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2. List of contributors

Author

Adhikari, Subhamay, primary, Agraharam, Gopikrishna, additional, Ahmadi, Amir Moghadam, additional, Ahmed, Noha A., additional, Ahmed, Osama M., additional, Almoiliqy, Marwan, additional, Arul Jothi, K.N., additional, Asir, A. Billy, additional, Ayoobi, Fatemeh, additional, Bahşi, Mert, additional, Banerjee, Antara, additional, Basalingappa, Kanthesh M., additional, Bhaskaran, Natarajan, additional, Bisgin, Atil, additional, Boga, Ibrahim, additional, Çelenk, Alper, additional, Chauhan, Nishtha, additional, Chawla, Shilpa, additional, Chopra, Tanishqua, additional, Cyril, Rozario, additional, Das, Alakesh, additional, Das, Amitava, additional, Dave, Megha, additional, Devadarshini, P., additional, Devi, Arikketh, additional, Dey, Amit, additional, Dharmarajan, Arun, additional, Dhinekaran, Aishwarya, additional, Di Liddo, Rosa, additional, Ezgin, Neriman, additional, Ghosh, Asit Ranjan, additional, Girigoswami, Agnishwar, additional, Girigoswami, Koyeli, additional, Gobianand, K., additional, Gopenath, T.S., additional, Gottardi, Michele, additional, Govindan, Ramajayam, additional, Graceline, Hepzibah, additional, Harini, Karthick, additional, Hemarangan, J., additional, Iffath, Aainaaz I., additional, Iyshwarya, B.K., additional, Jamali, Zahra, additional, Jayaraman, Selvaraj, additional, Jayasree, R., additional, Kalimuthu, Senthilkumar, additional, Kamath, Gayathri S., additional, Kanagaraj, Palaniyandi, additional, Kandir, Sinan, additional, Kaya, Meltem, additional, Keerthi, N., additional, Krishnamoorthy, Sneha, additional, Kulanthaivel, Langeswaran, additional, Kumaran, K., additional, Kumaran, R. Ileng, additional, Lakshmi, Mallela, additional, Lamloum, Nahed S., additional, Latheef, Fidha, additional, Leemon, Nikhila, additional, Maity, Shreya, additional, Maity, Sukhendu, additional, Marotta, Francesco, additional, Mathangi, Damal Chandrasekar, additional, Mohan, Manju, additional, Mukherjee, Raktim, additional, Muthusami, Sridhar, additional, Mythreyi, R., additional, Natarajan, Pandiyan, additional, Nidhu, A.B., additional, Pandiyan, Radha, additional, Panicker, Sreejith Parameswara, additional, Panneerselvam, Swetha, additional, Pathak, Surajit, additional, Patni, Anjali P., additional, Ponnusamy, Bhuvaneswari, additional, Poomarimuthu, Maheshkumar, additional, Pramanick, Kousik, additional, Rajagopal, Ponnulakshmi, additional, Rajasekaran, P.N., additional, Ramachandran, Ilangovan, additional, Ramachandran, Veerakumar, additional, Ramalingam, Satish, additional, Ramesh Bharadwaj, M.N., additional, Sasikumar, Greeshma, additional, Sharma, Girish, additional, Shriya, P., additional, Sivamani, Ganesan, additional, Sreeshma, Bhuvanadas, additional, Subbaraj, Gowtham Kumar, additional, Sudhakar Bhalerao, Supriya, additional, Thangam, C., additional, Thanikachalam, Puvithra, additional, Tuna, Gamze, additional, Varshini, Murugesan Amirtha, additional, Vasanth Kanth, T.L., additional, Veerabathiran, Ramakrishnan, additional, Veeraraghavan, Vishnupriya, additional, Venkataraman, P., additional, Vijay Murali, R.M., additional, Vinothkumar, G., additional, Yassin, Nour Y.S., additional, Yousefi-Ahmadipour, Aliakbar, additional, Yılmaz, Selda, additional, and Zaky, Mohamed Y., additional

