndrome (PIMS): EAACI Position Paper
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Feleszko, Wojciech, Okarska‐Napierała, Magdalena, Buddingh, Emilie Pauline, et al, Sokolowska, Milena, and University of Zurich
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10183 Swiss Institute of Allergy and Asthma Research ,Immunology ,Immunology and Allergy ,610 Medicine & health ,Perinatology and Child Health ,Pediatrics - Published
- 2023
- Full Text
- View/download PDF
40. An EAACI position paper on the investigation of perioperative immediate hypersensitivity reactions
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Didier G. Ebo, Ingrid Terreehorst, Susanna Voltolini, Tomaz Garcez, Peter Kopač, Jose Julio Laguna, Paul-Michel Mertes, Pascale Dewachter, Kathrin Scherer, Lene H. Garvey, Anca Mirela Chiriac, Ear, Nose and Throat, and AII - Inflammatory diseases
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0301 basic medicine ,Hypersensitivity, Immediate ,Premedication ,Severity of Illness Index ,antibiotics ,alergija in imunologija -- diagnostika ,opioid analgesics ,0302 clinical medicine ,opioidni analgetiki ,Immunology and Allergy ,opioidi ,Incidence ,Disease Management ,preobčutljivost za zdravila -- diagnostika ,anafilaksija ,Phenotype ,Disease Susceptibility ,medicine.medical_specialty ,udc:616.097:(615.211+615.216.2) ,non-steroidal opioids ,Immunology ,anesthesia ,anti-inflammatory agents ,anestezija ,Diagnosis, Differential ,03 medical and health sciences ,allergy and immunology -- diagnosis ,antibakterijska sredstva ,anti-bacterial agents ,anesthetics ,medicine ,anaphylaxis ,Humans ,anestetiki ,nesteroidna protivnetna sredstva ,Intensive care medicine ,Perioperative Period ,Skin Tests ,drug hypersensitivity -- diagnosis ,Task force ,business.industry ,Diagnostic Tests, Routine ,Perioperative ,Immunoglobulin E ,030104 developmental biology ,030228 respiratory system ,Position paper ,Allergists ,Human medicine ,business ,antibiotiki - Abstract
Perioperative immediate hypersensitivity reactions are rare. Subsequent allergy investigation is complicated by multiple simultaneous drug exposures, the use of drugs with potent effects and the many differential diagnoses to hypersensitivity in the perioperative setting. The approach to the investigation of these complex reactions is not standardized, and it is becoming increasingly apparent that collaboration between experts in the field of allergy/immunology/dermatology and anaesthesiology is needed to provide the best possible care for these patients. The EAACI task force behind this position paper has therefore combined the expertise of allergists, immunologists and anaesthesiologists. The aims of this position paper were to provide recommendations for the investigation of immediate-type perioperative hypersensitivity reactions and to provide practical information that can assist clinicians in planning and carrying out investigations.
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- 2020
41. VALUING RECYCLED WASTE PAPER BY THE DESIGN AND MANAGEMENT OF A BOOK COVER MODEL-YRR.18
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Jenny Ria Rajagukguk
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Microbiology (medical) ,Engineering ,Sales Value ,Design ,Waste management ,business.industry ,Immunology ,Immunology and Allergy ,Waste paper ,Management and Development Cover Book ,business ,Paper Waste Materials ,Book cover - Abstract
Natural materials are increasingly limited, encouraging the use of materials such as waste materials that have not been widely used for building materials or manufacturing products. Waste paper has been used as a material for the book-YRR.18 book cover through management and design approaches. The waste paper materials used are better than those used to produce this book cover: cellulose = 45.80% = pentosan 25.90% and lignin = 22.60%. Therefore, this research aims to provide product design from environmentally friendly materials and analysis of the value of its products in terms of loss-profit, so that it can be a profitable business potential for book producers in Indonesia as well as encourage book producers in Indonesia to being involved in efforts to save the environment. Keywords: Waste Paper Material; Product Value; Design Book Cover Model-YRR. 18. ABSTRAK Bahan-bahan alami yang semakin terbatas, mendorong penggunaan bahan-bahan seperti bahan limbah yang belum banyak dimanfaatkan untuk bahan bangunan atau pembuatan produk. Kertas bekas selama ini digunakan sebagai bahan pembuatan sampul buku Model -YRR.18 melalui pendekatan manajemen dan desain. Bahan limbah kertas yang digunakan lebih baik daripada yang digunakan untuk memproduksi sampul buku ini adalah: selulosa = 45,80% = pentosan 25,90% dan lignin = 22,60%. Oleh karena itu, penelitian ini bertujuan untuk memberikan desain produk dari bahan ramah lingkungan dan analisa nilai produknya dari sisi loss-profit, sehingga dapat menjadi potensi bisnis yang menguntungkan bagi produsen buku di Indonesia sekaligus terlibat dalam upaya penyelamatan lingkungan. Kata kunci : Bahan Limbah Kertas; Nilai Produk; Desain Sampul Buku Model-YRR.18.
