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1. Genetik absans epilepsili WAG/Rij sıçanlarda kardiyovasküler değişiklikler: Kronik etosüksimid tedavisinin etkileri

Author

Tuğçe Demi̇rtaş Şahi̇n, Tijen Utkan, Ayşe Karson, Yusufhan Yazır, and Erdal Karaoz

Subjects
absans epilepsi, wag/rij, etosüksimid, kalp hızı, kan basıncı, vasküler reaktivite, absence epilepsy, ethosuximide, heart rate, blood pressure, vascular reactivity, Medicine (General), R5-920
Abstract

Amaç: Bu çalışmada, genetik absans epilepsili WAG/Rij sıçanlarda kronik etosüksimid (ETS) tedavisinin absans nöbetler ve gözlenebilecek olası kardiyovasküler değişiklikler üzerindeki etkilerinin araştırılması amaçlanmıştır.Gereç ve Yöntem: İki aylık erkek Wistar ve WAG/Rij sıçanlar; Wistar kontrol, Wistar ETS, WAG/Rij kontrol ve WAG/Rij ETS gruplarına ayrılmıştır (n=20). ETS grupları 3 ay boyunca kronik ETS tedavisi (oral, 300 mg/kg/gün) almışlardır. Üç aylık tedavi periyodunun sonunda EEG kayıtları kullanılarak diken dalga deşarjlarının (DDD) toplam süre, ortalama süre ve sayısı değerlendirilmiştir. Ortalama arteriyel kan basıncı (OAB) ve kalp hızı (KH) ölçümleri gerçekleştirilmiştir. Bulgular: ETS tedavisi WAG/Rij sıçanlarda DDD’leri toplam süre, ortalama süre ve sayı açısından anlamlı olarak azaltmıştır. OAB, WAG/Rij kontrol grubunda Wistar kontrol grubuna göre anlamlı olarak artmıştır. KH, Wistar ETS grubunda Wistar kontrol grubuna göre anlamlı olarak azalmıştır. KCl aracılı kasılma yanıtlarında Wistar kontrol grubuna göre Wistar ETS grubunda anlamlı artma, WAG/Rij kontrol grubunda anlamlı azalma saptanmıştır. Sonuç: Sonuçlarımız OAB ve vasküler reaktivitenin WAG/Rij sıçanlarda arttığını göstermiştir. ETS tedavisi, WAG/Rij sıçanlarda kardiyovasküler parametreleri değiştirmezken Wistar sıçanlarda KH ve vasküler reaktiviteyi azaltmış OAB’yi etkilememiştir. Bu değişikliklerde T-tipi Ca++ kanallarının rol oynayabileceği düşünülmektedir.

Published
2020
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2. Resveratrolün streptozotosin ile diyabet oluşturulan sıçanlarda vas deferens kontraktilitesi üzerindeki antioksidan etkileri

Author

Tuğçe DEMİRTAŞ ŞAHİN

Subjects
diabetes mellitus, vas deferens, resveratrol, Medicine (General), R5-920
Abstract

Amaç: Bu çalışmanın amacı, streptozotosin (STZ) ile diyabet oluşturulmuş sıçanlarda vas deferens kontraktilitesi üzerinde resveratrolün antioksidan etkilerini araştırmaktır. Gereç ve Yöntem: Erişkin erkek Wistar Albino sıçanlar kontrol, diyabetik ve resveratrol tedavisi uygulanan diyabetik olarak üç gruba ayrılmıştır. Diyabet, tek doz i.p. STZ enjeksiyonuyla (50mg/kg) oluşturulmuş ve STZ enjeksiyonundan 2 gün sonra hiperglisemi (>300 mg/dl) olan hayvanlar diyabetik olarak kabul edilmiştir. Tedavi grubundaki sıçanlara 4 hafta boyunca (20 mg/kg/gün, i.p.) resveratrol uygulanmıştır. 4 hafta sonunda sıçanların vas deferens dokuları izole edilmiş ve bu dokularda noradrenalin, ATP, elektriksel alan uyarısı (EAU) aracılı yanıtlar elde edilmiştir. Bulgular: Diyabetik sıçanlarda kontrol grubuna göre noradrenalin ve ATP aracılı yanıtlar anlamlı olarak artarken, EAU aracılı yanıtlar azalmıştır. EAU aracılı yanıtlar pirogallol varlığında diyabetik sıçanlarda kontrol sıçanlarına göre daha fazla inhibe olmuştur. Tempol varlığında ise EAU aracılı yanıtlardaki artış, diyabetik grupta kontrol grubuna göre anlamlı olarak fazla bulunmuştur. Resveratrol tedavisi, diyabetik sıçanlarda artan noradrenalin ve ATP aracılı yanıtları anlamlı olarak azaltmış, azalan EAU aracılı yanıtları ise artırmıştır. Sonuç: Bu çalışma resveratrol tedavisinin diyabetik sıçanlarda vas deferens kontraktilitesindeki bozukluğu antioksidan etkileri aracılığıyla düzelttiğini ortaya koymuştur. Sonuçlar, diyabet ile ilişkili ejakülasyon bozukluklarında oksidatif stresin rol oynayabileceğini ve antioksidan tedavinin bu bozukluklarda etkili olabileceğini düşündürmektedir.

