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The article titled "Metal-(Acyclic Diaminocarbene) Complexes Demonstrate Nanomolar Antiproliferative Activity against Triple-Negative Breast Cancer" discusses the use of a palladium compound to target aggressive tumors while sparing normal cells and tissues. The authors draw inspiration from the protective figure of Pallas Athena, which symbolizes the original meaning of the word "palladium." The research article provides more detailed information on this topic and can be accessed using the provided DOI. [Extracted from the article]

Novel platinum(II) and palladium(II) chlorido complexes with tetrazole derivatives 1-(2-hydroxyethyl)tetrazole (het) and 1-[tris(hydroxymethyl)methyl]tetrazole (thm), viz. cis-[Pt(het)2Cl2], trans-[Pt(het)2Cl2], trans-[Pt(thm)2Cl2], trans-[Pd(het)2Cl2], and trans-[Pd(thm)2Cl2], were synthesized. The compounds were characterized by elemental and high-resolution electrospray ionization (HRESI) mass spectrometry, high-performance liquid chromatography (HPLC), 1H, 13C and 195Pt nuclear magnetic resonance (NMR) spectroscopy, thermal analyses, and Infrared (IR) spectroscopy. Molecular and crystal structures of trans-[PdL2Cl2] and trans-[PtL2Cl2] (L = het, thm) were established by single-crystal X-ray analysis. The complex cis-[Pt(het)2Cl2] was found to undergo cis–to–trans isomerization upon heating in acetonitrile solution and in the solid state. The synthesized complexes show rather high water solubility lying in the range of 2–10 mg/L. [ABSTRACT FROM AUTHOR]

While bis(1-methyl-1 H-tetra­zol-5-yl)diazene, C4H6N10, (I), has no crystallographically imposed symmetry, in the two title chloro­copper(I) complexes, [Cu2Cl2(C4H6N10)] n, (II), and [CuCl(C4H6N10)] n, (III), the organic ligands lie across centres of inversion; in (III), the Cu and Cl atoms additionally lie about a twofold rotation axis in the space group P2/ c. Complex (II) forms a two-dimensional coordination polymer containing tetra­hedrally coordinated CuI atoms, and complex (III) forms a one-dimensional coordination polymer containing five-coordinate square-pyramidal CuI atoms. [ABSTRACT FROM AUTHOR]

While bis(1-methyl-1 H-tetra­zol-5-yl)diazene, C4H6N10, (I), has no crystallographically imposed symmetry, in the two title chloro­copper(I) complexes, [Cu2Cl2(C4H6N10)] n, (II), and [CuCl(C4H6N10)] n, (III), the organic ligands lie across centres of inversion; in (III), the Cu and Cl atoms additionally lie about a twofold rotation axis in the space group P2/ c. Complex (II) forms a two-dimensional coordination polymer containing tetra­hedrally coordinated CuI atoms, and complex (III) forms a one-dimensional coordination polymer containing five-coordinate square-pyramidal CuI atoms. [ABSTRACT FROM AUTHOR]

Invited for the cover of this issue are Tatiyana Serebryanskaya, Mikhail Kinzhalov and co-workers at St. Petersburg State University, the Research Institute for Physical Chemical Problems, Belarusian State University, Togliatti State University and Blokhin National Medical Research Center of Oncology. The image depicts the shield of Pallas Athena with the structure of a palladium carbene complex that protects against triple-negative breast cancer. Read the full text of the article at 10.1002/chem.202400101., (© 2024 Wiley-VCH GmbH.)

The crystal structure of the title polymeric complex, [CuCl(2)(C(3)H(6)N(4)O)(2)](n), was obtained by the Rietveld refinement from laboratory X-ray powder diffraction data collected at room temperature. The unique Cu(II) ion lies on an inversion center and is in a slightly distorted octa-hedral coordination environment. In the hydroxy-ethyl group, all H atoms, the O atom and its attached C atom are disordered over two positions; the site occupancy factors are ca 0.6 and 0.4. The OH group is involved in an intra-molecular O-H⋯N hydrogen bond.

While bis(1-methyl-1H-tetrazol-5-yl)diazene, C4H6N10, (I), has no crystallographically imposed symmetry, in the two title chlorocopper(I) complexes, [Cu2Cl2(C4H6N10)]n, (II), and [CuCl(C4H6N10)]n, (III), the organic ligands lie across centres of inversion; in (III), the Cu and Cl atoms additionally lie about a twofold rotation axis in the space group P2/c. Complex (II) forms a two-dimensional coordination polymer containing tetrahedrally coordinated Cu(I) atoms, and complex (III) forms a one-dimensional coordination polymer containing five-coordinate square-pyramidal Cu(I) atoms.