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- 2020
42. Diagnosis and management of Non‐IgE gastrointestinal allergies in breastfed infants—An EAACI Position Paper
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Adriana Chebar Lozinsky, Christophe Dupont, George Du Toit, Mario C. Vieira, Rosan Meyer, Piınar Uysal, Ozlem Cavkaytar, Yvan Vandenplas, David Fleischer, Neil Shah, Rebecca Knibb, Carina Venter, Anna Nowak-Wegrzyn, Clinical sciences, Growth and Development, and Pediatrics
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Male ,0301 basic medicine ,Pediatrics ,medicine.medical_specialty ,Allergy ,breastfed children ,Gastrointestinal Diseases ,Immunology ,Breastfeeding ,Immunoglobulin E ,03 medical and health sciences ,0302 clinical medicine ,Allergic proctocolitis ,Food allergy ,Intervention (counseling) ,maternal elimination ,Humans ,Immunology and Allergy ,Medicine ,Medicine(all) ,food allergy ,biology ,business.industry ,Infant, Newborn ,Infant ,Guideline ,medicine.disease ,diagnosis of non-IgE-mediated allergy ,Breast Feeding ,030104 developmental biology ,non-IgE-mediated allergy ,030228 respiratory system ,biology.protein ,Position paper ,Female ,business ,Food Hypersensitivity - Abstract
It is well-established that food proteins, such as egg, soya, cow's milk and wheat, are detectable in breastmilk for many hours or days after ingestion. Exposure to these proteins is important to the process of developing tolerance but can also sometimes elicit IgE-mediated and non-IgE-mediated allergic symptoms in breastfed infants. Non-IgE-mediated allergy, outside of food protein-induced allergic proctocolitis and eosinophilic oesophagitis, is not well understood, leading to variations in the diagnosis and management thereof. A primary objective of the European Academy for Allergy and Clinical Immunology is to support breastfeeding in all infants, including those with food allergies. A Task Force was established, to explore the clinical spectrum of non-IgE-mediated allergies, and part of its objectives was to establish diagnosis and management of non-IgE-mediated allergies in breastfed infants. Eight questions were formulated using the Patient, Intervention, Comparison, Outcome (PICO) system and Scottish Intercollegiate Guideline Network (SIGN) criteria for data inclusion, and consensus was achieved on practice points through the Delphi method. This publication aims to provide a comprehensive overview on this topic with practice points for healthcare professionals.
