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1. Precision studies of QCD in the low energy domain of the EIC

Author

Burkert, V.D., Elouadrhiri, L., Afanasev, A., Arrington, J., Contalbrigo, M., Cosyn, W., Deshpande, A., Glazier, D.I., Ji, X., Liuti, S., Oh, Y., Richards, D., Satogata, T., Vossen, A., Abdolmaleki, H., Albataineh, A., Aidala, C.A., Alexandrou, C., Avagyan, H., Bacchetta, A., Baker, M., Benmokhtar, F., Bernauer, J.C., Bissolotti, C., Briscoe, W., Byers, D., Cao, Xu, Carlson, C.E., Cichy, K., Cloet, I.C., Cocuzza, C., Cole, P.L., Constantinou, M., Courtoy, A., Dahiyah, H., Dehmelt, K., Diehl, S., Dilks, C., Djalali, C., Dupré, R., Dusa, S.C., El-Bennich, B., El Fassi, L., Frederico, T., Freese, A., Gamage, B.R., Gamberg, L., Ghoshal, R.R., Girod, F.X., Goncalves, V.P., Gotra, Y., Guo, F.K., Guo, X., Hattawy, M., Hatta, Y., Hayward, T., Hen, O., Huber, G.M., Hyde, C., Isupov, E.L., Jacak, B., Jacobs, W., Jentsch, A., Ji, C.R., Joosten, S., Kalantarians, N., Kang, Z., Kim, A., Klein, S., Kriesten, B., Kumano, S., Kumar, A., Kumericki, K., Kuchera, M., Lai, W.K., Li, Jin, Li, Shujie, Li, W., Li, X., Lin, H.-W., Liu, K.F., Liu, Xiaohui, Markowitz, P., Mathieu, V., McEneaney, M., Mekki, A., de Melo, J.P.B.C., Meziani, Z.E., Milner, R., Mkrtchyan, H., Mochalov, V., Mokeev, V., Morozov, V., Moutarde, H., Murray, M., Mtingwa, S., Nadel-Turonski, P., Okorokov, V.A., Onyie, E., Pappalardo, L.L., Papandreou, Z., Pecar, C., Pilloni, A., Pire, B., Polys, N., Prokudin, A., Przybycien, M., Qiu, J.-W., Radici, M., Reed, R., Ringer, F., Roy, B.J., Sato, N., Schäfer, A., Schmookler, B., Schnell, G., Schweitzer, P., Seidl, R., Semenov-Tian-Shansky, K.M., Serna, F., Shaban, F., Shabestari, M.H., Shiells, K., Signori, A., Spiesberger, H., Strakovsky, I., Sufian, R.S., Szczepaniak, A., Teodorescu, L., Terry, J., Teryaev, O., Tessarotto, F., Timmer, C., Tawfik, Abdel Nasser, Cazares, L. Valenzuela, Vladimirov, A., Voutier, E., Watts, D., Wilson, D., Winney, D., Xiao, B., Ye, Z., Ye, Zh., Yuan, F., Zachariou, N., Zahed, I., Zhang, J.L., Zhang, Y., and Zhou, J.

Published
2023
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2. Science Requirements and Detector Concepts for the Electron-Ion Collider