Published
2020
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3. 9th International Congress on Psychopharmacology & 5th International Symposium on Child and Adolescent Psychopharmacology

Author

Hatice Dogan, Didem Oztop, Ozlem Olguner Eker, Saliha Demirel Ozsoy, Ceren Şahin Özkartal, Feyza Arıcıoğlu, Erdem Tüzün, Rümeysa Keleş, Cansu Kandemir, Serap Şirvancı, Cem İsmail Küçükali, Tijen Utkan, Tuğçe Demirtaş Şahin, Yusufhan Yazir, Zehra Seda Halbutoğulları, Semil Selcen Gocmez, Övgü Sinem Buğan Gülbahar, Abda Mahmood, Enikő Zsoldos, Charlotte L. Allan, Anya Topiwala, Klaus P. Ebmeier, Vedat Ceylan, Samet Kose, Ercan Akin, Mehmet Hakan Turkcapar, Gulizer Temel, Mehmet Yalcin, Hakan Turkcapar, Isa Badur, Naciye Bilgin Badur, Yüksel Kıvrak, Yasin Taşdelen, İbrahim Yağcı, Fatih Aydın, Ayca Idil Aytekin, Melek Saka, Sule Aydin, Beyazit Garip, Hakan Kayir, Pelin Öztürk, Serkan Zincir, Cihad Yükselir, Feyza Ersan Unal, Şakir Gıca, and Aytül Gürsu Hariri

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Published
2017
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4. 9th International Congress on Psychopharmacology & 5th International Symposium on Child and Adolescent Psychopharmacology

