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Considering the current limitations of intelligent interactive in electronic integration and luminescent modes, this paper proposes a novel fabrication method for pressure-sensing POF fabrics with a non-direct-contact conductive system. In this system, conductive materials are concealed in the fabric structure to avoid direct contact with the human body. It was enabled by integrating layered weave structure, POFs, conductive yarns, and fabric patches within the fabric. Laser engraving was also applied on the fabric surface to achieve intricate pattern design. Experimental tests were conducted on sensing and luminescent properties of this POF fabric. The circuit module and software were developed to support the interactive function. The potential application of this fabric in the interior components of intelligent cockpits was envisioned. The research results show that the POF fabric integrated with conductive yarns and conductive fabric patches has good pressure sensitivity, enabling control of the fabric’s luminescent color by pressing the fabric surface. The non-direct-contact conductive system developed in this study offers the advantage of electrical signal stability by avoiding interference from human body resistance and grounding conditions. The development of this type of interactive luminescent textile holds promising prospects for application and development in various fields, including intelligent cockpits.

Background: With the enormous morbidity and mortality caused by respiratory syncytial virus (RSV) infections among infants and the elderly, vaccines against RSV infections are in large market demand. Methods: We conducted a first-in-human (FIH), randomized, double-blind, placebo-controlled dose escalation study to evaluate the safety and immunogenicity response of the rRSV vaccine (BARS13) in healthy adults aged 18–45. A total of 60 eligible participants were randomly assigned to receive one of four dose levels or vaccination regimens of BARS13 or placebo at a 4:1 ratio. Results: The mean age was 27.40, and 23.3% (14/60) were men. No treatment-emergent adverse events (TEAEs) led to study withdrawal within 30 days after each vaccination. No serious adverse event (SAE) was reported. Most of the treatment-emergent adverse events (TEAEs) recorded were classified as mild. The high-dose repeat group had a serum-specific antibody GMC of 885.74 IU/mL (95% CI: 406.25–1931.17) 30 days after the first dose and 1482.12 IU/mL (706.56–3108.99) 30 days after the second dose, both higher than the GMC in the low-dose repeat group (885.74 IU/mL [406.25–1931.17] and 1187.10 IU/ mL [610.01–2310.13]). Conclusions: BARS13 had a generally good safety and tolerability profile, and no significant difference in terms of adverse reaction severity or frequency was observed between different dose groups. The immune response in repeat-dose recipients shows more potential in further study and has guiding significance for the dose selection of subsequent studies.

Although respiratory syncytial virus (RSV) infection in infants and young children is a global public health issue, development of a safe RSV vaccine has been impeded by formalin-inactivated RSV-enhanced respiratory disease (ERD). In developing a safer yet effective RSV vaccine for children, a strategy to decrease over-reactive T cells and increase neutralizing anti-RSV antibodies should be considered. We previously demonstrated that adult mice immunized with RSV recombinant G protein plus low-dose Cyclosporine A (G+ CsA) could, upon subsequent RSV challenge, produce increased levels of antigen-specific T regulatory cells in lungs that overcame the ERD. Neutralizing anti-RSV antibodies that prevented viral infection were also elicited. In this study, we investigated if such a G+ CsA vaccine could provide infant mice with the same protection from RSV infection without ERD. The results showed that the G+ CsA vaccine could prevent RSV infection with only a mild loss of body weight. Importantly, there was nearly normal morphology and no mucus appearance in lung tissues after RSV challenge. These results demonstrate that the G+ CsA vaccine strategy achieved similar benefits in the neonatal prime and infancy boost model as in the adult mouse model. The G+ CsA immunization strategy is potentially safe and effective in neonates and infants because it suppresses the devastating ERD.

The present study investigates the effect of matrine on colon cancer cell viability and apoptosis and tumor growth in mice xenograft model. The results from MTT assay revealed a concentration and time dependent reduction in viability of HCT8 and HT29 colon cancer cells by matrine. The viability of HCT8 and HT29 cells was reduced to 24.67 and 29.32% on treatment with 4 µM/ml concentration of matrine after 48 h (P

Background: The current study was designed to investigate the effect of crocetin on the proliferation inhibition of colon cancer cells and the underlying mechanism. Methods: MTT assay showed inhibition of proliferation of colon cancer cells in a dose based manner by crocetin treatment. At 30 µM concentration of crocetin proliferation rate of colon cancer cells was reduced to 14% after 24 h. Flow cytometry and fluorescence microscopy revealed induction of apoptosis in colon cancer cells on treatment with crocetin. The tube formation was suppressed significantly in the cultures of HUVEC treated with 30 µM concentration of crocetin compared to the control cultures. Results: The results from transwell assay revealed a significant reduction in the population of DU-145 cells passing through filters of transwell on treatment with crocetin compared to the control cells. Treatment of the DU-145 cells with crocetin caused a significant reduction in the expression levels of NF-κB, VEGF and MMP-9. The results from RT-PCR analysis revealed a significant reduction in the expression of genes involved in inflammation including, HMGB1, IL-6 and IL-8 on treatment of DU-145 cells with crocetin. However, the expression of NAG-1 gene was increased by crocetin treatment in DU-145 cells significantly compared to the control cells. Conclusion: Crocetin inhibits growth of colon cancer cells and prevents tube formation through induction of apoptosis. Therefore, crocetin can be used efficiently for the treatment of colon cancer. Keywords: Migration, Tube, Invasion, Transwell, Inflammation