Author

Abdul Khalek, R., Accardi, A., Adam, J., Adamiak, D., Akers, W., Albaladejo, M., Al-bataineh, A., Alexeev, M. G., Ameli, F., Antonioli, P., Armesto, N., Armstrong, W. R., Arratia, M., Arrington, J., Asaturyan, A., Asai, M., Aschenauer, E. C., Aune, S., Avagyan, H., Ayerbe Gayoso, C., Azmoun, B., Bacchetta, A., Baker, M. D., Barbosa, F., Barion, L., Barish, K. N., Barry, P. C., Battaglieri, M., Bazilevsky, A., Behera, N. K., Benmokhtar, F., Berdnikov, V. V., Bernauer, J. C., Bertone, V., Bhattacharya, S., Bissolotti, C., Boer, D., Boglione, M., Bondì, M., Boora, P., Borsa, I., Bossù, F., Bozzi, G., Brandenburg, J. D., Brei, N., Bressan, A., Brooks, W. K., Bufalino, S., Bukhari, M. H. S., Burkert, V., Buttimore, N. H., Camsonne, A., Celentano, A., Celiberto, F. G., Chang, W., Chatterjee, C., Chen, K., Chetry, T., Chiarusi, T., Chien, Y. -T., Chiosso, M., Chu, X., Chudakov, E., Cicala, G., Cisbani, E., Cloet, I. C., Cocuzza, C., Cole, P. L., Colella, D., Collins, J. L., Constantinou, M., Contalbrigo, M., Contin, G., Corliss, R., Cosyn, W., Courtoy, A., Crafts, J., Cruz-Torres, R., Cuevas, R. C., D'Alesio, U., Dalla Torre, S., Das, D., Dasgupta, S. S., Da Silva, C., Deconinck, W., Defurne, M., Degraw, W., Dehmelt, K., Del Dotto, A., Delcarro, F., Deshpande, A., Detmold, W., De Vita, R., Diefenthaler, M., Dilks, C., Dixit, D. U., Dulat, S., Dumitru, A., Dupré, R., Durham, J. M., Echevarria, M. G., El Fassi, L., Elia, D., Ent, R., Esha, R., Ethier, J. J., Evdokimov, O., Eyser, K. O., Fanelli, C., Fatemi, R., Fazio, S., Fernandez-Ramirez, C., Finger, M., Fitzgerald, D., Flore, C., Frederico, T., Friščić, I., Fucini, S., Furletov, S., Furletova, Y., Gal, C., Gamberg, L., Gao, H., Garg, P., Gaskell, D., Gates, K., Gay Ducati, M. B., Gericke, M., Gil Da Silveira, G., Girod, F. -X., Glazier, D. I., Gnanvo, K., Goncalves, V. P., Gonella, L., Gonzalez Hernandez, J. O., Goto, Y., Grancagnolo, F., Greiner, L. C., Guryn, W., Guzey, V., Hatta, Y., Hattawy, M., Hauenstein, F., He, X., Hemmick, T. K., Hen, O., Heyes, G., Higinbotham, D. W., Hiller Blin, A. N., Hobbs, T. J., Hohlmann, M., Horn, T., Hou, T. -J., Huang, J., Huang, Q., Huber, G. M., Hyde, C. E., Iakovidis, G., Ilieva, Y., Jacak, B. V., Jacobs, P. M., Jadhav, M., Janoska, Z., Jentsch, A., Jezo, T., Jing, X., Jones, P. G., Joo, K., Joosten, S., Kafka, V., Kalantarians, N., Kalicy, G., Kang, D., Kang, Z. B., Kauder, K., Kay, S. J. D., Keppel, C. E., Kim, J., Kiselev, A., Klasen, M., Klein, S., Klest, H. T., Korchak, O., Kostina, A., Kotko, P., Kovchegov, Y. V., Krelina, M., Kuleshov, S., Kumano, S., Kumar, K. S., Kumar, R., Kumar, L., Kumerički, K., Kusina, A., Kutak, K., Lai, Y. S., Lalwani, K., Lappi, T., Lauret, J., Lavinsky, M., Lawrence, D., Lednicky, D., Lee, C., Lee, K., Lee, S. H., Levorato, S., Li, H., Li, S., Li, W., Li, X., W. B., Li, Ligonzo, T., Liu, H., Liu, M. X., Liu, X., Liuti, S., Liyanage, N., Lorcé, C., Lu, Z., Lucero, G., Lukow, N. S., Lunghi, E., Majka, R., Makris, Y., Mandjavidze, I., Mantry, S., Mäntysaari, H., Marhauser, F., Markowitz, P., Marsicano, L., Mastroserio, A., Mathieu, V., Mehtar-Tani, Y., Melnitchouk, W., Mendez, L., Metz, A., Meziani, Z. -E., Mezrag, C., Mihovilovič, M., Milner, R., Mirazita, M., Mkrtchyan, H., Mkrtchyan, A., Mochalov, V., Moiseev, V., Mondal, M. M., Morreale, A., Morrison, D., Motyka, L., Moutarde, H., Muñoz