Author

Abdurrahim Bakirhan, Safak Yalcin Sahiner, Volkan Sahiner, Şahabettin Çeti̇n, Melike Ceyhan Balcı Şengül, Sema Kuş, Fatih Canan, Ali Erdoğan, Mehmet Murat Kuloğlu, Şengül Şahin, Gülçin Elboğa, Ahmet Zi̇ya Şahin, Ahmet Ünal, Abdurrahman Altındağ, Osman Hasan Tahsin Kılıç, Turkan Dogan, Gonul Kaygisiz, Zeynep Ezgi Bal, Mustafa Solmaz, Derya Adali Aker, Ercan Akin, Samet Kose, Deniz Deniz Özturan, Hatice Özyıldız Güz, Muhammet Emin Naldan, Ali Karayağmurlu, Mehmet Nuri Cevizci, Duygu Kara, Elif Oral Ahiskalioğlu, Pelin Aydın, Yıldız Marangoz, Burcu Akın Sarı, Zeren Barış, Figen Özçay, Başak Tüzün Mutluer, Tuna Güzide Yener Orum, Ebru Şahan, Sencan Sertcelik, Helin Yılmaz, N. Burcu Özbaran, Melis Palamar, Elif Demirkılıç Biler, Ertan Yi̇lmaz, Lut Tamam, Murat Altın, Ipek Fatma Ozaktac, Ayse Sena Sarıdogan, Figen Yavlal, Ceyda Tahincioğlu, Hakan Karaş, Hüseyin Ebadi, Suna Sogucak, Servet Karaca, Murat Kuloglu, Taner Öznur, Abdullah Bolu, Havva Öznur, Serdar Atik, Cemil Çelik, Özcan Uzun, Erol Göka, Tijen Utkan, Tuğçe Demirtaş Şahin, Yusufhan Yazir, Zehra Seda Halbutoğulları, Semil Selcen Gocmez, Feyza Arıcıoğlu, Övgü Sinem Buğan Gülbahar, Abda Mahmood, Enikő Zsoldos, Charlotte L. Allan, Anya Topiwala, Klaus P. Ebmeier, Jung Suk Lee, Jong Hun Kim, Seon-Koo Lee, Gökhan Ünal, Alim Hüseyin Dokumacı, Mükerrem Betül Aycan Yerer, Ceren Özkartal, Hülya Kamarlı Altun, İlkay Keser, Mehmet Mart, Didem Tezcan, Selim Tümkaya, Figen Çulha Ateşci, Cansu Baygın, Çağdaş Öykü Memiş, Bilge Doğan, Levent Sevinçok, Gonca Karakuş, Ceren Şahin Özkartal, Erdem Tüzün, Rümeysa Keleş, Cansu Kandemir, Serap Şirvancı, Cem İsmail Küçükali, Özgür Devrim Can, Umut İrfan Üçel, Ümide Demir Özkay, Emel Ulupınar, Nazlı Turan, Nafiz Öncü Can, Tuğçe Baştaşkın, Canan Yalçınkaya, Gülnaz Arkan, Yusuf Özkay, Serkan Levent, Feyza Alyu, Yusuf Öztürk, Bassem Sadek, Nadia Khan, Dorota Łażewska, Katarzyna Kieć Kononowicz, Mehmet Hamid Boztaş, Derya Arslan, Ayşegül Koç, Derya Öktem Aygün, Hülya Ensari, Ercan Akın, Vedat Ceylan, Mehmet Hakan Turkcapar, Mehmet Yalcin, Hakan Turkcapar, Feryal Cam Celikel, Güzin M Sevinçer, Aysenur Kaya, Suleyman Bozkurt, Nilufer Subasi Tekintas, Fatma Benk Durmus, Kemal Sayar, Fatma Kartal Sarıoğlu, Lale Gönenir Erbay, Rıfat Karlıdağ, Ebru Sekmen, Zeynep Selen Karalök, Zeynep Göker, Esra Çöp, Gülser Dinç, Özlem Hekim Bozkurt, Özden Şükran Üneri, Safinaz Ataoğlu, Handan Ankaralı, Seyit Ankaralı, Büşra Bahar Ataoğlu, Safiye Bahar Ölmez, Esra Çelebi, Özge Pasin, Rumeysa Samancı, Didem Ayyıldız, Neşe Perdahlı Fiş, Hatice Yardi̇m Özayhan, Ali Metehan Çalışkan, İkbal İnanlı, Halil İbrahim Öztürk, Tahsin Etli, İbrahim Eren, Hande Ayraler Taner, Fethiye Kilicaslan, Hamza Ayaydin, Ayca Idil Aytekin, Melek Saka, Sule Aydin, Beyazit Garip, Hakan Kayir, Görkem Karakaş Uğurlu, Mustafa Uğurlu, Ayza Mutlu Haydanlı, Ali Çayköylü, Semra Ulusoy Kaymak, Zuhal Koç Apaydın, Serdar Süleyman Can, Abdullah Bozkurt, Seher Akbaş, Burak Tander, Cengiz Kara, Ünal Bıçakçı, Hamiyet İpek Toz, Özhan Yalçi̇n, Şermin Yalın Sapmaz, Handan Özek Erkuran, Dilay Karaarslan, Masum Öztürk, Gülsüm Yörük Ülker, Burcu Serim Demirgören, Ertuğrul Köroğlu, Ömer Aydemir, Nefize Yalın, Canem Kavurma, Siğnem Öztekin, Birsen Şentürk Pilan, Neslihan Inal Emiroğlu, Dilek Ergin, Nesrin Şen Celasin, Öznur Bilaç, Duygu Kararslan, Mahmut Cem Tarakçıoğlu, Gülşah Acar, Kerime Bademli, Neslihan Lök, Ahmet Zihni Soyata, Mahmut Onur Karaytug, Necla Keskin, Nurgul Ozpoyraz, and Mehmet Emin Demirkol

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Published
2017
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5. 9th International Congress on Psychopharmacology & 5th International Symposium on Child and Adolescent Psychopharmacology

