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Objective: To investigate the effect of ultra-early stereotactic surgery on hypertensive intracerebral hemorrhage(HICH)and its influence on inflammatory factors and quality of life. Methods: 93 patients with HICH who were admitted to our hospital from March 2016 to January 2018 were selected, and they were divided into early group(n=45, operation within 6-24 hours of onset) and super-early group(n=48, operation within 6 hours of onset) according to the timing of operation. Relevant indexes of curative effect,inflammatory factors and quality of life were compared between the two groups, and the occurrence of postoperative complications was observed. Results: The mortality of super-early group was lower than that of early group, and the Glasgow coma score(GOS) excellent and good rate was higher than that of early group(P <0.05). There was no significant difference in the postoperative rebleeding rate between the two groups(P>0.05). The levels of interleukin-6(IL-6), high-sensitivity C-reactive protein(hs-CRP) and tumor necrosis factor-α(TNF-α) were decreased in the two groups at 2 weeks after operation, and those in the ultra-early group were lower than those in the early group(P <0.05). The scores of mental health, physical health, social function and material life in the ultra-early group at 3 months and 6 months after operation were higher than those in the early group(P <0.05). The total incidence of postoperative complications in the ultra-early group was lower than that in the early group(P<0.05). Conclusion: Ultra-early stereotactic surgery for HICH has remarkable curative effect, which can effectively improve inflammatory factors and quality of life, and it can also reduce the incidence of postoperative complications. [ABSTRACT FROM AUTHOR]

Objective: To investigate the severe brain injury after decompressive surgery of skull defects ultra-early (4-6 weeks) the feasibility of row three-dimensional titanium mesh skull patch and its impact on the long-term prognosis of patients, and to explore ultra-early skull repair surgery Are compared with conventional surgery exist advantages. Methods: A retrospective analysis from January 2012-January 2015 after the Brain Injury skull defect repair surgery 99 patients all patients after decompression interval skull patch into two groups according to craniectomy, 4. within-6 weeks for ultra-early group, 52 cases, 3-6 months for the conventional group, 47 cases. Skull patch after 1 month, 3 months, quality of life between the two groups of patients with different international scoring 12 months;comparative analysis peeling scalp surgery time and blood loss between the two groups;two groups were compared after 1 month, 3 months, 12 months, corresponding to the difference complications. Results: Ultra-early group patients after one month of GCS (Glasgow outcome scale, GOS), the US National Institutes of Health neurological deficits (NIHSS) and long-term Karnofsky functional status (Kamofsky performance status, KPS) score compared with the conventional group no significant difference (P＞0.05);super-early group patients 3 months and 12 months of GOS, NIHSS and KPS scores were significantly increased (P＜0.05) than the conventional group. Patients with ultra-early scalp skull patch set release time than conventional repair group was significantly shorter (P＜0.05), the amount of bleeding was significantly reduced (P＜0.05);the next two cranioplasty subdural effusion were significantly lower, the difference statistics significance (P＜0.05). However, the overall complication rate was no significant difference (P＞0.05). Conclusion: Severe brain injury patients after decompression craniectomy in the ultra-early (4-6 weeks) skull patch is clinically safe and effective, it can improve patient outcomes and reduce the probability of occurrence of postoperative complications, and can reduce blood loss during surgery scalp peeling time shortened. [ABSTRACT FROM AUTHOR]

To compare the effect of different surgical timing in the treatment of patients with ruptured intracranial anterior circulation aneurysms and its effect on the long-term prognosis of patients. The clinical data of 120 patients with ruptured intracranial anterior circulation aneurysms who were admitted in our hospital between March 2010 and October 2015were analyzed retrospectively. All patients were treated with microsurgical clipping. According to surgical timing, they were divided into ultra-early group (<24 h, n=43), early group (24-72 h, n=36) and delayed group (d = 10, n=41). The improvement of intracranial arterial embolization was compared between groups. The incidence rates of postoperative complications in all groups were statistically analyzed. Postoperative recovery of patients was evaluated by the Glasgow scale (GOC), and the long-term prognosis of patients was evaluated by modified Rankin scale (mRS). The rate of complete embolism in the ultra-early group was slightly higher than that in the early group and delayed group (P>0.05); The incidence rates of intraoperative and postoperative complications in ultra-early group were slightly lower than those in early group and delayed group (P>0.05); At 6, 12 and 24 months after surgery, GOS scores of the ultra-early group and delayed group were higher than those of the early group while mRS scores were lower than those of the early group. GOS scores of ultra-early group were higher than those of the delayed group while mRS scores were lower than those of the delayed group (P<0.05). There are no significant differences in surgical effects of different timing of surgery in the treatment of intracranial anterior circulation aneurysm rupture. However, the postoperative recovery and prognosis scores of patients undergoing ultra-early and delayed surgery are slightly better than early surgery. [ABSTRACT FROM AUTHOR]