Published
2024
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3. Stem cell aging: role of signaling pathways and microRNAs

Author

Muthusami, Sridhar, primary, Mohan, Manju, additional, Krishnamoorthy, Sneha, additional, Kanagaraj, Palaniyandi, additional, Kumaran, R. Ileng, additional, Dharmarajan, Arun, additional, Ramachandran, Ilangovan, additional, and Bhaskaran, Natarajan, additional

Published
2024
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5. Animal Models of Gynecological Cancers

Author

Venkata, Prabhakar Pitta, Medina, Daisy, Nirzhor, Saif S. R., Sittadjody, Sivanandane, Kumaran, R. Ileng, Ramachandran, Ilangovan, Subbarayalu, Panneerdoss, Pathak, Surajit, editor, Banerjee, Antara, editor, and Bisgin, Atil, editor

Published
2023
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7. Targeting the Metabolism in Cancer Cells for Cancer Therapy

Author

Mohan, Manju, Rafi, Shabana Thabassum Mohammed, Muthusami, Sridhar, Ramalingam, Satish, Sambandam, Yuvaraj, Selvendiran, Karuppaiyah, Ramachandran, Ilangovan, Kumaran, R. Ileng, Robinson, Nirmal, Section editor, Amalinei, Cornelia, Section editor, Das, Amitava, Section editor, Pathak, Surajit, Section editor, Mohanty, Sujata, Section editor, and Chakraborti, Sajal, editor

Published
2022
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8. Reactive Oxygen Species and Cancer Stem Cells: Molecular Interactions and Their Implications in Cancer

Author

Chengizkhan, Gautham, Sukumar, Kavitha, Kunnumakkara, Ajaikumar B., Queimado, Lurdes, Munirajan, Arasambattu Kannan, Bhaskaran, Ravi Sankar, Kumaran, R. Ileng, Ramachandran, Ilangovan, Robinson, Nirmal, Section editor, Amalinei, Cornelia, Section editor, Das, Amitava, Section editor, Pathak, Surajit, Section editor, Mohanty, Sujata, Section editor, and Chakraborti, Sajal, editor

Published
2022
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12. Insights on the Radiation-Induced Adaptive Response at the Cellular Level and Its Implications in Cancer Therapy.

Author

Thathamangalam Ananthanarayanan, Aishwarya, Raavi, Venkateswarlu, Srinivas Kondaveeti, Satish, Ramachandran, Ilangovan, and Perumal, Venkatachalam

Subjects
BACKGROUND radiation, IONIZING radiation, EXPOSURE dose, CANCER treatment, RADIATION protection, RADIATION doses
Abstract

Background: Development of resistance upon exposure to small doses of ionizing radiation followed by higher doses is known as radiation-induced adaptive response (RIAR). Traditionally, the induction of the RIAR phenomenon at the cellular level has been examined in cell lines, animal models, and epidemiological studies where people live in high natural background radiation. Summary: The primary intention of the earlier studies was to corroborate the existence of RIAR and the mechanism involved in mediating the response surveyed by exposure to a low dose of radiation (<500 mGy) as priming dose toward the radiation protection point of view. However, the investigation has shifted the focus to understand the relevance of this phenomenon at clinically relevant set-ups (high doses in the order of Gy) and can be exploited during radiotherapy as RIAR is considered a mechanism for the development of radioresistance. Although the knowledge of molecular mechanisms at the cellular level has evolved significantly in multi-fractionated radiotherapy regimes, its relevance in developing radioresistance at low doses remains elusive. The authors recapitulate the existing knowledge on RIAR at cellular levels, specifically after low-dose exposure as an adaptive dose, and discussed its potential implications in clinical radiotherapy outcomes. Key Messages: Recent studies have contributed to understand the signaling molecules, pathways, and inhibitors to mitigate RIAR-mediated radiation resistance and persistent radio-tolerance at the cellular level. Monitoring the disease progression in tumor samples or liquid biopsies before, during, and after therapy with suitable biomarkers has been proposed as a strategy to translate the phenomena into clinical scenario. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Animal Models of Gynecological Cancers