Author

Muharrem Burak Baytunca, Tugba Kalyoncu, Ismail Ozel, Serpil Erermis, Bulent Kayahan, Dost Ongur, Demet Sağlam Aykut, Hasret Karabulut Gül, Tuba Şerife Elmas, Memduha Aydın, Bilge Çetin İlhan, Yusuf Çokünlü, İbrahim Eren, İlker Ozdemir, Onur Gokcen, Erkan Kuru, Erkan Demir, Gökhan Ünal, Feyza Arıcıoğlu, Ayşe Nur Hazar Yavuz, Orkun Aydın, Kuzeymen Balıkçı, Cumhur Taş, Pınar Ünal Aydın, Deniz Torun, Hakan Kayır, Ayşen Esen Danacı, Safiye Bahar Ölmez, Büşra Bahar Ataoğlu, Zehra Başar Kocagöz, Neslihan Yazar, Ahmet Ataoğlu, Adnan Özçetin, Mehmet Asoğlu, Hatice Doğan, Didem Behice Öztop, Özlem Olguner Eker, Saliha Demirel Özsoy, Özalp Ekinci, Çetin Okuyaz, Serkan Güneş, Meltem Çobanoğulları Direk, Nuran Ekinci, Halenur Teke, Merve Kalınlı, Çiğdem Toklu Yalvaç, Tülin Fidan, Burcu Akın Sarı, Güler Özkula, Remzi Karaokur, Halime Tuna Çak Esen, Songül Atasavun Uysal, Hesna Gül, Olcay Güngör, Şermin Yalın Sapmaz, Burcu Serim Demirgören, Masum Öztürk, Öznur Bilaç, Handan Özek Erkuran, Ertuğrul Köroğlu, Ömer Aydemir, Kemal Utku Yazici, Ipek Percinel Yazici, Bilal Ustundag, Hatice Altun, Nilfer Şahin, Ergül Belge Kurutaş, Damla Balkan, Hakan Karaş, Elif Mutlu, Selin Birgül Baran, Ali Dayı, Filiz Şükrü Gürbüz, Emine Zinnur Kılıç, Medine Giynas Ayhan, Hilal Seven, Ali Hakan Öztürk, Seda Kırcı Ercan, Başak Demirel, Mahmut Selçuk, Halil Ibrahim Ozturk, Hilal Atila Uygur, Nalan Varsak, Suleyman Ozbek, Ibrahim Eren, Ali Erdoğan, Fatih Canan, Şima Ceren Pak, Mehmet Murat Kuloğlu, Sema Kuş, Mehmet Öztürk, İlker Özdemir, Yasir Şafak, İsmail Volkan Şahiner, Şafak Şahiner, Mehmet Ozturk, İsmail Volkan Sahiner, Yasir Safak, Suat Ekinci, Hanife Uğur Kural, Cenk Varlık, Hüseyin Ünübol, Züleyha İclal Balak, Abdurrahim Bakirhan, Safak Yalcin Sahiner, Süleyman Özbek, İbrahim Güler, Seda Yıldırım Özbek, Mehmet Er, İsmet Tolu, Cagatay Ugur, Mehmet Sertceli̇k, Ozden Uneri, Gulser Senses Dinc, Ebru Sekmen, Esra Solmaz, Başar Ayrıbaş, Kemal Sayar, Pelin Öztürk, Serkan Zincir, Cihad Yükselir, Feyza Ersan Unal, Şakir Gıca, Aytül Gürsu Hariri, Gul Dikeç, Leyla Baysan Arabacı, Gülçin Uzunoğlu, Selin Demet Mızrak, Çiğdem Yektaş, Başak Paşabeyoğlu, Ayten Erdoğan, Caner Mutlu, Tuğçe Demirtaş Şahin, Tijen Utkan, Ayşe Karson, Semil Selcen Gocmez, Feyza Aricioglu, Süheyla Tağcı, Sevcan Karakoç Demirkaya, Hatice Aksu, İsa Badur, Serhat Çıtak, Burcu Bakar, Selma Hilal Avcı, Cihad Yüksellr, Safinaz Ataoğlu, Handan Ankaralı, Semra Ulusoy Kaymak, Seda Norçin Demirtaş, Mustafa Uğurlu, Murat İlhan Atagün, Görkem Karakaş Uğurlu, Serdar Süleyman Can, Zuhal Koç, Ali Çayköylü, Meryem Kaşak, Selma Tural Hesapçıoğlu, Mehmet Fatih Ceylan, Hatice Güneş, Sabri Hergüner, Canan Tanıdır, Hilal Adaletli, Zerrin Önal, Esra Kutlu, Hasan Önal, Kerim Münir, Serhat Nasıroğlu, Bengi Semerci, Nagihan Saday Duman, Emel Sarı Gökten, Hasan Nadir Rana, Filiz Özdemiroğlu, Çağdaş Öykü Memiş, Bilge Doğan, Kadir Karakuş, Levent Sevinçok, Merve Çukurova, Sevda Bağ, Çağatay Karşıdağ, Özge Şahmelikoğlu, Ömer Akay, Suat Yalçın, Gamze Kutlu, Kübra Kocagöz, Filiz Civil Arslan, Evrim Özkorumak Karagüzel, Ahmet Tiryaki, Gülhan Örekeci, Emre Köroğlu, Volkan Topçuoğlu, Seyit Ankaralı, Ebru Fındıklı, Özge Şahmelikoğlu Onur, Ender Cesur, Gülşen Teksin Ünal, Melike Yerebakan Tüzer, Didem Yalçın, Filiz Yıldız Aydın, Hasan Mervan Aytaç, Nazan Aydın, Ahmet Gül, Ummuhan Ceviz Ozkal, Zeliha Kıncır, Gözde Gültekin, Murat Emul, Bahar Yeşil, Süheyla Ünal, Halil Ay, Ezgi Selçuk, Selin Uysal, Ayşe Çakır, Vahdet Gormez, Abdurrahman Cahid Örengül, Behice Han Almış, Yüksel Kıvrak, Yasin Taşdelen, İbrahim Yağcı, Fatih Aydın, Muhammet Emin Tan, Oktay Kocabaş, Mihriban Yıldırım, Emel Uysal, Süleyman Güven, Gülay Sezer, Zafer Sezer, İhsan Çetin, and Ömer Faruk Demirel

