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Your search keyword '"Jingping Kou"' showing total 2 results
Start Over Author "Jingping Kou" Topic 0104 chemical sciences
2 results on '"Jingping Kou"'

1. Development of a Robust and Scalable Process for the Large-Scale Preparation of Vadadustat

Author

Zhongqing Wang, Xiao Qingbo, Li Yinglong, Shuming Wu, Hu Ji'an, Jianbing Li, Lin Biyue, Jingping Kou, and Xuerong Cai

Subjects
010405 organic chemistry, business.industry, Computer science, Scale (chemistry), Organic Chemistry, Process (computing), Vadadustat, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences, Scalability, Physical and Theoretical Chemistry, Process engineering, business
Abstract

A novel and scalable process is developed for the industrial synthesis of vadadustat. The four-step process is one step shorter compared to the reported routes with an increase in total yield to 49...

Published
2021
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2. Development of a Quality Controllable and Scalable Process for the Preparation of 7,8-Difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-ol: A Key Intermediate for Baloxavir Marboxil

Author

Shuming Wu, Wu Xiwei, Zhou Zihong, Chuan-hua Li, Yuan Xi, Jingping Kou, Gaohong Liao, Junrong Zhang, and Zhongqing Wang

Subjects
Diphenyl disulfide, chemistry.chemical_compound, chemistry, 010405 organic chemistry, Thiophenol, Organic Chemistry, chemistry.chemical_element, Physical and Theoretical Chemistry, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, Sulfur, 0104 chemical sciences
Abstract

A novel six-step synthesis of 7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-ol (1) is described. Starting with 3,4-difloro-2-methylbenzoic acid and using diphenyl disulfide as an ideal sulfur sou...

Published
2019
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