Camacho, C., Murgia, F., Murray, M. J., Musico, P., Nadel-Turonski, P., Nadolsky, P. M., Nam, J., Newman, P. R., Neyret, D., Nguyen, D., Nocera, E. R., Noferini, F., Noto, F., Nunes, A. S., Okorokov, V. A., Olness, F., Osborn, J. D., Page, B. S., Park, S., Parker, A., Paschke, K., Pasquini, B., Paukkunen, H., Paul, S., Pecar, C., Pegg, I. L., Pellegrino, C., Peng, C., Pentchev, L., Perrino, R., Petriello, F., Petti, R., Pilloni, A., Pinkenburg, C., Pire, B., Pisano, C., Pitonyak, D., Poblaguev, A. A., Polakovic, T., Posik, M., Potekhin, M., Preghenella, R., Preins, S., Prokudin, A., Pujahari, P., Purschke, M. L., Pybus, J. R., Radici, M., Rajput-Ghoshal, R., Reimer, P. E., Rinaldi, M., Ringer, F., Roberts, C. D., Rodini, S., Rojo, J., Romanov, D., Rossi, P., Santopinto, E., Sarsour, M., Sassot, R., Sato, N., Schenke, B., Schmidke, W. B., Schmidt, I., Schmidt, A., Schmookler, B., Schnell, G., Schweitzer, P., Schwiening, J., Scimemi, I., Scopetta, S., Segovia, J., Seidl, R., Sekula, S., Semenov-Tian-Shanskiy, K., Shao, D. Y., Sherrill, N., Sichtermann, E., Siddikov, M., Signori, A., Singh, B. K., Širca, S., Slifer, K., Slominski, W., Sokhan, D., Sondheim, W. E., Song, Y., Soto, O., Spiesberger, H., Stasto, A. M., Stepanov, P., Sterman, G., Stevens, J. R., Stewart, I. W., Strakovsky, I., Strikman, M., Sturm, M., Stutzman, M. L., Sullivan, M., Surrow, B., Svihra, P., Syritsyn, S., Szczepaniak, A., Sznajder, P., Szumila-Vance, H., Szymanowski, L., Tadepalli, A. S., Tapia Takaki, J. D., Tassielli, G. F., Terry, J., Tessarotto, F., Tezgin, K., Tomasek, L., Torales Acosta, F., Tribedy, P., Tricoli, A., Triloki, Null, Tripathi, S., Trotta, R. L., Tsai, O. D., Tu, Z., Tuvè, C., Ullrich, T., Ungaro, M., Urciuoli, G. M., Valentini, A., Vancura, P., Vandenbroucke, M., Van Hulse, C., Varner, G., Venugopalan, R., Vitev, I., Vladimirov, A., Volpe, G., Vossen, A., Voutier, E., Wagner, J., Wallon, S., Wang, H., Wang, Q., Wang, X., Wei, S. Y., Weiss, C., Wenaus, T., Wennlöf, H., Wickramaarachchi, N., Wikramanayake, A., Winney, D., Wong, C. P., Woody, C., Xia, L., Xiao, B. W., Xie, J., Xing, H., Q. H., Xu, Zhang, J., Zhang, S., Zhang, Z., Zhao, Z. W., Zhao, Y. X., Zheng, L., Zhou, Y., Zurita, P., Abdul Khalek, R., Accardi, A., Adam, J., Adamiak, D., Akers, W., Albaladejo, M., Al-bataineh, A., Alexeev, M. G., Ameli, F., Antonioli, P., Armesto, N., Armstrong, W. R., Arratia, M., Arrington, J., Asaturyan, A., Asai, M., Aschenauer, E. C., Aune, S., Avagyan, H., Ayerbe Gayoso, C., Azmoun, B., Bacchetta, A., Baker, M. D., Barbosa, F., Barion, L., Barish, K. N., Barry, P. C., Battaglieri, M., Bazilevsky, A., Behera, N. K., Benmokhtar, F., Berdnikov, V. V., Bernauer, J. C., Bertone, V., Bhattacharya, S., Bissolotti, C., Boer, D., Boglione, M., Bondì, M., Boora, P., Borsa, I., Bossù, F., Bozzi, G., Brandenburg, J. D., Brei, N., Bressan, A., Brooks, W. K., Bufalino, S., Bukhari, M. H. S., Burkert, V., Buttimore, N. H., Camsonne, A., Celentano, A., Celiberto, F. G., Chang, W., Chatterjee, C., Chen, K., Chetry, T., Chiarusi, T., Chien, Y. -T., Chiosso, M., Chu, X., Chudakov, E., Cicala, G., Cisbani, E., Cloet, I. C., Cocuzza, C., Cole, P. L., Colella, D., Collins, J. L., Constantinou, M., Contalbrigo, M., Contin, G., Corliss, R., Cosyn, W., Courtoy, A., Crafts, J., Cruz-Torres, R., Cuevas, R. C., D'Alesio, U., Dalla Torre, S., Das, D., Dasgupta, S. S., Da Silva, C., Deconinck, W., Defurne, M., Degraw, W., Dehmelt, K., Del Dotto, A., Delcarro, F., Deshpande, A., Detmold, W., De Vita, R., Diefenthaler, M., Dilks, C., Dixit, D. U., Dulat, S., Dumitru, A., Dupré, R., Durham, J. M., Echevarria, M. G., El Fassi, L., Elia, D., Ent, R., Esha, R., Ethier, J. J., Evdokimov, O., Eyser, K. O., Fanelli, C., Fatemi, R., Fazio, S., Fernandez-Ramirez, C., Finger, M., Fitzgerald, D., Flore, C., Frederico, T., Friščić, I., Fucini, S., Furletov, S., Furletova, Y., Gal, C., Gamberg, L., Gao, H., Garg, P., Gaskell, D., Gates, K., Gay Ducati, M. B., Gericke, M., Gil Da Silveira, G., Girod, F. -X., Glazier, D. I., Gnanvo, K., Goncalves, V. P., Gonella, L., Gonzalez