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Published
2017
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6. Etanercept Prevents Endothelial Dysfunction in Cafeteria Diet-Fed Rats

Author

Scăunaşu Răzvan-Valentin, Sertaç Ata Güler, Tijen Utkan, Tuğçe Demirtaş Şahin, Gulcin Gacar, Yusufhan Yazir, Selenay Furat Rencber, Lupușoru Mircea, Bălălău Cristian, Popescu Bogdan, and Nihat Zafer Utkan

Subjects
Male, Tumor Necrosis Factor-alpha, Health, Toxicology and Mutagenesis, Public Health, Environmental and Occupational Health, Nitric Oxide, Diet, Etanercept, Rats, cafeteria diet, endothelial dysfunction, etanercept, inflammation, nitric oxide TNF-α, Animals, Endothelium, Vascular, Vascular Diseases, Rats, Wistar, skin and connective tissue diseases
Abstract

Obesity is associated with endothelial dysfunction and this relationship is probably mediated in part by inflammation. Objective: The current study evaluated the effects of etanercept, a tumor necrosis factor-alpha (TNF-α) inhibitor, on endothelial and vascular reactivity, endothelial nitric oxide synthase (eNOS) immunoreactivity, and serum and aortic concentrations of TNF-α in a diet-induced rat model. Design and results: Male weanling Wistar rats were exposed to a standard diet and cafeteria diet (CD) for 12 weeks and etanercept was administered during CD treatment. Isolated aortas of the rats were used for isometric tension recording. Carbachol-induced relaxant responses were impaired in CD-fed rats, while etanercept treatment improved these endothelium-dependent relaxations. No significant change was observed in papaverine- and sodium nitroprusside (SNP)-induced relaxant responses. eNOS expression decreased in CD-fed rats, but no change was observed between etanercept-treated CD-fed rats and control rats. CD significantly increased both the serum and the aortic levels of TNF-α, while etanercept treatment suppressed these elevated levels. CD resulted in a significant increase in the body weight of the rats. Etanercept-treated (ETA) CD-fed rats gained less weight than both CD-fed and control rats.

Published
2022
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7. Restorative effect of resveratrol on expression of endothelial and neuronal nitric oxide synthase in cavernous tissues of chronic unpredictable mild stress-exposed rats: an impact of inflammation

Author

Yusufhan Yazir, Tijen Utkan, Selenay Furat Rençber, Gulcin Gacar, Feyza Aricioglu, Zehra Seda Halbutoğulları, and Tuğçe Demirtaş Şahin

Subjects
Male, medicine.medical_specialty, Nitric Oxide Synthase Type III, Urology, Inflammation, Nitric Oxide Synthase Type I, Resveratrol, Proinflammatory cytokine, Random Allocation, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Erectile Dysfunction, Corticosterone, Enos, Internal medicine, Animals, Medicine, Testosterone, Rats, Wistar, Swimming, 030219 obstetrics & reproductive medicine, biology, Depression, business.industry, biology.organism_classification, medicine.disease, Antidepressive Agents, Rats, Erectile dysfunction, Endocrinology, chemistry, medicine.symptom, business, Biomarkers, Stress, Psychological, 030217 neurology & neurosurgery, Penis
Abstract

