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Start Over Author "Alison Campbell Brewer" Topic 010405 organic chemistry
2 results on '"Alison Campbell Brewer"'

1. Development and Scale-Up of a Direct Asymmetric Reductive Amination with Ammonia

Author

Alison Campbell Brewer, H. George Vandeveer, Scott Alan Frank, J. Craig Ruble, and C. Richard Nevill

Subjects
Primary (chemistry), 010405 organic chemistry, Chemistry, Organic Chemistry, chemistry.chemical_element, 010402 general chemistry, 01 natural sciences, Reductive amination, Combinatorial chemistry, 0104 chemical sciences, Ruthenium, Ammonia, chemistry.chemical_compound, Physical and Theoretical Chemistry
Abstract

Direct asymmetric reductive amination represents an efficient means of converting ketones to α-chiral primary amines, but reported examples are very limited. We describe the development of two sets...

Published
2021
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2. Development and Scale-Up of a Continuous Aerobic Oxidative Chan–Lam Coupling

Author

Alison Campbell Brewer, David C. Robbins, Joseph R. Martinelli, Nessa Mullane, Philip C. Hoffman, and Kobierski Michael Edward

Subjects
Active ingredient, 010405 organic chemistry, Chemistry, Organic Chemistry, Homogeneous catalysis, Continuous manufacturing, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences, Chan-Lam coupling, Atom economy, SCALE-UP, Physical and Theoretical Chemistry
Abstract

Despite the benefits of high atom economy and low cost, aerobic oxidations have found limited use in the synthesis of active pharmaceutical ingredients (APIs) because of safety concerns and poor se...

Published
2019
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