1. Metal–Organic Frameworks as Efficient Oral Detoxifying Agents
- Author
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Saad Saguem, Patricia Horcajada, Lisbeth Manchego, Christian Serre, Tarek Baati, Nissem Abdeljelil, Sara Rojas, Fadoua Neffati, Leila Njim, Mohamed Fadhel Najjar, and Abdelfateh Zakhama
- Subjects
Biodistribution ,Antidotes ,Administration, Oral ,02 engineering and technology ,In vivo toxicity ,Pharmacology ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Catalysis ,Health problems ,Colloid and Surface Chemistry ,Oral administration ,Detoxification ,Animals ,Tissue Distribution ,Rats, Wistar ,Metal-Organic Frameworks ,Aspirin ,Chemistry ,Salicylate overdose ,Stomach ,fungi ,General Chemistry ,021001 nanoscience & nanotechnology ,Biocompatible material ,3. Good health ,0104 chemical sciences ,Jejunum ,Liver ,Gastrointestinal Absorption ,Toxicity ,Female ,Adsorption ,Drug Overdose ,0210 nano-technology - Abstract
Poisoning and accidental oral intoxication are major health problems worldwide. Considering the insufficient efficacy of the currently available detoxification treatments, a pioneering oral detoxifying adsorbent agent based on a single biocompatible metal-organic framework (MOF) is here proposed for the efficient decontamination of drugs commonly implicated in accidental or voluntary poisoning. Furthermore, the in vivo toxicity and biodistribution of a MOF via oral administration have been investigated for the first time. Orally administered upon a salicylate overdose, this MOF is able to reduce the salicylate gastrointestinal absorption and toxicity more than 40-fold (avoiding histological damage) while exhibiting exceptional gastrointestinal stability (
- Published
- 2018
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