We investigated the effect of resveratrol on endothelial and neuronal nitric oxide synthase (eNOS and nNOS) expression in the corpus cavernosum from chronic unpredictable mild stress (CUMS)-exposed rats in order to examine possible role of proinflammatory cytokines, which might play a role on erectile dysfunction (ED). Rats were randomly and equally divided into four groups such as control, control+resveratrol, CUMS and CUMS + resveratrol (20 mg/kg/day, i.p/8 weeks). Sucrose intake and forced swimming tests were used to evaluate depressive-like behaviors. nNOS, eNOS expressions, inflammatory markers, corticosterone and testosterone levels were analyzed either in blood samples and/or penile tissues. CUMS-exposed rats displayed depressive-like behaviors, reduced penile nNOS and eNOS expressions, and serum testosterone levels and enhanced serum and penile tissue levels of proinflammatory markers compared to controls. Resveratrol reversed depressive-like behaviors and suppressed serum and penile levels of proinflammatory markers, increased nNOS and eNOS expressions and testosterone levels in CUMS-exposed rats. Resveratrol exerted antidepressant-like effects and protected the development of CUMS-induced impairment of cavernosal eNOS and nNOS expressions associated with ED, which might be related to its anti-inflammatory action.

Published
2018
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8. TNF-α antagonism with etanercept enhances penile NOS expression, cavernosal reactivity, and testosterone levels in aged rats

Author

Semil Selcen Gocmez, Tuğçe Demirtaş Şahin, Selenay Furat Rençber, Gulcin Gacar, Tijen Utkan, and Yusufhan Yazir

Subjects
Male, Aging, medicine.medical_specialty, Nitric Oxide Synthase Type III, Endothelium, Physiology, 030232 urology & nephrology, Inflammation, Nitric Oxide Synthase Type I, Etanercept, 03 medical and health sciences, 0302 clinical medicine, Enos, Physiology (medical), Internal medicine, medicine, Animals, Testosterone, Rats, Wistar, Pharmacology, 030219 obstetrics & reproductive medicine, biology, Tumor Necrosis Factor-alpha, business.industry, Body Weight, Organ Size, General Medicine, biology.organism_classification, medicine.disease, Electric Stimulation, Vasodilation, Endocrinology, medicine.anatomical_structure, Erectile dysfunction, Carbachol, Tumor necrosis factor alpha, Endothelium, Vascular, medicine.symptom, business, Antagonism, Biomarkers, Penis, medicine.drug
Abstract

Erectile dysfunction (ED) has been reported to be associated with inflammation. This study investigated the effects of tumor necrosis factor alpha (TNF-α) inhibitor etanercept on penile neuronal nitric oxide synthase (nNOS) and endothelial nitric oxide synthase (eNOS) expressions, testosterone concentrations, neurogenic and endothelium-dependent relaxations of corpus cavernosum (CC), and circulating and cavernosal levels of inflammatory markers in aged rats. Animals were separated into control, aged, and etanercept-treated aged groups. Aged rats displayed significantly increased serum and cavernosal TNF-α, C-reactive protein (CRP), monocyte chemoattractant protein-1 (MCP-1) and intercellular adhesion molecule (ICAM–1) levels, and decreased penile nNOS and eNOS expressions and serum testosterone levels compared with controls. In etanercept-treated aged group, NOS expressions were similar to that of the control group. The circulating and cavernosal concentrations of TNF-α, CRP, MCP-1, ICAM-1, and testosterone were also normalized by etanercept. Neurogenic and endothelium-dependent relaxant responses significantly decreased in aged rats and etanercept treatment markedly improved these relaxation responses. Our findings indicate that aging decreases penile NOS expression, neurogenic and endothelium-dependent relaxations of CC, and also suppresses serum testosterone levels by inducing inflammatory response that may contribute to the development of ED. TNF-α antagonism may be a novel strategy to treat aging-associated ED.

Published
2018
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9. Etanercept rescues cognitive deficits, depression-like symptoms, and spike-wave discharge incidence in WAG/Rij rat model of absence epilepsy

Author

Tuğçe Demirtaş Şahin, Fuat Balcı, Tijen Utkan, Ayşe Karson, Nurbay Ates, and Sertan Arkan

Subjects
Male, medicine.medical_specialty, Morris water navigation task, Electroencephalography, Etanercept, 03 medical and health sciences, Behavioral Neuroscience, Epilepsy, Cognition, 0302 clinical medicine, Internal medicine, medicine, Animals, Humans, Cognitive Dysfunction, 030212 general & internal medicine, Rats, Wistar, Depression (differential diagnoses), medicine.diagnostic_test, Depression, business.industry, Incidence, Therapeutic effect, medicine.disease, Patient Discharge, Rats, Disease Models, Animal, Endocrinology, Epilepsy, Absence, Neurology, Tumor necrosis factor alpha, Neurology (clinical), business, human activities, 030217 neurology & neurosurgery, medicine.drug
Abstract