Author

Venkata, Prabhakar Pitta, primary, Medina, Daisy, additional, Nirzhor, Saif S. R., additional, Sittadjody, Sivanandane, additional, Kumaran, R. Ileng, additional, Ramachandran, Ilangovan, additional, and Subbarayalu, Panneerdoss, additional

Published
2022
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14. Exposure to Secondhand Smoke Extract Increases Cisplatin Resistance in Head and Neck Cancer Cells

Author

Sadhasivam, Balaji, primary, Manyanga, Jimmy, additional, Ganapathy, Vengatesh, additional, Acharya, Pawan, additional, Bouharati, Célia, additional, Chinnaiyan, Mayilvanan, additional, Mehta, Toral, additional, Mathews, Basil, additional, Castles, Samuel, additional, Rubenstein, David A., additional, Tackett, Alayna P., additional, Zhao, Yan D., additional, Ramachandran, Ilangovan, additional, and Queimado, Lurdes, additional

Published
2024
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18. Types of Cancer Stem Cells

Author

Chengizkhan, Gautham, Bisht, Bharti, Muthusami, Sridhar, Anbalagan, Muralidharan, Ramachandran, Ilangovan, Kumaran, R. Ileng, Pathak, Surajit, editor, and Banerjee, Antara, editor

Published
2020
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23. Skeletal muscle cell aging and stem cells

Author

Rafi, Shabana Thabassum Mohammed, primary, Sambandam, Yuvaraj, additional, Sittadjody, Sivanandane, additional, Pathak, Surajit, additional, Ramachandran, Ilangovan, additional, and Kumaran, R. Ileng, additional

Published
2021
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24. Cellular senescence and aging in bone

Author

Mohan, Manju, primary, Muthusami, Sridhar, additional, Selvamurugan, Nagarajan, additional, Narasimhan, Srinivasan, additional, Kumaran, R. Ileng, additional, and Ramachandran, Ilangovan, additional

Published
2021
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25. Contributors

Author

Akila, M., primary, Ali, Aamina, additional, Anbalagan, Muralidharan, additional, Arias, Nataly, additional, Ayala, Antonio, additional, Balakrishnan, Anandan, additional, Balakrishnan, Baskar, additional, Balasubramanian, Sundaravadivel, additional, Banerjee, Antara, additional, Banu, L. Husaina, additional, Barrios, Albert, additional, Bhaskaran, Natarajan, additional, Bhatiya, Meenu, additional, Bhattacharyya, Sinjini, additional, Bisgin, Atil, additional, Bizzaro, Debora, additional, Burra, Patrizia, additional, Catanzaro, Roberto, additional, Chakravarty, Shouvik, additional, Chatterjee, Bhaswati, additional, Das, Alakesh, additional, Das, Sreemanti, additional, Deka, Dikshita, additional, Devaraj, Ezhilarasan, additional, Devi, Arikketh, additional, Elizabeth, K. Roshini, additional, Girigoswami, Agnishwar, additional, Girigoswami, Koyeli, additional, Gopikar, A. Sai Rishika, additional, Grajeda, Yander, additional, He, Fang, additional, Ileng Kumaran, R., additional, Jain, Mayur Vilas, additional, Jangamreddy, Jaganmohan R., additional, Jayaraman, Selvaraj, additional, Joseph, Joel P., additional, Khuda-Bukhsh, Anisur Rahman, additional, Macrin, D., additional, Marotta, Francesco, additional, Metkar, Sanjay Kisan, additional, Mohan, Manju, additional, Muthusami, Sridhar, additional, Narasimhan, Srinivasan, additional, Opara, Emmanuel C., additional, Palaniyandi, Kanagaraj, additional, Pathak, Surajit, additional, Patni, Anjali P., additional, Pavane, M.S., additional, Periyasamy, Vijayalakshmi, additional, Pervin, Shehla, additional, Rafi, Shabana Thabassum Mohammed, additional, Rajagopal, Ponnulakshmi, additional, Rajasingh, Johnson, additional, Rajendran, Vijayalakshmi, additional, Ramachandran, Ilangovan, additional, Ramachandran, Vinu, additional, Ramalingam, Satish, additional, Reddy, Sakamuri V., additional, Russo, Francesco Paolo, additional, Samadder, Asmita, additional, Sambandam, Yuvaraj, additional, Selvamurugan, Nagarajan, additional, Sharma, Sumit, additional, Singh, Rajan, additional, Sittadjody, Sivanandane, additional, Subramanyam, Deepa, additional, Thakur, Suman S., additional, Thangasamy, Thilakavathy, additional, Thathapudi, Neethi Chandra, additional, Tiwari, Mahak, additional, and Yazdani, Azam, additional