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- 2019
43. Position paper on the specific allergen immunotherapy. Part 4
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Ewa Cichocka-Jarosz, Marek Jutel, and Maciej Kupczyk
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Allergen immunotherapy ,business.industry ,Immunology ,General Earth and Planetary Sciences ,Medicine ,Position paper ,business ,General Environmental Science - Published
- 2019
44. EULAR 75-year anniversary: commentaries on ARD papers from 50 years ago
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Johannes Bijlsma
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Rheumatology ,Immunology ,Immunology and Allergy ,General Biochemistry, Genetics and Molecular Biology - Published
- 2022
45. A review of hematopoietic stem cell transplantation for autoimmune diseases: multiple sclerosis, systemic sclerosis and Crohn s disease. Position paper of the Brazilian Society of Bone Marrow Transplantation
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Daniela A. Moraes, Morgani Rodrigues, Nelson Hamerschlak, Belinda Pinto Simões, Lilian Piron-Ruiz, Milton Arthur Ruiz, Andreza Alice Feitosa Ribeiro, Juliana Bernardes Elias, and Maria Carolina Oliveira
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Bone marrow transplantation ,medicine.medical_treatment ,Disease ,Hematopoietic stem cell transplantation ,Review Article ,Systemic scleroderma ,Multiple sclerosis ,Diffuse scleroderma ,medicine ,Immunology and Allergy ,Crohn's disease ,business.industry ,lcsh:RC633-647.5 ,Crohn disease ,Hematology ,lcsh:Diseases of the blood and blood-forming organs ,medicine.disease ,DOENÇAS AUTOIMUNES ,surgical procedures, operative ,Immunology ,Position paper ,Stem cell ,business - Abstract
Autoimmune diseases are an important field for the development of bone marrow transplantation, or hematopoietic stem cell transplantation. In Europe alone, almost 3000 procedures have been registered so far. The Brazilian Society for Bone Marrow Transplantation (Sociedade Brasileira de Transplantes de Medula Óssea) organized consensus meetings for the Autoimmune Diseases Group, to review the available literature on hematopoietic stem cell transplantation for autoimmune diseases, aiming to gather data that support the procedure for these patients. Three autoimmune diseases for which there are evidence-based indications for hematopoietic stem cell transplantation are multiple sclerosis, systemic sclerosis and Crohn's disease. The professional stem cell transplant societies in America, Europe and Brazil (Sociedade Brasileira de Transplantes de Medula Óssea) currently consider hematopoietic stem cell transplantation as a therapeutic modality for these three autoimmune diseases. This article reviews the evidence available.
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- 2021
46. An eaaci task force position paper
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Price, Oliver J, Walsted, Emil S, Bonini, Matteo, Brannan, John D, Bougault, Valerie, Carlsen, Kai-Håkon, Couto, Mariana, Kippelen, Pascale, Moreira, Andre, Pite, Helena, Rukhadze, Maia, Hull, James H, Centro de Estudos de Doenças Crónicas (CEDOC), and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
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Allergy ,Physiology ,Immunology ,sport ,Exercise - Abstract
Allergy and respiratory disorders are common in young athletic individuals. In the context of elite sport, it is essential to secure an accurate diagnosis in order to optimise health and performance. It is also important, however, to consider the potential impact or consequences of these disorders, in recreationally active individuals engaging in structured exercise and/or physical activity to maintain health and well-being across the lifespan. This EAACI Task Force was therefore established, to develop an up-to-date, research-informed position paper, detailing the optimal approach to the diagnosis and management of common exercise-related allergic and respiratory conditions. The recommendations are informed by a multidisciplinary panel of experts including allergists, pulmonologists, physiologists, and sports physicians. The report is structured as a concise, practically focussed document, incorporating diagnostic and treatment algorithms, to provide a source of reference to aid clinical decision making. Throughout, we signpost relevant learning resources to consolidate knowledge and understanding and conclude by highlighting future research priorities and unmet needs. publishersversion published