Pro-inflammatory cytokines have been shown to be associated with the development of seizures in the WAG/Rij rat model of absence epilepsy. Importantly, WAG/Rij rats also exhibit cognitive deficits and depression-like behaviors. It is possible that pro-inflammatory cytokines mediate these comorbid conditions of absence epilepsy given their well-established effects on cognition and affective responses. The current study investigated the potential therapeutic effect of etanercept (tumor necrosis factor inhibitor) on cognitive impairment, depression-like behavior, and spike-wave discharges (SWDs) typically observed in the WAG/Rij rats. Eight-month-old male WAG/Rij rats and Wistar controls were tested in Morris water maze (MWM), passive avoidance (PA), forced swimming, sucrose preference, and locomotor activity tests, and electroencephalogram (EEG) recordings were taken from a separate group of WAG/Rij rats after 8 weeks of etanercept or vehicle treatment. Consistent with earlier work, WAG/Rij rats exhibited cognitive deficits and depression-like behavior. From these, the cognitive deficits and despair-like behavior were rescued by etanercept administration, which also reduced the frequency of SWDs without affecting their duration. Our results support the hypothesis that pro-inflammatory cytokines mediate the absence seizures and comorbid symptoms of absence epilepsy.

Published
2021
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10. Depression induced by chronic stress leads to penile cavernosal dysfunction: protective effect of anti-TNF-α treatment

Author

Tuğçe Demirtaş Şahin, Yusufhan Yazir, Gulcin Gacar, Tijen Utkan, Semil Selcen Gocmez, and Zehra Seda Halbutoğulları

Subjects
Male, medicine.medical_specialty, Time Factors, Nitric Oxide Synthase Type III, Physiology, Inflammation, Nitric Oxide Synthase Type I, medicine.disease_cause, Gene Expression Regulation, Enzymologic, Etanercept, 03 medical and health sciences, 0302 clinical medicine, Erectile Dysfunction, Physiology (medical), Internal medicine, medicine, Psychological stress, Animals, Chronic stress, Endothelium, Rats, Wistar, Depression (differential diagnoses), Pharmacology, 030219 obstetrics & reproductive medicine, Behavior, Animal, business.industry, Depression, Tumor Necrosis Factor-alpha, Body Weight, General Medicine, medicine.disease, Rats, Vasodilation, Endocrinology, Erectile dysfunction, Anti tnf α, medicine.symptom, business, 030217 neurology & neurosurgery, Locomotion, Stress, Psychological, medicine.drug
Abstract

Psychological stress may lead to erectile dysfunction (ED), and inflammation has been evaluated as a major contributing factor. The goal of this study was to investigate the effects of etanercept (ETN), an anti-tumor necrosis factor α (TNF-α) protein, on cavernosal function in the unpredictable chronic mild stress (UCMS) rat model of depression. Animals were divided into 4 groups: animals not exposed to UCMS, animals not exposed to UCMS and treated with ETN, animals exposed to UCMS, and animals treated with ETN while exposed to UCMS. UCMS significantly impaired the neurogenic and endothelium-dependent relaxation responses; reduced cavernosal endothelial nitric oxide (NO) synthase (eNOS) and neuronal NO synthase (nNOS) expressions; decreased testosterone levels; enhanced systemic levels of corticosterone, TNF-α, interleukin 1β (IL-1β), interleukin 6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and intercellular adhesion molecule 1 (ICAM-1); and also increased cavernosal levels of TNF-α, IL-1β, and IL-6 in rats. ETN administration restored NO-mediated neurogenic and endothelium-dependent relaxation responses of the corpus cavernosum, increased cavernosal eNOS and nNOS expressions, enhanced testosterone levels, and decreased corticosterone levels in UCMS-exposed rats. Also, systemic inflammatory markers and cavernosal proinflammatory cytokine levels were reduced by ETN. Our results demonstrate the role of TNF-α-mediated inflammation in the development of depression and ED in rats exposed to chronic stress.