Hernandez, J. O., Goto, Y., Grancagnolo, F., Greiner, L. C., Guryn, W., Guzey, V., Hatta, Y., Hattawy, M., Hauenstein, F., He, X., Hemmick, T. K., Hen, O., Heyes, G., Higinbotham, D. W., Hiller Blin, A. N., Hobbs, T. J., Hohlmann, M., Horn, T., Hou, T. -J., Huang, J., Huang, Q., Huber, G. M., Hyde, C. E., Iakovidis, G., Ilieva, Y., Jacak, B. V., Jacobs, P. M., Jadhav, M., Janoska, Z., Jentsch, A., Jezo, T., Jing, X., Jones, P. G., Joo, K., Joosten, S., Kafka, V., Kalantarians, N., Kalicy, G., Kang, D., Kang, Z. B., Kauder, K., Kay, S. J. D., Keppel, C. E., Kim, J., Kiselev, A., Klasen, M., Klein, S., Klest, H. T., Korchak, O., Kostina, A., Kotko, P., Kovchegov, Y. V., Krelina, M., Kuleshov, S., Kumano, S., Kumar, K. S., Kumar, R., Kumar, L., Kumerički, K., Kusina, A., Kutak, K., Lai, Y. S., Lalwani, K., Lappi, T., Lauret, J., Lavinsky, M., Lawrence, D., Lednicky, D., Lee, C., Lee, K., Lee, S. H., Levorato, S., Li, H., Li, S., Li, W., Li, X., Li, W. B., Ligonzo, T., Liu, H., Liu, M. X., Liu, X., Liuti, S., Liyanage, N., Lorcé, C., Lu, Z., Lucero, G., Lukow, N. S., Lunghi, E., Majka, R., Makris, Y., Mandjavidze, I., Mantry, S., Mäntysaari, H., Marhauser, F., Markowitz, P., Marsicano, L., Mastroserio, A., Mathieu, V., Mehtar-Tani, Y., Melnitchouk, W., Mendez, L., Metz, A., Meziani, Z. -E., Mezrag, C., Mihovilovič, M., Milner, R., Mirazita, M., Mkrtchyan, H., Mkrtchyan, A., Mochalov, V., Moiseev, V., Mondal, M. M., Morreale, A., Morrison, D., Motyka, L., Moutarde, H., Muñoz Camacho, C., Murgia, F., Murray, M. J., Musico, P., Nadel-Turonski, P., Nadolsky, P. M., Nam, J., Newman, P. R., Neyret, D., Nguyen, D., Nocera, E. R., Noferini, F., Noto, F., Nunes, A. S., Okorokov, V. A., Olness, F., Osborn, J. D., Page, B. S., Park, S., Parker, A., Paschke, K., Pasquini, B., Paukkunen, H., Paul, S., Pecar, C., Pegg, I. L., Pellegrino, C., Peng, C., Pentchev, L., Perrino, R., Petriello, F., Petti, R., Pilloni, A., Pinkenburg, C., Pire, B., Pisano, C., Pitonyak, D., Poblaguev, A. A., Polakovic, T., Posik, M., Potekhin, M., Preghenella, R., Preins, S., Prokudin, A., Pujahari, P., Purschke, M. L., Pybus, J. R., Radici, M., Rajput-Ghoshal, R., Reimer, P. E., Rinaldi, M., Ringer, F., Roberts, C. D., Rodini, S., Rojo, J., Romanov, D., Rossi, P., Santopinto, E., Sarsour, M., Sassot, R., Sato, N., Schenke, B., Schmidke, W. B., Schmidt, I., Schmidt, A., Schmookler, B., Schnell, G., Schweitzer, P., Schwiening, J., Scimemi, I., Scopetta, S., Segovia, J., Seidl, R., Sekula, S., Semenov-Tian-Shanskiy, K., Shao, D. Y., Sherrill, N., Sichtermann, E., Siddikov, M., Signori, A., Singh, B. K., Širca, S., Slifer, K., Slominski, W., Sokhan, D., Sondheim, W. E., Song, Y., Soto, O., Spiesberger, H., Stasto, A. M., Stepanov, P., Sterman, G., Stevens, J. R., Stewart, I. W., Strakovsky, I., Strikman, M., Sturm, M., Stutzman, M. L., Sullivan, M., Surrow, B., Svihra, P., Syritsyn, S., Szczepaniak, A., Sznajder, P., Szumila-Vance, H., Szymanowski, L., Tadepalli, A. S., Tapia Takaki, J. D., Tassielli, G. F., Terry, J., Tessarotto, F., Tezgin, K., Tomasek, L., Torales Acosta, F., Tribedy, P., Tricoli, A., Triloki, Null, Tripathi, S., Trotta, R. L., Tsai, O. D., Tu, Z., Tuvè, C., Ullrich, T., Ungaro, M., Urciuoli, G. M., Valentini, A., Vancura, P., Vandenbroucke, M., Van Hulse, C., Varner, G., Venugopalan, R., Vitev, I., Vladimirov, A., Volpe, G., Vossen, A., Voutier, E., Wagner, J., Wallon, S., Wang, H., Wang, Q., Wang, X., Wei, S. Y., Weiss, C., Wenaus, T., Wennlöf, H., Wickramaarachchi, N., Wikramanayake, A., Winney, D., Wong, C. P., Woody, C., Xia, L., Xiao, B. W., Xie, J., Xing, H., Xu, Q. H., Zhang, J., Zhang, S., Zhang, Z., Zhao, Z. W., Zhao, Y. X., Zheng, L., Zhou, Y., and Zurita, P.