Published
2021
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32. Male reproductive toxicity of CrVI: In-utero exposure to CrVI at the critical window of testis differentiation represses the expression of Sertoli cell tight junction proteins and hormone receptors in adult F1 progeny rats

Author

Kumar, Kathiresh M., Aruldhas, Mariajoseph Michael, Banu, Sheerin L., Sadasivam, Balaji, Vengatesh, Ganapathy, Ganesh, Karthik M., Navaneethabalakrishnan, Shobana, Navin, Ajith Kumar, Michael, Felicia Mary, Venkatachalam, Sankar, Stanley, Jone A., Ramachandran, Ilangovan, Banu, Sakhila K., and Akbarsha, Mohammad Abdulkader

Published
2017
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35. List of contributors

Author

Aarthi, V., Abrahamse, Heidi, Adhikary, Subhamay, Agarwal, Sparsh, Ahmed, Osama M., Allahverdi, Amir, Amalinei, Cornelia, Anbalagan, Muralidharan, Asadi, Fatemeh, Ashokkumar, Swetha, Balakrishnan, Anandan, Banerjee, Antara, Basak, Sanjay, Basalingappa, Kanthesh M., Baskaran, Ravishankar, Beyaztas, Hakan, Bhagavatheeswaran, Sambhavi, Bhasin, Nobel, Bishayee, Kausik, Bitla, Shreeja, Bozali, Kubra, Chaaudhary, Somya, Chandran, Rahul, Chatterjee, Bhaswati, Chattopadhyay, Indranil, Chengizkhan, Gautham, Chhetri, Dibyashree, Chinnadurai, Raj Kumar, Corrales, Elizabeth, Dabral, Prerna, Darko, Samuel, Das, Amitava, Dawes, McKenna, Dey, Amit, Didamson, Onyisi Christiana, Dumlu, Fatma Sena, Dutt, Shilpee, Ellis, Beanca, Garg, Khushi, Garg, Sandini, Ghosh, Amlan, Gnanasampanthapandian, Dhanavathy, Gobianand, Kuppannan, Gopan, Pournami, Gopenath, T.S., Gor, Ravi, Grigoraş, Adriana, Guler, Eray Metin, Hernandez, Erika, Huisso, Ayivi, Jayaraman, Selvaraj, Joassaint, Naphtalie, Karri, Urekha, Kathpalia, Meghavi, Kaur, Navkiran, Khan, Hafsa, Koc, Sumeyye, Krishnamoorthy, Kalaiselvi, Krishnamoorthy, Sneha, Kumar, Dinesh, Kumar, Rajappan Chandra Satish, Kumar, Subodh, Kumar, Vijay, Kumar Das, Jayanta, Kumaran, R. Ileng, M.N., Ramesh Bharadwaj, Madhumita Das, Majhi, Anjoy, Manzon, Alessandra, Morsy, Hadeer M., Moses, Leah, Munirathinam, Gnanasekar, Munuswamy-Ramanujam, Ganesh, Muruganantham, Bharathi, Muthusami, Sridhar, Narayan, Shoba, Natarajan, Aravindan, Natarajan, Gopalan, Nehru, Mohanraj, Ozkan, Beyza Nur, Palaniyandi, Kanagaraj, Palol, Varsha Virendra, Panigrahi, Ankita, Panneerselvam, Swetha, Pathak, Nishtha, Pathak, Surajit, Paul, Sandip, Paul, Solomon F.D., Periyasamy, Loganayaki, Pirsadeghi, Ali, Ponnusamy, Bhuvaneswari, Prabhu, Venkatraman, Pricope, Diana-Lavinia, Queimado, Lurdes, R., Mythreyi, Rajagopal, Ponnulakshmi, Ramachandran, Ilangovan, Ramalingam, Ravi, Ramalingam, Satish, Saha, Anwesha, Saha, Linkon, Saravanan, Suresh Kumar, Saunders, Myra, Sehgal, Rashi, Selvendiran, Karuppaiyah, Sherman, Marilyn, Shivhare, Surbhi, Singh, Bhawna, Sohani, Advait, Somasundaram, Dinesh Babu, Stella, John H., Stiffin, Rose Mary, Subramanian, Poorvi, Subramanian, Prasanth, Subramanyam, Veni, Sundaram, Jagan, Thakur, Shriya, Thakur, Suman S., Thangaraj, Kavitha R., Thangavelu, Sathish Kumar, Thomas, Amy, Varma, Saikanth, Veeraraghavan, Vishnupriya, Verma, Ranjan, Verma, Yogesh Kumar, Vijay, Amulya, Volety, Pranav, Yadav, Rahul, Yearde, Oneilia, Yousefi-Ahmadipour, Aliakbar, and Zaky, Mohamed Y.