Published
2018

13. T40. Resveratrol Improves Cognitive Performance and Endothelial Function by Increasing BDNF Expression and Preventing Oxidative Stress During Experimental Vascular Dementia in Streptozotocin-Induced Diabetic Rats

Author

Selen Polat, Tijen Utkan, Yusufhan Yazir, Tuğçe Demirtaş Şahin, Fatma Ceyla Eraldemir, and Semil Selcen Gocmez

Subjects
medicine.medical_specialty, business.industry, Resveratrol, medicine.disease_cause, Streptozotocin, medicine.disease, chemistry.chemical_compound, Endocrinology, chemistry, Internal medicine, Medicine, Effects of sleep deprivation on cognitive performance, business, Vascular dementia, Biological Psychiatry, Oxidative stress, Function (biology), medicine.drug
Published
2018
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14. Poster Presentations

Author

Arif Önder, Aslı Sürer Adanır, Öznur Bilaç, Canem Kavurma, Yakup Doğan, Şermin Yalın Sapmaz, Nurcan Bektaş Türkmen, Feyza Alyu Tekeş, Rana Arslan, Betül Kurtses Gürsoy, Büşra Öztürk, Yetiş Işıldar, Gülçin Bölük Uzunoğlu, Nuran Bilgen, Bilge Doğan, Ali Duman, Çağdaş Öykü Memiş, Oktay Kocabaş, Levent Sevinçok, Umut İrfan Üçel, Ümide Demir Özkay, Özgür Devrim Can, Kemal Akpınar, Osman İsmail Özdel, Sultan Taş Bora, Kadriye Buldukoğlu, Serdar Karatoprak, Yunus Emre Dönmez, Özlem Özcan, Hatice Altun, İdiris Altun, Ferhat Can Ardic, Samet Kose, Mustafa Solmaz, Filiz Kulacaoglu, Yasin Hasan Balcioglu, Yusuf Olğar, Belma Turan, Yusuf Öztürk, Volkan Gelegen, Lut Tamam, Şerife Aslan, Nevzat Çamlı, Osman Zülkif Topak, Selim Tümkaya, Figen Çulha Ateşci, Ozge Metin, Perihan Cam Ray, Gamze Yapca Kaypakli, Ezgi Eynalli, Aysegul Yolga Tahiroglu, Canan Kuygun Karci, Gonca Gul Celik, Alper Çimik, Feyza Alyu, Alper Zıblak, Ayşe Nur İnci Kenar, Nazlı Turan Yücel, Mustafa Burak Barbaros, Dilan Eker, Esen Çimen, İbrahim Gündoğmuş, Ayhan Algül, Abdulkadir Karagöz, Murat Kıyançiçek, Pelin Kalcı, Hakan Karaş, Aslıhan Polat, Zehra Alğan, Aslıhan Okan İbiloğlu, İbrahim İbiloglu, Dilek Aslaner, Mevlut Comlekci, Selim Sagir, Tuba Basoglu, Murat Eren Özen, Mehmet Hamdi Örüm, Aysun Kalenderoğlu, Gülümser Peltek, Salih Selek, Murad Atmaca, Mehmet Vural, Halef Aydın, Sedat Yılmaz, Ramazan İlyas Öner, Ayşe Sevgi Karadağ, Mahmut Zabit Kara, Miraç Barış Usta, Koray Karabekiroğlu, Berkan Şahin, Muazzez Aydın, Abdullah Bozkurt, Tolga Karaosman, Armağan Aral, Cansu Çobanoğlu, Ayşegül Duman Kurt, Neriman Kesim, İrem Şahin, Emre Ürer, Oğuzhan Bekir Eğilmez, Tijen Utkan, Tugce Demirtas Sahin, Semil Selcen Gocmez, Yusufhan Yazir, Feyza Aricioglu, Cangül Yurtdaş, Hacer Zortul, Bayram Yilmaz, Feyza Arıcıoğlu, Hatice Kübra Parlaktaş, Aylin Yaba Uçar, Bayram Yılmaz, Neslihan Kurtul, Asiye Arıcı, Ece Merve Yazar, Necati Uzun, Ömer Faruk Akça, İbrahim Kılınç, Tevfik Balcı, Ozge Bayru, Osman Bertizlioğlu, Funda Yiğit Yalçın, Abdullah Bolu, Hatice Akar, Mehmet Sinan Aydın, Ali Doruk, Tuğba Mutu, Esra Yazici, Derya Guzel, Atila Erol, Elvan Çiftçi, Heysem Kaya, Hüseyin Güleç, Albert Ali Salah, Tuğba Kalyoncu, Deniz Argüz Çıldır, Fazilet Ergüvendi, Ulkar Shamkhalova, Ezgi Eynallı Gok, Sakir Altunbasak, Seyda Besen Dogankoc, Nefise Hilal Cansever Ovetti, Özge Metin, and Ulkhar Shamkhalova

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Published
2018
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