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- 2022
47. In-vivo diagnostic test allergens in Europe: A call to action and proposal for recovery plan--An EAACI position paper
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Hans Jürgen Hoffmann, Matteo Bonini, Victoria Cardona, Markus Ollert, Oliver Pfaar, Pascal Demoly, Peter Schmid-Grendelmeier, Mohamed H. Shamji, Vera Mahler, Helen A. Brough, Peter Hellings, Torsten Zuberbier, Karin Hoffmann-Sommergruber, Sten Dreborg, Carsten B. Schmidt-Weber, Marek Jutel, Stefan Vieths, Oscar Palomares, Ludger Klimek, Ayse Fusun Kalpaklioglu, Sergio Bonini, Andreas Bonertz, Antonella Muraro, Jean Bousquet, Ioana Agache, Todor A. Popov, Ear, Nose and Throat, KKÜ, University of Zurich, and Klimek, Ludger
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0301 basic medicine ,Allergy ,IMPACT ,CHILDREN ,allergen provocation test ,Settore MED/10 - MALATTIE DELL'APPARATO RESPIRATORIO ,GUIDELINES ,0302 clinical medicine ,immune system diseases ,European Pharmacopoeia ,Immunology and Allergy ,Reimbursement ,10177 Dermatology Clinic ,Diagnostic test ,respiratory system ,marketing authorization ,regulatory framework ,skin prick test ,skin test allergens ,Call to action ,Europe ,DISEASES ,Action plan ,2723 Immunology and Allergy ,Skin prick test ,Skin test allergens ,allergen challenge test ,reimbursement ,Medical emergency ,Life Sciences & Biomedicine ,Immunology ,Allergen Provocation Test ,Marketing Authorization ,Regulatory Framework ,Skin Prick Test ,Skin Test Allergens ,610 Medicine & health ,Marketing authorization ,LEGISLATION ,03 medical and health sciences ,Pharmacovigilance ,Hypersensitivity ,medicine ,Humans ,IMMUNOTHERAPY ,PROVOCATION ,Skin Tests ,2403 Immunology ,Science & Technology ,Diagnostic Tests, Routine ,AVAILABILITY ,Allergens ,medicine.disease ,respiratory tract diseases ,030104 developmental biology ,030228 respiratory system ,Position paper ,Allergists ,Business - Abstract
Bonertz, Andreas/0000-0002-6846-9265; Brough, Helen/0000-0001-7203-0813; Hoffmann, Hans Jurgen/0000-0002-6743-7931; Hoffmann-Sommergruber, Karin/0000-0002-8830-058X; Schmid-Grendelmeier, Peter/0000-0003-3215-3370 WOS:000569864500002 PubMed: 32306414 Diagnostic allergens are defined as medicinal products in the EU. Marketing authorization by national authorities is necessary; however, diagnostic allergens are not homogeneously regulated in different EU member states. Allergen manufacturers argue with increasing costs forcing them to continuously reduce the diagnostic allergen portfolios offered to allergists. In contrast, EAACI and national European Allergy Societies see the need for the availability of a wide range of high-quality diagnostic allergens for in vivo diagnosis of IgE-mediated allergies not only covering predominant but also less frequent allergen sources. In a recent EAACI task force survey, the current practice of allergy diagnosis was shown to rely on skin tests as first option in almost 2/3 of all types of allergic diseases and in 90% regarding respiratory allergies. With the need to ensure the availability of high-quality diagnostic allergens in the EU, an action plan has been set up by EAACI to analyse the current regulatory demands in EU member states and to define possible solutions stated in this document: (a) simplification of authorization for diagnostic allergens; (b) specific regulation of special types of diagnostic allergens; (c) new models beyond the current model of homologous groups; (d) simplification of pharmacovigilance reporting; (e) reduction of regulation fees for diagnostic allergens; (f) reimbursement for diagnostic allergens. Joining forces of allergists, manufacturers and authorities are of high importance to ensure remaining relevant allergens in the EU markets to facilitate a sustainable and comprehensive service for the diagnosis and treatment of allergic diseases.