Published
2024
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41. Role of Inflammation in the Development of Colorectal Cancer

Author

Muthusami, Sridhar, primary, Ramachandran, Ileng Kumaran, additional, Babu, Kokelavani Nampalli, additional, Krishnamoorthy, Sneha, additional, Guruswamy, Akash, additional, Queimado, Lurdes, additional, Chaudhuri, Gautam, additional, and Ramachandran, Ilangovan, additional

Published
2021
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43. CUGBP2 downregulation by prostaglandin [E.sub.2] protects colon cancer cells from radiation-induced mitotic catastrophe

Author

Natarajan, Gopalan, Ramalingam, Satish, Ramachandran, Ilangovan, May, Randal, Queimado, Lurdes, Houchen, Courtney W., and Anant, Shrikant

Subjects
Prostaglandins -- Properties, Cell cycle -- Evaluation, Apoptosis -- Evaluation, Binding proteins -- Properties, Colon cancer -- Physiological aspects, Physiological research, Biological sciences
Abstract

Prostaglandin [E.sub.2] (PG[E.sub.2]) is a potent inhibitor of ionizing radiation (IR)-induced cell death. Exposure of colon cancer cells to IR leads to increased CUGBP2 expression. Therefore, we tested the hypothesis that PG[E.sub.2] radioprotects colon cancer cells by inhibiting CUGBP2 expression. Exposure of HCT-116 cells to [gamma]-IR (0-12 Gy) resulted in a dose-dependent reduction in cell growth and an increase in the [G.sub.2]-M phase of the cell cycle. Western blot analyses demonstrated increased levels of activated caspase 9 and caspase 3. In addition, whereas Bax expression is increased, that of Bcl-2 and Bcl-[X.sub.L] was reduced. Further analyses demonstrated increased activation of Chk1 and Chk2 kinases, coupled with higher levels of nuclear cyclin B1 and Cdc2. Pretreatment with PG[E.sub.2] suppressed the activation of caspase 3 and caspase 7 and inhibited Bax expression. In addition, PG[E.sub.2] treatment restored growth and colony formation to control levels. IR significantly upregulated the expression of CUGBP2 in the cells, which was suppressed when cells were pretreated with PG[E.sub.2]. Ectopic overexpression of CUGBP2 also induced apoptosis. Furthermore, it reversed the PG[E.sub.2]-mediated protection from IR-induced mitotic catastrophe. Furthermore, there was an increase in nuclear localization of cyclin B1 and Cdc2 coupled with increased phosphorylation of p53, Chk1, Chk2, and Cdc25c proteins. Cell cycle analysis also demonstrated increased [G.sub.2]-M transition. In contrast, siRNA-mediated suppression of CUGBP2 expression restored normal cell cycle progression and decreased IR-induced apoptosis. Taken together, these data demonstrate that PG[E.sub.2] protects colon cancer cells from IR-induced mitotic catastrophe in part through suppression of CUGBP2 expression. cell cycle; apoptosis; caspase; check point kinases; RNA binding protein