Subjects
DIS, Nuclear and High Energy Physics, EIC, Electron-Ion Collider, Detectors, SIDIS
Abstract

This report describes the physics case, the resulting detector requirements, and the evolving detector concepts for the experimental program at the Electron-Ion Col- lider (EIC). The EIC will be a powerful new high-luminosity facility in the United States with the capability to collide high-energy electron beams with high-energy proton and ion beams, providing access to those regions in the nucleon and nu- clei where their structure is dominated by gluons. Moreover, polarized beams in the EIC will give unprecedented access to the spatial and spin structure of the proton, neutron, and light ions. The studies leading to this document were com- missioned and organized by the EIC User Group with the objective of advancing the state and detail of the physics program and developing detector concepts that meet the emerging requirements in preparation for the realization of the EIC. The effort aims to provide the basis for further development of concepts for experimen- tal equipment best suited for the science needs, including the importance of two complementary detectors and interaction regions. This report consists of three volumes. Volume I is an executive summary of our findings and developed concepts. In Volume II we describe studies of a wide range of physics measurements and the emerging requirements on detector acceptance and performance. Volume III discusses general-purpose detector concepts and the underlying technologies to meet the physics requirements. These considerations will form the basis for a world-class experimental program that aims to increase our understanding of the fundamental structure of all visible matter.