- Published
- 2020
48. Value of implementation science and hybrid implementation research designs for nursing education research: A discussion paper
- Author
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Ahtisham Younas
- Subjects
Microbiology (medical) ,Immunology ,Immunology and Allergy - Published
- 2023
49. White paper on microbial anti-cancer therapy and prevention
- Author
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Ke Liu, Steve H. Thorne, Daniel A. Saltzman, Peter Tattersall, Grant McFadden, Liang Deng, Balveen Kaur, Laura Evgin, Steve Fiering, Richard G. Vile, Sheryl Ruppel, Herbert Kim Lyerly, Robert M. Hoffman, James L. Gulley, Robert Coffin, Matthew Giacalone, Claudia Gravekamp, Ariel E. Marciscano, Halle Huihong Zhang, Neil S. Forbes, Eddie Moradian, Shibin Zhou, and Hal Gunn
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0301 basic medicine ,Cancer Research ,medicine.medical_specialty ,Genetic Vectors ,Immunology ,Treatment outcome ,Drug Evaluation, Preclinical ,Cancer therapy ,Cancer Vaccines ,lcsh:RC254-282 ,03 medical and health sciences ,0302 clinical medicine ,White paper ,Neoplasms ,medicine ,Animals ,Humans ,Immunology and Allergy ,Combined Modality Therapy ,Viral therapy ,Intensive care medicine ,Oncolytic Virotherapy ,Pharmacology ,Immune Stimulation ,Bacteria ,business.industry ,Clinical Studies as Topic ,Neoplasms therapy ,Cancer ,medicine.disease ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Biological Therapy ,Treatment Outcome ,030104 developmental biology ,Oncology ,030220 oncology & carcinogenesis ,Viruses ,Molecular Medicine ,Genetic Engineering ,business ,Research Article - Abstract
In this White Paper, we discuss the current state of microbial cancer therapy. This paper resulted from a meeting (‘Microbial Based Cancer Therapy’) at the US National Cancer Institute in the summer of 2017. Here, we define ‘Microbial Therapy’ to include both oncolytic viral therapy and bacterial anticancer therapy. Both of these fields exploit tumor-specific infectious microbes to treat cancer, have similar mechanisms of action, and are facing similar challenges to commercialization. We designed this paper to nucleate this growing field of microbial therapeutics and increase interactions between researchers in it and related fields. The authors of this paper include many primary researchers in this field. In this paper, we discuss the potential, status and opportunities for microbial therapy as well as strategies attempted to date and important questions that need to be addressed. The main areas that we think will have the greatest impact are immune stimulation, control of efficacy, control of delivery, and safety. There is much excitement about the potential of this field to treat currently intractable cancer. Much of the potential exists because these therapies utilize unique mechanisms of action, difficult to achieve with other biological or small molecule drugs. By better understanding and controlling these mechanisms, we will create new therapies that will become integral components of cancer care.
- Published
- 2018
50. A simple and low-cost portable paper-based ABO blood typing device for point-of-care testing
- Author
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Suntree Kulkeratiyut, Witsanuwat Khumchanta, Temsiri Songjaroen, Vitsarut Primpray, Thawintra Manosarn, Wanida Laiwattanapaisal, and Tasanee Sakuldamrongpanich
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Paper ,medicine.medical_specialty ,Materials science ,Hemagglutination ,Sample (material) ,Point-of-care testing ,Clinical Biochemistry ,Immunology ,02 engineering and technology ,01 natural sciences ,ABO Blood-Group System ,ABO blood group system ,medicine ,Humans ,Immunology and Allergy ,Whole blood ,Blood type ,Chromatography ,Elution ,010401 analytical chemistry ,Transfusion medicine ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,Medical Laboratory Technology ,Point-of-Care Testing ,0210 nano-technology - Abstract
ABO blood group is the most important blood type system for transfusion medicine. A paper-based analytical device (PAD) for ABO blood typing has been proposed. The device was composed of Whatman No. 113 paper, an absorbent gel pad, and a 3D-printing cassette. The 3D-printing cassette contained two circular holes for display of letters “A” and “B” on the PAD. Whole blood was dropped onto hydrophilic letters A and B on the PAD, in which the anti-A and anti-B were pre-immobilized, respectively. An absorbent gel pad was used to adsorb excess blood sample and washing solution during the washing step. The particle size of agglutinated red blood cells (RBCs) could not be eluted out of the paper by the elution solution. In contrast, non-agglutinated RBCs were washed out by means of elution solution. The devices could be used for real blood samples in a wide range of hematocrit levels, 21–59%. Unknown blood group samples (n = 500) were identified by the developed device and the results were compared with the conventional method, revealing 100% accuracy. Because of its compact size with low-cost fabrication, the portable ABO blood typing device has great potential for point-of-care testing, particularly in developing countries.
- Published
- 2018
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