Published
2008

44. Translation inhibition during cell cycle arrest and apoptosis: Mc1-1 is a novel target for RNA binding protein CUGBP2

Author

Subramaniam, Dharmalingam, Natarajan, Gopalan, Ramalingam, Satish, Ramachandran, Ilangovan, May, Randal, Queimado, Lurdes, Houchen, Courtney W., and Anant, Shrikant

Subjects
Cell cycle -- Physiological aspects, Apoptosis -- Physiological aspects, Binding proteins -- Physiological aspects, Biological sciences
Abstract

CUGBP2, a translation inhibitor, induces colon cancer cells to undergo apoptosis. Mc1-1, an antiapoptotic Bc1-2 family protein, interferes with mitochondrial activation to inhibit apoptosis. Here, we have determined the effect of CUGBP2 on Mc1-1 expression. We developed a HCUG2 cell line by stably expressing CUGBP2 in the HCT-116 colon cancer cells. HCUG2 cells demonstrate decreased levels of proliferation and increased apoptosis, compared with HCT-116 cells. Flow cytometry analysis demonstrated higher levels of cells in the [G.sub.2]-M phase. Western blot analyses demonstrated that there was decreased Bc1-2 and Mc1-1 protein but increased expression of Bax, cyclin B1, and Cdc2. Immunocytochemistry also demonstrated increased levels of cyclin B1 and Cdc2 in the nucleus of HCUG2 cells. However, there was colocalization of phosphorylated histone H3 with transferase-mediated dUTP nick-end labeling (TUNEL). Furthermore, immunostaining for [alpha]-tubulin demonstrated that there was disorganization of microtubules. These data suggest that CUGBP2 expression in HCUG2 cells induces the cells to undergo apoptosis during the [G.sub.2]-M phase of the cell cycle. We next determined the mechanism of CUGBP2mediated reduction in Mc1-1 expression. Mc1-1 protein, but not Mcl-1 mRNA, was lower in HCUG2 cells, suggesting translation inhibition. CUGBP2 binds to Mc1-1 3'-untranslated region (3'-UTR) both in vitro and in HCUG2 cells. Furthermore, CUGBP2 increased the stability of both endogenous Mc1-1 and luciferase mRNA containing the Mc1-1 3'-UTR. However, luciferase protein expression from the luciferase-Mc1-1 3'-UTR mRNA was suppressed. Taken together, these data demonstrate that CUGBP2 inhibits Mc1-1 expression by inhibiting Mc1-1 mRNA translation, resulting in driving the cells to apoptosis during the [G.sub.2] phase of the cell cycle. Bc1-2 family member; [G.sub.2]-M arrest; checkpoint kinases; RNA stability

Published
2008

45. Novel intestinal splice variants of RNA-binding protein CUGBP2: isoform-specific effects on mitotic catastrophe

Author

Ramalingam, Satish, Natarajan, Gopalan, Schafer, Chris, Subramaniam, Dharmalingam, May, Randal, Ramachandran, Ilangovan, Queimado, Lurdes, Houchen, Courtney W., and Anant, Shrikant

Subjects
Apoptosis -- Analysis, Apoptosis -- Physiological aspects, Apoptosis -- Genetic aspects, Genetic translation -- Analysis, Cell cycle -- Analysis, Biological sciences
Abstract