Published
2022
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3. NOVEL METHOD OF CARDIAC ACTIVITY EXTRACTION IN L-BAND CW RADARS.

Author

AVAGYAN, H., HAKHOUMIAN, A., HAYRAPETYAN, H., POGHOSYAN, N., and ZAKARYAN, T.

Subjects
*DOPPLER radar, *OSCILLATIONS, *SCANNING antennas, *NATURAL disasters, *TELEMEDICINE
Abstract

Azimuthal scanning of the human body by CW Doppler radar is considered. The method of separation of oscillation activities of various internal organs in the microwave Doppler spectra is proposed. Two possible setups with fixed human body + scanning antennas and fixed antennas + rotating human body have been investigated. [ABSTRACT FROM AUTHOR]

Published
2013

4. PORTABLE NON-CONTACT MICROWAVE DOPPLER RADAR FOR RESPIRATION AND HEARTBEAT SENSING.

Author

Avagyan, H., Hakhoumian, A., Hayrapetyan, H., Pogosyan, N., and Zakaryan, T.

Subjects
*DOPPLER radar, *MICROWAVES, *RESPIRATION, *HEART beat measurement, *MEDICAL physics
Abstract

Microwave L-band Doppler radar has been developed for pulmonic and cardiac activities investigation. Model of reflected signal spectra has been proposed, which is in qualitative agreement with both pulmonic and cardiac spectra. Distance sensitivity and penetration ability of the radar allows to quality it for typical indoor applications, as well as for life signal detection under avalanche. [ABSTRACT FROM AUTHOR]

Published
2012

5. Selective cytotoxicity and modification activity of picornaviruses on transformed cell lines.

Author

Karalyan, Z. A. and Avagyan, H. R.

Subjects
*CELL-mediated cytotoxicity, *PICORNAVIRUSES, *CELL culture, *CYTOCHEMISTRY, *PHENOTYPES, *CELL proliferation
Abstract

Aim. We do analyze of the dynamics of morphometabolic changes in transformed cells (of susceptoible lines) demonstrating resistance to picrnaviral infection. Methods. The study was performed by application of cell culture technology and a complex of cytochemical and cytophotometric assays. Were used picornaviruses from various genu. Results. According to the results obtained, resistant to picornavirus infection cells of different susceptible lines have similar changes in the phenotype. They have decreased number of nucleoli and increased percentage of euploidy (and near euploid). In resistant cells of all cultures the reduction in amount of DNA and RNA both in nucleus and in cytoplasm was found. All these data correlated with the increased euploidy (and near euploid) of the resistant population. All picornavirus resistant cells had a less transformed phenotype, and decreased proliferative activity. Decreased nucleolar status becomes apparent by reduction of all nucleolar indices. Conclusions. Picornaviruses on the susceptible cells produce 2 types of changes - selection and modification. Whatever the mechanism, it is specific for an individual virus, since no restrictions occur in case of infection caused by another picornavirus. [ABSTRACT FROM AUTHOR]

Published
2011
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6. 1alpha,25-dihydroxyvitamin D3 interacts with curcuminoids to stimulate amyloid-beta clearance by macrophages of Alzheimer's disease patients.

