122 results on '"Hatters, Danny M."'
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2. Longitudinal spatial mapping of lipid metabolites reveals pre-symptomatic changes in the hippocampi of Huntington's disease transgenic mice
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3. Arginine-rich C9ORF72 ALS proteins stall ribosomes in a manner distinct from a canonical ribosome-associated quality control substrate
4. Sequence grammar underlying the unfolding and phase separation of globular proteins
5. A biosensor of protein foldedness identifies increased “holdase” activity of chaperones in the nucleus following increased cytosolic protein aggregation
6. Protein painting reveals pervasive remodeling of conserved proteostasis machinery in response to pharmacological stimuli
7. Hidden information on protein function in censuses of proteome foldedness
8. Widespread remodeling of proteome solubility in response to different protein homeostasis stresses
9. Arginine in C9ORF72 Dipolypeptides Mediates Promiscuous Proteome Binding and Multiple Modes of Toxicity
10. Protein aggregation in cell biology: An aggregomics perspective of health and disease
11. Modest Declines in Proteome Quality Impair Hematopoietic Stem Cell Self-Renewal
12. Tadpole-like Conformations of Huntingtin Exon 1 Are Characterized by Conformational Heterogeneity that Persists regardless of Polyglutamine Length
13. Transcriptional profiles for distinct aggregation states of mutant Huntingtin exon 1 protein unmask new Huntington's disease pathways
14. Misfolded Polyglutamine, Polyalanine, and Superoxide Dismutase 1 Aggregate via Distinct Pathways in the Cell
15. A Platform to View Huntingtin Exon 1 Aggregation Flux in the Cell Reveals Divergent Influences from Chaperones hsp40 and hsp70
16. The Allosteric Mechanism Induced by Protein Kinase A (PKA) Phosphorylation of Dematin (Band 4.9)
17. AMP-Activated Protein Kinase β-Subunit Requires Internal Motion for Optimal Carbohydrate Binding
18. Sedimentation velocity analysis of amyloid oligomers and fibrils using fluorescence detection
19. Walking the tightrope: proteostasis and neurodegenerative disease
20. Tracking Mutant Huntingtin Aggregation Kinetics in Cells Reveals Three Major Populations That Include an Invariant Oligomer Pool
21. VLDL lipolysis products increase VLDL fluidity and convert apolipoprotein E4 into a more expanded conformation
22. Conformation Sensors that Distinguish Monomeric Proteins from Oligomers in Live Cells
23. Insight on the Molecular Envelope of Lipid-Bound Apolipoprotein E from Electron Paramagnetic Resonance Spectroscopy
24. High-Throughput Quantitation of Intracellular Trafficking and Organelle Disruption by Flow Cytometry
25. Apolipoprotein E structure: insights into function
26. The structural basis for amyloid formation by plasma apolipoproteins: a review
27. A Census of Hsp70-Mediated Proteome Solubility Changes upon Recovery from Heat Stress.
28. Model of Biologically Active Apolipoprotein E Bound to Dipalmitoylphosphatidylcholine
29. Amino-terminal Domain Stability Mediates Apolipoprotein E Aggregation into Neurotoxic Fibrils
30. Cross-linking and amyloid formation by N- and C-terminal cysteine derivatives of human apolipoprotein C-II
31. NMR structure of human apolipoprotein C-II in the presence of sodium dodecyl sulfate
32. Human apolipoprotein C-II forms twisted amyloid ribbons and closed loops
33. Apolipoprotein C-II (sub)39-62 activates lipoprotein lipase by direct lipid-independent binding
34. Modulation of Apolipoprotein E Structure by Domain Interaction: DIFFERENCES IN LIPID-BOUND AND LIPID-FREE FORMS
35. Engineering Conformational Destabilization into Mouse Apolipoprotein E: A MODEL FOR A UNIQUE PROPERTY OF HUMAN APOLIPOPROTEIN E4
36. Fibrillar Amyloid Protein Present in Atheroma Activates CD36 Signal Transduction
37. Suppression of apolipoprotein C-II amyloid formation by the extracellular chaperone, clusterin
38. Sedimentation Velocity Analysis of Flexible Macromolecules: Self-Association and Tangling of Amyloid Fibrils
39. The Circularization of Amyloid Fibrils Formed by Apolipoprotein C-II
40. Phospholipid Complexation and Association with Apolipoprotein C-II: Insights from Mass Spectrometry
41. Apolipoprotein E4 Forms a Molten Globule: A POTENTIAL BASIS FOR ITS ASSOCIATION WITH DISEASE
42. Macromolecular Crowding Accelerates Amyloid Formation by Human Apolipoprotein C-II
43. The Molecular Chaperone, α-Crystallin, Inhibits Amyloid Formation by Apolipoprotein C-II
44. Sub-micellar phospholipid accelerates amyloid formation by apolipoprotein C-II
45. Sedimentation Analysis of Novel DNA Structures Formed by Homo-Oligonucleotides
46. Immiscible inclusion bodies formed by polyglutamine and poly(glycine-alanine) are enriched with distinct proteomes but converge in proteins that are risk factors for disease and involved in protein degradation.
47. Nascent mutant Huntingtin exon 1 chains do not stall on ribosomes during translation but aggregates do recruit machinery involved in ribosome quality control and RNA.
48. Widespread remodeling of proteome solubility in response to different protein homeostasis stresses.
49. A biosensor-based framework to measure latent proteostasis capacity.
50. A thiol probe for measuring unfolded protein load and proteostasis in cells.
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