1. Cotard syndrome in anti-NMDAR encephalitis: two patients and insights from molecular imaging.
- Author
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Ramirez Bermúdez, J, Bustamante-Gomez, P, Espínola-Nadurille, M, Kerik, NE, Dias Meneses, IE, Restrepo-Martinez, M, and Mendez, MF
- Subjects
ENCEPHALITIS ,ANTI-NMDA receptor encephalitis ,OCCIPITAL lobe ,PARIETAL lobe ,CINGULATE cortex ,SYNDROMES - Abstract
Cotard syndrome is a clinical condition defined by the presence of nihilistic delusions. We report two patients with Cotard syndrome in whom anti-NMDAR encephalitis (ANMDARE) was confirmed. Both cases showed features of affective psychosis, developed catatonic syndrome, and worsened after the use of antipsychotics. 18F-FDG PET brain studies showed a bilateral hemispheric pattern of hypometabolism in posterior regions, mainly in the cingulate cortex and in the medial aspects of parietal and occipital lobes. A more severe hypometabolism was observed in the right hemisphere of both patients. Both cases remitted with the use of specific immunotherapy for ANMDARE. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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