1. Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C. elegans
- Author
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Haeshim Baek, Eunseok Choi, Mihwa Seo, Chang Man Ha, Tae-Young Roh, Ao Lin Hsu, Sung Key Jang, Youngjae Ryu, Seon Woo A. An, Seokjin Ham, Seung-Jae Lee, Keunhee Seo, Yujin Lee, Heehwa G. Son, Eunju Kim, and Sangsoon Park
- Subjects
Transcriptional Activation ,0301 basic medicine ,endocrine system ,media_common.quotation_subject ,Longevity ,03 medical and health sciences ,Subcutaneous Tissue ,0302 clinical medicine ,Heat shock protein ,Genetics ,Daf-16 ,Animals ,Insulin ,Insulin-Like Growth Factor I ,Caenorhabditis elegans ,Caenorhabditis elegans Proteins ,HSF1 ,Transcription factor ,media_common ,biology ,Forkhead Transcription Factors ,Prefoldin ,Cell biology ,Intestines ,030104 developmental biology ,Chaperone (protein) ,biology.protein ,Chaperone complex ,030217 neurology & neurosurgery ,Research Paper ,Molecular Chaperones ,Protein Binding ,Signal Transduction ,Transcription Factors ,Developmental Biology - Abstract
Heat shock factor 1 (HSF-1) and forkhead box O (FOXO) are key transcription factors that protect cells from various stresses. In Caenorhabditis elegans, HSF-1 and FOXO together promote a long life span when insulin/IGF-1 signaling (IIS) is reduced. However, it remains poorly understood how HSF-1 and FOXO cooperate to confer IIS-mediated longevity. Here, we show that prefoldin 6 (PFD-6), a component of the molecular chaperone prefoldin-like complex, relays longevity response from HSF-1 to FOXO under reduced IIS. We found that PFD-6 was specifically required for reduced IIS-mediated longevity by acting in the intestine and hypodermis. We showed that HSF-1 increased the levels of PFD-6 proteins, which in turn directly bound FOXO and enhanced its transcriptional activity. Our work suggests that the prefoldin-like chaperone complex mediates longevity response from HSF-1 to FOXO to increase the life span in animals with reduced IIS.
- Published
- 2018