Author

Masoumi A, Goldenson B, Ghirmai S, Avagyan H, Zaghi J, Abel K, Zheng X, Espinosa-Jeffrey A, Mahanian M, Liu PT, Hewison M, Mizwickie M, Cashman J, Fiala M, Masoumi, Ava, Goldenson, Ben, Ghirmai, Senait, Avagyan, Hripsime, Zaghi, Justin, and Abel, Ken

Abstract

Patients with Alzheimer's disease (AD) suffer from brain amyloidosis related to defective clearance of amyloid-beta (Abeta) by the innate immune system. To improve the innate immune system of AD patients, we studied immune stimulation of macrophages by 1alpha,25(OH)2-vitamin D3(1,25D3) in combination with curcuminoids. AD patients' macrophages segregate into Type I (positively stimulated by curcuminoids regarding MGAT-III transcription) and Type II (not stimulated). In both Type I and Type II macrophages, 1,25D3 strongly stimulated Abeta phagocytosis and clearance while protecting against apoptosis. Certain synthetic curcuminoids in combination with 1,25D3 had additive effects on phagocytosis in Type I but not Type II macrophages. In addition, we investigated the mechanisms of 1,25D3 and curcuminoids in macrophages. The 1,25D3 genomic antagonist analog MK inhibited 1,25D3 but not curcuminoid effects, suggesting that 1,25D3 acts through the genomic pathway. In silico, 1,25D3 showed preferential binding to the genomic pocket of the vitamin D receptor, whereas bisdemethoxycurcumin showed preference for the non-genomic pocket. 1,25D3 is a promising hormone for AD immunoprophylaxis because in Type I macrophages combined treatment with 1,25D3 and curcuminoids has additive effects, and in Type II macrophages 1,25D3 treatment is effective alone. Human macrophages are a new paradigm for testing immune therapies for AD. [ABSTRACT FROM AUTHOR]

Published
2009
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7. DIPEPTIDYLE PEPTIDASE IV/CD26 AND ADENOSINE DEAMINASE DURING IMMUNE RESPONSE AT RATS.

Author

Harutyunyan, H., Mardanyan, S., Sharoyan, S., Antonyan, A., Movsesyan, A., and Avagyan, H.

Subjects
PEPTIDASE, IMMUNOGLOBULINS, IMMUNE system, IMMUNE response, ADENOSINE deaminase, CELLULAR immunity, PHARMACEUTICAL research
Abstract

The dynamics of Dipeptidyl peptidase IV (DPPIV/CD26), a marker of activated T cells, and of Adenosine deaminase (ADA) during immunity development in rats were studied. Rats were immunized with human red blood cells (HRBC) intraperitoneally. DPPIV and ADA activities, as well as IgG and IgM titers were monitored during 30 days after immunization. We have described the dynamics of the enzymes activities and antibodies appearances. More over some similarities between immunoglobulins and enzymes development during immune response were found. Experimental data let us to suggest the possibility of participation of ADA in Th2 immunity and DPP IV in Th2 and Th1 immunity. [ABSTRACT FROM AUTHOR]

Published
2007

9. Presence and survival of African swine fever virus in leeches.

Author

Karalyan, Z., Avetisyan, A., Avagyan, H., Ghazaryan, H., Vardanyan, T., Manukyan, A., Semerjyan, A., and Voskanyan, H.

Subjects
*AFRICAN swine fever virus, *AFRICAN swine fever, *LEECHES, *ALVEOLAR macrophages
Abstract

