1. Epidemiology of norovirus gastroenteritis in hospitalized children under five years old in western China, 2015–2019
- Author
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Baoning Wang, Yu Kuang, Yuan Yang, Linlin Zhou, Hongren Wang, Xiaozhen Ma, Mingyuan Li, Wanyi Li, Jiangzhou You, Zhong-Yi Zhao, Ran-Ran Cao, and Min Ren
- Subjects
Male ,0301 basic medicine ,Genes, Viral ,Epidemiology ,viruses ,medicine.disease_cause ,Feces ,fluids and secretions ,0302 clinical medicine ,Risk Factors ,Rotavirus ,Genotype ,Immunology and Allergy ,030212 general & internal medicine ,Children ,Phylogeny ,Caliciviridae Infections ,biology ,Under-five ,Coinfection ,virus diseases ,General Medicine ,QR1-502 ,Gastroenteritis ,Hospitalization ,Infectious Diseases ,Child, Preschool ,Viruses ,Female ,Seasons ,Microbiology (medical) ,China ,medicine.medical_specialty ,Genotypes ,030106 microbiology ,West China ,Microbiology ,Virus ,Astrovirus ,03 medical and health sciences ,medicine ,Humans ,General Immunology and Microbiology ,business.industry ,Norovirus ,Infant, Newborn ,Infant ,Sapovirus ,biology.organism_classification ,Virology ,digestive system diseases ,business - Abstract
Objectives: Norovirus is associated with one-fifth of all gastroenteritis cases, but basic epidemiological data is lacking, especially in developing countries. As long-term surveillance on norovirus gastroenteritis is scarce in western China, this study aims to update the epidemiological knowledge of norovirus gastroenteritis and to characterize the genotypes of norovirus strains. Methods: Stool samples were collected from hospitalized children under 5 years old with gastroenteritis in Chengdu, China. All samples were tested for norovirus as well as rotavirus, sapovirus, enteric adenovirus, and astrovirus by real-time RT-PCR. RdRp and VP1 genes were sequenced in norovirus-positive samples to investigate viral phylogenies. Results: Of the 1181 samples collected from 2015 to 2019, 242 (20.5%) were positive for norovirus.Among norovirus-positive cases, 65 cases had co-infection with another virus; norovirus/enteric adenovirus was most frequently detected (50.8%, 33/65). The highest positive rate was observed in children aged 13–18 months (23.7%, 68/287). Norovirus infection peaked in autumn (36.6%, 91/249), followed by summer (20.3%, 70/345). Pearson correlation analysis showed significant correlation between the norovirus-positive rate and humidity (r = 0.773, P
- Published
- 2021