CUG triplet repeat-binding protein 2 (CUGBP2) is a RNA-binding protein that regulates mRNA translation and modulates apoptosis. Here, we report the identification of two splice variants (termed variants 2 and 3) in cultured human intestinal epithelial cells and in mouse gastrointestinal tract. The variants are generated from alternative upstream promoters resulting in the inclusion of additional [NH.sub.2]-terminal residues. Although variant 2 is the predominant isoform in normal intestine, its expression is reduced, whereas variant 1 is overexpressed following -y-irradiation. All three variants bind cyclooxygenase-2 (COX-2) mRNA. However, only variant 1 inhibits the translation of the endogenous COX-2 mRNA and a chimeric luciferase mRNA containing the COX-2 3'untranslated region. Furthermore, whereas variant 1 is predominantly nuclear, variants 2 and 3 are predominantly cytoplasmic. These data imply that the additional amino acids affect CUGBP2 function. Previous studies have demonstrated that variant 1 induces intestinal epithelial cells to undergo apoptosis. However, in contrast to variant 1, the two novel variants do not affect proliferation or apoptosis of HCT116 cells. In addition, only variant 1 induced [G.sub.2]/M cell cycle arrest, which was overcome by prostaglandin E2. Moreover, variant 1 increased cellular levels of phosphorylated p53 and Bax and decreased Bc12. Caspase-3 and -9 were also activated, suggesting the initiation of the intrinsic apoptotic pathway. Furthermore, increased phosphorylation of checkpoint kinase (Chk)l and Chk2 kinases and increased nuclear localization of Cdc2 and cyclin B1 suggested that cells were in mitotic transition. Taken together, these data demonstrate that cells expressing CUGBP2 variant 1 undergo apoptosis during mitosis, suggesting mitotic catastrophe. cell cycle; apoptosis; [G.sub.2]/M arrest; checkpoint kinases

Published
2008

46. Tamoxifen induces stem-like phenotypes and multidrug resistance by altering epigenetic regulators in ERα+ breast cancer cells

Author

Kalyanaraman, Aparna, primary, Gnanasampanthapandian, Dhanavathy, additional, Shanmughan, Prasad, additional, Kishore, Puneet, additional, Ramalingam, Satish, additional, Arunachalam, Rathnaswami, additional, Jayaraman, Selvaraj, additional, Kaliappan, Ilango, additional, Munuswamy-Ramanujam, Ganesh, additional, Ramachandran, Ilangovan, additional, Sambandam, Yuvaraj, additional, Anbalagan, Muralidharan, additional, Chandrakesan, Parthasarathy, additional, and Palaniyandi, Kanagaraj, additional

Published
2020
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47. Neuro-protective effects of nano-formulated hesperetin in a traumatic brain injury model of

Author

Pragyan, Paramita, Sai Nivethitha, Sethu, Namasivayam, Subhapradha, Vijayashree, Ragavan, Ramachandran, Ilangovan, Anandan, Balakrishnan, Narasimhan, Srinivasan, Ramachandran, Murugesan, and Ambigapathi, Moorthi

Subjects
Hesperidin, Brain Injuries, Traumatic, Spectroscopy, Fourier Transform Infrared, Animals, Humans, Zebrafish
Abstract

Understanding the mechanism behind neuronal regeneration is critical for treating ischemic stroke and traumatic brain injury. The presence of neural stem cells in and around the sub-ventricular zone of human and also in zebrafish is evidenced. In this current study, the neuro-protective potential of nano-formulated hesperetin on injury-induced neurogenesis in zebrafish was assessed. Nanoformulation of hesperetin was prepared by anti-solvent precipitation technique using sodium dodecyl sulfate (SDS) as the stabilizing agent. The synthesized particles were characterized using SEM, DLS, XRD and FT-IR. Anti-oxidant capacity of nano hesperetin (nHST) in

Published
2020

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