• ASFV can spread in the environment and infect pigs via water and food, mostly through ingestion and occasionally through skin contact. • ASFV is able to survive in several environments, notably in water, food and soil. • The aim was to study the ability of leeches to persistently harbor ASFV. • Also leeches excrete the virus, we observed the features of this excretion, as well as the persistence of indefectibility of the excreted viruses. This research is focused on the study of African swine fever virus (ASFV) survival in the leech Hirudo medicinalis. To detect the infection route of the virus in leeches, two introduction methods were used: blood-feeding from infected swine hosts and exposure to ASFV-contaminated water (leeches cultivated with ASFV). This study found that the survival of ASFV in leeches was much longer than that in leech-free medium. The persistent presence of the virus in leeches and leech excretion was detected in both groups. The virus excreted from both groups of leeches in the terminal stages of the experiment was able to induce productive infection in porcine alveolar macrophages. In an attempt to understand ASFV, transmission to pigs was conducted through the ingestion of leech-cultivated water and leeches that had fed on ASFV-infected animals or that were cultivated environmentally with the virus. The ingestion of some samples at 60–80 days after cultivation demonstrated successful ASFV transmission via per os infection. In conclusion, leeches can serve as a possible reservoirs for ASFV in the absence of its main hosts – pigs and some ticks of the genus Ornithodoros. [ABSTRACT FROM AUTHOR]

Published
2019
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10. A multidimensional study of the structure function ratio [formula omitted] from hard exclusive π+ electro-production off protons in the GPD regime.

Author

Diehl, S., Kim, A., Joo, K., Achenbach, P., Akbar, Z., Amaryan, M.J., Atac, H., Avagyan, H., Ayerbe Gayoso, C., Baashen, L., Barion, L., Bashkanov, M., Battaglieri, M., Bedlinskiy, I., Benkel, B., Benmokhtar, F., Bianconi, A., Biselli, A.S., Bondi, M., and Booth, W.A.

Subjects
*PARTICLES (Nuclear physics), *PROTONS, *ELECTRON beams, *PROTON-proton interactions, *RESONANCE, *PHOTONS, *REGGE formalism
Abstract

A multidimensional extraction of the structure function ratio σ L T ′ / σ 0 from the hard exclusive e → p → e ′ n π + reaction above the resonance region has been performed. The study was done based on beam-spin asymmetry measurements using a 10.6 GeV incident electron beam on a liquid-hydrogen target and the CLAS12 spectrometer at Jefferson Lab. The measurements focus on the very forward regime (t / Q 2 ≪ 1) with a wide kinematic range of x B in the valence regime (0.17 < x B < 0.55), and virtualities Q 2 ranging from 1.5 GeV2 up to 6 GeV2. The results and their comparison to theoretical models based on Generalized Parton Distributions demonstrate the sensitivity to chiral-odd GPDs and the directly related tensor charge of the nucleon. In addition, the data is compared to an extension of a Regge formalism at high photon virtualities. It was found that the Regge model provides a better description at low Q 2 , while the GPD model is more appropriate at high Q 2. [ABSTRACT FROM AUTHOR]

Published
2023
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11. Interferon status and white blood cells during infection with African swine fever virus in vivo

Author

Karalyan, Z., Zakaryan, H., Sargsyan, Kh., Voskanyan, H., Arzumanyan, H., Avagyan, H., and Karalova, E.

Subjects
*AFRICAN swine fever virus, *INTERFERONS, *LEUCOCYTES, *ENZYME-linked immunosorbent assay, *MORTALITY, *DNA viruses
Abstract

Abstract: African swine fever virus (ASFV) is the causative agent of African swine fever that is the significant disease of domestic pigs, with high rates of mortality. ASFV is double-stranded DNA virus whose genes encode some proteins that are implicated in the suppression of host immune response. In this study, we have modeled in vivo infection of ASFV for determination of interferon (IFN) status in infected pigs. We measured the level of IFN-α, -β and -γ by enzyme-linked immunosorbent assay and showed that the level of IFN-α sharply decreased during infection. Unlike IFN-α, the level of IFN-β and -γ increased from the 2nd and 4th days post-infection, respectively. Also, we analyzed the population dynamics of peripheral white blood cells of infected pigs due to their important role in host immune system. We showed that the atypical lymphocytes appeared after short time of infection and this result is in accordance with our previous study done in vitro. At the last day of infection about 50% of the total white blood cells were destroyed, and the remaining cells were represented mainly by small-sized lymphocytes, reactive lymphocytes and lymphoblasts. [Copyright &y& Elsevier]

Published
2012
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