Coupled Map Lattice (CML) usually serves as a pseudo-random number generator for encrypting digital images. Based on our analysis, the existing CML-based systems still suffer from problems like limited parameter space and local chaotic behavior. In this paper, we propose a novel intermittent jumping CML system based on multiple chaotic maps. The intermittent jumping mechanism seeks to incorporate the multi-chaos, and to dynamically switch coupling states and coupling relations, varying with spatiotemporal indices. Extensive numerical simulations and comparative studies demonstrate that, compared with the existing CML-based systems, the proposed system has a larger parameter space, better chaotic behavior, and comparable computational complexity. These results highlight the potential of our proposal for deployment into an image cryptosystem.

Based on orthogonal Latin cubes, an image cryptosystem with confusion–diffusion–confusion cipher architecture has been proposed recently (Inf. Sci.2019, 478, 1–14). However, we find that there are four fatal vulnerabilities in this image cryptosystem, which leave open doors for cryptanalysis. In this paper, we propose a reference-validation inference algorithm and design screening-based rules to efficiently break the image cryptosystem. Compared with an existing cryptanalysis algorithm, the proposed method requires fewer pairs of chosen plain-cipher images, and behaves stably since different keys, positions of chosen bits and contents of plain images will not affect the cryptanalysis performance. Experimental results show that our cryptanalysis algorithm only requires 8×H×W3+3 pairs of chosen plain-cipher images, where H×W represents the image’s resolution. Comparative studies demonstrate effectiveness and superiority of the proposed cryptanalysis algorithm.

Recompression supercritical carbon dioxide (SCO2) Brayton Cycle for the Chinese Initiative Accelerator Driven System (CiADS) is taken into account, and flexible thermodynamic modeling method is presented. The influences of the key parameters on thermodynamic properties of SCO2 Brayton Cycle are discussed and the comparative analyses on genetic algorithm and pattern search algorithm are conducted. It is shown that the cycle parameters such as turbine inlet temperature, pressure ratio, outlet temperature at the hot end of condenser, and terminal temperature difference of regenerator 1 and regenerator 2 have significant effects on the cycle thermal efficiency. The calculation results indicate that pattern search algorithm has better optimization performance and quicker calculating speed than genetic algorithm. The result of optimization of the parameters for CiADS with supercritical carbon dioxide Brayton Cycle is 35.97%. Compared with other nuclear power plants of SCO2 Brayton Cycle, CiADS with SCO2 Brayton Cycle does not have the best thermal efficiency, but the thermal efficiency can be improved with the reactor outlet temperature increases.

Mega electronvolt ion implantation and subsequent annealing were used to reduce crystalline disorders in molecular beam epitaxy GaAs films on Si. Results show that the success of the recrystallization process relies on the proper selection of the ion beam dose and energy. Further experimentation showed that complete recrystallization with improved quality is possible through proper implantation and subsequent annealing. The improved layers displayed defect densities that were lower than the amorphous-grown layers, particularly near the interface.

Presents information on a study which described a method for the analysis of concentration ratios of nitrogen and silicon, and oxygen and silicon in silicon nitride and oxide layers on silicon substrate using proton elastic backscattering. Methods; Results; Discussion.

The frequent occurrence of electrical fire is harmful to human's lives and property. Arc fault is an important reason for the cause of electric fire, comprehensive and effective detection of fault arc is the content of this paper. In the comparisons, the current signal is used for the detection physical parameter and the wavelet transform is used to study the arc fault detection. First constructed the wavelet function, then carried out the arc fault's wavelet singularity detection, finally analyzed the current signal by the method of wavelet approximation. [ABSTRACT FROM AUTHOR]

Respiratory syncytial virus (RSV) infection can cause severe disease in the lower respiratory tract of infants and older people. Vaccination with a formalin-inactivated RSV vaccine (FI-RSV) and subsequent RSV infection has led to mild to severe pneumonia with two deaths among vaccinees. The vaccine-enhanced disease (VED) was recently demonstrated to be due to an elevated level of Th2 cell responses following loss of regulatory T (Treg) cells from the lungs. To induce high levels of neutralizing Abs and minimize Pathogenic T cell responses, we developed a novel strategy of immunizing animals with a recombinant RSV G protein together with cyclosporine A. This novel vaccine induced not only a higher level of neutralizing Abs against RSV infection, but, most importantly, also significantly higher levels of Treg cells that suppressed VED in the lung after RSV infection. The induced responses provided protection against RSV challenge with no sign of pneumonia or bronchitis. Treg cell production of IL-10 was one of the key factors to suppress VED. These finding indicate that G protein plus cyclosporine A could be a promising vaccine against RSV infection in children and older people. [ABSTRACT FROM AUTHOR]