1. Assessment of targeted non-intentionally added substances in cosmetics in contact with plastic packagings. Analytical and toxicological aspects
- Author
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Pauline Murat, Sylvie Coslédan, Pierre-Jacques Ferret, Valérie Simon, Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE), Institut National de la Recherche Agronomique - INRA (FRANCE), Laboratoires Pierre Fabre (FRANCE), Laboratoire de Chimie Agro-Industrielle - LCA (Toulouse, France), Laboratoires Pierre Fabre, Laboratoire de Chimie Agro-Industrielle (LCA), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Supérieure de Chimie de Toulouse, Chimie Agro-Industrielle (CAI), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole nationale supérieure des ingénieurs en arts chimiques et technologiques-Institut National de la Recherche Agronomique (INRA), Centre de Recherche Pierre Fabre, and Institut National Polytechnique de Toulouse - INPT (FRANCE)
- Subjects
Bisphenol A ,media_common.quotation_subject ,Container-content interactions ,Phthalic Acids ,Cosmetics ,Toxicology ,Consumer safety ,03 medical and health sciences ,chemistry.chemical_compound ,0404 agricultural biotechnology ,Phenols ,Limit of Detection ,[SDV.IDA]Life Sciences [q-bio]/Food engineering ,Benzhydryl Compounds ,030304 developmental biology ,media_common ,0303 health sciences ,Chemistry ,Reproducibility of Results ,04 agricultural and veterinary sciences ,General Medicine ,Diisobutyl phthalate ,Contamination ,[SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences ,Non-intentionally added substances ,Pulp and paper industry ,040401 food science ,Packaging ,Safety assessment ,[SDV.TOX]Life Sciences [q-bio]/Toxicology ,Gas chromatography-mass spectrometry ,Sciences pharmaceutiques ,Cosmetic industry ,Plastics ,Food Science - Abstract
International audience; Container-content interactions are common in the food and pharmaceutical industries. However, these studies are more complicated in the cosmetic industry, and it is necessary to ensure consumer safety. The objective of this work was to develop a strategy for the toxicological evaluation of leachables for cosmetic packagings. Eleven common plastic packagings were selected to evaluate interactions with 5 simulants (acidic, alkaline and neutral water, 30% and 96% ethanol) chosen to mimic cosmetics behavior. A GC-MS method was developed to screen for 12 non-intentionally added substances of particular concern: 10 phthalates, bisphenol A and distearyl thiodipropionate (European Pharmacopoeia plastic additive 17). Results were analyzed using a toxicological procedure established for this study. Some phthalates and bisphenol A were detected in several samples, but only one contaminant, diisobutyl phthalate (DiBP), was found to be above the set concentration threshold. Using toxicological data, this concentration was found to be safe for users. 96% ethanol appeared to be the strongest simulant in term of extraction, with a maximum concentration of 491 μg/L for DiBP in a 100% styrene-acrylonitrile copolymer packaging. In water simulants, less contaminants were extracted, with concentrations under 20 μg/L.
- Published
- 2018
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