1. PD-1 is expressed by and regulates human group 3 innate lymphoid cells in human decidua
- Author
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Emanuela Marcenaro, Marco Greppi, Enrico Munari, Paola Vacca, Maria Cristina Mingari, Alessandro Moretta, Silvia Pesce, Lorenzo Moretta, Ezio Fulcheri, Daniel Olive, Department of Experimental Medicine - DIMES [Genoa, Italy] (DIMES), University of Genoa (UNIGE), Department of Experimental Medicine, University of Genoa, D.I.C.M.I., Universita degli studi di Genova, Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Istituto Nazionale per la Ricerca sul Cancro, Genova, Immunologia, Università di Genova, Dipartimento di Medicina Sperimentale, IRCCS Istituto Giannina Gaslini, Genova, and Università degli studi di Genova = University of Genoa (UniGe)
- Subjects
MESH: Signal Transduction ,0301 basic medicine ,MESH: Trophoblasts ,[SDV]Life Sciences [q-bio] ,Programmed Cell Death 1 Receptor ,B7-H1 Antigen ,MESH: Decidua ,Immune tolerance ,MESH: Pregnancy ,0302 clinical medicine ,Pregnancy ,MESH: B7-H1 Antigen ,Homeostasis ,Innate ,Immunology and Allergy ,Lymphocytes ,Receptor ,Hepatitis A Virus Cellular Receptor 2 ,MESH: Cytokines ,Innate lymphoid cell ,Decidua ,MESH: Programmed Cell Death 1 Receptor ,Trophoblasts ,MESH: Placental Circulation ,3. Good health ,Cell biology ,medicine.anatomical_structure ,MESH: Homeostasis ,Cytokines ,Female ,MESH: Immunity, Innate ,Signal transduction ,Signal Transduction ,Programmed cell death ,MESH: Immune Tolerance ,T cell ,Immunology ,[SDV.BC]Life Sciences [q-bio]/Cellular Biology ,Biology ,03 medical and health sciences ,Immune system ,Immune Tolerance ,medicine ,Humans ,Placental Circulation ,MESH: Humans ,Immunity ,Immunity, Innate ,MESH: Hepatitis A Virus Cellular Receptor 2 ,030104 developmental biology ,MESH: Lymphocytes ,MESH: Female ,030215 immunology - Abstract
International audience; Group 3 innate lymphoid cells (ILC3) have been detected in both murine and human decidual tissues where they are thought to play a relevant role in the induction and maintenance of pregnancy. However, limited information exists on the molecular mechanisms that regulate these cells, including immune checkpoints. Here, we show that ILC3 express the inhibitory checkpoints programmed cell death (PD-1) and T cell immunoglobulin and mucin domain containing protein 3 (TIM-3) during the first trimester of pregnancy and that these receptors could regulate production of cytokines, including IL-22, IL-8, and TNF-α, induced by IL-23. We also show that the intermediate extravillous trophoblast (iEVT) expresses high levels of the PD-1-ligand PD-L1, suggesting that PD-1/PD-L1 interaction may regulate ILC3 function at the feto-maternal interface. Our present data provide the first evidence that human decidual ILC3 express a functional PD-1. It is possible that an altered expression or function of PD-1 may break the immune-tolerance resulting in pregnancy failure.
- Published
- 2019